Full text data of RNF121
RNF121
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
RING finger protein 121
RING finger protein 121
UniProt
Q9H920
ID RN121_HUMAN Reviewed; 327 AA.
AC Q9H920; Q6IA57; Q6P449; Q96DB4;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2001, sequence version 1.
DT 22-JAN-2014, entry version 92.
DE RecName: Full=RING finger protein 121;
GN Name=RNF121;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-327.
RC TISSUE=Duodenum, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- SIMILARITY: Belongs to the RNF121 family.
CC -!- SIMILARITY: Contains 1 RING-type zinc finger.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH09672.2; Type=Erroneous initiation;
CC Sequence=AAH63680.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK023139; BAB14423.1; -; mRNA.
DR EMBL; CR457298; CAG33579.1; -; mRNA.
DR EMBL; BC009672; AAH09672.2; ALT_INIT; mRNA.
DR EMBL; BC063680; AAH63680.1; ALT_INIT; mRNA.
DR RefSeq; NP_060790.2; NM_018320.4.
DR UniGene; Hs.368554; -.
DR ProteinModelPortal; Q9H920; -.
DR SMR; Q9H920; 219-289.
DR STRING; 9606.ENSP00000354571; -.
DR PhosphoSite; Q9H920; -.
DR DMDM; 74761545; -.
DR PaxDb; Q9H920; -.
DR PRIDE; Q9H920; -.
DR DNASU; 55298; -.
DR Ensembl; ENST00000361756; ENSP00000354571; ENSG00000137522.
DR GeneID; 55298; -.
DR KEGG; hsa:55298; -.
DR UCSC; uc001ora.3; human.
DR CTD; 55298; -.
DR GeneCards; GC11P071640; -.
DR HGNC; HGNC:21070; RNF121.
DR HPA; HPA046041; -.
DR neXtProt; NX_Q9H920; -.
DR PharmGKB; PA134985388; -.
DR eggNOG; NOG327922; -.
DR HOGENOM; HOG000021822; -.
DR HOVERGEN; HBG061177; -.
DR InParanoid; Q9H920; -.
DR KO; K15698; -.
DR OMA; VIENTYK; -.
DR OrthoDB; EOG7R831T; -.
DR GenomeRNAi; 55298; -.
DR NextBio; 59508; -.
DR PRO; PR:Q9H920; -.
DR ArrayExpress; Q9H920; -.
DR Bgee; Q9H920; -.
DR CleanEx; HS_RNF121; -.
DR Genevestigator; Q9H920; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS00518; ZF_RING_1; FALSE_NEG.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Membrane; Metal-binding;
KW Reference proteome; Transmembrane; Transmembrane helix; Zinc;
KW Zinc-finger.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 327 RING finger protein 121.
FT /FTId=PRO_0000261407.
FT TRANSMEM 50 70 Helical; (Potential).
FT TRANSMEM 79 99 Helical; (Potential).
FT TRANSMEM 100 120 Helical; (Potential).
FT TRANSMEM 148 168 Helical; (Potential).
FT TRANSMEM 172 192 Helical; (Potential).
FT TRANSMEM 306 326 Helical; (Potential).
FT ZN_FING 226 276 RING-type; atypical.
FT MOD_RES 2 2 N-acetylalanine.
FT CONFLICT 327 327 E -> D (in Ref. 2; CAG33579).
SQ SEQUENCE 327 AA; 37882 MW; FFC170FF52AB15CD CRC64;
MAAVVEVEVG GGAAGERELD EVDMSDLSPE EQWRVEHARM HAKHRGHEAM HAEMVLILIA
TLVVAQLLLV QWKQRHPRSY NMVTLFQMWV VPLYFTVKLH WWRFLVIWIL FSAVTAFVTF
RATRKPLVQT TPRLVYKWFL LIYKISYATG IVGYMAVMFT LFGLNLLFKI KPEDAMDFGI
SLLFYGLYYG VLERDFAEMC ADYMASTIGF YSESGMPTKH LSDSVCAVCG QQIFVDVSEE
GIIENTYRLS CNHVFHEFCI RGWCIVGKKQ TCPYCKEKVD LKRMFSNPWE RPHVMYGQLL
DWLRYLVAWQ PVIIGVVQGI NYILGLE
//
ID RN121_HUMAN Reviewed; 327 AA.
AC Q9H920; Q6IA57; Q6P449; Q96DB4;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2001, sequence version 1.
DT 22-JAN-2014, entry version 92.
DE RecName: Full=RING finger protein 121;
GN Name=RNF121;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-327.
RC TISSUE=Duodenum, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- SIMILARITY: Belongs to the RNF121 family.
CC -!- SIMILARITY: Contains 1 RING-type zinc finger.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH09672.2; Type=Erroneous initiation;
CC Sequence=AAH63680.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK023139; BAB14423.1; -; mRNA.
DR EMBL; CR457298; CAG33579.1; -; mRNA.
DR EMBL; BC009672; AAH09672.2; ALT_INIT; mRNA.
DR EMBL; BC063680; AAH63680.1; ALT_INIT; mRNA.
DR RefSeq; NP_060790.2; NM_018320.4.
DR UniGene; Hs.368554; -.
DR ProteinModelPortal; Q9H920; -.
DR SMR; Q9H920; 219-289.
DR STRING; 9606.ENSP00000354571; -.
DR PhosphoSite; Q9H920; -.
DR DMDM; 74761545; -.
DR PaxDb; Q9H920; -.
DR PRIDE; Q9H920; -.
DR DNASU; 55298; -.
DR Ensembl; ENST00000361756; ENSP00000354571; ENSG00000137522.
DR GeneID; 55298; -.
DR KEGG; hsa:55298; -.
DR UCSC; uc001ora.3; human.
DR CTD; 55298; -.
DR GeneCards; GC11P071640; -.
DR HGNC; HGNC:21070; RNF121.
DR HPA; HPA046041; -.
DR neXtProt; NX_Q9H920; -.
DR PharmGKB; PA134985388; -.
DR eggNOG; NOG327922; -.
DR HOGENOM; HOG000021822; -.
DR HOVERGEN; HBG061177; -.
DR InParanoid; Q9H920; -.
DR KO; K15698; -.
DR OMA; VIENTYK; -.
DR OrthoDB; EOG7R831T; -.
DR GenomeRNAi; 55298; -.
DR NextBio; 59508; -.
DR PRO; PR:Q9H920; -.
DR ArrayExpress; Q9H920; -.
DR Bgee; Q9H920; -.
DR CleanEx; HS_RNF121; -.
DR Genevestigator; Q9H920; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS00518; ZF_RING_1; FALSE_NEG.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Membrane; Metal-binding;
KW Reference proteome; Transmembrane; Transmembrane helix; Zinc;
KW Zinc-finger.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 327 RING finger protein 121.
FT /FTId=PRO_0000261407.
FT TRANSMEM 50 70 Helical; (Potential).
FT TRANSMEM 79 99 Helical; (Potential).
FT TRANSMEM 100 120 Helical; (Potential).
FT TRANSMEM 148 168 Helical; (Potential).
FT TRANSMEM 172 192 Helical; (Potential).
FT TRANSMEM 306 326 Helical; (Potential).
FT ZN_FING 226 276 RING-type; atypical.
FT MOD_RES 2 2 N-acetylalanine.
FT CONFLICT 327 327 E -> D (in Ref. 2; CAG33579).
SQ SEQUENCE 327 AA; 37882 MW; FFC170FF52AB15CD CRC64;
MAAVVEVEVG GGAAGERELD EVDMSDLSPE EQWRVEHARM HAKHRGHEAM HAEMVLILIA
TLVVAQLLLV QWKQRHPRSY NMVTLFQMWV VPLYFTVKLH WWRFLVIWIL FSAVTAFVTF
RATRKPLVQT TPRLVYKWFL LIYKISYATG IVGYMAVMFT LFGLNLLFKI KPEDAMDFGI
SLLFYGLYYG VLERDFAEMC ADYMASTIGF YSESGMPTKH LSDSVCAVCG QQIFVDVSEE
GIIENTYRLS CNHVFHEFCI RGWCIVGKKQ TCPYCKEKVD LKRMFSNPWE RPHVMYGQLL
DWLRYLVAWQ PVIIGVVQGI NYILGLE
//