Full text data of RSU1
RSU1
(RSP1)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Ras suppressor protein 1; RSP-1; Rsu-1
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Ras suppressor protein 1; RSP-1; Rsu-1
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q15404
ID RSU1_HUMAN Reviewed; 277 AA.
AC Q15404; A8KA46; D3DRU3; Q6FI17;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 3.
DT 22-JAN-2014, entry version 117.
DE RecName: Full=Ras suppressor protein 1;
DE Short=RSP-1;
DE Short=Rsu-1;
GN Name=RSU1; Synonyms=RSP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=8288261; DOI=10.1006/geno.1993.1503;
RA Tsuda T., Cutler M.L.;
RT "Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human
RT chromosome 10.";
RL Genomics 18:461-462(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Thalamus, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG NHLBI resequencing and genotyping service (RS&G;);
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PROTEIN SEQUENCE OF 2-13 (ISOFORM 1).
RC TISSUE=Platelet;
RX PubMed=12665801; DOI=10.1038/nbt810;
RA Gevaert K., Goethals M., Martens L., Van Damme J., Staes A.,
RA Thomas G.R., Vandekerckhove J.;
RT "Exploring proteomes and analyzing protein processing by mass
RT spectrometric identification of sorted N-terminal peptides.";
RL Nat. Biotechnol. 21:566-569(2003).
RN [9]
RP PROTEIN SEQUENCE OF 138-155 AND 192-208.
RC TISSUE=Adipocyte;
RX PubMed=15242332; DOI=10.1042/BJ20040647;
RA Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.;
RT "Vectorial proteomics reveal targeting, phosphorylation and specific
RT fragmentation of polymerase I and transcript release factor (PTRF) at
RT the surface of caveolae in human adipocytes.";
RL Biochem. J. 383:237-248(2004).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [11]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Potentially plays a role in the Ras signal transduction
CC pathway. Capable of suppressing v-Ras transformation in vitro.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q15404-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q15404-2; Sequence=VSP_043831;
CC -!- SIMILARITY: Contains 7 LRR (leucine-rich) repeats.
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DR EMBL; L12535; AAA60292.1; -; mRNA.
DR EMBL; AK292911; BAF85600.1; -; mRNA.
DR EMBL; AK312520; BAG35419.1; -; mRNA.
DR EMBL; CR536521; CAG38758.1; -; mRNA.
DR EMBL; CR541840; CAG46639.1; -; mRNA.
DR EMBL; EF445013; ACA06048.1; -; Genomic_DNA.
DR EMBL; EF445013; ACA06049.1; -; Genomic_DNA.
DR EMBL; EF445013; ACA06050.1; -; Genomic_DNA.
DR EMBL; AL365215; CAH73632.1; -; Genomic_DNA.
DR EMBL; AC073367; CAH73632.1; JOINED; Genomic_DNA.
DR EMBL; AL365215; CAH73633.1; -; Genomic_DNA.
DR EMBL; AC073367; CAH73633.1; JOINED; Genomic_DNA.
DR EMBL; CH471072; EAW86222.1; -; Genomic_DNA.
DR EMBL; CH471072; EAW86223.1; -; Genomic_DNA.
DR EMBL; CH471072; EAW86224.1; -; Genomic_DNA.
DR EMBL; BC005993; AAH05993.1; -; mRNA.
DR EMBL; BC008691; AAH08691.1; -; mRNA.
DR EMBL; BC015644; AAH15644.1; -; mRNA.
DR PIR; I60122; I60122.
DR RefSeq; NP_036557.1; NM_012425.3.
DR RefSeq; NP_689937.2; NM_152724.2.
DR UniGene; Hs.524161; -.
DR ProteinModelPortal; Q15404; -.
DR SMR; Q15404; 3-230.
DR IntAct; Q15404; 6.
DR MINT; MINT-3031279; -.
DR STRING; 9606.ENSP00000339521; -.
DR PhosphoSite; Q15404; -.
DR DMDM; 2498866; -.
DR OGP; Q15404; -.
DR PaxDb; Q15404; -.
DR PRIDE; Q15404; -.
DR DNASU; 6251; -.
DR Ensembl; ENST00000345264; ENSP00000339521; ENSG00000148484.
DR Ensembl; ENST00000377921; ENSP00000367154; ENSG00000148484.
DR Ensembl; ENST00000602389; ENSP00000473588; ENSG00000148484.
DR GeneID; 6251; -.
DR KEGG; hsa:6251; -.
DR UCSC; uc001iok.3; human.
DR CTD; 6251; -.
DR GeneCards; GC10M016672; -.
DR HGNC; HGNC:10464; RSU1.
DR HPA; HPA025927; -.
DR MIM; 179555; gene.
DR neXtProt; NX_Q15404; -.
DR PharmGKB; PA34876; -.
DR eggNOG; COG4886; -.
DR HOGENOM; HOG000116557; -.
DR HOVERGEN; HBG002478; -.
DR OMA; CDRGISN; -.
DR OrthoDB; EOG7CNZGH; -.
DR PhylomeDB; Q15404; -.
DR Reactome; REACT_111155; Cell-Cell communication.
DR SignaLink; Q15404; -.
DR ChiTaRS; RSU1; human.
DR GeneWiki; RSU1; -.
DR GenomeRNAi; 6251; -.
DR NextBio; 24271; -.
DR PRO; PR:Q15404; -.
DR Bgee; Q15404; -.
DR CleanEx; HS_RSU1; -.
DR Genevestigator; Q15404; -.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0034329; P:cell junction assembly; TAS:Reactome.
DR GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF12799; LRR_4; 1.
DR SMART; SM00369; LRR_TYP; 1.
DR PROSITE; PS51450; LRR; 7.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Complete proteome;
KW Direct protein sequencing; Leucine-rich repeat; Reference proteome;
KW Repeat.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 277 Ras suppressor protein 1.
FT /FTId=PRO_0000097499.
FT REPEAT 41 63 LRR 1.
FT REPEAT 64 85 LRR 2.
FT REPEAT 87 109 LRR 3.
FT REPEAT 110 133 LRR 4.
FT REPEAT 135 156 LRR 5.
FT REPEAT 158 179 LRR 6.
FT REPEAT 181 202 LRR 7.
FT MOD_RES 2 2 N-acetylserine.
FT VAR_SEQ 1 53 Missing (in isoform 2).
FT /FTId=VSP_043831.
SQ SEQUENCE 277 AA; 31540 MW; 6EDB2E033F417468 CRC64;
MSKSLKKLVE ESREKNQPEV DMSDRGISNM LDVNGLFTLS HITQLVLSHN KLTMVPPNIA
ELKNLEVLNF FNNQIEELPT QISSLQKLKH LNLGMNRLNT LPRGFGSLPA LEVLDLTYNN
LSENSLPGNF FYLTTLRALY LSDNDFEILP PDIGKLTKLQ ILSLRDNDLI SLPKEIGELT
QLKELHIQGN RLTVLPPELG NLDLTGQKQV FKAENNPWVT PIADQFQLGV SHVFEYIRSE
TYKYLYGRHM QANPEPPKKN NDKSKKISRK PLAAKNR
//
ID RSU1_HUMAN Reviewed; 277 AA.
AC Q15404; A8KA46; D3DRU3; Q6FI17;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 3.
DT 22-JAN-2014, entry version 117.
DE RecName: Full=Ras suppressor protein 1;
DE Short=RSP-1;
DE Short=Rsu-1;
GN Name=RSU1; Synonyms=RSP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=8288261; DOI=10.1006/geno.1993.1503;
RA Tsuda T., Cutler M.L.;
RT "Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human
RT chromosome 10.";
RL Genomics 18:461-462(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Thalamus, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG NHLBI resequencing and genotyping service (RS&G;);
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PROTEIN SEQUENCE OF 2-13 (ISOFORM 1).
RC TISSUE=Platelet;
RX PubMed=12665801; DOI=10.1038/nbt810;
RA Gevaert K., Goethals M., Martens L., Van Damme J., Staes A.,
RA Thomas G.R., Vandekerckhove J.;
RT "Exploring proteomes and analyzing protein processing by mass
RT spectrometric identification of sorted N-terminal peptides.";
RL Nat. Biotechnol. 21:566-569(2003).
RN [9]
RP PROTEIN SEQUENCE OF 138-155 AND 192-208.
RC TISSUE=Adipocyte;
RX PubMed=15242332; DOI=10.1042/BJ20040647;
RA Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.;
RT "Vectorial proteomics reveal targeting, phosphorylation and specific
RT fragmentation of polymerase I and transcript release factor (PTRF) at
RT the surface of caveolae in human adipocytes.";
RL Biochem. J. 383:237-248(2004).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [11]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Potentially plays a role in the Ras signal transduction
CC pathway. Capable of suppressing v-Ras transformation in vitro.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q15404-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q15404-2; Sequence=VSP_043831;
CC -!- SIMILARITY: Contains 7 LRR (leucine-rich) repeats.
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DR EMBL; L12535; AAA60292.1; -; mRNA.
DR EMBL; AK292911; BAF85600.1; -; mRNA.
DR EMBL; AK312520; BAG35419.1; -; mRNA.
DR EMBL; CR536521; CAG38758.1; -; mRNA.
DR EMBL; CR541840; CAG46639.1; -; mRNA.
DR EMBL; EF445013; ACA06048.1; -; Genomic_DNA.
DR EMBL; EF445013; ACA06049.1; -; Genomic_DNA.
DR EMBL; EF445013; ACA06050.1; -; Genomic_DNA.
DR EMBL; AL365215; CAH73632.1; -; Genomic_DNA.
DR EMBL; AC073367; CAH73632.1; JOINED; Genomic_DNA.
DR EMBL; AL365215; CAH73633.1; -; Genomic_DNA.
DR EMBL; AC073367; CAH73633.1; JOINED; Genomic_DNA.
DR EMBL; CH471072; EAW86222.1; -; Genomic_DNA.
DR EMBL; CH471072; EAW86223.1; -; Genomic_DNA.
DR EMBL; CH471072; EAW86224.1; -; Genomic_DNA.
DR EMBL; BC005993; AAH05993.1; -; mRNA.
DR EMBL; BC008691; AAH08691.1; -; mRNA.
DR EMBL; BC015644; AAH15644.1; -; mRNA.
DR PIR; I60122; I60122.
DR RefSeq; NP_036557.1; NM_012425.3.
DR RefSeq; NP_689937.2; NM_152724.2.
DR UniGene; Hs.524161; -.
DR ProteinModelPortal; Q15404; -.
DR SMR; Q15404; 3-230.
DR IntAct; Q15404; 6.
DR MINT; MINT-3031279; -.
DR STRING; 9606.ENSP00000339521; -.
DR PhosphoSite; Q15404; -.
DR DMDM; 2498866; -.
DR OGP; Q15404; -.
DR PaxDb; Q15404; -.
DR PRIDE; Q15404; -.
DR DNASU; 6251; -.
DR Ensembl; ENST00000345264; ENSP00000339521; ENSG00000148484.
DR Ensembl; ENST00000377921; ENSP00000367154; ENSG00000148484.
DR Ensembl; ENST00000602389; ENSP00000473588; ENSG00000148484.
DR GeneID; 6251; -.
DR KEGG; hsa:6251; -.
DR UCSC; uc001iok.3; human.
DR CTD; 6251; -.
DR GeneCards; GC10M016672; -.
DR HGNC; HGNC:10464; RSU1.
DR HPA; HPA025927; -.
DR MIM; 179555; gene.
DR neXtProt; NX_Q15404; -.
DR PharmGKB; PA34876; -.
DR eggNOG; COG4886; -.
DR HOGENOM; HOG000116557; -.
DR HOVERGEN; HBG002478; -.
DR OMA; CDRGISN; -.
DR OrthoDB; EOG7CNZGH; -.
DR PhylomeDB; Q15404; -.
DR Reactome; REACT_111155; Cell-Cell communication.
DR SignaLink; Q15404; -.
DR ChiTaRS; RSU1; human.
DR GeneWiki; RSU1; -.
DR GenomeRNAi; 6251; -.
DR NextBio; 24271; -.
DR PRO; PR:Q15404; -.
DR Bgee; Q15404; -.
DR CleanEx; HS_RSU1; -.
DR Genevestigator; Q15404; -.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0034329; P:cell junction assembly; TAS:Reactome.
DR GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF12799; LRR_4; 1.
DR SMART; SM00369; LRR_TYP; 1.
DR PROSITE; PS51450; LRR; 7.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Complete proteome;
KW Direct protein sequencing; Leucine-rich repeat; Reference proteome;
KW Repeat.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 277 Ras suppressor protein 1.
FT /FTId=PRO_0000097499.
FT REPEAT 41 63 LRR 1.
FT REPEAT 64 85 LRR 2.
FT REPEAT 87 109 LRR 3.
FT REPEAT 110 133 LRR 4.
FT REPEAT 135 156 LRR 5.
FT REPEAT 158 179 LRR 6.
FT REPEAT 181 202 LRR 7.
FT MOD_RES 2 2 N-acetylserine.
FT VAR_SEQ 1 53 Missing (in isoform 2).
FT /FTId=VSP_043831.
SQ SEQUENCE 277 AA; 31540 MW; 6EDB2E033F417468 CRC64;
MSKSLKKLVE ESREKNQPEV DMSDRGISNM LDVNGLFTLS HITQLVLSHN KLTMVPPNIA
ELKNLEVLNF FNNQIEELPT QISSLQKLKH LNLGMNRLNT LPRGFGSLPA LEVLDLTYNN
LSENSLPGNF FYLTTLRALY LSDNDFEILP PDIGKLTKLQ ILSLRDNDLI SLPKEIGELT
QLKELHIQGN RLTVLPPELG NLDLTGQKQV FKAENNPWVT PIADQFQLGV SHVFEYIRSE
TYKYLYGRHM QANPEPPKKN NDKSKKISRK PLAAKNR
//
MIM
179555
*RECORD*
*FIELD* NO
179555
*FIELD* TI
*179555 RAS SUPPRESSOR PROTEIN 1; RSU1
*FIELD* TX
CLONING
Cutler et al. (1992) isolated mouse Rsu1 (formerly referred to as Rsp1),
read morea novel cDNA capable of suppressing Ki-ras transformation. They showed
that Rsu1 is phylogenetically conserved and ubiquitously expressed,
suggesting that it may interact with other highly conserved proteins and
function in a Ras signal transduction pathway in higher eukaryotes.
Tsuda and Cutler (1993) isolated human RSU1 cDNA from a lambda gt10
primary skin fibroblast cDNA library and showed that the human protein
exhibits more than 95% conservation with the murine Rsu1 protein.
MAPPING
By hybridization of a human RSU1 cDNA probe to a set of hamster-human
somatic cell hybrids, Tsuda and Cutler (1993) assigned the RSU1 gene to
chromosome 10. Because several neoplastic disease loci had been mapped
to chromosome 10, Tsuda and Cutler (1993) raised the question of RSU1
involvement in neoplastic disease.
*FIELD* RF
1. Cutler, M. L.; Bassin, R. H.; Zanoni, L.; Talbot, N.: Isolation
of rsp-1, a novel cDNA capable of suppressing v-Ras transformation. Molec.
Cell. Biol. 12: 3750-3756, 1992.
2. Tsuda, T.; Cutler, M. L.: Human RSU1 is highly homologous to mouse
Rsu-1 and localizes to human chromosome 10. Genomics 18: 461-462,
1993.
*FIELD* CD
Victor A. McKusick: 11/18/1993
*FIELD* ED
carol: 10/19/2009
carol: 12/9/1993
carol: 11/18/1993
*RECORD*
*FIELD* NO
179555
*FIELD* TI
*179555 RAS SUPPRESSOR PROTEIN 1; RSU1
*FIELD* TX
CLONING
Cutler et al. (1992) isolated mouse Rsu1 (formerly referred to as Rsp1),
read morea novel cDNA capable of suppressing Ki-ras transformation. They showed
that Rsu1 is phylogenetically conserved and ubiquitously expressed,
suggesting that it may interact with other highly conserved proteins and
function in a Ras signal transduction pathway in higher eukaryotes.
Tsuda and Cutler (1993) isolated human RSU1 cDNA from a lambda gt10
primary skin fibroblast cDNA library and showed that the human protein
exhibits more than 95% conservation with the murine Rsu1 protein.
MAPPING
By hybridization of a human RSU1 cDNA probe to a set of hamster-human
somatic cell hybrids, Tsuda and Cutler (1993) assigned the RSU1 gene to
chromosome 10. Because several neoplastic disease loci had been mapped
to chromosome 10, Tsuda and Cutler (1993) raised the question of RSU1
involvement in neoplastic disease.
*FIELD* RF
1. Cutler, M. L.; Bassin, R. H.; Zanoni, L.; Talbot, N.: Isolation
of rsp-1, a novel cDNA capable of suppressing v-Ras transformation. Molec.
Cell. Biol. 12: 3750-3756, 1992.
2. Tsuda, T.; Cutler, M. L.: Human RSU1 is highly homologous to mouse
Rsu-1 and localizes to human chromosome 10. Genomics 18: 461-462,
1993.
*FIELD* CD
Victor A. McKusick: 11/18/1993
*FIELD* ED
carol: 10/19/2009
carol: 12/9/1993
carol: 11/18/1993