Full text data of RPUSD1
RPUSD1
(C16orf40, RLUCL)
[Confidence: low (only semi-automatic identification from reviews)]
RNA pseudouridylate synthase domain-containing protein 1 (Ribosomal large subunit pseudouridine synthase C-like protein)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
RNA pseudouridylate synthase domain-containing protein 1 (Ribosomal large subunit pseudouridine synthase C-like protein)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9UJJ7
ID RUSD1_HUMAN Reviewed; 312 AA.
AC Q9UJJ7; D3DU66;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAY-2000, sequence version 1.
DT 22-JAN-2014, entry version 91.
DE RecName: Full=RNA pseudouridylate synthase domain-containing protein 1;
DE AltName: Full=Ribosomal large subunit pseudouridine synthase C-like protein;
GN Name=RPUSD1; Synonyms=C16orf40, RLUCL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K.,
RA Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J.,
RA Higgs D.R.;
RT "Sequence, structure and pathology of the fully annotated terminal 2
RT Mb of the short arm of human chromosome 16.";
RL Hum. Mol. Genet. 10:339-352(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AE006465; AAK61255.1; -; Genomic_DNA.
DR EMBL; AL031033; CAB53055.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85712.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85713.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85715.1; -; Genomic_DNA.
DR EMBL; BC011783; AAH11783.1; -; mRNA.
DR RefSeq; NP_478072.1; NM_058192.2.
DR UniGene; Hs.101742; -.
DR ProteinModelPortal; Q9UJJ7; -.
DR SMR; Q9UJJ7; 9-227.
DR IntAct; Q9UJJ7; 1.
DR STRING; 9606.ENSP00000007264; -.
DR PhosphoSite; Q9UJJ7; -.
DR DMDM; 74753357; -.
DR PRIDE; Q9UJJ7; -.
DR DNASU; 113000; -.
DR Ensembl; ENST00000007264; ENSP00000007264; ENSG00000007376.
DR Ensembl; ENST00000561734; ENSP00000455026; ENSG00000007376.
DR GeneID; 113000; -.
DR KEGG; hsa:113000; -.
DR UCSC; uc002cka.3; human.
DR CTD; 113000; -.
DR GeneCards; GC16M000834; -.
DR HGNC; HGNC:14173; RPUSD1.
DR HPA; HPA041144; -.
DR HPA; HPA041938; -.
DR neXtProt; NX_Q9UJJ7; -.
DR PharmGKB; PA25556; -.
DR eggNOG; COG0564; -.
DR HOGENOM; HOG000047212; -.
DR HOVERGEN; HBG096261; -.
DR InParanoid; Q9UJJ7; -.
DR OMA; AYRCFKD; -.
DR OrthoDB; EOG74FF19; -.
DR PhylomeDB; Q9UJJ7; -.
DR GenomeRNAi; 113000; -.
DR NextBio; 78731; -.
DR PRO; PR:Q9UJJ7; -.
DR ArrayExpress; Q9UJJ7; -.
DR Bgee; Q9UJJ7; -.
DR CleanEx; HS_RPUSD1; -.
DR Genevestigator; Q9UJJ7; -.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluD.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; SSF55120; 1.
DR PROSITE; PS01129; PSI_RLU; FALSE_NEG.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Polymorphism; Reference proteome.
FT CHAIN 1 312 RNA pseudouridylate synthase domain-
FT containing protein 1.
FT /FTId=PRO_0000300816.
FT COMPBIAS 258 290 Pro-rich.
FT ACT_SITE 67 67 By similarity.
FT MOD_RES 1 1 N-acetylmethionine.
FT VARIANT 124 124 E -> Q (in dbSNP:rs2272898).
FT /FTId=VAR_034883.
FT VARIANT 247 247 L -> P (in dbSNP:rs3751672).
FT /FTId=VAR_034884.
SQ SEQUENCE 312 AA; 34756 MW; 0D4A31752A0D6AED CRC64;
MEPGSVENLS IVYRSRDFLV VNKHWDVRID SKAWRETLTL QKQLRYRFPE LADPDTCYGF
RFCHQLDFST SGALCVALNK AAAGSAYRCF KERRVTKAYL ALLRGHIQES RVTISHAIGR
NSTEGRAHTM CIEGSQGCEN PKPSLTDLVV LEHGLYAGDP VSKVLLKPLT GRTHQLRVHC
SALGHPVVGD LTYGEVSGRE DRPFRMMLHA FYLRIPTDTE CVEVCTPDPF LPSLDACWSP
HTLLQSLDQL VQALRATPDP DPEDRGPRPG SPSALLPGPG RPPPPPTKPP ETEAQRGPCL
QWLSEWTLEP DS
//
ID RUSD1_HUMAN Reviewed; 312 AA.
AC Q9UJJ7; D3DU66;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAY-2000, sequence version 1.
DT 22-JAN-2014, entry version 91.
DE RecName: Full=RNA pseudouridylate synthase domain-containing protein 1;
DE AltName: Full=Ribosomal large subunit pseudouridine synthase C-like protein;
GN Name=RPUSD1; Synonyms=C16orf40, RLUCL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11157797; DOI=10.1093/hmg/10.4.339;
RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K.,
RA Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J.,
RA Higgs D.R.;
RT "Sequence, structure and pathology of the fully annotated terminal 2
RT Mb of the short arm of human chromosome 16.";
RL Hum. Mol. Genet. 10:339-352(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AE006465; AAK61255.1; -; Genomic_DNA.
DR EMBL; AL031033; CAB53055.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85712.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85713.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85715.1; -; Genomic_DNA.
DR EMBL; BC011783; AAH11783.1; -; mRNA.
DR RefSeq; NP_478072.1; NM_058192.2.
DR UniGene; Hs.101742; -.
DR ProteinModelPortal; Q9UJJ7; -.
DR SMR; Q9UJJ7; 9-227.
DR IntAct; Q9UJJ7; 1.
DR STRING; 9606.ENSP00000007264; -.
DR PhosphoSite; Q9UJJ7; -.
DR DMDM; 74753357; -.
DR PRIDE; Q9UJJ7; -.
DR DNASU; 113000; -.
DR Ensembl; ENST00000007264; ENSP00000007264; ENSG00000007376.
DR Ensembl; ENST00000561734; ENSP00000455026; ENSG00000007376.
DR GeneID; 113000; -.
DR KEGG; hsa:113000; -.
DR UCSC; uc002cka.3; human.
DR CTD; 113000; -.
DR GeneCards; GC16M000834; -.
DR HGNC; HGNC:14173; RPUSD1.
DR HPA; HPA041144; -.
DR HPA; HPA041938; -.
DR neXtProt; NX_Q9UJJ7; -.
DR PharmGKB; PA25556; -.
DR eggNOG; COG0564; -.
DR HOGENOM; HOG000047212; -.
DR HOVERGEN; HBG096261; -.
DR InParanoid; Q9UJJ7; -.
DR OMA; AYRCFKD; -.
DR OrthoDB; EOG74FF19; -.
DR PhylomeDB; Q9UJJ7; -.
DR GenomeRNAi; 113000; -.
DR NextBio; 78731; -.
DR PRO; PR:Q9UJJ7; -.
DR ArrayExpress; Q9UJJ7; -.
DR Bgee; Q9UJJ7; -.
DR CleanEx; HS_RPUSD1; -.
DR Genevestigator; Q9UJJ7; -.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluD.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; SSF55120; 1.
DR PROSITE; PS01129; PSI_RLU; FALSE_NEG.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Polymorphism; Reference proteome.
FT CHAIN 1 312 RNA pseudouridylate synthase domain-
FT containing protein 1.
FT /FTId=PRO_0000300816.
FT COMPBIAS 258 290 Pro-rich.
FT ACT_SITE 67 67 By similarity.
FT MOD_RES 1 1 N-acetylmethionine.
FT VARIANT 124 124 E -> Q (in dbSNP:rs2272898).
FT /FTId=VAR_034883.
FT VARIANT 247 247 L -> P (in dbSNP:rs3751672).
FT /FTId=VAR_034884.
SQ SEQUENCE 312 AA; 34756 MW; 0D4A31752A0D6AED CRC64;
MEPGSVENLS IVYRSRDFLV VNKHWDVRID SKAWRETLTL QKQLRYRFPE LADPDTCYGF
RFCHQLDFST SGALCVALNK AAAGSAYRCF KERRVTKAYL ALLRGHIQES RVTISHAIGR
NSTEGRAHTM CIEGSQGCEN PKPSLTDLVV LEHGLYAGDP VSKVLLKPLT GRTHQLRVHC
SALGHPVVGD LTYGEVSGRE DRPFRMMLHA FYLRIPTDTE CVEVCTPDPF LPSLDACWSP
HTLLQSLDQL VQALRATPDP DPEDRGPRPG SPSALLPGPG RPPPPPTKPP ETEAQRGPCL
QWLSEWTLEP DS
//