Full text data of RSPRY1
RSPRY1
(KIAA1972)
[Confidence: low (only semi-automatic identification from reviews)]
RING finger and SPRY domain-containing protein 1; Flags: Precursor
Note: presumably soluble (membrane word is not in UniProt keywords or features)
RING finger and SPRY domain-containing protein 1; Flags: Precursor
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q96DX4
ID RSPRY_HUMAN Reviewed; 576 AA.
AC Q96DX4; Q6UX21; Q8ND53;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 89.
DE RecName: Full=RING finger and SPRY domain-containing protein 1;
DE Flags: Precursor;
GN Name=RSPRY1; Synonyms=KIAA1972; ORFNames=UNQ328/PRO444;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXII.
RT The complete sequences of 50 new cDNA clones which code for large
RT proteins.";
RL DNA Res. 8:319-327(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 492-576 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96DX4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96DX4-2; Sequence=VSP_023382, VSP_023383;
CC -!- SIMILARITY: Contains 1 B30.2/SPRY domain.
CC -!- SIMILARITY: Contains 1 RING-type zinc finger.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB075852; BAB85558.1; -; mRNA.
DR EMBL; AY358548; AAQ88912.1; -; mRNA.
DR EMBL; AK172845; BAD18809.1; -; mRNA.
DR EMBL; BC013173; AAH13173.1; -; mRNA.
DR EMBL; AL834402; CAD39064.1; -; mRNA.
DR RefSeq; NP_588609.1; NM_133368.1.
DR RefSeq; XP_005256277.1; XM_005256220.1.
DR RefSeq; XP_005256278.1; XM_005256221.1.
DR RefSeq; XP_005256279.1; XM_005256222.1.
DR RefSeq; XP_005256280.1; XM_005256223.1.
DR RefSeq; XP_005256281.1; XM_005256224.1.
DR RefSeq; XP_005256282.1; XM_005256225.1.
DR UniGene; Hs.460885; -.
DR ProteinModelPortal; Q96DX4; -.
DR SMR; Q96DX4; 488-575.
DR IntAct; Q96DX4; 2.
DR MINT; MINT-5006550; -.
DR STRING; 9606.ENSP00000377942; -.
DR PhosphoSite; Q96DX4; -.
DR DMDM; 74731506; -.
DR PaxDb; Q96DX4; -.
DR PRIDE; Q96DX4; -.
DR DNASU; 89970; -.
DR Ensembl; ENST00000394420; ENSP00000377942; ENSG00000159579.
DR Ensembl; ENST00000537866; ENSP00000443176; ENSG00000159579.
DR GeneID; 89970; -.
DR KEGG; hsa:89970; -.
DR UCSC; uc002elb.3; human.
DR CTD; 89970; -.
DR GeneCards; GC16P057220; -.
DR HGNC; HGNC:29420; RSPRY1.
DR HPA; HPA003729; -.
DR neXtProt; NX_Q96DX4; -.
DR PharmGKB; PA143485602; -.
DR eggNOG; NOG303191; -.
DR HOGENOM; HOG000261619; -.
DR HOVERGEN; HBG057205; -.
DR InParanoid; Q96DX4; -.
DR OMA; SIRDNCC; -.
DR OrthoDB; EOG7NCV36; -.
DR PhylomeDB; Q96DX4; -.
DR ChiTaRS; RSPRY1; human.
DR GenomeRNAi; 89970; -.
DR NextBio; 76466; -.
DR PRO; PR:Q96DX4; -.
DR ArrayExpress; Q96DX4; -.
DR Bgee; Q96DX4; -.
DR CleanEx; HS_RSPRY1; -.
DR Genevestigator; Q96DX4; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR008985; ConA-like_lec_gl_sf.
DR InterPro; IPR018355; SPla/RYanodine_receptor_subgr.
DR InterPro; IPR003877; SPRY_rcpt.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS00518; ZF_RING_1; FALSE_NEG.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Glycoprotein; Metal-binding;
KW Reference proteome; Secreted; Signal; Zinc; Zinc-finger.
FT SIGNAL 1 16 Potential.
FT CHAIN 17 576 RING finger and SPRY domain-containing
FT protein 1.
FT /FTId=PRO_0000278786.
FT DOMAIN 300 483 B30.2/SPRY.
FT ZN_FING 527 562 RING-type.
FT CARBOHYD 314 314 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 117 117 N -> K (in isoform 2).
FT /FTId=VSP_023382.
FT VAR_SEQ 118 576 Missing (in isoform 2).
FT /FTId=VSP_023383.
SQ SEQUENCE 576 AA; 64180 MW; 8598E43E96691F9B CRC64;
MIVFGWAVFL ASRSLGQGLL LTLEEHIAHF LGTGGAATTM GNSCICRDDS GTDDSVDTQQ
QQAENSAVPT ADTRSQPRDP VRPPRRGRGP HEPRRKKQNV DGLVLDTLAV IRTLVDNDQE
PPYSMITLHE MAETDEGWLD VVQSLIRVIP LEDPLGPAVI TLLLDECPLP TKDALQKLTE
ILNLNGEVAC QDSSHPAKHR NTSAVLGCLA EKLAGPASIG LLSPGILEYL LQCLKLQSHP
TVMLFALIAL EKFAQTSENK LTISESSISD RLVTLESWAN DPDYLKRQVG FCAQWSLDNL
FLKEGRQLTY EKVNLSSIRA MLNSNDVSEY LKISPHGLEA RCDASSFESV RCTFCVDAGV
WYYEVTVVTS GVMQIGWATR DSKFLNHEGY GIGDDEYSCA YDGCRQLIWY NARSKPHIHP
CWKEGDTVGF LLDLNEKQMI FFLNGNQLPP EKQVFSSTVS GFFAAASFMS YQQCEFNFGA
KPFKYPPSMK FSTFNDYAFL TAEEKIILPR HRRLALLKQV SIRENCCSLC CDEVADTQLK
PCGHSDLCMD CALQLETCPL CRKEIVSRIR QISHIS
//
ID RSPRY_HUMAN Reviewed; 576 AA.
AC Q96DX4; Q6UX21; Q8ND53;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 89.
DE RecName: Full=RING finger and SPRY domain-containing protein 1;
DE Flags: Precursor;
GN Name=RSPRY1; Synonyms=KIAA1972; ORFNames=UNQ328/PRO444;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXII.
RT The complete sequences of 50 new cDNA clones which code for large
RT proteins.";
RL DNA Res. 8:319-327(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 492-576 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96DX4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96DX4-2; Sequence=VSP_023382, VSP_023383;
CC -!- SIMILARITY: Contains 1 B30.2/SPRY domain.
CC -!- SIMILARITY: Contains 1 RING-type zinc finger.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB075852; BAB85558.1; -; mRNA.
DR EMBL; AY358548; AAQ88912.1; -; mRNA.
DR EMBL; AK172845; BAD18809.1; -; mRNA.
DR EMBL; BC013173; AAH13173.1; -; mRNA.
DR EMBL; AL834402; CAD39064.1; -; mRNA.
DR RefSeq; NP_588609.1; NM_133368.1.
DR RefSeq; XP_005256277.1; XM_005256220.1.
DR RefSeq; XP_005256278.1; XM_005256221.1.
DR RefSeq; XP_005256279.1; XM_005256222.1.
DR RefSeq; XP_005256280.1; XM_005256223.1.
DR RefSeq; XP_005256281.1; XM_005256224.1.
DR RefSeq; XP_005256282.1; XM_005256225.1.
DR UniGene; Hs.460885; -.
DR ProteinModelPortal; Q96DX4; -.
DR SMR; Q96DX4; 488-575.
DR IntAct; Q96DX4; 2.
DR MINT; MINT-5006550; -.
DR STRING; 9606.ENSP00000377942; -.
DR PhosphoSite; Q96DX4; -.
DR DMDM; 74731506; -.
DR PaxDb; Q96DX4; -.
DR PRIDE; Q96DX4; -.
DR DNASU; 89970; -.
DR Ensembl; ENST00000394420; ENSP00000377942; ENSG00000159579.
DR Ensembl; ENST00000537866; ENSP00000443176; ENSG00000159579.
DR GeneID; 89970; -.
DR KEGG; hsa:89970; -.
DR UCSC; uc002elb.3; human.
DR CTD; 89970; -.
DR GeneCards; GC16P057220; -.
DR HGNC; HGNC:29420; RSPRY1.
DR HPA; HPA003729; -.
DR neXtProt; NX_Q96DX4; -.
DR PharmGKB; PA143485602; -.
DR eggNOG; NOG303191; -.
DR HOGENOM; HOG000261619; -.
DR HOVERGEN; HBG057205; -.
DR InParanoid; Q96DX4; -.
DR OMA; SIRDNCC; -.
DR OrthoDB; EOG7NCV36; -.
DR PhylomeDB; Q96DX4; -.
DR ChiTaRS; RSPRY1; human.
DR GenomeRNAi; 89970; -.
DR NextBio; 76466; -.
DR PRO; PR:Q96DX4; -.
DR ArrayExpress; Q96DX4; -.
DR Bgee; Q96DX4; -.
DR CleanEx; HS_RSPRY1; -.
DR Genevestigator; Q96DX4; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR008985; ConA-like_lec_gl_sf.
DR InterPro; IPR018355; SPla/RYanodine_receptor_subgr.
DR InterPro; IPR003877; SPRY_rcpt.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS00518; ZF_RING_1; FALSE_NEG.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Glycoprotein; Metal-binding;
KW Reference proteome; Secreted; Signal; Zinc; Zinc-finger.
FT SIGNAL 1 16 Potential.
FT CHAIN 17 576 RING finger and SPRY domain-containing
FT protein 1.
FT /FTId=PRO_0000278786.
FT DOMAIN 300 483 B30.2/SPRY.
FT ZN_FING 527 562 RING-type.
FT CARBOHYD 314 314 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 117 117 N -> K (in isoform 2).
FT /FTId=VSP_023382.
FT VAR_SEQ 118 576 Missing (in isoform 2).
FT /FTId=VSP_023383.
SQ SEQUENCE 576 AA; 64180 MW; 8598E43E96691F9B CRC64;
MIVFGWAVFL ASRSLGQGLL LTLEEHIAHF LGTGGAATTM GNSCICRDDS GTDDSVDTQQ
QQAENSAVPT ADTRSQPRDP VRPPRRGRGP HEPRRKKQNV DGLVLDTLAV IRTLVDNDQE
PPYSMITLHE MAETDEGWLD VVQSLIRVIP LEDPLGPAVI TLLLDECPLP TKDALQKLTE
ILNLNGEVAC QDSSHPAKHR NTSAVLGCLA EKLAGPASIG LLSPGILEYL LQCLKLQSHP
TVMLFALIAL EKFAQTSENK LTISESSISD RLVTLESWAN DPDYLKRQVG FCAQWSLDNL
FLKEGRQLTY EKVNLSSIRA MLNSNDVSEY LKISPHGLEA RCDASSFESV RCTFCVDAGV
WYYEVTVVTS GVMQIGWATR DSKFLNHEGY GIGDDEYSCA YDGCRQLIWY NARSKPHIHP
CWKEGDTVGF LLDLNEKQMI FFLNGNQLPP EKQVFSSTVS GFFAAASFMS YQQCEFNFGA
KPFKYPPSMK FSTFNDYAFL TAEEKIILPR HRRLALLKQV SIRENCCSLC CDEVADTQLK
PCGHSDLCMD CALQLETCPL CRKEIVSRIR QISHIS
//