Full text data of RER1
RER1
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Protein RER1
Protein RER1
UniProt
O15258
ID RER1_HUMAN Reviewed; 196 AA.
AC O15258; O95322;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JAN-1998, sequence version 1.
DT 22-JAN-2014, entry version 109.
DE RecName: Full=Protein RER1;
GN Name=RER1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Mammary cancer;
RX PubMed=9309388;
RA Fuellekrug J., Boehm J., Roettger S., Nilsson T., Mieskes G.,
RA Schmitt H.;
RT "Human Rer1 is localized to the Golgi apparatus and complements the
RT deletion of the homologous Rer1 protein of Saccharomyces cerevisiae.";
RL Eur. J. Cell Biol. 74:31-40(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Barrow I.K.-P., Boguski M.S., Touchman J.W., Spencer F.;
RT "Full-insert sequence of mapped XREF EST.";
RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-95, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of
RT the kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, AND MASS
RP SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE
RP SCALE ANALYSIS] AT SER-6 AND SER-95, AND MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, AND MASS
RP SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Involved in the retrieval of endoplasmic reticulum
CC membrane proteins from the early Golgi compartment (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the RER1 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AJ001421; CAA04754.1; -; mRNA.
DR EMBL; AF091071; AAC72940.1; -; mRNA.
DR EMBL; BC004965; AAH04965.1; -; mRNA.
DR RefSeq; NP_008964.3; NM_007033.4.
DR RefSeq; XP_005244769.1; XM_005244712.1.
DR RefSeq; XP_005244770.1; XM_005244713.1.
DR UniGene; Hs.525527; -.
DR ProteinModelPortal; O15258; -.
DR IntAct; O15258; 6.
DR MINT; MINT-4726643; -.
DR STRING; 9606.ENSP00000302088; -.
DR TCDB; 9.B.82.1.2; endoplasmic reticulum retrieval protein1 (putative heavy metal transporter) (rer1) family.
DR PhosphoSite; O15258; -.
DR PaxDb; O15258; -.
DR PRIDE; O15258; -.
DR DNASU; 11079; -.
DR Ensembl; ENST00000488353; ENSP00000464222; ENSG00000157916.
DR Ensembl; ENST00000605895; ENSP00000475168; ENSG00000157916.
DR GeneID; 11079; -.
DR KEGG; hsa:11079; -.
DR UCSC; uc001aje.2; human.
DR CTD; 11079; -.
DR GeneCards; GC01P002313; -.
DR HGNC; HGNC:30309; RER1.
DR HPA; CAB037240; -.
DR neXtProt; NX_O15258; -.
DR PharmGKB; PA134901074; -.
DR eggNOG; COG5249; -.
DR HOVERGEN; HBG002871; -.
DR InParanoid; O15258; -.
DR OMA; HGKRRYR; -.
DR OrthoDB; EOG7QRQVV; -.
DR ChiTaRS; RER1; human.
DR GenomeRNAi; 11079; -.
DR NextBio; 42122; -.
DR PRO; PR:O15258; -.
DR ArrayExpress; O15258; -.
DR Bgee; O15258; -.
DR CleanEx; HS_RER1; -.
DR Genevestigator; O15258; -.
DR GO; GO:0030173; C:integral to Golgi membrane; IDA:UniProtKB.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IDA:UniProtKB.
DR InterPro; IPR004932; Rer1.
DR PANTHER; PTHR10743; PTHR10743; 1.
DR Pfam; PF03248; Rer1; 1.
DR PIRSF; PIRSF016013; AtER_Rer1p; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Golgi apparatus; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 196 Protein RER1.
FT /FTId=PRO_0000207589.
FT TRANSMEM 41 61 Helical; (Potential).
FT TRANSMEM 63 83 Helical; (Potential).
FT TRANSMEM 140 160 Helical; (Potential).
FT MOD_RES 2 2 N-acetylserine.
FT MOD_RES 6 6 Phosphoserine.
FT MOD_RES 95 95 Phosphoserine.
FT CONFLICT 123 196 HAATKGILVAMVCTFFDAFNVPVFWPILVMYFIMLFCITMK
FT RQIKHMIKYRYIPFTHGKRRYRGKEDAGKAFAS -> DASV
FT CGDGRCSCKAGGGRQCPVLAADAALTFSPHLKACGYQGHPC
FT GYGLYFLRRFQRPGVLADSGDVLHHALLYHDEEANQAHD
FT (in Ref. 2; AAC72940).
SQ SEQUENCE 196 AA; 22958 MW; 0FF7F3CDC9F88A69 CRC64;
MSEGDSVGES VHGKPSVVYR FFTRLGQIYQ SWLDKSTPYT AVRWVVTLGL SFVYMIRVYL
LQGWYIVTYA LGIYHLNLFI AFLSPKVDPS LMEDSDDGPS LPTKQNEEFR PFIRRLPEFK
FWHAATKGIL VAMVCTFFDA FNVPVFWPIL VMYFIMLFCI TMKRQIKHMI KYRYIPFTHG
KRRYRGKEDA GKAFAS
//
ID RER1_HUMAN Reviewed; 196 AA.
AC O15258; O95322;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JAN-1998, sequence version 1.
DT 22-JAN-2014, entry version 109.
DE RecName: Full=Protein RER1;
GN Name=RER1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Mammary cancer;
RX PubMed=9309388;
RA Fuellekrug J., Boehm J., Roettger S., Nilsson T., Mieskes G.,
RA Schmitt H.;
RT "Human Rer1 is localized to the Golgi apparatus and complements the
RT deletion of the homologous Rer1 protein of Saccharomyces cerevisiae.";
RL Eur. J. Cell Biol. 74:31-40(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Barrow I.K.-P., Boguski M.S., Touchman J.W., Spencer F.;
RT "Full-insert sequence of mapped XREF EST.";
RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-95, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of
RT the kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, AND MASS
RP SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE
RP SCALE ANALYSIS] AT SER-6 AND SER-95, AND MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, AND MASS
RP SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Involved in the retrieval of endoplasmic reticulum
CC membrane proteins from the early Golgi compartment (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the RER1 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AJ001421; CAA04754.1; -; mRNA.
DR EMBL; AF091071; AAC72940.1; -; mRNA.
DR EMBL; BC004965; AAH04965.1; -; mRNA.
DR RefSeq; NP_008964.3; NM_007033.4.
DR RefSeq; XP_005244769.1; XM_005244712.1.
DR RefSeq; XP_005244770.1; XM_005244713.1.
DR UniGene; Hs.525527; -.
DR ProteinModelPortal; O15258; -.
DR IntAct; O15258; 6.
DR MINT; MINT-4726643; -.
DR STRING; 9606.ENSP00000302088; -.
DR TCDB; 9.B.82.1.2; endoplasmic reticulum retrieval protein1 (putative heavy metal transporter) (rer1) family.
DR PhosphoSite; O15258; -.
DR PaxDb; O15258; -.
DR PRIDE; O15258; -.
DR DNASU; 11079; -.
DR Ensembl; ENST00000488353; ENSP00000464222; ENSG00000157916.
DR Ensembl; ENST00000605895; ENSP00000475168; ENSG00000157916.
DR GeneID; 11079; -.
DR KEGG; hsa:11079; -.
DR UCSC; uc001aje.2; human.
DR CTD; 11079; -.
DR GeneCards; GC01P002313; -.
DR HGNC; HGNC:30309; RER1.
DR HPA; CAB037240; -.
DR neXtProt; NX_O15258; -.
DR PharmGKB; PA134901074; -.
DR eggNOG; COG5249; -.
DR HOVERGEN; HBG002871; -.
DR InParanoid; O15258; -.
DR OMA; HGKRRYR; -.
DR OrthoDB; EOG7QRQVV; -.
DR ChiTaRS; RER1; human.
DR GenomeRNAi; 11079; -.
DR NextBio; 42122; -.
DR PRO; PR:O15258; -.
DR ArrayExpress; O15258; -.
DR Bgee; O15258; -.
DR CleanEx; HS_RER1; -.
DR Genevestigator; O15258; -.
DR GO; GO:0030173; C:integral to Golgi membrane; IDA:UniProtKB.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IDA:UniProtKB.
DR InterPro; IPR004932; Rer1.
DR PANTHER; PTHR10743; PTHR10743; 1.
DR Pfam; PF03248; Rer1; 1.
DR PIRSF; PIRSF016013; AtER_Rer1p; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Golgi apparatus; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 196 Protein RER1.
FT /FTId=PRO_0000207589.
FT TRANSMEM 41 61 Helical; (Potential).
FT TRANSMEM 63 83 Helical; (Potential).
FT TRANSMEM 140 160 Helical; (Potential).
FT MOD_RES 2 2 N-acetylserine.
FT MOD_RES 6 6 Phosphoserine.
FT MOD_RES 95 95 Phosphoserine.
FT CONFLICT 123 196 HAATKGILVAMVCTFFDAFNVPVFWPILVMYFIMLFCITMK
FT RQIKHMIKYRYIPFTHGKRRYRGKEDAGKAFAS -> DASV
FT CGDGRCSCKAGGGRQCPVLAADAALTFSPHLKACGYQGHPC
FT GYGLYFLRRFQRPGVLADSGDVLHHALLYHDEEANQAHD
FT (in Ref. 2; AAC72940).
SQ SEQUENCE 196 AA; 22958 MW; 0FF7F3CDC9F88A69 CRC64;
MSEGDSVGES VHGKPSVVYR FFTRLGQIYQ SWLDKSTPYT AVRWVVTLGL SFVYMIRVYL
LQGWYIVTYA LGIYHLNLFI AFLSPKVDPS LMEDSDDGPS LPTKQNEEFR PFIRRLPEFK
FWHAATKGIL VAMVCTFFDA FNVPVFWPIL VMYFIMLFCI TMKRQIKHMI KYRYIPFTHG
KRRYRGKEDA GKAFAS
//