Full text data of RPL18
RPL18
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
60S ribosomal protein L18
Note: presumably soluble (membrane word is not in UniProt keywords or features)
60S ribosomal protein L18
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q07020
ID RL18_HUMAN Reviewed; 188 AA.
AC Q07020; Q8WTZ6;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 128.
DE RecName: Full=60S ribosomal protein L18;
GN Name=RPL18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Colon;
RX PubMed=8218404; DOI=10.1016/0167-4781(93)90050-N;
RA Puder M., Barnard G.F., Staniunas R.J., Steele G.D. Jr., Chen L.B.;
RT "Nucleotide and deduced amino acid sequence of human ribosomal protein
RT L18.";
RL Biochim. Biophys. Acta 1216:134-136(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875025; DOI=10.1101/gr.214202;
RA Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S.,
RA Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.;
RT "The human ribosomal protein genes: sequencing and comparative
RT analysis of 73 genes.";
RL Genome Res. 12:379-390(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 2-14, AND MASS SPECTROMETRY.
RX PubMed=12962325; DOI=10.1023/A:1025068419698;
RA Odintsova T.I., Muller E.C., Ivanov A.V., Egorov T.A., Bienert R.,
RA Vladimirov S.N., Kostka S., Otto A., Wittmann-Liebold B.,
RA Karpova G.G.;
RT "Characterization and analysis of posttranslational modifications of
RT the human large cytoplasmic ribosomal subunit proteins by mass
RT spectrometry and Edman sequencing.";
RL J. Protein Chem. 22:249-258(2003).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=16964243; DOI=10.1038/nbt1240;
RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
RT "A probability-based approach for high-throughput protein
RT phosphorylation analysis and site localization.";
RL Nat. Biotechnol. 24:1285-1292(2006).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of
RT the kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130 AND THR-158, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASS
RP SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [11]
RP STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the ribosomal protein L18e family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; L11566; AAA16329.1; -; mRNA.
DR EMBL; AB061825; BAB79463.1; -; Genomic_DNA.
DR EMBL; BC000374; AAH00374.1; -; mRNA.
DR EMBL; BC009708; AAH09708.1; -; mRNA.
DR EMBL; BC021743; AAH21743.1; -; mRNA.
DR PIR; S38352; S38352.
DR RefSeq; NP_000970.1; NM_000979.3.
DR UniGene; Hs.515517; -.
DR PDB; 3J3B; EM; 5.00 A; Q=1-188.
DR PDBsum; 3J3B; -.
DR ProteinModelPortal; Q07020; -.
DR SMR; Q07020; 1-188.
DR IntAct; Q07020; 20.
DR MINT; MINT-5000047; -.
DR STRING; 9606.ENSP00000084795; -.
DR PhosphoSite; Q07020; -.
DR DMDM; 548749; -.
DR SWISS-2DPAGE; Q07020; -.
DR PaxDb; Q07020; -.
DR PeptideAtlas; Q07020; -.
DR PRIDE; Q07020; -.
DR DNASU; 6141; -.
DR Ensembl; ENST00000549920; ENSP00000447001; ENSG00000063177.
DR GeneID; 6141; -.
DR KEGG; hsa:6141; -.
DR UCSC; uc002pjq.2; human.
DR CTD; 6141; -.
DR GeneCards; GC19M049118; -.
DR H-InvDB; HIX0018528; -.
DR HGNC; HGNC:10310; RPL18.
DR HPA; HPA046572; -.
DR MIM; 604179; gene.
DR neXtProt; NX_Q07020; -.
DR PharmGKB; PA34679; -.
DR eggNOG; COG1727; -.
DR HOGENOM; HOG000213425; -.
DR HOVERGEN; HBG000875; -.
DR InParanoid; Q07020; -.
DR KO; K02883; -.
DR OrthoDB; EOG7PS1GP; -.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_17015; Metabolism of proteins.
DR Reactome; REACT_1762; 3' -UTR-mediated translational regulation.
DR Reactome; REACT_21257; Metabolism of RNA.
DR Reactome; REACT_71; Gene Expression.
DR ChiTaRS; RPL18; human.
DR GeneWiki; RPL18; -.
DR GenomeRNAi; 6141; -.
DR NextBio; 23857; -.
DR PRO; PR:Q07020; -.
DR ArrayExpress; Q07020; -.
DR Bgee; Q07020; -.
DR CleanEx; HS_RPL18; -.
DR Genevestigator; Q07020; -.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; TAS:ProtInc.
DR GO; GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
DR GO; GO:0006414; P:translational elongation; TAS:Reactome.
DR GO; GO:0006413; P:translational initiation; TAS:Reactome.
DR GO; GO:0006415; P:translational termination; TAS:Reactome.
DR GO; GO:0019083; P:viral transcription; TAS:Reactome.
DR InterPro; IPR000039; Ribosomal_L18e.
DR InterPro; IPR021131; Ribosomal_L18e/L15P.
DR InterPro; IPR021132; Ribosomal_L18e_CS.
DR PANTHER; PTHR10934; PTHR10934; 1.
DR Pfam; PF00828; Ribosomal_L18e; 1.
DR SUPFAM; SSF52080; SSF52080; 1.
DR PROSITE; PS01106; RIBOSOMAL_L18E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing;
KW Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 188 60S ribosomal protein L18.
FT /FTId=PRO_0000132769.
FT MOD_RES 130 130 Phosphoserine.
FT MOD_RES 158 158 Phosphothreonine.
FT CONFLICT 62 62 S -> C (in Ref. 3; AAH21743).
SQ SEQUENCE 188 AA; 21634 MW; C4E416E7A5329B7C CRC64;
MGVDIRHNKD RKVRRKEPKS QDIYLRLLVK LYRFLARRTN STFNQVVLKR LFMSRTNRPP
LSLSRMIRKM KLPGRENKTA VVVGTITDDV RVQEVPKLKV CALRVTSRAR SRILRAGGKI
LTFDQLALDS PKGCGTVLLS GPRKGREVYR HFGKAPGTPH SHTKPYVRSK GRKFERARGR
RASRGYKN
//
ID RL18_HUMAN Reviewed; 188 AA.
AC Q07020; Q8WTZ6;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 128.
DE RecName: Full=60S ribosomal protein L18;
GN Name=RPL18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Colon;
RX PubMed=8218404; DOI=10.1016/0167-4781(93)90050-N;
RA Puder M., Barnard G.F., Staniunas R.J., Steele G.D. Jr., Chen L.B.;
RT "Nucleotide and deduced amino acid sequence of human ribosomal protein
RT L18.";
RL Biochim. Biophys. Acta 1216:134-136(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875025; DOI=10.1101/gr.214202;
RA Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S.,
RA Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N.;
RT "The human ribosomal protein genes: sequencing and comparative
RT analysis of 73 genes.";
RL Genome Res. 12:379-390(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PROTEIN SEQUENCE OF 2-14, AND MASS SPECTROMETRY.
RX PubMed=12962325; DOI=10.1023/A:1025068419698;
RA Odintsova T.I., Muller E.C., Ivanov A.V., Egorov T.A., Bienert R.,
RA Vladimirov S.N., Kostka S., Otto A., Wittmann-Liebold B.,
RA Karpova G.G.;
RT "Characterization and analysis of posttranslational modifications of
RT the human large cytoplasmic ribosomal subunit proteins by mass
RT spectrometry and Edman sequencing.";
RL J. Protein Chem. 22:249-258(2003).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=16964243; DOI=10.1038/nbt1240;
RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
RT "A probability-based approach for high-throughput protein
RT phosphorylation analysis and site localization.";
RL Nat. Biotechnol. 24:1285-1292(2006).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of
RT the kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130 AND THR-158, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, AND MASS
RP SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [11]
RP STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the ribosomal protein L18e family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; L11566; AAA16329.1; -; mRNA.
DR EMBL; AB061825; BAB79463.1; -; Genomic_DNA.
DR EMBL; BC000374; AAH00374.1; -; mRNA.
DR EMBL; BC009708; AAH09708.1; -; mRNA.
DR EMBL; BC021743; AAH21743.1; -; mRNA.
DR PIR; S38352; S38352.
DR RefSeq; NP_000970.1; NM_000979.3.
DR UniGene; Hs.515517; -.
DR PDB; 3J3B; EM; 5.00 A; Q=1-188.
DR PDBsum; 3J3B; -.
DR ProteinModelPortal; Q07020; -.
DR SMR; Q07020; 1-188.
DR IntAct; Q07020; 20.
DR MINT; MINT-5000047; -.
DR STRING; 9606.ENSP00000084795; -.
DR PhosphoSite; Q07020; -.
DR DMDM; 548749; -.
DR SWISS-2DPAGE; Q07020; -.
DR PaxDb; Q07020; -.
DR PeptideAtlas; Q07020; -.
DR PRIDE; Q07020; -.
DR DNASU; 6141; -.
DR Ensembl; ENST00000549920; ENSP00000447001; ENSG00000063177.
DR GeneID; 6141; -.
DR KEGG; hsa:6141; -.
DR UCSC; uc002pjq.2; human.
DR CTD; 6141; -.
DR GeneCards; GC19M049118; -.
DR H-InvDB; HIX0018528; -.
DR HGNC; HGNC:10310; RPL18.
DR HPA; HPA046572; -.
DR MIM; 604179; gene.
DR neXtProt; NX_Q07020; -.
DR PharmGKB; PA34679; -.
DR eggNOG; COG1727; -.
DR HOGENOM; HOG000213425; -.
DR HOVERGEN; HBG000875; -.
DR InParanoid; Q07020; -.
DR KO; K02883; -.
DR OrthoDB; EOG7PS1GP; -.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_17015; Metabolism of proteins.
DR Reactome; REACT_1762; 3' -UTR-mediated translational regulation.
DR Reactome; REACT_21257; Metabolism of RNA.
DR Reactome; REACT_71; Gene Expression.
DR ChiTaRS; RPL18; human.
DR GeneWiki; RPL18; -.
DR GenomeRNAi; 6141; -.
DR NextBio; 23857; -.
DR PRO; PR:Q07020; -.
DR ArrayExpress; Q07020; -.
DR Bgee; Q07020; -.
DR CleanEx; HS_RPL18; -.
DR Genevestigator; Q07020; -.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; TAS:ProtInc.
DR GO; GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
DR GO; GO:0006414; P:translational elongation; TAS:Reactome.
DR GO; GO:0006413; P:translational initiation; TAS:Reactome.
DR GO; GO:0006415; P:translational termination; TAS:Reactome.
DR GO; GO:0019083; P:viral transcription; TAS:Reactome.
DR InterPro; IPR000039; Ribosomal_L18e.
DR InterPro; IPR021131; Ribosomal_L18e/L15P.
DR InterPro; IPR021132; Ribosomal_L18e_CS.
DR PANTHER; PTHR10934; PTHR10934; 1.
DR Pfam; PF00828; Ribosomal_L18e; 1.
DR SUPFAM; SSF52080; SSF52080; 1.
DR PROSITE; PS01106; RIBOSOMAL_L18E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing;
KW Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 188 60S ribosomal protein L18.
FT /FTId=PRO_0000132769.
FT MOD_RES 130 130 Phosphoserine.
FT MOD_RES 158 158 Phosphothreonine.
FT CONFLICT 62 62 S -> C (in Ref. 3; AAH21743).
SQ SEQUENCE 188 AA; 21634 MW; C4E416E7A5329B7C CRC64;
MGVDIRHNKD RKVRRKEPKS QDIYLRLLVK LYRFLARRTN STFNQVVLKR LFMSRTNRPP
LSLSRMIRKM KLPGRENKTA VVVGTITDDV RVQEVPKLKV CALRVTSRAR SRILRAGGKI
LTFDQLALDS PKGCGTVLLS GPRKGREVYR HFGKAPGTPH SHTKPYVRSK GRKFERARGR
RASRGYKN
//
MIM
604179
*RECORD*
*FIELD* NO
604179
*FIELD* TI
*604179 RIBOSOMAL PROTEIN L18; RPL18
*FIELD* TX
The mammalian ribosome is composed of 4 RNA species (see 180450) and
read moreapproximately 80 different proteins (see 180466).
Puder et al. (1993) isolated a partial human RPL18 cDNA from a cDNA
library generated by subtracting a normal colon cDNA library from a
colon tumor cDNA library. By PCR of a human normal colon cDNA library
using oligonucleotides based on the partial cDNA, they cloned a
full-length RPL18 cDNA. The deduced 188-amino acid human RPL18 protein
is 97% identical to rat Rpl18. Northern blot analysis detected an
approximately 650-bp RPL18 transcript in human liver and colon.
By somatic cell hybrid and radiation hybrid mapping analyses, Kenmochi
et al. (1998) mapped the human RPL18 gene to 19q.
*FIELD* RF
1. Kenmochi, N.; Kawaguchi, T.; Rozen, S.; Davis, E.; Goodman, N.;
Hudson, T. J.; Tanaka, T.; Page, D. C.: A map of 75 human ribosomal
protein genes. Genome Res. 8: 509-523, 1998.
2. Puder, M.; Barnard, G. F.; Staniunas, R. J.; Steele, G. D., Jr.;
Chen, L. B.: Nucleotide and deduced amino acid sequence of human
ribosomal protein L18. Biochim. Biophys. Acta 1216: 134-136, 1993.
*FIELD* CD
Patti M. Sherman: 9/21/1999
*FIELD* ED
mgross: 09/23/1999
psherman: 9/22/1999
*RECORD*
*FIELD* NO
604179
*FIELD* TI
*604179 RIBOSOMAL PROTEIN L18; RPL18
*FIELD* TX
The mammalian ribosome is composed of 4 RNA species (see 180450) and
read moreapproximately 80 different proteins (see 180466).
Puder et al. (1993) isolated a partial human RPL18 cDNA from a cDNA
library generated by subtracting a normal colon cDNA library from a
colon tumor cDNA library. By PCR of a human normal colon cDNA library
using oligonucleotides based on the partial cDNA, they cloned a
full-length RPL18 cDNA. The deduced 188-amino acid human RPL18 protein
is 97% identical to rat Rpl18. Northern blot analysis detected an
approximately 650-bp RPL18 transcript in human liver and colon.
By somatic cell hybrid and radiation hybrid mapping analyses, Kenmochi
et al. (1998) mapped the human RPL18 gene to 19q.
*FIELD* RF
1. Kenmochi, N.; Kawaguchi, T.; Rozen, S.; Davis, E.; Goodman, N.;
Hudson, T. J.; Tanaka, T.; Page, D. C.: A map of 75 human ribosomal
protein genes. Genome Res. 8: 509-523, 1998.
2. Puder, M.; Barnard, G. F.; Staniunas, R. J.; Steele, G. D., Jr.;
Chen, L. B.: Nucleotide and deduced amino acid sequence of human
ribosomal protein L18. Biochim. Biophys. Acta 1216: 134-136, 1993.
*FIELD* CD
Patti M. Sherman: 9/21/1999
*FIELD* ED
mgross: 09/23/1999
psherman: 9/22/1999