Full text data of S100A7
S100A7
(PSOR1, S100A7C)
[Confidence: low (only semi-automatic identification from reviews)]
Protein S100-A7 (Psoriasin; S100 calcium-binding protein A7)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Protein S100-A7 (Psoriasin; S100 calcium-binding protein A7)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
P31151
ID S10A7_HUMAN Reviewed; 101 AA.
AC P31151; Q5SY67; Q6FGE3; Q9H1E2;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
read moreDT 26-FEB-2008, sequence version 4.
DT 22-JAN-2014, entry version 143.
DE RecName: Full=Protein S100-A7;
DE AltName: Full=Psoriasin;
DE AltName: Full=S100 calcium-binding protein A7;
GN Name=S100A7; Synonyms=PSOR1, S100A7C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ASP-28.
RC TISSUE=Keratinocyte;
RX PubMed=1940442; DOI=10.1111/1523-1747.ep12484041;
RA Madsen P., Rasmussen H.H., Leffers H., Honore B., Dejgaard K.,
RA Olsen E., Kiil J., Walbum E., Andersen A.H., Basse B., Lauridsen J.B.,
RA Ratz G.P., Celis A., Vandekerckhove J., Celis J.E.;
RT "Molecular cloning, occurrence, and expression of a novel partially
RT secreted protein 'psoriasin' that is highly up-regulated in psoriatic
RT skin.";
RL J. Invest. Dermatol. 97:701-712(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-28.
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
RA Korn B., Zuo D., Hu Y., LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-28.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-89, AND VARIANT ASP-28.
RA Glaeser R., Harder J., Christophers E., Schroeder J.M.;
RT "Genomic organization of human psoriasin (S100A7) gene.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP PROTEIN SEQUENCE OF 2-101, MASS SPECTROMETRY, AND ACETYLATION AT
RP SER-2.
RC TISSUE=Psoriatic skin;
RX PubMed=8526920; DOI=10.1006/bbrc.1995.2772;
RA Burgisser D.M., Siegenthaler G., Kuster T., Hellman U., Hunziker P.,
RA Birchler N., Heizmann C.W.;
RT "Amino acid sequence analysis of human S100A7 (psoriasin) by tandem
RT mass spectrometry.";
RL Biochem. Biophys. Res. Commun. 217:257-263(1995).
RN [7]
RP PROTEIN SEQUENCE OF 9-19; 38-48; 50-61; 69-87 AND 89-101.
RC TISSUE=Keratinocyte;
RX PubMed=1286667; DOI=10.1002/elps.11501301199;
RA Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E.,
RA Vandekerckhove J.;
RT "Microsequences of 145 proteins recorded in the two-dimensional gel
RT protein database of normal human epidermal keratinocytes.";
RL Electrophoresis 13:960-969(1992).
RN [8]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=8618345; DOI=10.1097/00005392-199606000-00098;
RA Celis J.E., Rasmussen H.H., Vorum H., Madsen P., Honore B., Wolf H.,
RA Orntoft T.F.;
RT "Bladder squamous cell carcinomas express psoriasin and externalize it
RT to the urine.";
RL J. Urol. 155:2105-2112(1996).
RN [9]
RP INTERACTION WITH RANBP9.
RX PubMed=12421467; DOI=10.1186/1471-2407-2-28;
RA Emberley E.D., Gietz R.D., Campbell J.D., Hayglass K.T., Murphy L.C.,
RA Watson P.H.;
RT "RanBPM interacts with psoriasin in vitro and their expression
RT correlates with specific clinical features in vivo in breast cancer.";
RL BMC Cancer 2:28-28(2002).
RN [10]
RP GENOMIC ORGANIZATION.
RX PubMed=12664160; DOI=10.1007/s00239-002-2410-5;
RA Kulski J.K., Lim C.P., Dunn D.S., Bellgard M.;
RT "Genomic and phylogenetic analysis of the S100A7 (psoriasin) gene
RT duplications within the region of the S100 gene cluster on human
RT chromosome 1q21.";
RL J. Mol. Evol. 56:397-406(2003).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [12]
RP X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS).
RX PubMed=9562557; DOI=10.1016/S0969-2126(98)00049-5;
RA Brodersen D.E., Etzerodt M., Madsen P., Celis J.E., Thoegersen H.C.,
RA Nyborg J., Kjeldgaard M.;
RT "EF-hands at atomic resolution: the structure of human psoriasin
RT (S100A7) solved by MAD phasing.";
RL Structure 6:477-489(1998).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS).
RX PubMed=10026247; DOI=10.1021/bi982483d;
RA Brodersen D.E., Nyborg J., Kjeldgaard M.;
RT "Zinc-binding site of an S100 protein revealed. Two crystal structures
RT of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-
RT free states.";
RL Biochemistry 38:1695-1704(1999).
CC -!- SUBUNIT: Interacts with RANBP9.
CC -!- INTERACTION:
CC Q96S59:RANBP9; NbExp=3; IntAct=EBI-357520, EBI-636085;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Secreted. Note=Secreted by a non-
CC classical secretory pathway.
CC -!- TISSUE SPECIFICITY: Fetal ear, skin, and tongue and human cell
CC lines. Highly up-regulated in psoriatic epidermis. Also highly
CC expressed in the urine of bladder squamous cell carcinoma (SCC)
CC bearing patients.
CC -!- MASS SPECTROMETRY: Mass=11365; Mass_error=0.7;
CC Method=Electrospray; Range=2-101; Source=PubMed:8526920;
CC -!- SIMILARITY: Belongs to the S-101 family.
CC -!- SIMILARITY: Contains 2 EF-hand domains.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC and Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/S100A7ID42194ch1q21.html";
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DR EMBL; M86757; AAA60210.1; -; mRNA.
DR EMBL; CR542164; CAG46961.1; -; mRNA.
DR EMBL; AL591704; CAI19502.1; -; Genomic_DNA.
DR EMBL; BC034687; AAH34687.1; -; mRNA.
DR EMBL; AJ012825; CAC20409.1; -; Genomic_DNA.
DR EMBL; BR000043; FAA00017.1; -; Genomic_DNA.
DR PIR; A54327; A54327.
DR RefSeq; NP_002954.2; NM_002963.3.
DR RefSeq; XP_005245488.1; XM_005245431.1.
DR UniGene; Hs.112408; -.
DR PDB; 1PSR; X-ray; 1.05 A; A/B=2-101.
DR PDB; 2PSR; X-ray; 2.05 A; A=2-101.
DR PDB; 2WND; X-ray; 1.60 A; A=2-97.
DR PDB; 2WOR; X-ray; 1.70 A; A=2-101.
DR PDB; 2WOS; X-ray; 1.70 A; A=2-101.
DR PDB; 3PSR; X-ray; 2.50 A; A/B=2-101.
DR PDB; 4AQJ; X-ray; 1.60 A; A=1-101.
DR PDBsum; 1PSR; -.
DR PDBsum; 2PSR; -.
DR PDBsum; 2WND; -.
DR PDBsum; 2WOR; -.
DR PDBsum; 2WOS; -.
DR PDBsum; 3PSR; -.
DR PDBsum; 4AQJ; -.
DR ProteinModelPortal; P31151; -.
DR SMR; P31151; 2-101.
DR IntAct; P31151; 9.
DR MINT; MINT-1156620; -.
DR STRING; 9606.ENSP00000357711; -.
DR PhosphoSite; P31151; -.
DR DMDM; 172046820; -.
DR UCD-2DPAGE; P31151; -.
DR PaxDb; P31151; -.
DR PeptideAtlas; P31151; -.
DR PRIDE; P31151; -.
DR DNASU; 6278; -.
DR Ensembl; ENST00000368722; ENSP00000357711; ENSG00000143556.
DR Ensembl; ENST00000368723; ENSP00000357712; ENSG00000143556.
DR GeneID; 6278; -.
DR KEGG; hsa:6278; -.
DR UCSC; uc001fbv.1; human.
DR CTD; 6278; -.
DR GeneCards; GC01M153430; -.
DR H-InvDB; HIX0200006; -.
DR HGNC; HGNC:10497; S100A7.
DR HPA; CAB001453; -.
DR HPA; CAB033766; -.
DR HPA; HPA006997; -.
DR MIM; 600353; gene.
DR neXtProt; NX_P31151; -.
DR PharmGKB; PA34909; -.
DR eggNOG; NOG78008; -.
DR HOGENOM; HOG000154231; -.
DR HOVERGEN; HBG095357; -.
DR InParanoid; P31151; -.
DR OMA; SHGAPAC; -.
DR OrthoDB; EOG7RZ5SH; -.
DR PhylomeDB; P31151; -.
DR EvolutionaryTrace; P31151; -.
DR GeneWiki; S100A7; -.
DR GenomeRNAi; 6278; -.
DR NextBio; 24369; -.
DR PRO; PR:P31151; -.
DR Bgee; P31151; -.
DR CleanEx; HS_S100A7; -.
DR Genevestigator; P31151; -.
DR GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0005925; C:focal adhesion; NAS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IDA:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; NAS:UniProtKB.
DR GO; GO:0001525; P:angiogenesis; NAS:UniProtKB.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:UniProtKB.
DR GO; GO:0045087; P:innate immune response; NAS:UniProtKB.
DR GO; GO:0030216; P:keratinocyte differentiation; NAS:UniProtKB.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
DR GO; GO:0071624; P:positive regulation of granulocyte chemotaxis; IDA:UniProtKB.
DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:UniProtKB.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IDA:UniProtKB.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEP:UniProtKB.
DR GO; GO:0000302; P:response to reactive oxygen species; IDA:UniProtKB.
DR GO; GO:0051238; P:sequestering of metal ion; IDA:UniProtKB.
DR Gene3D; 1.10.238.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR001751; S100/CaBP-9k_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR InterPro; IPR028477; S100A7.
DR PANTHER; PTHR11639:SF1; PTHR11639:SF1; 1.
DR Pfam; PF01023; S_100; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Calcium; Complete proteome; Cytoplasm;
KW Direct protein sequencing; Disulfide bond; Metal-binding;
KW Polymorphism; Reference proteome; Repeat; Secreted; Zinc.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 101 Protein S100-A7.
FT /FTId=PRO_0000143990.
FT DOMAIN 13 48 EF-hand 1.
FT DOMAIN 50 85 EF-hand 2.
FT CA_BIND 63 74 2; high affinity.
FT METAL 18 18 Zinc.
FT METAL 25 25 Zinc.
FT METAL 87 87 Zinc.
FT METAL 91 91 Zinc.
FT MOD_RES 2 2 N-acetylserine.
FT DISULFID 47 96
FT VARIANT 28 28 E -> D (in dbSNP:rs3014837).
FT /FTId=VAR_039118.
FT HELIX 5 19
FT HELIX 29 39
FT HELIX 41 49
FT HELIX 54 56
FT HELIX 58 62
FT STRAND 67 70
FT HELIX 72 89
FT TURN 90 92
SQ SEQUENCE 101 AA; 11471 MW; 02C4CE39BF140971 CRC64;
MSNTQAERSI IGMIDMFHKY TRRDDKIEKP SLLTMMKENF PNFLSACDKK GTNYLADVFE
KKDKNEDKKI DFSEFLSLLG DIATDYHKQS HGAAPCSGGS Q
//
ID S10A7_HUMAN Reviewed; 101 AA.
AC P31151; Q5SY67; Q6FGE3; Q9H1E2;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
read moreDT 26-FEB-2008, sequence version 4.
DT 22-JAN-2014, entry version 143.
DE RecName: Full=Protein S100-A7;
DE AltName: Full=Psoriasin;
DE AltName: Full=S100 calcium-binding protein A7;
GN Name=S100A7; Synonyms=PSOR1, S100A7C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ASP-28.
RC TISSUE=Keratinocyte;
RX PubMed=1940442; DOI=10.1111/1523-1747.ep12484041;
RA Madsen P., Rasmussen H.H., Leffers H., Honore B., Dejgaard K.,
RA Olsen E., Kiil J., Walbum E., Andersen A.H., Basse B., Lauridsen J.B.,
RA Ratz G.P., Celis A., Vandekerckhove J., Celis J.E.;
RT "Molecular cloning, occurrence, and expression of a novel partially
RT secreted protein 'psoriasin' that is highly up-regulated in psoriatic
RT skin.";
RL J. Invest. Dermatol. 97:701-712(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-28.
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
RA Korn B., Zuo D., Hu Y., LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-28.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-89, AND VARIANT ASP-28.
RA Glaeser R., Harder J., Christophers E., Schroeder J.M.;
RT "Genomic organization of human psoriasin (S100A7) gene.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP PROTEIN SEQUENCE OF 2-101, MASS SPECTROMETRY, AND ACETYLATION AT
RP SER-2.
RC TISSUE=Psoriatic skin;
RX PubMed=8526920; DOI=10.1006/bbrc.1995.2772;
RA Burgisser D.M., Siegenthaler G., Kuster T., Hellman U., Hunziker P.,
RA Birchler N., Heizmann C.W.;
RT "Amino acid sequence analysis of human S100A7 (psoriasin) by tandem
RT mass spectrometry.";
RL Biochem. Biophys. Res. Commun. 217:257-263(1995).
RN [7]
RP PROTEIN SEQUENCE OF 9-19; 38-48; 50-61; 69-87 AND 89-101.
RC TISSUE=Keratinocyte;
RX PubMed=1286667; DOI=10.1002/elps.11501301199;
RA Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E.,
RA Vandekerckhove J.;
RT "Microsequences of 145 proteins recorded in the two-dimensional gel
RT protein database of normal human epidermal keratinocytes.";
RL Electrophoresis 13:960-969(1992).
RN [8]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=8618345; DOI=10.1097/00005392-199606000-00098;
RA Celis J.E., Rasmussen H.H., Vorum H., Madsen P., Honore B., Wolf H.,
RA Orntoft T.F.;
RT "Bladder squamous cell carcinomas express psoriasin and externalize it
RT to the urine.";
RL J. Urol. 155:2105-2112(1996).
RN [9]
RP INTERACTION WITH RANBP9.
RX PubMed=12421467; DOI=10.1186/1471-2407-2-28;
RA Emberley E.D., Gietz R.D., Campbell J.D., Hayglass K.T., Murphy L.C.,
RA Watson P.H.;
RT "RanBPM interacts with psoriasin in vitro and their expression
RT correlates with specific clinical features in vivo in breast cancer.";
RL BMC Cancer 2:28-28(2002).
RN [10]
RP GENOMIC ORGANIZATION.
RX PubMed=12664160; DOI=10.1007/s00239-002-2410-5;
RA Kulski J.K., Lim C.P., Dunn D.S., Bellgard M.;
RT "Genomic and phylogenetic analysis of the S100A7 (psoriasin) gene
RT duplications within the region of the S100 gene cluster on human
RT chromosome 1q21.";
RL J. Mol. Evol. 56:397-406(2003).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [12]
RP X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS).
RX PubMed=9562557; DOI=10.1016/S0969-2126(98)00049-5;
RA Brodersen D.E., Etzerodt M., Madsen P., Celis J.E., Thoegersen H.C.,
RA Nyborg J., Kjeldgaard M.;
RT "EF-hands at atomic resolution: the structure of human psoriasin
RT (S100A7) solved by MAD phasing.";
RL Structure 6:477-489(1998).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS).
RX PubMed=10026247; DOI=10.1021/bi982483d;
RA Brodersen D.E., Nyborg J., Kjeldgaard M.;
RT "Zinc-binding site of an S100 protein revealed. Two crystal structures
RT of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-
RT free states.";
RL Biochemistry 38:1695-1704(1999).
CC -!- SUBUNIT: Interacts with RANBP9.
CC -!- INTERACTION:
CC Q96S59:RANBP9; NbExp=3; IntAct=EBI-357520, EBI-636085;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Secreted. Note=Secreted by a non-
CC classical secretory pathway.
CC -!- TISSUE SPECIFICITY: Fetal ear, skin, and tongue and human cell
CC lines. Highly up-regulated in psoriatic epidermis. Also highly
CC expressed in the urine of bladder squamous cell carcinoma (SCC)
CC bearing patients.
CC -!- MASS SPECTROMETRY: Mass=11365; Mass_error=0.7;
CC Method=Electrospray; Range=2-101; Source=PubMed:8526920;
CC -!- SIMILARITY: Belongs to the S-101 family.
CC -!- SIMILARITY: Contains 2 EF-hand domains.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
CC and Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/S100A7ID42194ch1q21.html";
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
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DR EMBL; M86757; AAA60210.1; -; mRNA.
DR EMBL; CR542164; CAG46961.1; -; mRNA.
DR EMBL; AL591704; CAI19502.1; -; Genomic_DNA.
DR EMBL; BC034687; AAH34687.1; -; mRNA.
DR EMBL; AJ012825; CAC20409.1; -; Genomic_DNA.
DR EMBL; BR000043; FAA00017.1; -; Genomic_DNA.
DR PIR; A54327; A54327.
DR RefSeq; NP_002954.2; NM_002963.3.
DR RefSeq; XP_005245488.1; XM_005245431.1.
DR UniGene; Hs.112408; -.
DR PDB; 1PSR; X-ray; 1.05 A; A/B=2-101.
DR PDB; 2PSR; X-ray; 2.05 A; A=2-101.
DR PDB; 2WND; X-ray; 1.60 A; A=2-97.
DR PDB; 2WOR; X-ray; 1.70 A; A=2-101.
DR PDB; 2WOS; X-ray; 1.70 A; A=2-101.
DR PDB; 3PSR; X-ray; 2.50 A; A/B=2-101.
DR PDB; 4AQJ; X-ray; 1.60 A; A=1-101.
DR PDBsum; 1PSR; -.
DR PDBsum; 2PSR; -.
DR PDBsum; 2WND; -.
DR PDBsum; 2WOR; -.
DR PDBsum; 2WOS; -.
DR PDBsum; 3PSR; -.
DR PDBsum; 4AQJ; -.
DR ProteinModelPortal; P31151; -.
DR SMR; P31151; 2-101.
DR IntAct; P31151; 9.
DR MINT; MINT-1156620; -.
DR STRING; 9606.ENSP00000357711; -.
DR PhosphoSite; P31151; -.
DR DMDM; 172046820; -.
DR UCD-2DPAGE; P31151; -.
DR PaxDb; P31151; -.
DR PeptideAtlas; P31151; -.
DR PRIDE; P31151; -.
DR DNASU; 6278; -.
DR Ensembl; ENST00000368722; ENSP00000357711; ENSG00000143556.
DR Ensembl; ENST00000368723; ENSP00000357712; ENSG00000143556.
DR GeneID; 6278; -.
DR KEGG; hsa:6278; -.
DR UCSC; uc001fbv.1; human.
DR CTD; 6278; -.
DR GeneCards; GC01M153430; -.
DR H-InvDB; HIX0200006; -.
DR HGNC; HGNC:10497; S100A7.
DR HPA; CAB001453; -.
DR HPA; CAB033766; -.
DR HPA; HPA006997; -.
DR MIM; 600353; gene.
DR neXtProt; NX_P31151; -.
DR PharmGKB; PA34909; -.
DR eggNOG; NOG78008; -.
DR HOGENOM; HOG000154231; -.
DR HOVERGEN; HBG095357; -.
DR InParanoid; P31151; -.
DR OMA; SHGAPAC; -.
DR OrthoDB; EOG7RZ5SH; -.
DR PhylomeDB; P31151; -.
DR EvolutionaryTrace; P31151; -.
DR GeneWiki; S100A7; -.
DR GenomeRNAi; 6278; -.
DR NextBio; 24369; -.
DR PRO; PR:P31151; -.
DR Bgee; P31151; -.
DR CleanEx; HS_S100A7; -.
DR Genevestigator; P31151; -.
DR GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0005925; C:focal adhesion; NAS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IDA:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; NAS:UniProtKB.
DR GO; GO:0001525; P:angiogenesis; NAS:UniProtKB.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:UniProtKB.
DR GO; GO:0045087; P:innate immune response; NAS:UniProtKB.
DR GO; GO:0030216; P:keratinocyte differentiation; NAS:UniProtKB.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
DR GO; GO:0071624; P:positive regulation of granulocyte chemotaxis; IDA:UniProtKB.
DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IDA:UniProtKB.
DR GO; GO:0010820; P:positive regulation of T cell chemotaxis; IDA:UniProtKB.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEP:UniProtKB.
DR GO; GO:0000302; P:response to reactive oxygen species; IDA:UniProtKB.
DR GO; GO:0051238; P:sequestering of metal ion; IDA:UniProtKB.
DR Gene3D; 1.10.238.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR001751; S100/CaBP-9k_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR InterPro; IPR028477; S100A7.
DR PANTHER; PTHR11639:SF1; PTHR11639:SF1; 1.
DR Pfam; PF01023; S_100; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Calcium; Complete proteome; Cytoplasm;
KW Direct protein sequencing; Disulfide bond; Metal-binding;
KW Polymorphism; Reference proteome; Repeat; Secreted; Zinc.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 101 Protein S100-A7.
FT /FTId=PRO_0000143990.
FT DOMAIN 13 48 EF-hand 1.
FT DOMAIN 50 85 EF-hand 2.
FT CA_BIND 63 74 2; high affinity.
FT METAL 18 18 Zinc.
FT METAL 25 25 Zinc.
FT METAL 87 87 Zinc.
FT METAL 91 91 Zinc.
FT MOD_RES 2 2 N-acetylserine.
FT DISULFID 47 96
FT VARIANT 28 28 E -> D (in dbSNP:rs3014837).
FT /FTId=VAR_039118.
FT HELIX 5 19
FT HELIX 29 39
FT HELIX 41 49
FT HELIX 54 56
FT HELIX 58 62
FT STRAND 67 70
FT HELIX 72 89
FT TURN 90 92
SQ SEQUENCE 101 AA; 11471 MW; 02C4CE39BF140971 CRC64;
MSNTQAERSI IGMIDMFHKY TRRDDKIEKP SLLTMMKENF PNFLSACDKK GTNYLADVFE
KKDKNEDKKI DFSEFLSLLG DIATDYHKQS HGAAPCSGGS Q
//
MIM
600353
*RECORD*
*FIELD* NO
600353
*FIELD* TI
*600353 S100 CALCIUM-BINDING PROTEIN A7; S100A7
;;PSORIASIN; PSOR1
*FIELD* TX
CLONING
read more
Celis et al. (1990) established a computer-accessible 2D gel protein
database of epidermal keratinocytes from normal and psoriatic skin. As a
result of these studies, Celis et al. (1990) identified several low
molecular mass proteins that were highly upregulated in psoriatic
epidermis. Madsen et al. (1991) reported the molecular cloning and
expression of one of these proteins, which they termed psoriasin. The
sequence predicts a protein of molecular mass 11,457 Da. The predicted
amino acid sequence includes a potential calcium-binding sequence of the
EF-hand type. Schafer et al. (1995) isolated a YAC clone from 1q21 on
which 9 different genes coding for S100 calcium-binding proteins could
be localized. Clustered organization of these S100 genes allowed
introduction of a new and logical nomenclature based on their physical
arrangement; the 9 genes were symbolized S100A1 (176940), which is
nearest the telomere, to S100A9 (123886), which is nearest the
centromere. In this nomenclature, the gene encoding psoriasin was
symbolized S100A7, rather than PSOR1.
GENE FUNCTION
Jinquan et al. (1996) reported that human psoriasin is a potent and
selected chemotactic inflammatory protein for CD4+ T lymphocytes and
neutrophils at a low concentration. Psoriasin is not structurally
related to the alpha- or the beta-chemokine subfamilies or to
lymphotactin (600250), a member of a unique class of chemokines.
Glaser et al. (2005) analyzed skin extracts by affinity chromatography,
HPLC, and mass spectrophotometry and found that the 11-kD psoriasin
protein preferentially killed the gut bacterium Escherichia coli, but
had little or no activity against Staphylococcus aureus or other
bacteria. The activity could be inhibited by zinc, but not by other
bivalent ions, suggesting that psoriasin kills E. coli by sequestration
of zinc. Immunohistochemical analysis demonstrated intense expression of
psoriasin in healthy skin, particularly in the face, scalp, and
sebaceous glands. Real-time PCR and ELISA analysis of keratinocytes
stimulated with E. coli culture supernatants induced transcription of
psoriasin and its secretion. Stimulation with IL1B (147720) or, to a
lesser extent, with TNF (191160) also induced psoriasin transcription
and secretion. Glaser et al. (2005) concluded that psoriasin is key to
the local innate defense against E. coli on body surfaces and kills the
bacteria by sequestering essential transition metal ions.
GENE STRUCTURE
Semprini et al. (1999) determined the genomic structure and
characterized the promoter of S100A7. The gene contains 3 exons spanning
2.7 kb.
MAPPING
Hardas et al. (1993) mapped the S100A7 gene to 1q21 by fluorescence in
situ hybridization and YAC analysis. By Southern blot analysis of
human/rodent somatic cell hybrids, Borglum et al. (1995) mapped the
S100A7 gene to chromosome 1. By multipoint linkage analysis they
assigned the locus to a site proximal to MUC1 (158340) and distal to
AMY2B (104660).
MOLECULAR GENETICS
Mutation analysis by Semprini et al. (1999) using SSCP and direct
sequencing of 15 unrelated psoriasis patients from 1q-linked pedigrees
and 25 normal controls failed to identify any mutations, excluding
S100A7 as a candidate gene for familial psoriasis susceptibility.
*FIELD* RF
1. Borglum, A. D.; Flint, T.; Madsen, P.; Celis, J. E.; Kruse, T.
A.: Refined mapping of the psoriasin gene S100A7 to chromosome 1cen-q21. Hum.
Genet. 96: 592-596, 1995.
2. Celis, J. E.; Cruger, D.; Kiil, J.; Dejgaard, K.; Lauridsen, J.
B.; Ratz, G. P.; Basse, B.; Celis, A.; Rasmussen, H. H.; Bauw, G.;
Vanderkerckhove, J.: A two-dimensional gel protein database of noncultured
total normal human epidermal keratinocytes: identification of proteins
strongly up-regulated in psoriatic epidermis. Electrophoresis 11:
242-254, 1990.
3. Celis, J. E.; Cruger, D.; Kiil, J.; Lauridsen, J. B.; Ratz, G.;
Basse, B.; Celis, A.: Identification of a group of proteins that
are strongly up-regulated in total epidermal keratinocytes from psoriatic
skin. FEBS Lett. 262: 159-164, 1990. Note: Erratum: FEBS Lett. 267:
317 only, 1990.
4. Glaser, R.; Harder, J.; Lange, H.; Bartels, J.; Christophers, E.;
Schroder, J.-M.: Antimicrobial psoriasin (S100A7) protects human
skin from Escherichia coli infection. Nature Immun. 6: 57-64, 2005.
5. Hardas, B. D.; Cromie, M. A.; Elder, J. T.: Psoriasin is tightly
linked to CRABP-II and MRP 14 on human chromosome 1q21: coordinate
overexpression of clustered genes in psoriatic and RA-treated skin.
(Abstract) J. Invest. Derm. 100: 517, 1993.
6. Jinquan, T.; Vorum, H.; Larsen, C. G.; Madsen, P.; Rasmussen, H.
H.; Gesser, B.; Etzerodt, M.; Honore, B.; Celis, J. E.; Thestrup-Pedersen,
K.: Psoriasin: a novel chemotactic protein. J. Invest. Derm. 107:
5-10, 1996.
7. Madsen, P.; Rasmussen, H. H.; Leffers, H.; Honore, B.; Dejgaard,
K.; Olsen, E.; Kiil, J.; Walbum, E.; Andersen, A. H.; Basse, B.; Lauridsen,
J. B.; Ratz, G. P.; Celis, A.; Vandekerckhove, J.; Celis, J. E.:
Molecular cloning, occurrence, and expression of a novel partially
secreted protein 'psoriasin' that is highly up-regulated in psoriatic
skin. J. Invest. Derm. 97: 701-712, 1991.
8. Schafer, B. W.; Wicki, R.; Engelkamp, D.; Mattei, M.-G.; Heizmann,
C. W.: Isolation of a YAC clone covering a cluster of nine S100 genes
on human chromosome 1q21: rationale for a new nomenclature of the
S100 calcium-binding protein family. Genomics 25: 638-643, 1995.
9. Semprini, S.; Capon, F.; Bovolenta, S.; Bruscia, E.; Pizzuti, A.;
Fabrizi, G.; Schietroma, C.; Zambruno, G.; Dallapiccola, B.; Novelli,
G.: Genomic structure, promoter characterisation and mutational analysis
of the S100A7 gene: exclusion of a candidate for familial psoriasis
susceptibility. Hum. Genet. 104: 130-134, 1999.
*FIELD* CN
Paul J. Converse - updated: 5/11/2005
Victor A. McKusick - updated: 10/9/2002
Ada Hamosh - updated: 3/18/1999
*FIELD* CD
Victor A. McKusick: 1/27/1995
*FIELD* ED
tpirozzi: 10/01/2013
terry: 9/24/2012
carol: 1/19/2011
mgross: 5/13/2005
terry: 5/11/2005
mgross: 5/11/2005
carol: 10/11/2002
tkritzer: 10/10/2002
terry: 10/9/2002
alopez: 3/18/1999
alopez: 10/12/1998
terry: 1/17/1997
jenny: 12/6/1996
terry: 11/15/1996
terry: 3/26/1996
mark: 1/28/1996
terry: 1/23/1996
mimadm: 9/23/1995
mark: 6/15/1995
carol: 1/27/1995
*RECORD*
*FIELD* NO
600353
*FIELD* TI
*600353 S100 CALCIUM-BINDING PROTEIN A7; S100A7
;;PSORIASIN; PSOR1
*FIELD* TX
CLONING
read more
Celis et al. (1990) established a computer-accessible 2D gel protein
database of epidermal keratinocytes from normal and psoriatic skin. As a
result of these studies, Celis et al. (1990) identified several low
molecular mass proteins that were highly upregulated in psoriatic
epidermis. Madsen et al. (1991) reported the molecular cloning and
expression of one of these proteins, which they termed psoriasin. The
sequence predicts a protein of molecular mass 11,457 Da. The predicted
amino acid sequence includes a potential calcium-binding sequence of the
EF-hand type. Schafer et al. (1995) isolated a YAC clone from 1q21 on
which 9 different genes coding for S100 calcium-binding proteins could
be localized. Clustered organization of these S100 genes allowed
introduction of a new and logical nomenclature based on their physical
arrangement; the 9 genes were symbolized S100A1 (176940), which is
nearest the telomere, to S100A9 (123886), which is nearest the
centromere. In this nomenclature, the gene encoding psoriasin was
symbolized S100A7, rather than PSOR1.
GENE FUNCTION
Jinquan et al. (1996) reported that human psoriasin is a potent and
selected chemotactic inflammatory protein for CD4+ T lymphocytes and
neutrophils at a low concentration. Psoriasin is not structurally
related to the alpha- or the beta-chemokine subfamilies or to
lymphotactin (600250), a member of a unique class of chemokines.
Glaser et al. (2005) analyzed skin extracts by affinity chromatography,
HPLC, and mass spectrophotometry and found that the 11-kD psoriasin
protein preferentially killed the gut bacterium Escherichia coli, but
had little or no activity against Staphylococcus aureus or other
bacteria. The activity could be inhibited by zinc, but not by other
bivalent ions, suggesting that psoriasin kills E. coli by sequestration
of zinc. Immunohistochemical analysis demonstrated intense expression of
psoriasin in healthy skin, particularly in the face, scalp, and
sebaceous glands. Real-time PCR and ELISA analysis of keratinocytes
stimulated with E. coli culture supernatants induced transcription of
psoriasin and its secretion. Stimulation with IL1B (147720) or, to a
lesser extent, with TNF (191160) also induced psoriasin transcription
and secretion. Glaser et al. (2005) concluded that psoriasin is key to
the local innate defense against E. coli on body surfaces and kills the
bacteria by sequestering essential transition metal ions.
GENE STRUCTURE
Semprini et al. (1999) determined the genomic structure and
characterized the promoter of S100A7. The gene contains 3 exons spanning
2.7 kb.
MAPPING
Hardas et al. (1993) mapped the S100A7 gene to 1q21 by fluorescence in
situ hybridization and YAC analysis. By Southern blot analysis of
human/rodent somatic cell hybrids, Borglum et al. (1995) mapped the
S100A7 gene to chromosome 1. By multipoint linkage analysis they
assigned the locus to a site proximal to MUC1 (158340) and distal to
AMY2B (104660).
MOLECULAR GENETICS
Mutation analysis by Semprini et al. (1999) using SSCP and direct
sequencing of 15 unrelated psoriasis patients from 1q-linked pedigrees
and 25 normal controls failed to identify any mutations, excluding
S100A7 as a candidate gene for familial psoriasis susceptibility.
*FIELD* RF
1. Borglum, A. D.; Flint, T.; Madsen, P.; Celis, J. E.; Kruse, T.
A.: Refined mapping of the psoriasin gene S100A7 to chromosome 1cen-q21. Hum.
Genet. 96: 592-596, 1995.
2. Celis, J. E.; Cruger, D.; Kiil, J.; Dejgaard, K.; Lauridsen, J.
B.; Ratz, G. P.; Basse, B.; Celis, A.; Rasmussen, H. H.; Bauw, G.;
Vanderkerckhove, J.: A two-dimensional gel protein database of noncultured
total normal human epidermal keratinocytes: identification of proteins
strongly up-regulated in psoriatic epidermis. Electrophoresis 11:
242-254, 1990.
3. Celis, J. E.; Cruger, D.; Kiil, J.; Lauridsen, J. B.; Ratz, G.;
Basse, B.; Celis, A.: Identification of a group of proteins that
are strongly up-regulated in total epidermal keratinocytes from psoriatic
skin. FEBS Lett. 262: 159-164, 1990. Note: Erratum: FEBS Lett. 267:
317 only, 1990.
4. Glaser, R.; Harder, J.; Lange, H.; Bartels, J.; Christophers, E.;
Schroder, J.-M.: Antimicrobial psoriasin (S100A7) protects human
skin from Escherichia coli infection. Nature Immun. 6: 57-64, 2005.
5. Hardas, B. D.; Cromie, M. A.; Elder, J. T.: Psoriasin is tightly
linked to CRABP-II and MRP 14 on human chromosome 1q21: coordinate
overexpression of clustered genes in psoriatic and RA-treated skin.
(Abstract) J. Invest. Derm. 100: 517, 1993.
6. Jinquan, T.; Vorum, H.; Larsen, C. G.; Madsen, P.; Rasmussen, H.
H.; Gesser, B.; Etzerodt, M.; Honore, B.; Celis, J. E.; Thestrup-Pedersen,
K.: Psoriasin: a novel chemotactic protein. J. Invest. Derm. 107:
5-10, 1996.
7. Madsen, P.; Rasmussen, H. H.; Leffers, H.; Honore, B.; Dejgaard,
K.; Olsen, E.; Kiil, J.; Walbum, E.; Andersen, A. H.; Basse, B.; Lauridsen,
J. B.; Ratz, G. P.; Celis, A.; Vandekerckhove, J.; Celis, J. E.:
Molecular cloning, occurrence, and expression of a novel partially
secreted protein 'psoriasin' that is highly up-regulated in psoriatic
skin. J. Invest. Derm. 97: 701-712, 1991.
8. Schafer, B. W.; Wicki, R.; Engelkamp, D.; Mattei, M.-G.; Heizmann,
C. W.: Isolation of a YAC clone covering a cluster of nine S100 genes
on human chromosome 1q21: rationale for a new nomenclature of the
S100 calcium-binding protein family. Genomics 25: 638-643, 1995.
9. Semprini, S.; Capon, F.; Bovolenta, S.; Bruscia, E.; Pizzuti, A.;
Fabrizi, G.; Schietroma, C.; Zambruno, G.; Dallapiccola, B.; Novelli,
G.: Genomic structure, promoter characterisation and mutational analysis
of the S100A7 gene: exclusion of a candidate for familial psoriasis
susceptibility. Hum. Genet. 104: 130-134, 1999.
*FIELD* CN
Paul J. Converse - updated: 5/11/2005
Victor A. McKusick - updated: 10/9/2002
Ada Hamosh - updated: 3/18/1999
*FIELD* CD
Victor A. McKusick: 1/27/1995
*FIELD* ED
tpirozzi: 10/01/2013
terry: 9/24/2012
carol: 1/19/2011
mgross: 5/13/2005
terry: 5/11/2005
mgross: 5/11/2005
carol: 10/11/2002
tkritzer: 10/10/2002
terry: 10/9/2002
alopez: 3/18/1999
alopez: 10/12/1998
terry: 1/17/1997
jenny: 12/6/1996
terry: 11/15/1996
terry: 3/26/1996
mark: 1/28/1996
terry: 1/23/1996
mimadm: 9/23/1995
mark: 6/15/1995
carol: 1/27/1995