Full text data of RPL9
RPL9
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
60S ribosomal protein L9
Note: presumably soluble (membrane word is not in UniProt keywords or features)
60S ribosomal protein L9
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
P32969
ID RL9_HUMAN Reviewed; 192 AA.
AC P32969;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-1993, sequence version 1.
DT 22-JAN-2014, entry version 145.
DE RecName: Full=60S ribosomal protein L9;
GN Name=RPL9; ORFNames=OK/SW-cl.103;
GN and
GN Name=RPL9P7;
GN and
GN Name=RPL9P8;
GN and
GN Name=RPL9P9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=8415001; DOI=10.1093/nar/21.18.4395;
RA Hori N., Murakawa K., Matoba R., Fukushima A., Okubo K., Matsubara K.;
RT "A new human ribosomal protein sequence, homologue of rat L9.";
RL Nucleic Acids Res. 21:4395-4395(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Retina;
RX PubMed=8597601; DOI=10.1016/0167-4781(95)00201-4;
RA Mazuruk K., Schoen T.J., Chader G.J., Iwata T., Rodriguez I.R.;
RT "Structural organization and chromosomal localization of the human
RT ribosomal protein L9 gene.";
RL Biochim. Biophys. Acta 1305:151-162(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Williams J.H., Pearse M.J., Power D.A.;
RT "Human homolog of rat ribosomal protein L9.";
RL Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon adenocarcinoma;
RA Shichijo S., Itoh K.;
RT "Identification of immuno-peptidmics that are recognized by tumor-
RT reactive CTL generated from TIL of colon cancer patients.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Muscle, Placenta, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 1-21; 36-51; 94-115; 142-168 AND 174-184, LACK OF
RP N-TERMINAL ACETYLATION, AND MASS SPECTROMETRY.
RC TISSUE=Colon carcinoma;
RA Bienvenut W.V., Bilsland A.E., Keith W.N.;
RL Submitted (JAN-2010) to UniProtKB.
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 146-192.
RX PubMed=9582194;
RA Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N.,
RA Hudson T.J., Tanaka T., Page D.C.;
RT "A map of 75 human ribosomal protein genes.";
RL Genome Res. 8:509-523(1998).
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-121, AND MASS SPECTROMETRY.
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA Walther T.C., Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [11]
RP STRUCTURE BY NMR OF 1-87.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the N-terminal domain of human ribosomal
RT protein L9.";
RL Submitted (NOV-2005) to the PDB data bank.
RN [12]
RP STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS) OF 80S RIBOSOME.
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- SIMILARITY: Belongs to the ribosomal protein L6P family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; D14531; BAA03401.1; -; mRNA.
DR EMBL; U09953; AAB01040.1; -; mRNA.
DR EMBL; U09954; AAB01041.1; -; Genomic_DNA.
DR EMBL; U21138; AAA63752.1; -; mRNA.
DR EMBL; AB062431; BAB93494.1; -; mRNA.
DR EMBL; BC000483; AAH00483.1; -; mRNA.
DR EMBL; BC004156; AAH04156.1; -; mRNA.
DR EMBL; BC004206; AAH04206.1; -; mRNA.
DR EMBL; BC007967; AAH07967.1; -; mRNA.
DR EMBL; BC012149; AAH12149.1; -; mRNA.
DR EMBL; BC031906; AAH31906.1; -; mRNA.
DR EMBL; BC066318; AAH66318.1; -; mRNA.
DR EMBL; BC070214; AAH70214.1; -; mRNA.
DR EMBL; AB007169; BAA25830.1; -; Genomic_DNA.
DR PIR; S65792; S65792.
DR RefSeq; NP_000652.2; NM_000661.4.
DR RefSeq; NP_001020092.1; NM_001024921.2.
DR RefSeq; XP_005262718.1; XM_005262661.1.
DR UniGene; Hs.412370; -.
DR UniGene; Hs.513083; -.
DR UniGene; Hs.730597; -.
DR PDB; 2CQL; NMR; -; A=1-87.
DR PDB; 3J3B; EM; 5.00 A; H=1-192.
DR PDBsum; 2CQL; -.
DR PDBsum; 3J3B; -.
DR ProteinModelPortal; P32969; -.
DR SMR; P32969; 1-191.
DR IntAct; P32969; 17.
DR MINT; MINT-5000985; -.
DR STRING; 9606.ENSP00000346022; -.
DR PhosphoSite; P32969; -.
DR DMDM; 417677; -.
DR SWISS-2DPAGE; P32969; -.
DR PaxDb; P32969; -.
DR PeptideAtlas; P32969; -.
DR PRIDE; P32969; -.
DR DNASU; 6133; -.
DR Ensembl; ENST00000295955; ENSP00000346022; ENSG00000163682.
DR Ensembl; ENST00000449470; ENSP00000400467; ENSG00000163682.
DR GeneID; 6133; -.
DR KEGG; hsa:6133; -.
DR UCSC; uc003gub.3; human.
DR CTD; 6133; -.
DR HGNC; HGNC:10369; RPL9.
DR HPA; HPA003372; -.
DR MIM; 603686; gene.
DR neXtProt; NX_P32969; -.
DR PharmGKB; PA34769; -.
DR eggNOG; COG0097; -.
DR HOGENOM; HOG000039905; -.
DR HOVERGEN; HBG000942; -.
DR InParanoid; P32969; -.
DR KO; K02940; -.
DR OMA; LKVVYSH; -.
DR OrthoDB; EOG7353Z4; -.
DR PhylomeDB; P32969; -.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_17015; Metabolism of proteins.
DR Reactome; REACT_1762; 3' -UTR-mediated translational regulation.
DR Reactome; REACT_21257; Metabolism of RNA.
DR Reactome; REACT_71; Gene Expression.
DR EvolutionaryTrace; P32969; -.
DR GeneWiki; RPL9; -.
DR GenomeRNAi; 6133; -.
DR NextBio; 23821; -.
DR PRO; PR:P32969; -.
DR ArrayExpress; P32969; -.
DR Bgee; P32969; -.
DR CleanEx; HS_RPL9; -.
DR Genevestigator; P32969; -.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0003723; F:RNA binding; TAS:ProtInc.
DR GO; GO:0019843; F:rRNA binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
DR GO; GO:0006414; P:translational elongation; TAS:Reactome.
DR GO; GO:0006413; P:translational initiation; TAS:Reactome.
DR GO; GO:0006415; P:translational termination; TAS:Reactome.
DR GO; GO:0019083; P:viral transcription; TAS:Reactome.
DR Gene3D; 3.90.930.12; -; 2.
DR InterPro; IPR000702; Ribosomal_L6.
DR InterPro; IPR020040; Ribosomal_L6_a/b-dom.
DR InterPro; IPR002359; Ribosomal_L6_CS2.
DR PANTHER; PTHR11655; PTHR11655; 1.
DR Pfam; PF00347; Ribosomal_L6; 2.
DR PIRSF; PIRSF002162; Ribosomal_L6; 1.
DR SUPFAM; SSF56053; SSF56053; 2.
DR PROSITE; PS00700; RIBOSOMAL_L6_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Complete proteome;
KW Direct protein sequencing; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1 192 60S ribosomal protein L9.
FT /FTId=PRO_0000131097.
FT SITE 1 1 Not acetylated.
FT MOD_RES 121 121 N6-acetyllysine.
FT CONFLICT 11 11 D -> E (in Ref. 2; AAB01040/AAB01041).
FT STRAND 8 10
FT STRAND 17 21
FT STRAND 24 29
FT STRAND 32 37
FT STRAND 44 48
FT STRAND 50 52
FT STRAND 54 58
FT STRAND 61 63
FT HELIX 65 85
SQ SEQUENCE 192 AA; 21863 MW; 0249E6CA12F77934 CRC64;
MKTILSNQTV DIPENVDITL KGRTVIVKGP RGTLRRDFNH INVELSLLGK KKKRLRVDKW
WGNRKELATV RTICSHVQNM IKGVTLGFRY KMRSVYAHFP INVVIQENGS LVEIRNFLGE
KYIRRVRMRP GVACSVSQAQ KDELILEGND IELVSNSAAL IQQATTVKNK DIRKFLDGIY
VSEKGTVQQA DE
//
ID RL9_HUMAN Reviewed; 192 AA.
AC P32969;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-1993, sequence version 1.
DT 22-JAN-2014, entry version 145.
DE RecName: Full=60S ribosomal protein L9;
GN Name=RPL9; ORFNames=OK/SW-cl.103;
GN and
GN Name=RPL9P7;
GN and
GN Name=RPL9P8;
GN and
GN Name=RPL9P9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=8415001; DOI=10.1093/nar/21.18.4395;
RA Hori N., Murakawa K., Matoba R., Fukushima A., Okubo K., Matsubara K.;
RT "A new human ribosomal protein sequence, homologue of rat L9.";
RL Nucleic Acids Res. 21:4395-4395(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Retina;
RX PubMed=8597601; DOI=10.1016/0167-4781(95)00201-4;
RA Mazuruk K., Schoen T.J., Chader G.J., Iwata T., Rodriguez I.R.;
RT "Structural organization and chromosomal localization of the human
RT ribosomal protein L9 gene.";
RL Biochim. Biophys. Acta 1305:151-162(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Williams J.H., Pearse M.J., Power D.A.;
RT "Human homolog of rat ribosomal protein L9.";
RL Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon adenocarcinoma;
RA Shichijo S., Itoh K.;
RT "Identification of immuno-peptidmics that are recognized by tumor-
RT reactive CTL generated from TIL of colon cancer patients.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Muscle, Placenta, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 1-21; 36-51; 94-115; 142-168 AND 174-184, LACK OF
RP N-TERMINAL ACETYLATION, AND MASS SPECTROMETRY.
RC TISSUE=Colon carcinoma;
RA Bienvenut W.V., Bilsland A.E., Keith W.N.;
RL Submitted (JAN-2010) to UniProtKB.
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 146-192.
RX PubMed=9582194;
RA Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N.,
RA Hudson T.J., Tanaka T., Page D.C.;
RT "A map of 75 human ribosomal protein genes.";
RL Genome Res. 8:509-523(1998).
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-121, AND MASS SPECTROMETRY.
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA Walther T.C., Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [11]
RP STRUCTURE BY NMR OF 1-87.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the N-terminal domain of human ribosomal
RT protein L9.";
RL Submitted (NOV-2005) to the PDB data bank.
RN [12]
RP STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS) OF 80S RIBOSOME.
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- SIMILARITY: Belongs to the ribosomal protein L6P family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; D14531; BAA03401.1; -; mRNA.
DR EMBL; U09953; AAB01040.1; -; mRNA.
DR EMBL; U09954; AAB01041.1; -; Genomic_DNA.
DR EMBL; U21138; AAA63752.1; -; mRNA.
DR EMBL; AB062431; BAB93494.1; -; mRNA.
DR EMBL; BC000483; AAH00483.1; -; mRNA.
DR EMBL; BC004156; AAH04156.1; -; mRNA.
DR EMBL; BC004206; AAH04206.1; -; mRNA.
DR EMBL; BC007967; AAH07967.1; -; mRNA.
DR EMBL; BC012149; AAH12149.1; -; mRNA.
DR EMBL; BC031906; AAH31906.1; -; mRNA.
DR EMBL; BC066318; AAH66318.1; -; mRNA.
DR EMBL; BC070214; AAH70214.1; -; mRNA.
DR EMBL; AB007169; BAA25830.1; -; Genomic_DNA.
DR PIR; S65792; S65792.
DR RefSeq; NP_000652.2; NM_000661.4.
DR RefSeq; NP_001020092.1; NM_001024921.2.
DR RefSeq; XP_005262718.1; XM_005262661.1.
DR UniGene; Hs.412370; -.
DR UniGene; Hs.513083; -.
DR UniGene; Hs.730597; -.
DR PDB; 2CQL; NMR; -; A=1-87.
DR PDB; 3J3B; EM; 5.00 A; H=1-192.
DR PDBsum; 2CQL; -.
DR PDBsum; 3J3B; -.
DR ProteinModelPortal; P32969; -.
DR SMR; P32969; 1-191.
DR IntAct; P32969; 17.
DR MINT; MINT-5000985; -.
DR STRING; 9606.ENSP00000346022; -.
DR PhosphoSite; P32969; -.
DR DMDM; 417677; -.
DR SWISS-2DPAGE; P32969; -.
DR PaxDb; P32969; -.
DR PeptideAtlas; P32969; -.
DR PRIDE; P32969; -.
DR DNASU; 6133; -.
DR Ensembl; ENST00000295955; ENSP00000346022; ENSG00000163682.
DR Ensembl; ENST00000449470; ENSP00000400467; ENSG00000163682.
DR GeneID; 6133; -.
DR KEGG; hsa:6133; -.
DR UCSC; uc003gub.3; human.
DR CTD; 6133; -.
DR HGNC; HGNC:10369; RPL9.
DR HPA; HPA003372; -.
DR MIM; 603686; gene.
DR neXtProt; NX_P32969; -.
DR PharmGKB; PA34769; -.
DR eggNOG; COG0097; -.
DR HOGENOM; HOG000039905; -.
DR HOVERGEN; HBG000942; -.
DR InParanoid; P32969; -.
DR KO; K02940; -.
DR OMA; LKVVYSH; -.
DR OrthoDB; EOG7353Z4; -.
DR PhylomeDB; P32969; -.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_17015; Metabolism of proteins.
DR Reactome; REACT_1762; 3' -UTR-mediated translational regulation.
DR Reactome; REACT_21257; Metabolism of RNA.
DR Reactome; REACT_71; Gene Expression.
DR EvolutionaryTrace; P32969; -.
DR GeneWiki; RPL9; -.
DR GenomeRNAi; 6133; -.
DR NextBio; 23821; -.
DR PRO; PR:P32969; -.
DR ArrayExpress; P32969; -.
DR Bgee; P32969; -.
DR CleanEx; HS_RPL9; -.
DR Genevestigator; P32969; -.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0003723; F:RNA binding; TAS:ProtInc.
DR GO; GO:0019843; F:rRNA binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
DR GO; GO:0006414; P:translational elongation; TAS:Reactome.
DR GO; GO:0006413; P:translational initiation; TAS:Reactome.
DR GO; GO:0006415; P:translational termination; TAS:Reactome.
DR GO; GO:0019083; P:viral transcription; TAS:Reactome.
DR Gene3D; 3.90.930.12; -; 2.
DR InterPro; IPR000702; Ribosomal_L6.
DR InterPro; IPR020040; Ribosomal_L6_a/b-dom.
DR InterPro; IPR002359; Ribosomal_L6_CS2.
DR PANTHER; PTHR11655; PTHR11655; 1.
DR Pfam; PF00347; Ribosomal_L6; 2.
DR PIRSF; PIRSF002162; Ribosomal_L6; 1.
DR SUPFAM; SSF56053; SSF56053; 2.
DR PROSITE; PS00700; RIBOSOMAL_L6_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Complete proteome;
KW Direct protein sequencing; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1 192 60S ribosomal protein L9.
FT /FTId=PRO_0000131097.
FT SITE 1 1 Not acetylated.
FT MOD_RES 121 121 N6-acetyllysine.
FT CONFLICT 11 11 D -> E (in Ref. 2; AAB01040/AAB01041).
FT STRAND 8 10
FT STRAND 17 21
FT STRAND 24 29
FT STRAND 32 37
FT STRAND 44 48
FT STRAND 50 52
FT STRAND 54 58
FT STRAND 61 63
FT HELIX 65 85
SQ SEQUENCE 192 AA; 21863 MW; 0249E6CA12F77934 CRC64;
MKTILSNQTV DIPENVDITL KGRTVIVKGP RGTLRRDFNH INVELSLLGK KKKRLRVDKW
WGNRKELATV RTICSHVQNM IKGVTLGFRY KMRSVYAHFP INVVIQENGS LVEIRNFLGE
KYIRRVRMRP GVACSVSQAQ KDELILEGND IELVSNSAAL IQQATTVKNK DIRKFLDGIY
VSEKGTVQQA DE
//
MIM
603686
*RECORD*
*FIELD* NO
603686
*FIELD* TI
*603686 RIBOSOMAL PROTEIN L9; RPL9
*FIELD* TX
The eukaryotic ribosome, which consists of a large (60S) subunit and a
read moresmall (40S) subunit, is composed of 4 RNA species (see 180450) and
approximately 80 different proteins. The ribosomal protein genes appear
to be members of multigene families, most of which are composed of
multiple intronless pseudogenes and 1 intron-containing functional gene.
Hori et al. (1993) isolated a cDNA encoding the 60S ribosomal protein L9
(RPL9) from a human liver cancer cell line (HepG2) cDNA library. The
deduced 192-amino acid human RPL9 protein differs from the rat Rpl9
protein by 2 amino acids. Northern blot analysis detected an
approximately 800-bp RPL9 transcript in HepG2 cells.
Mazuruk et al. (1996) isolated RPL9 cDNAs and genomic clones. The RPL9
gene contains 8 exons and spans approximately 5.5 kb. Northern blot
analysis showed expression of an approximately 700-bp RPL9 transcript in
all human adult and fetal tissues examined. The authors detected at
least 8 putative processed RPL9 pseudogenes.
Using somatic cell hybrid analysis and FISH, Mazuruk et al. (1996)
mapped the intron-containing RPL9 gene to 4p13. Kenmochi et al. (1998)
confirmed the RPL9 mapping assignment reported by Mazuruk et al. (1996).
Mazuruk et al. (1996) mapped an RPL9 pseudogene (GenBank GENBANK U09955)
to Xpter-p21.
*FIELD* RF
1. Hori, N.; Murakawa, K.; Matoba, R.; Fukushima, A.; Okubo, K.; Matsubara,
K.: A new human ribosomal protein sequence, homologue of rat L9. Nucleic
Acids Res. 21: 4395 only, 1993.
2. Kenmochi, N.; Kawaguchi, T.; Rozen, S.; Davis, E.; Goodman, N.;
Hudson, T. J.; Tanaka, T.; Page, D. C.: A map of 75 human ribosomal
protein genes. Genome Res. 8: 509-523, 1998.
3. Mazuruk, K.; Schoen, T. J.; Chader, G. J.; Iwata, T.; Rodriguez,
I. R.: Structural organization and chromosomal localization of the
human ribosomal protein L9 gene. Biochim. Biophys. Acta 1305: 151-162,
1996.
*FIELD* CD
Patti M. Sherman: 3/31/1999
*FIELD* ED
carol: 04/16/1999
*RECORD*
*FIELD* NO
603686
*FIELD* TI
*603686 RIBOSOMAL PROTEIN L9; RPL9
*FIELD* TX
The eukaryotic ribosome, which consists of a large (60S) subunit and a
read moresmall (40S) subunit, is composed of 4 RNA species (see 180450) and
approximately 80 different proteins. The ribosomal protein genes appear
to be members of multigene families, most of which are composed of
multiple intronless pseudogenes and 1 intron-containing functional gene.
Hori et al. (1993) isolated a cDNA encoding the 60S ribosomal protein L9
(RPL9) from a human liver cancer cell line (HepG2) cDNA library. The
deduced 192-amino acid human RPL9 protein differs from the rat Rpl9
protein by 2 amino acids. Northern blot analysis detected an
approximately 800-bp RPL9 transcript in HepG2 cells.
Mazuruk et al. (1996) isolated RPL9 cDNAs and genomic clones. The RPL9
gene contains 8 exons and spans approximately 5.5 kb. Northern blot
analysis showed expression of an approximately 700-bp RPL9 transcript in
all human adult and fetal tissues examined. The authors detected at
least 8 putative processed RPL9 pseudogenes.
Using somatic cell hybrid analysis and FISH, Mazuruk et al. (1996)
mapped the intron-containing RPL9 gene to 4p13. Kenmochi et al. (1998)
confirmed the RPL9 mapping assignment reported by Mazuruk et al. (1996).
Mazuruk et al. (1996) mapped an RPL9 pseudogene (GenBank GENBANK U09955)
to Xpter-p21.
*FIELD* RF
1. Hori, N.; Murakawa, K.; Matoba, R.; Fukushima, A.; Okubo, K.; Matsubara,
K.: A new human ribosomal protein sequence, homologue of rat L9. Nucleic
Acids Res. 21: 4395 only, 1993.
2. Kenmochi, N.; Kawaguchi, T.; Rozen, S.; Davis, E.; Goodman, N.;
Hudson, T. J.; Tanaka, T.; Page, D. C.: A map of 75 human ribosomal
protein genes. Genome Res. 8: 509-523, 1998.
3. Mazuruk, K.; Schoen, T. J.; Chader, G. J.; Iwata, T.; Rodriguez,
I. R.: Structural organization and chromosomal localization of the
human ribosomal protein L9 gene. Biochim. Biophys. Acta 1305: 151-162,
1996.
*FIELD* CD
Patti M. Sherman: 3/31/1999
*FIELD* ED
carol: 04/16/1999