Full text data of RPS15A
RPS15A
[Confidence: low (only semi-automatic identification from reviews)]
40S ribosomal protein S15a
Note: presumably soluble (membrane word is not in UniProt keywords or features)
40S ribosomal protein S15a
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
P62244
ID RS15A_HUMAN Reviewed; 130 AA.
AC P62244; P39027; P39031; Q3MHD9; Q8C023; Q9BV24;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 105.
DE RecName: Full=40S ribosomal protein S15a;
GN Name=RPS15A; ORFNames=OK/SW-cl.82;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Schwabe G.;
RL Submitted (OCT-1991) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Carcinoma;
RA Mays G., Burchert-Graeve M.;
RL Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Lian Z., Liu J., Li L., Li X., Tufan S.N.L., Wu M.-C., Wang H.,
RA Arbuthnot P., Kew M.K., Feitelson M.M.;
RT "Human S15a expression is up-regulated by HBV X protein.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon adenocarcinoma;
RA Shichijo S., Itoh K.;
RT "Identification of immuno-peptidmics that are recognized by tumor-
RT reactive CTL generated from TIL of colon cancer patients.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye, Lung, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 2-17 AND 33-60.
RC TISSUE=Placenta;
RX PubMed=8706699; DOI=10.1111/j.1432-1033.1996.0144u.x;
RA Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K.,
RA Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.;
RT "Characterization of the human small-ribosomal-subunit proteins by N-
RT terminal and internal sequencing, and mass spectrometry.";
RL Eur. J. Biochem. 239:144-149(1996).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-54.
RX PubMed=9582194;
RA Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N.,
RA Hudson T.J., Tanaka T., Page D.C.;
RT "A map of 75 human ribosomal protein genes.";
RL Genome Res. 8:509-523(1998).
RN [8]
RP PARTIAL PROTEIN SEQUENCE.
RX PubMed=8185605; DOI=10.1006/bbrc.1994.1620;
RA Chan Y.-L., Olvera J., Paz V., Wool I.G.;
RT "The primary structure of rat ribosomal protein S15a.";
RL Biochem. Biophys. Res. Commun. 200:1498-1504(1994).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- INTERACTION:
CC Q13838:DDX39B; NbExp=1; IntAct=EBI-347895, EBI-348622;
CC -!- SIMILARITY: Belongs to the ribosomal protein S8P family.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA44568.1; Type=Frameshift; Positions=24, 37;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; X62691; CAA44568.1; ALT_FRAME; mRNA.
DR EMBL; X84407; CAA59127.1; -; mRNA.
DR EMBL; AY208299; AAO48936.1; -; mRNA.
DR EMBL; AB062400; BAB93487.1; -; mRNA.
DR EMBL; BC001697; AAH01697.1; -; mRNA.
DR EMBL; BC030569; AAH30569.1; -; mRNA.
DR EMBL; BC046113; AAH46113.1; -; mRNA.
DR EMBL; BC105273; AAI05274.1; -; mRNA.
DR EMBL; BC105292; AAI05293.1; -; mRNA.
DR EMBL; AB007154; BAA28592.1; -; Genomic_DNA.
DR PIR; S52339; S52339.
DR RefSeq; NP_001010.2; NM_001019.4.
DR RefSeq; NP_001025180.1; NM_001030009.1.
DR RefSeq; XP_005255522.1; XM_005255465.1.
DR UniGene; Hs.370504; -.
DR PDB; 3J3A; EM; 5.00 A; W=1-130.
DR PDBsum; 3J3A; -.
DR ProteinModelPortal; P62244; -.
DR SMR; P62244; 2-130.
DR IntAct; P62244; 14.
DR MINT; MINT-1036414; -.
DR STRING; 9606.ENSP00000318646; -.
DR PhosphoSite; P62244; -.
DR DMDM; 50403624; -.
DR SWISS-2DPAGE; P62244; -.
DR PaxDb; P62244; -.
DR PeptideAtlas; P62244; -.
DR PRIDE; P62244; -.
DR DNASU; 6210; -.
DR Ensembl; ENST00000322989; ENSP00000318646; ENSG00000134419.
DR Ensembl; ENST00000563390; ENSP00000457000; ENSG00000134419.
DR Ensembl; ENST00000565420; ENSP00000458115; ENSG00000134419.
DR Ensembl; ENST00000572008; ENSP00000458528; ENSG00000134419.
DR GeneID; 6210; -.
DR KEGG; hsa:6210; -.
DR UCSC; uc002dfh.1; human.
DR CTD; 6210; -.
DR GeneCards; GC16M018701; -.
DR H-InvDB; HIX0033054; -.
DR HGNC; HGNC:10389; RPS15A.
DR HPA; HPA047103; -.
DR MIM; 603674; gene.
DR neXtProt; NX_P62244; -.
DR PharmGKB; PA34788; -.
DR eggNOG; COG0096; -.
DR HOGENOM; HOG000204097; -.
DR HOVERGEN; HBG056618; -.
DR InParanoid; P62244; -.
DR KO; K02957; -.
DR OMA; LPAKNFG; -.
DR OrthoDB; EOG77Q4ZM; -.
DR PhylomeDB; P62244; -.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_17015; Metabolism of proteins.
DR Reactome; REACT_1762; 3' -UTR-mediated translational regulation.
DR Reactome; REACT_21257; Metabolism of RNA.
DR Reactome; REACT_71; Gene Expression.
DR GeneWiki; RPS15A; -.
DR GenomeRNAi; 6210; -.
DR NextBio; 24123; -.
DR PMAP-CutDB; P62244; -.
DR PRO; PR:P62244; -.
DR ArrayExpress; P62244; -.
DR Bgee; P62244; -.
DR CleanEx; HS_RPS15A; -.
DR Genevestigator; P62244; -.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; NAS:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; IDA:UniProtKB.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
DR GO; GO:0045787; P:positive regulation of cell cycle; IDA:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
DR GO; GO:0009615; P:response to virus; IDA:UniProtKB.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
DR GO; GO:0006414; P:translational elongation; TAS:Reactome.
DR GO; GO:0006413; P:translational initiation; TAS:Reactome.
DR GO; GO:0006415; P:translational termination; TAS:Reactome.
DR GO; GO:0019083; P:viral transcription; TAS:Reactome.
DR InterPro; IPR000630; Ribosomal_S8.
DR PANTHER; PTHR11758; PTHR11758; 1.
DR Pfam; PF00410; Ribosomal_S8; 1.
DR SUPFAM; SSF56047; SSF56047; 1.
DR PROSITE; PS00053; RIBOSOMAL_S8; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Direct protein sequencing;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 130 40S ribosomal protein S15a.
FT /FTId=PRO_0000126602.
FT CONFLICT 3 3 R -> C (in Ref. 6; AA sequence).
FT CONFLICT 40 40 V -> L (in Ref. 2; CAA59127).
FT CONFLICT 79 79 F -> S (in Ref. 5; AAH01697).
SQ SEQUENCE 130 AA; 14840 MW; D4AC1E8864E3A184 CRC64;
MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF EIIDDHRAGK
IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG FIVLTTSAGI MDHEEARRKH
TGGKILGFFF
//
ID RS15A_HUMAN Reviewed; 130 AA.
AC P62244; P39027; P39031; Q3MHD9; Q8C023; Q9BV24;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 105.
DE RecName: Full=40S ribosomal protein S15a;
GN Name=RPS15A; ORFNames=OK/SW-cl.82;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Schwabe G.;
RL Submitted (OCT-1991) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Carcinoma;
RA Mays G., Burchert-Graeve M.;
RL Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Lian Z., Liu J., Li L., Li X., Tufan S.N.L., Wu M.-C., Wang H.,
RA Arbuthnot P., Kew M.K., Feitelson M.M.;
RT "Human S15a expression is up-regulated by HBV X protein.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon adenocarcinoma;
RA Shichijo S., Itoh K.;
RT "Identification of immuno-peptidmics that are recognized by tumor-
RT reactive CTL generated from TIL of colon cancer patients.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye, Lung, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 2-17 AND 33-60.
RC TISSUE=Placenta;
RX PubMed=8706699; DOI=10.1111/j.1432-1033.1996.0144u.x;
RA Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K.,
RA Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.;
RT "Characterization of the human small-ribosomal-subunit proteins by N-
RT terminal and internal sequencing, and mass spectrometry.";
RL Eur. J. Biochem. 239:144-149(1996).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-54.
RX PubMed=9582194;
RA Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N.,
RA Hudson T.J., Tanaka T., Page D.C.;
RT "A map of 75 human ribosomal protein genes.";
RL Genome Res. 8:509-523(1998).
RN [8]
RP PARTIAL PROTEIN SEQUENCE.
RX PubMed=8185605; DOI=10.1006/bbrc.1994.1620;
RA Chan Y.-L., Olvera J., Paz V., Wool I.G.;
RT "The primary structure of rat ribosomal protein S15a.";
RL Biochem. Biophys. Res. Commun. 200:1498-1504(1994).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- INTERACTION:
CC Q13838:DDX39B; NbExp=1; IntAct=EBI-347895, EBI-348622;
CC -!- SIMILARITY: Belongs to the ribosomal protein S8P family.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA44568.1; Type=Frameshift; Positions=24, 37;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; X62691; CAA44568.1; ALT_FRAME; mRNA.
DR EMBL; X84407; CAA59127.1; -; mRNA.
DR EMBL; AY208299; AAO48936.1; -; mRNA.
DR EMBL; AB062400; BAB93487.1; -; mRNA.
DR EMBL; BC001697; AAH01697.1; -; mRNA.
DR EMBL; BC030569; AAH30569.1; -; mRNA.
DR EMBL; BC046113; AAH46113.1; -; mRNA.
DR EMBL; BC105273; AAI05274.1; -; mRNA.
DR EMBL; BC105292; AAI05293.1; -; mRNA.
DR EMBL; AB007154; BAA28592.1; -; Genomic_DNA.
DR PIR; S52339; S52339.
DR RefSeq; NP_001010.2; NM_001019.4.
DR RefSeq; NP_001025180.1; NM_001030009.1.
DR RefSeq; XP_005255522.1; XM_005255465.1.
DR UniGene; Hs.370504; -.
DR PDB; 3J3A; EM; 5.00 A; W=1-130.
DR PDBsum; 3J3A; -.
DR ProteinModelPortal; P62244; -.
DR SMR; P62244; 2-130.
DR IntAct; P62244; 14.
DR MINT; MINT-1036414; -.
DR STRING; 9606.ENSP00000318646; -.
DR PhosphoSite; P62244; -.
DR DMDM; 50403624; -.
DR SWISS-2DPAGE; P62244; -.
DR PaxDb; P62244; -.
DR PeptideAtlas; P62244; -.
DR PRIDE; P62244; -.
DR DNASU; 6210; -.
DR Ensembl; ENST00000322989; ENSP00000318646; ENSG00000134419.
DR Ensembl; ENST00000563390; ENSP00000457000; ENSG00000134419.
DR Ensembl; ENST00000565420; ENSP00000458115; ENSG00000134419.
DR Ensembl; ENST00000572008; ENSP00000458528; ENSG00000134419.
DR GeneID; 6210; -.
DR KEGG; hsa:6210; -.
DR UCSC; uc002dfh.1; human.
DR CTD; 6210; -.
DR GeneCards; GC16M018701; -.
DR H-InvDB; HIX0033054; -.
DR HGNC; HGNC:10389; RPS15A.
DR HPA; HPA047103; -.
DR MIM; 603674; gene.
DR neXtProt; NX_P62244; -.
DR PharmGKB; PA34788; -.
DR eggNOG; COG0096; -.
DR HOGENOM; HOG000204097; -.
DR HOVERGEN; HBG056618; -.
DR InParanoid; P62244; -.
DR KO; K02957; -.
DR OMA; LPAKNFG; -.
DR OrthoDB; EOG77Q4ZM; -.
DR PhylomeDB; P62244; -.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_17015; Metabolism of proteins.
DR Reactome; REACT_1762; 3' -UTR-mediated translational regulation.
DR Reactome; REACT_21257; Metabolism of RNA.
DR Reactome; REACT_71; Gene Expression.
DR GeneWiki; RPS15A; -.
DR GenomeRNAi; 6210; -.
DR NextBio; 24123; -.
DR PMAP-CutDB; P62244; -.
DR PRO; PR:P62244; -.
DR ArrayExpress; P62244; -.
DR Bgee; P62244; -.
DR CleanEx; HS_RPS15A; -.
DR Genevestigator; P62244; -.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; NAS:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; IDA:UniProtKB.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
DR GO; GO:0045787; P:positive regulation of cell cycle; IDA:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
DR GO; GO:0009615; P:response to virus; IDA:UniProtKB.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
DR GO; GO:0006414; P:translational elongation; TAS:Reactome.
DR GO; GO:0006413; P:translational initiation; TAS:Reactome.
DR GO; GO:0006415; P:translational termination; TAS:Reactome.
DR GO; GO:0019083; P:viral transcription; TAS:Reactome.
DR InterPro; IPR000630; Ribosomal_S8.
DR PANTHER; PTHR11758; PTHR11758; 1.
DR Pfam; PF00410; Ribosomal_S8; 1.
DR SUPFAM; SSF56047; SSF56047; 1.
DR PROSITE; PS00053; RIBOSOMAL_S8; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Direct protein sequencing;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 130 40S ribosomal protein S15a.
FT /FTId=PRO_0000126602.
FT CONFLICT 3 3 R -> C (in Ref. 6; AA sequence).
FT CONFLICT 40 40 V -> L (in Ref. 2; CAA59127).
FT CONFLICT 79 79 F -> S (in Ref. 5; AAH01697).
SQ SEQUENCE 130 AA; 14840 MW; D4AC1E8864E3A184 CRC64;
MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF EIIDDHRAGK
IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG FIVLTTSAGI MDHEEARRKH
TGGKILGFFF
//
MIM
603674
*RECORD*
*FIELD* NO
603674
*FIELD* TI
*603674 RIBOSOMAL PROTEIN S15a; RPS15A
*FIELD* TX
The mammalian ribosome is composed of 4 RNA species (see 180450) and
read moreapproximately 80 different proteins.
The deduced ribosomal protein 15a (RPS15A) has 130 amino acids
(SWISS-PROT SWISSPROT P39027).
By somatic cell hybrid and radiation hybrid mapping analyses, Kenmochi
et al. (1998) mapped the human RPS15A gene to 16p.
*FIELD* RF
1. Kenmochi, N.; Kawaguchi, T.; Rozen, S.; Davis, E.; Goodman, N.;
Hudson, T. J.; Tanaka, T.; Page, D. C.: A map of 75 human ribosomal
protein genes. Genome Res. 8: 509-523, 1998.
*FIELD* CD
Patti M. Sherman: 3/25/1999
*FIELD* ED
carol: 03/31/1999
*RECORD*
*FIELD* NO
603674
*FIELD* TI
*603674 RIBOSOMAL PROTEIN S15a; RPS15A
*FIELD* TX
The mammalian ribosome is composed of 4 RNA species (see 180450) and
read moreapproximately 80 different proteins.
The deduced ribosomal protein 15a (RPS15A) has 130 amino acids
(SWISS-PROT SWISSPROT P39027).
By somatic cell hybrid and radiation hybrid mapping analyses, Kenmochi
et al. (1998) mapped the human RPS15A gene to 16p.
*FIELD* RF
1. Kenmochi, N.; Kawaguchi, T.; Rozen, S.; Davis, E.; Goodman, N.;
Hudson, T. J.; Tanaka, T.; Page, D. C.: A map of 75 human ribosomal
protein genes. Genome Res. 8: 509-523, 1998.
*FIELD* CD
Patti M. Sherman: 3/25/1999
*FIELD* ED
carol: 03/31/1999