Full text data of RPL7A
RPL7A
(SURF-3, SURF3)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
60S ribosomal protein L7a (PLA-X polypeptide; Surfeit locus protein 3)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
60S ribosomal protein L7a (PLA-X polypeptide; Surfeit locus protein 3)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
P62424
ID RL7A_HUMAN Reviewed; 266 AA.
AC P62424; P11518; Q5T8U4;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 103.
DE RecName: Full=60S ribosomal protein L7a;
DE AltName: Full=PLA-X polypeptide;
DE AltName: Full=Surfeit locus protein 3;
GN Name=RPL7A; Synonyms=SURF-3, SURF3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RX PubMed=2966065;
RA Kozma S.C., Redmond S.M.S., Saurer S.M., Groner B., Hynes N.E.;
RT "Activation of the receptor kinase domain of the trk oncogene by
RT recombination with two different cellular sequences.";
RL EMBO J. 7:147-154(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1756182; DOI=10.1016/0167-4781(91)90218-B;
RA Colombo P., Yon J., Fried M.;
RT "The organization and expression of the human L7a ribosomal protein
RT gene.";
RL Biochim. Biophys. Acta 1129:93-95(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8482538; DOI=10.1016/0378-1119(93)90371-9;
RA De Falco S., Russo G., Angiolillo A., Pietropaolo C.;
RT "Human L7a ribosomal protein: sequence, structural organization, and
RT expression of a functional gene.";
RL Gene 126:227-235(1993).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1696715; DOI=10.1073/pnas.87.16.6039;
RA Ben-Ishai R., Scharf R., Sharon R., Kapten I.;
RT "A human cellular sequence implicated in trk oncogene activation is
RT DNA damage inducible.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:6039-6043(1990).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA Rogers J., Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=B-cell, Eye, Lung, Placenta, Skin, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-34; LYS-97 AND LYS-217, AND
RP MASS SPECTROMETRY.
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA Walther T.C., Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [11]
RP STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- INTERACTION:
CC O95793:STAU1; NbExp=2; IntAct=EBI-354172, EBI-358174;
CC -!- DISEASE: Note=Chromosomal recombination involving RPL7A activates
CC the receptor kinase domain of the TRK oncogene.
CC -!- SIMILARITY: Belongs to the ribosomal protein L7Ae family.
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DR EMBL; X06705; CAA29889.1; -; mRNA.
DR EMBL; X52138; CAA36383.1; -; Genomic_DNA.
DR EMBL; X61923; CAA43925.1; -; Genomic_DNA.
DR EMBL; M36072; AAA60282.1; -; mRNA.
DR EMBL; AK291123; BAF83812.1; -; mRNA.
DR EMBL; AK311743; BAG34686.1; -; mRNA.
DR EMBL; AL158826; CAI12832.1; -; Genomic_DNA.
DR EMBL; CH471090; EAW88063.1; -; Genomic_DNA.
DR EMBL; BC005128; AAH05128.1; -; mRNA.
DR EMBL; BC021979; AAH21979.1; -; mRNA.
DR EMBL; BC023594; AAH23594.1; -; mRNA.
DR EMBL; BC023624; AAH23624.1; -; mRNA.
DR EMBL; BC071900; AAH71900.1; -; mRNA.
DR EMBL; BC071901; AAH71901.1; -; mRNA.
DR EMBL; BC073802; AAH73802.1; -; mRNA.
DR EMBL; BC105290; AAI05291.1; -; mRNA.
DR PIR; S19717; R5HU7A.
DR RefSeq; NP_000963.1; NM_000972.2.
DR UniGene; Hs.499839; -.
DR PDB; 3J3B; EM; 5.00 A; G=1-266.
DR PDBsum; 3J3B; -.
DR ProteinModelPortal; P62424; -.
DR SMR; P62424; 21-266.
DR IntAct; P62424; 28.
DR MINT; MINT-1149515; -.
DR STRING; 9606.ENSP00000361076; -.
DR PhosphoSite; P62424; -.
DR DMDM; 54039239; -.
DR SWISS-2DPAGE; P62424; -.
DR PaxDb; P62424; -.
DR PRIDE; P62424; -.
DR DNASU; 6130; -.
DR Ensembl; ENST00000323345; ENSP00000361076; ENSG00000148303.
DR Ensembl; ENST00000564892; ENSP00000455188; ENSG00000260501.
DR GeneID; 6130; -.
DR KEGG; hsa:6130; -.
DR UCSC; uc004cde.1; human.
DR CTD; 6130; -.
DR GeneCards; GC09P136215; -.
DR HGNC; HGNC:10364; RPL7A.
DR HPA; HPA046794; -.
DR MIM; 185640; gene.
DR neXtProt; NX_P62424; -.
DR PharmGKB; PA34760; -.
DR eggNOG; COG1358; -.
DR HOGENOM; HOG000216644; -.
DR HOVERGEN; HBG002936; -.
DR InParanoid; P62424; -.
DR KO; K02936; -.
DR OMA; SIAFTQV; -.
DR PhylomeDB; P62424; -.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_17015; Metabolism of proteins.
DR Reactome; REACT_1762; 3' -UTR-mediated translational regulation.
DR Reactome; REACT_21257; Metabolism of RNA.
DR Reactome; REACT_71; Gene Expression.
DR ChiTaRS; RPL7A; human.
DR GeneWiki; RPL7A; -.
DR GenomeRNAi; 6130; -.
DR NextBio; 23809; -.
DR PRO; PR:P62424; -.
DR ArrayExpress; P62424; -.
DR Bgee; P62424; -.
DR CleanEx; HS_RPL7A; -.
DR Genevestigator; P62424; -.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0016020; C:membrane; IDA:BHF-UCL.
DR GO; GO:0042788; C:polysomal ribosome; IDA:HGNC.
DR GO; GO:0003723; F:RNA binding; TAS:ProtInc.
DR GO; GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:InterPro.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
DR GO; GO:0006414; P:translational elongation; TAS:Reactome.
DR GO; GO:0006413; P:translational initiation; TAS:Reactome.
DR GO; GO:0006415; P:translational termination; TAS:Reactome.
DR GO; GO:0019083; P:viral transcription; TAS:Reactome.
DR InterPro; IPR001921; Ribosomal_L7A/L8.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR InterPro; IPR018492; Ribosomal_L7Ae/L8/Nhp2.
DR InterPro; IPR004037; Ribosomal_L7Ae_CS.
DR PANTHER; PTHR23105:SF1; PTHR23105:SF1; 1.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR PRINTS; PR00881; L7ARS6FAMILY.
DR PRINTS; PR00882; RIBOSOMALL7A.
DR PROSITE; PS01082; RIBOSOMAL_L7AE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Chromosomal rearrangement;
KW Complete proteome; Polymorphism; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT INIT_MET 1 1 Removed (By similarity).
FT CHAIN 2 266 60S ribosomal protein L7a.
FT /FTId=PRO_0000136747.
FT MOD_RES 34 34 N6-acetyllysine.
FT MOD_RES 97 97 N6-acetyllysine.
FT MOD_RES 217 217 N6-acetyllysine.
FT VARIANT 24 24 A -> V (in dbSNP:rs12295).
FT /FTId=VAR_014721.
SQ SEQUENCE 266 AA; 29996 MW; 54EF43F221D9F704 CRC64;
MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD LTRFVKWPRY
IRLQRQRAIL YKRLKVPPAI NQFTQALDRQ TATQLLKLAH KYRPETKQEK KQRLLARAEK
KAAGKGDVPT KRPPVLRAGV NTVTTLVENK KAQLVVIAHD VDPIELVVFL PALCRKMGVP
YCIIKGKARL GRLVHRKTCT TVAFTQVNSE DKGALAKLVE AIRTNYNDRY DEIRRHWGGN
VLGPKSVARI AKLEKAKAKE LATKLG
//
ID RL7A_HUMAN Reviewed; 266 AA.
AC P62424; P11518; Q5T8U4;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 103.
DE RecName: Full=60S ribosomal protein L7a;
DE AltName: Full=PLA-X polypeptide;
DE AltName: Full=Surfeit locus protein 3;
GN Name=RPL7A; Synonyms=SURF-3, SURF3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RX PubMed=2966065;
RA Kozma S.C., Redmond S.M.S., Saurer S.M., Groner B., Hynes N.E.;
RT "Activation of the receptor kinase domain of the trk oncogene by
RT recombination with two different cellular sequences.";
RL EMBO J. 7:147-154(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1756182; DOI=10.1016/0167-4781(91)90218-B;
RA Colombo P., Yon J., Fried M.;
RT "The organization and expression of the human L7a ribosomal protein
RT gene.";
RL Biochim. Biophys. Acta 1129:93-95(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8482538; DOI=10.1016/0378-1119(93)90371-9;
RA De Falco S., Russo G., Angiolillo A., Pietropaolo C.;
RT "Human L7a ribosomal protein: sequence, structural organization, and
RT expression of a functional gene.";
RL Gene 126:227-235(1993).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1696715; DOI=10.1073/pnas.87.16.6039;
RA Ben-Ishai R., Scharf R., Sharon R., Kapten I.;
RT "A human cellular sequence implicated in trk oncogene activation is
RT DNA damage inducible.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:6039-6043(1990).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA Rogers J., Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=B-cell, Eye, Lung, Placenta, Skin, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-34; LYS-97 AND LYS-217, AND
RP MASS SPECTROMETRY.
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA Walther T.C., Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [11]
RP STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- INTERACTION:
CC O95793:STAU1; NbExp=2; IntAct=EBI-354172, EBI-358174;
CC -!- DISEASE: Note=Chromosomal recombination involving RPL7A activates
CC the receptor kinase domain of the TRK oncogene.
CC -!- SIMILARITY: Belongs to the ribosomal protein L7Ae family.
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DR EMBL; X06705; CAA29889.1; -; mRNA.
DR EMBL; X52138; CAA36383.1; -; Genomic_DNA.
DR EMBL; X61923; CAA43925.1; -; Genomic_DNA.
DR EMBL; M36072; AAA60282.1; -; mRNA.
DR EMBL; AK291123; BAF83812.1; -; mRNA.
DR EMBL; AK311743; BAG34686.1; -; mRNA.
DR EMBL; AL158826; CAI12832.1; -; Genomic_DNA.
DR EMBL; CH471090; EAW88063.1; -; Genomic_DNA.
DR EMBL; BC005128; AAH05128.1; -; mRNA.
DR EMBL; BC021979; AAH21979.1; -; mRNA.
DR EMBL; BC023594; AAH23594.1; -; mRNA.
DR EMBL; BC023624; AAH23624.1; -; mRNA.
DR EMBL; BC071900; AAH71900.1; -; mRNA.
DR EMBL; BC071901; AAH71901.1; -; mRNA.
DR EMBL; BC073802; AAH73802.1; -; mRNA.
DR EMBL; BC105290; AAI05291.1; -; mRNA.
DR PIR; S19717; R5HU7A.
DR RefSeq; NP_000963.1; NM_000972.2.
DR UniGene; Hs.499839; -.
DR PDB; 3J3B; EM; 5.00 A; G=1-266.
DR PDBsum; 3J3B; -.
DR ProteinModelPortal; P62424; -.
DR SMR; P62424; 21-266.
DR IntAct; P62424; 28.
DR MINT; MINT-1149515; -.
DR STRING; 9606.ENSP00000361076; -.
DR PhosphoSite; P62424; -.
DR DMDM; 54039239; -.
DR SWISS-2DPAGE; P62424; -.
DR PaxDb; P62424; -.
DR PRIDE; P62424; -.
DR DNASU; 6130; -.
DR Ensembl; ENST00000323345; ENSP00000361076; ENSG00000148303.
DR Ensembl; ENST00000564892; ENSP00000455188; ENSG00000260501.
DR GeneID; 6130; -.
DR KEGG; hsa:6130; -.
DR UCSC; uc004cde.1; human.
DR CTD; 6130; -.
DR GeneCards; GC09P136215; -.
DR HGNC; HGNC:10364; RPL7A.
DR HPA; HPA046794; -.
DR MIM; 185640; gene.
DR neXtProt; NX_P62424; -.
DR PharmGKB; PA34760; -.
DR eggNOG; COG1358; -.
DR HOGENOM; HOG000216644; -.
DR HOVERGEN; HBG002936; -.
DR InParanoid; P62424; -.
DR KO; K02936; -.
DR OMA; SIAFTQV; -.
DR PhylomeDB; P62424; -.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_17015; Metabolism of proteins.
DR Reactome; REACT_1762; 3' -UTR-mediated translational regulation.
DR Reactome; REACT_21257; Metabolism of RNA.
DR Reactome; REACT_71; Gene Expression.
DR ChiTaRS; RPL7A; human.
DR GeneWiki; RPL7A; -.
DR GenomeRNAi; 6130; -.
DR NextBio; 23809; -.
DR PRO; PR:P62424; -.
DR ArrayExpress; P62424; -.
DR Bgee; P62424; -.
DR CleanEx; HS_RPL7A; -.
DR Genevestigator; P62424; -.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0016020; C:membrane; IDA:BHF-UCL.
DR GO; GO:0042788; C:polysomal ribosome; IDA:HGNC.
DR GO; GO:0003723; F:RNA binding; TAS:ProtInc.
DR GO; GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:InterPro.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
DR GO; GO:0006414; P:translational elongation; TAS:Reactome.
DR GO; GO:0006413; P:translational initiation; TAS:Reactome.
DR GO; GO:0006415; P:translational termination; TAS:Reactome.
DR GO; GO:0019083; P:viral transcription; TAS:Reactome.
DR InterPro; IPR001921; Ribosomal_L7A/L8.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR InterPro; IPR018492; Ribosomal_L7Ae/L8/Nhp2.
DR InterPro; IPR004037; Ribosomal_L7Ae_CS.
DR PANTHER; PTHR23105:SF1; PTHR23105:SF1; 1.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR PRINTS; PR00881; L7ARS6FAMILY.
DR PRINTS; PR00882; RIBOSOMALL7A.
DR PROSITE; PS01082; RIBOSOMAL_L7AE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Chromosomal rearrangement;
KW Complete proteome; Polymorphism; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT INIT_MET 1 1 Removed (By similarity).
FT CHAIN 2 266 60S ribosomal protein L7a.
FT /FTId=PRO_0000136747.
FT MOD_RES 34 34 N6-acetyllysine.
FT MOD_RES 97 97 N6-acetyllysine.
FT MOD_RES 217 217 N6-acetyllysine.
FT VARIANT 24 24 A -> V (in dbSNP:rs12295).
FT /FTId=VAR_014721.
SQ SEQUENCE 266 AA; 29996 MW; 54EF43F221D9F704 CRC64;
MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD LTRFVKWPRY
IRLQRQRAIL YKRLKVPPAI NQFTQALDRQ TATQLLKLAH KYRPETKQEK KQRLLARAEK
KAAGKGDVPT KRPPVLRAGV NTVTTLVENK KAQLVVIAHD VDPIELVVFL PALCRKMGVP
YCIIKGKARL GRLVHRKTCT TVAFTQVNSE DKGALAKLVE AIRTNYNDRY DEIRRHWGGN
VLGPKSVARI AKLEKAKAKE LATKLG
//
MIM
185640
*RECORD*
*FIELD* NO
185640
*FIELD* TI
*185640 RIBOSOMAL PROTEIN L7a; RPL7A
;;SURFEIT 3; SURF3
*FIELD* TX
The mammalian ribosome is composed of 4 RNA species (see 180450) and
read moreapproximately 80 different proteins (see 180466).
CLONING
Giallongo et al. (1989) demonstrated that the SURF3 gene encodes the L7a
ribosomal protein. The first 2 exons of the human SURF3 gene have been
found to be capable of activating the TRK oncogene (see 191315). The
SURF3 gene appears to be the only intron-containing member of the
surfeit family cluster on chromosome 9q34 (see SURF1, 185620).
GENE STRUCTURE
Angiolillo et al. (2002) determined that transcription start sites of
the MED22 (185641) and RPL7A genes are separated by a 110-bp region that
shows bidirectional promoter activity. This promoter region lacks a TATA
box but is characterized by a CpG island that extends through the first
exon into the first intron of both genes.
MAPPING
Yon et al. (1993) mapped the RPLA7 gene to chromosome 9q34.1. Kenmochi
et al. (1998) confirmed the mapping assignment.
MOLECULAR GENETICS
Mor et al. (1996) described a common polymorphism in the surfeit gene
cluster that was of interest because it occurs in the TSC1 (191100)
region of chromosome 9q34. By database analysis, Smith (1997) found that
the polymorphism reported by Mor et al. (1996) is due to mutation in the
SURF3 gene.
*FIELD* RF
1. Angiolillo, A.; Russo, G.; Procellini, A.; Smaldone, S.; D'Alessandro,
F.; Pietropaolo, C.: The human homologue of the mouse Surf5 gene
encodes multiple alternatively spliced transcripts. Gene 284: 169-178,
2002.
2. Giallongo, A.; Yon, J.; Fried, M.: The ribosomal protein L7a is
encoded by a gene (Surf-3) within the tightly clustered mouse surfeit
locus. Molec. Cell. Biol. 9: 224-231, 1989.
3. Kenmochi, N.; Kawaguchi, T.; Rozen, S.; Davis, E.; Goodman, N.;
Hudson, T. J.; Tanaka, T.; Page, D. C.: A map of 75 human ribosomal
protein genes. Genome Res. 8: 509-523, 1998.
4. Mor, O.; Duhig, T.; Fried, M.: A high frequency polymorphism in
the candidate region for tuberous sclerosis 1 (TSC1) at 9q34. Ann.
Hum. Genet. 60: 259-260, 1996.
5. Smith, M.: Personal Communication. Baltimore, Md. 1/2/1997.
6. Yon, J.; Jones, T.; Garson, K.; Sheer, D.; Fried, M.: The organization
and conservation of the human Surfeit gene cluster and its localization
telomeric to the c-abl and can proto-oncogenes at chromosome band
9q34.1. Hum. Molec. Genet. 2: 237-240, 1993.
*FIELD* CN
Patricia A. Hartz - updated: 10/30/2008
Patti M. Sherman - updated: 9/21/2000
Moyra Smith - updated: 1/2/1997
*FIELD* CD
Victor A. McKusick: 8/29/1989
*FIELD* ED
wwang: 10/30/2008
terry: 10/30/2008
carol: 8/20/2008
carol: 2/24/2004
psherman: 9/21/2000
psherman: 9/10/1999
psherman: 2/2/1999
terry: 8/12/1998
mark: 1/2/1997
carol: 9/13/1994
supermim: 3/16/1992
supermim: 3/20/1990
carol: 12/15/1989
ddp: 10/27/1989
root: 8/29/1989
*RECORD*
*FIELD* NO
185640
*FIELD* TI
*185640 RIBOSOMAL PROTEIN L7a; RPL7A
;;SURFEIT 3; SURF3
*FIELD* TX
The mammalian ribosome is composed of 4 RNA species (see 180450) and
read moreapproximately 80 different proteins (see 180466).
CLONING
Giallongo et al. (1989) demonstrated that the SURF3 gene encodes the L7a
ribosomal protein. The first 2 exons of the human SURF3 gene have been
found to be capable of activating the TRK oncogene (see 191315). The
SURF3 gene appears to be the only intron-containing member of the
surfeit family cluster on chromosome 9q34 (see SURF1, 185620).
GENE STRUCTURE
Angiolillo et al. (2002) determined that transcription start sites of
the MED22 (185641) and RPL7A genes are separated by a 110-bp region that
shows bidirectional promoter activity. This promoter region lacks a TATA
box but is characterized by a CpG island that extends through the first
exon into the first intron of both genes.
MAPPING
Yon et al. (1993) mapped the RPLA7 gene to chromosome 9q34.1. Kenmochi
et al. (1998) confirmed the mapping assignment.
MOLECULAR GENETICS
Mor et al. (1996) described a common polymorphism in the surfeit gene
cluster that was of interest because it occurs in the TSC1 (191100)
region of chromosome 9q34. By database analysis, Smith (1997) found that
the polymorphism reported by Mor et al. (1996) is due to mutation in the
SURF3 gene.
*FIELD* RF
1. Angiolillo, A.; Russo, G.; Procellini, A.; Smaldone, S.; D'Alessandro,
F.; Pietropaolo, C.: The human homologue of the mouse Surf5 gene
encodes multiple alternatively spliced transcripts. Gene 284: 169-178,
2002.
2. Giallongo, A.; Yon, J.; Fried, M.: The ribosomal protein L7a is
encoded by a gene (Surf-3) within the tightly clustered mouse surfeit
locus. Molec. Cell. Biol. 9: 224-231, 1989.
3. Kenmochi, N.; Kawaguchi, T.; Rozen, S.; Davis, E.; Goodman, N.;
Hudson, T. J.; Tanaka, T.; Page, D. C.: A map of 75 human ribosomal
protein genes. Genome Res. 8: 509-523, 1998.
4. Mor, O.; Duhig, T.; Fried, M.: A high frequency polymorphism in
the candidate region for tuberous sclerosis 1 (TSC1) at 9q34. Ann.
Hum. Genet. 60: 259-260, 1996.
5. Smith, M.: Personal Communication. Baltimore, Md. 1/2/1997.
6. Yon, J.; Jones, T.; Garson, K.; Sheer, D.; Fried, M.: The organization
and conservation of the human Surfeit gene cluster and its localization
telomeric to the c-abl and can proto-oncogenes at chromosome band
9q34.1. Hum. Molec. Genet. 2: 237-240, 1993.
*FIELD* CN
Patricia A. Hartz - updated: 10/30/2008
Patti M. Sherman - updated: 9/21/2000
Moyra Smith - updated: 1/2/1997
*FIELD* CD
Victor A. McKusick: 8/29/1989
*FIELD* ED
wwang: 10/30/2008
terry: 10/30/2008
carol: 8/20/2008
carol: 2/24/2004
psherman: 9/21/2000
psherman: 9/10/1999
psherman: 2/2/1999
terry: 8/12/1998
mark: 1/2/1997
carol: 9/13/1994
supermim: 3/16/1992
supermim: 3/20/1990
carol: 12/15/1989
ddp: 10/27/1989
root: 8/29/1989