Full text data of RWDD1
RWDD1
(DFRP2)
[Confidence: low (only semi-automatic identification from reviews)]
RWD domain-containing protein 1 (DRG family-regulatory protein 2)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
RWD domain-containing protein 1 (DRG family-regulatory protein 2)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9H446
ID RWDD1_HUMAN Reviewed; 243 AA.
AC Q9H446; A8K3W2; A8MT24; Q9Y313; Q9Y6B3;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2001, sequence version 1.
DT 22-JAN-2014, entry version 93.
DE RecName: Full=RWD domain-containing protein 1;
DE AltName: Full=DRG family-regulatory protein 2;
GN Name=RWDD1; Synonyms=DFRP2; ORFNames=CGI-24, PTD013;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pituitary tumor;
RA Song H., Peng Y., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G.,
RA Luo M., Chen J., Hu R.;
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-144, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [10]
RP STRUCTURE BY NMR OF 1-121.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the RWD domain of human RWD domain containing
RT protein 1.";
RL Submitted (AUG-2007) to the PDB data bank.
CC -!- FUNCTION: Protects DRG2 from proteolytic degradation (By
CC similarity).
CC -!- SUBUNIT: Interacts with DRG2. Interacts with androgen receptor (By
CC similarity).
CC -!- INTERACTION:
CC Q9Y295:DRG1; NbExp=2; IntAct=EBI-748952, EBI-719554;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H446-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H446-2; Sequence=VSP_044500;
CC -!- SIMILARITY: Belongs to the RWDD1/GIR2 family.
CC -!- SIMILARITY: Contains 1 RWD domain.
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DR EMBL; AF132958; AAD27733.1; -; mRNA.
DR EMBL; AF092134; AAD40376.1; -; mRNA.
DR EMBL; AK290727; BAF83416.1; -; mRNA.
DR EMBL; AK301089; BAG62691.1; -; mRNA.
DR EMBL; AL121953; CAC14427.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48221.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48222.1; -; Genomic_DNA.
DR EMBL; BC015802; AAH15802.1; -; mRNA.
DR RefSeq; NP_001007465.1; NM_001007464.2.
DR RefSeq; NP_057036.2; NM_015952.3.
DR RefSeq; NP_057188.2; NM_016104.3.
DR UniGene; Hs.532164; -.
DR PDB; 2EBM; NMR; -; A=1-121.
DR PDBsum; 2EBM; -.
DR ProteinModelPortal; Q9H446; -.
DR SMR; Q9H446; 1-121.
DR DIP; DIP-34520N; -.
DR IntAct; Q9H446; 4.
DR MINT; MINT-1436573; -.
DR STRING; 9606.ENSP00000420357; -.
DR PhosphoSite; Q9H446; -.
DR DMDM; 34098713; -.
DR PaxDb; Q9H446; -.
DR PRIDE; Q9H446; -.
DR DNASU; 51389; -.
DR Ensembl; ENST00000392526; ENSP00000376311; ENSG00000111832.
DR Ensembl; ENST00000466444; ENSP00000420357; ENSG00000111832.
DR Ensembl; ENST00000487832; ENSP00000428778; ENSG00000111832.
DR GeneID; 51389; -.
DR KEGG; hsa:51389; -.
DR UCSC; uc003pxb.3; human.
DR CTD; 51389; -.
DR GeneCards; GC06P116938; -.
DR HGNC; HGNC:20993; RWDD1.
DR HPA; HPA028712; -.
DR HPA; HPA028713; -.
DR neXtProt; NX_Q9H446; -.
DR PharmGKB; PA134967923; -.
DR eggNOG; NOG301416; -.
DR HOGENOM; HOG000237961; -.
DR HOVERGEN; HBG060864; -.
DR InParanoid; Q9H446; -.
DR OMA; WKAKFEL; -.
DR OrthoDB; EOG779NZV; -.
DR PhylomeDB; Q9H446; -.
DR EvolutionaryTrace; Q9H446; -.
DR GenomeRNAi; 51389; -.
DR NextBio; 54913; -.
DR PRO; PR:Q9H446; -.
DR ArrayExpress; Q9H446; -.
DR Bgee; Q9H446; -.
DR CleanEx; HS_RWDD1; -.
DR Genevestigator; Q9H446; -.
DR Gene3D; 3.10.110.10; -; 1.
DR InterPro; IPR006575; RWD-domain.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR Pfam; PF05773; RWD; 1.
DR SMART; SM00591; RWD; 1.
DR SUPFAM; SSF54495; SSF54495; 1.
DR PROSITE; PS50908; RWD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Alternative splicing; Complete proteome;
KW Phosphoprotein; Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 243 RWD domain-containing protein 1.
FT /FTId=PRO_0000097540.
FT DOMAIN 10 114 RWD.
FT REGION 142 197 Interaction with DRG2 (By similarity).
FT MOD_RES 2 2 N-acetylthreonine.
FT MOD_RES 144 144 Phosphothreonine.
FT VAR_SEQ 1 96 Missing (in isoform 2).
FT /FTId=VSP_044500.
FT CONFLICT 120 130 TRREEEKKQKE -> LEERRKNKR (in Ref. 1;
FT AAD27733).
FT CONFLICT 139 139 Q -> R (in Ref. 2; AAD40376).
FT HELIX 4 18
FT STRAND 20 25
FT STRAND 28 30
FT STRAND 32 35
FT STRAND 49 55
FT TURN 60 62
FT STRAND 66 74
FT HELIX 77 94
FT HELIX 100 117
FT HELIX 118 120
SQ SEQUENCE 243 AA; 27940 MW; A7AABD457136B4DA CRC64;
MTDYGEEQRN ELEALESIYP DSFTVLSENP PSFTITVTSE AGENDETVQT TLKFTYSEKY
PDEAPLYEIF SQENLEDNDV SDILKLLALQ AEENLGMVMI FTLVTAVQEK LNEIVDQIKT
RREEEKKQKE KEAEEAEKQL FHGTPVTIEN FLNWKAKFDA ELLEIKKKRM KEEEQAGKNK
LSGKQLFETD HNLDTSDIQF LEDAGNNVEV DESLFQEMDD LELEDDEDDP DYNPADPESD
SAD
//
ID RWDD1_HUMAN Reviewed; 243 AA.
AC Q9H446; A8K3W2; A8MT24; Q9Y313; Q9Y6B3;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2001, sequence version 1.
DT 22-JAN-2014, entry version 93.
DE RecName: Full=RWD domain-containing protein 1;
DE AltName: Full=DRG family-regulatory protein 2;
GN Name=RWDD1; Synonyms=DFRP2; ORFNames=CGI-24, PTD013;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pituitary tumor;
RA Song H., Peng Y., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G.,
RA Luo M., Chen J., Hu R.;
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-144, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [10]
RP STRUCTURE BY NMR OF 1-121.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the RWD domain of human RWD domain containing
RT protein 1.";
RL Submitted (AUG-2007) to the PDB data bank.
CC -!- FUNCTION: Protects DRG2 from proteolytic degradation (By
CC similarity).
CC -!- SUBUNIT: Interacts with DRG2. Interacts with androgen receptor (By
CC similarity).
CC -!- INTERACTION:
CC Q9Y295:DRG1; NbExp=2; IntAct=EBI-748952, EBI-719554;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H446-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H446-2; Sequence=VSP_044500;
CC -!- SIMILARITY: Belongs to the RWDD1/GIR2 family.
CC -!- SIMILARITY: Contains 1 RWD domain.
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DR EMBL; AF132958; AAD27733.1; -; mRNA.
DR EMBL; AF092134; AAD40376.1; -; mRNA.
DR EMBL; AK290727; BAF83416.1; -; mRNA.
DR EMBL; AK301089; BAG62691.1; -; mRNA.
DR EMBL; AL121953; CAC14427.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48221.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48222.1; -; Genomic_DNA.
DR EMBL; BC015802; AAH15802.1; -; mRNA.
DR RefSeq; NP_001007465.1; NM_001007464.2.
DR RefSeq; NP_057036.2; NM_015952.3.
DR RefSeq; NP_057188.2; NM_016104.3.
DR UniGene; Hs.532164; -.
DR PDB; 2EBM; NMR; -; A=1-121.
DR PDBsum; 2EBM; -.
DR ProteinModelPortal; Q9H446; -.
DR SMR; Q9H446; 1-121.
DR DIP; DIP-34520N; -.
DR IntAct; Q9H446; 4.
DR MINT; MINT-1436573; -.
DR STRING; 9606.ENSP00000420357; -.
DR PhosphoSite; Q9H446; -.
DR DMDM; 34098713; -.
DR PaxDb; Q9H446; -.
DR PRIDE; Q9H446; -.
DR DNASU; 51389; -.
DR Ensembl; ENST00000392526; ENSP00000376311; ENSG00000111832.
DR Ensembl; ENST00000466444; ENSP00000420357; ENSG00000111832.
DR Ensembl; ENST00000487832; ENSP00000428778; ENSG00000111832.
DR GeneID; 51389; -.
DR KEGG; hsa:51389; -.
DR UCSC; uc003pxb.3; human.
DR CTD; 51389; -.
DR GeneCards; GC06P116938; -.
DR HGNC; HGNC:20993; RWDD1.
DR HPA; HPA028712; -.
DR HPA; HPA028713; -.
DR neXtProt; NX_Q9H446; -.
DR PharmGKB; PA134967923; -.
DR eggNOG; NOG301416; -.
DR HOGENOM; HOG000237961; -.
DR HOVERGEN; HBG060864; -.
DR InParanoid; Q9H446; -.
DR OMA; WKAKFEL; -.
DR OrthoDB; EOG779NZV; -.
DR PhylomeDB; Q9H446; -.
DR EvolutionaryTrace; Q9H446; -.
DR GenomeRNAi; 51389; -.
DR NextBio; 54913; -.
DR PRO; PR:Q9H446; -.
DR ArrayExpress; Q9H446; -.
DR Bgee; Q9H446; -.
DR CleanEx; HS_RWDD1; -.
DR Genevestigator; Q9H446; -.
DR Gene3D; 3.10.110.10; -; 1.
DR InterPro; IPR006575; RWD-domain.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR Pfam; PF05773; RWD; 1.
DR SMART; SM00591; RWD; 1.
DR SUPFAM; SSF54495; SSF54495; 1.
DR PROSITE; PS50908; RWD; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Alternative splicing; Complete proteome;
KW Phosphoprotein; Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 243 RWD domain-containing protein 1.
FT /FTId=PRO_0000097540.
FT DOMAIN 10 114 RWD.
FT REGION 142 197 Interaction with DRG2 (By similarity).
FT MOD_RES 2 2 N-acetylthreonine.
FT MOD_RES 144 144 Phosphothreonine.
FT VAR_SEQ 1 96 Missing (in isoform 2).
FT /FTId=VSP_044500.
FT CONFLICT 120 130 TRREEEKKQKE -> LEERRKNKR (in Ref. 1;
FT AAD27733).
FT CONFLICT 139 139 Q -> R (in Ref. 2; AAD40376).
FT HELIX 4 18
FT STRAND 20 25
FT STRAND 28 30
FT STRAND 32 35
FT STRAND 49 55
FT TURN 60 62
FT STRAND 66 74
FT HELIX 77 94
FT HELIX 100 117
FT HELIX 118 120
SQ SEQUENCE 243 AA; 27940 MW; A7AABD457136B4DA CRC64;
MTDYGEEQRN ELEALESIYP DSFTVLSENP PSFTITVTSE AGENDETVQT TLKFTYSEKY
PDEAPLYEIF SQENLEDNDV SDILKLLALQ AEENLGMVMI FTLVTAVQEK LNEIVDQIKT
RREEEKKQKE KEAEEAEKQL FHGTPVTIEN FLNWKAKFDA ELLEIKKKRM KEEEQAGKNK
LSGKQLFETD HNLDTSDIQF LEDAGNNVEV DESLFQEMDD LELEDDEDDP DYNPADPESD
SAD
//