Full text data of S100A11
S100A11
(MLN70, S100C)
[Confidence: low (only semi-automatic identification from reviews)]
Protein S100-A11 (Calgizzarin; Metastatic lymph node gene 70 protein; MLN 70; Protein S100-C; S100 calcium-binding protein A11; Protein S100-A11, N-terminally processed)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Protein S100-A11 (Calgizzarin; Metastatic lymph node gene 70 protein; MLN 70; Protein S100-C; S100 calcium-binding protein A11; Protein S100-A11, N-terminally processed)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
P31949
ID S10AB_HUMAN Reviewed; 105 AA.
AC P31949; Q5VTK0;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-1996, sequence version 2.
DT 22-JAN-2014, entry version 148.
DE RecName: Full=Protein S100-A11;
DE AltName: Full=Calgizzarin;
DE AltName: Full=Metastatic lymph node gene 70 protein;
DE Short=MLN 70;
DE AltName: Full=Protein S100-C;
DE AltName: Full=S100 calcium-binding protein A11;
DE Contains:
DE RecName: Full=Protein S100-A11, N-terminally processed;
GN Name=S100A11; Synonyms=MLN70, S100C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7889529; DOI=10.1016/0304-3835(94)03687-E;
RA Tanaka M., Adzuma K., Iwami M., Yoshimoto K., Monden Y., Itakura M.;
RT "Human calgizzarin; one colorectal cancer-related gene selected by a
RT large scale random cDNA sequencing and northern blot analysis.";
RL Cancer Lett. 89:195-200(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Mammary carcinoma;
RX PubMed=7490069; DOI=10.1006/geno.1995.1163;
RA Tomasetto C.L., Regnier C.H., Moog-Lutz C., Mattei M.-G.,
RA Chenard M.-P., Lidereau R., Basset P., Rio M.-C.;
RT "Identification of four novel human genes amplified and overexpressed
RT in breast carcinoma and localized to the q11-q21.3 region of
RT chromosome 17.";
RL Genomics 28:367-376(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RA Nakatani K., Kato A., Sugimoto M., Kumano K., Komada T., Tsunoda H.,
RA Ito M., Nakano T., Shima T., Tanaka T.;
RT "Isolation and characterization of cDNA for human S100C protein and a
RT related gene.";
RL Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Fujiwara T., Kawai A., Shimizu F., Shinomiya K., Hirano H., Okuno S.,
RA Ozaki K., Katagiri T., Takeda S., Kuga Y., Shimada Y., Nagata M.,
RA Takaichi A., Watanabe T., Horie M., Nakamura Y., Takahashi E.,
RA Hirai Y.;
RT "Molecular cloning of a human homologue of the two calcium binding
RT protein, porcine S100 and rabbit calgizzarin.";
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT vector.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta, and Urinary bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PROTEIN SEQUENCE OF 4-12; 43-51 AND 56-62.
RC TISSUE=Keratinocyte;
RX PubMed=1286667; DOI=10.1002/elps.11501301199;
RA Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E.,
RA Vandekerckhove J.;
RT "Microsequences of 145 proteins recorded in the two-dimensional gel
RT protein database of normal human epidermal keratinocytes.";
RL Electrophoresis 13:960-969(1992).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-3, MASS
RP SPECTROMETRY, AND CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA Walther T.C., Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [13]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND ALA-2, AND MASS
RP SPECTROMETRY.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [14]
RP STRUCTURE BY NMR OF 1-19, DISULFIDE BOND, PHOSPHORYLATION AT THR-10,
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=18618420; DOI=10.1002/psc.1050;
RA Kouno T., Mizuguchi M., Sakaguchi M., Makino E., Mori Y., Shinoda H.,
RA Aizawa T., Demura M., Huh N.H., Kawano K.;
RT "The structure of S100A11 fragment explains a local structural change
RT induced by phosphorylation.";
RL J. Pept. Sci. 14:1129-1138(2008).
CC -!- FUNCTION: Facilitates the differentiation and the cornification of
CC keratinocytes.
CC -!- SUBUNIT: Homodimer; disulfide-linked.
CC -!- INTERACTION:
CC P04271:S100B; NbExp=5; IntAct=EBI-701862, EBI-458391;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC -!- PTM: Phosphorylation at Thr-10 by PRKCA significantly suppresses
CC homodimerization and promotes association with NCL/nucleolin which
CC induces nuclear translocation.
CC -!- MISCELLANEOUS: Binds two calcium ions per molecule with an
CC affinity similar to that of the S-100 proteins (By similarity).
CC -!- SIMILARITY: Belongs to the S-100 family.
CC -!- SIMILARITY: Contains 2 EF-hand domains.
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DR EMBL; D38583; BAA07597.1; -; mRNA.
DR EMBL; X80201; CAA56492.1; -; mRNA.
DR EMBL; D49355; BAA08354.1; -; mRNA.
DR EMBL; D50374; BAA23325.1; -; mRNA.
DR EMBL; BT009912; AAP88914.1; -; mRNA.
DR EMBL; AL591893; CAH72895.1; -; Genomic_DNA.
DR EMBL; BC001410; AAH01410.1; -; mRNA.
DR EMBL; BC014354; AAH14354.1; -; mRNA.
DR PIR; I37080; I37080.
DR RefSeq; NP_005611.1; NM_005620.1.
DR UniGene; Hs.417004; -.
DR PDB; 1V4Z; NMR; -; A=1-19.
DR PDB; 1V50; NMR; -; A=1-19.
DR PDB; 2LUC; NMR; -; A/B=1-105.
DR PDBsum; 1V4Z; -.
DR PDBsum; 1V50; -.
DR PDBsum; 2LUC; -.
DR ProteinModelPortal; P31949; -.
DR SMR; P31949; 1-105.
DR IntAct; P31949; 7.
DR MINT; MINT-5002556; -.
DR STRING; 9606.ENSP00000271638; -.
DR PhosphoSite; P31949; -.
DR DMDM; 1710818; -.
DR DOSAC-COBS-2DPAGE; P31949; -.
DR SWISS-2DPAGE; P31949; -.
DR PaxDb; P31949; -.
DR PeptideAtlas; P31949; -.
DR PRIDE; P31949; -.
DR DNASU; 6282; -.
DR Ensembl; ENST00000271638; ENSP00000271638; ENSG00000163191.
DR GeneID; 6282; -.
DR KEGG; hsa:6282; -.
DR UCSC; uc001ezn.3; human.
DR CTD; 6282; -.
DR GeneCards; GC01M152004; -.
DR HGNC; HGNC:10488; S100A11.
DR HPA; CAB034320; -.
DR HPA; HPA042745; -.
DR MIM; 603114; gene.
DR neXtProt; NX_P31949; -.
DR PharmGKB; PA34900; -.
DR eggNOG; NOG29318; -.
DR HOGENOM; HOG000246968; -.
DR HOVERGEN; HBG001479; -.
DR InParanoid; P31949; -.
DR OMA; ACHDSFM; -.
DR OrthoDB; EOG7XH6SB; -.
DR PhylomeDB; P31949; -.
DR EvolutionaryTrace; P31949; -.
DR GeneWiki; S100A11; -.
DR GenomeRNAi; 6282; -.
DR NextBio; 24385; -.
DR PRO; PR:P31949; -.
DR Bgee; P31949; -.
DR CleanEx; HS_S100A11; -.
DR Genevestigator; P31949; -.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0001726; C:ruffle; IDA:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048306; F:calcium-dependent protein binding; IDA:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
DR GO; GO:0008156; P:negative regulation of DNA replication; TAS:ProtInc.
DR GO; GO:0007165; P:signal transduction; TAS:UniProtKB.
DR Gene3D; 1.10.238.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR001751; S100/CaBP-9k_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR InterPro; IPR028482; S100A11.
DR PANTHER; PTHR11639:SF7; PTHR11639:SF7; 1.
DR Pfam; PF00036; EF-hand_1; 1.
DR Pfam; PF01023; S_100; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Calcium; Complete proteome; Cytoplasm;
KW Direct protein sequencing; Disulfide bond; Metal-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1 105 Protein S100-A11.
FT /FTId=PRO_0000424465.
FT INIT_MET 1 1 Removed; alternate.
FT CHAIN 2 105 Protein S100-A11, N-terminally processed.
FT /FTId=PRO_0000144009.
FT DOMAIN 13 49 EF-hand 1.
FT DOMAIN 55 90 EF-hand 2.
FT CA_BIND 25 38 1; low affinity (Potential).
FT CA_BIND 68 79 2; high affinity (Potential).
FT MOD_RES 1 1 N-acetylmethionine.
FT MOD_RES 2 2 N-acetylalanine; in Protein S100-A11, N-
FT terminally processed.
FT MOD_RES 3 3 N6-acetyllysine.
FT MOD_RES 6 6 Phosphoserine.
FT MOD_RES 10 10 Phosphothreonine.
FT DISULFID 13 13 Interchain.
FT HELIX 7 18
FT STRAND 30 32
FT HELIX 36 45
FT HELIX 48 54
FT HELIX 58 67
FT STRAND 70 75
FT HELIX 77 96
SQ SEQUENCE 105 AA; 11740 MW; 1729ED680290CFE4 CRC64;
MAKISSPTET ERCIESLIAV FQKYAGKDGY NYTLSKTEFL SFMNTELAAF TKNQKDPGVL
DRMMKKLDTN SDGQLDFSEF LNLIGGLAMA CHDSFLKAVP SQKRT
//
ID S10AB_HUMAN Reviewed; 105 AA.
AC P31949; Q5VTK0;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-1996, sequence version 2.
DT 22-JAN-2014, entry version 148.
DE RecName: Full=Protein S100-A11;
DE AltName: Full=Calgizzarin;
DE AltName: Full=Metastatic lymph node gene 70 protein;
DE Short=MLN 70;
DE AltName: Full=Protein S100-C;
DE AltName: Full=S100 calcium-binding protein A11;
DE Contains:
DE RecName: Full=Protein S100-A11, N-terminally processed;
GN Name=S100A11; Synonyms=MLN70, S100C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7889529; DOI=10.1016/0304-3835(94)03687-E;
RA Tanaka M., Adzuma K., Iwami M., Yoshimoto K., Monden Y., Itakura M.;
RT "Human calgizzarin; one colorectal cancer-related gene selected by a
RT large scale random cDNA sequencing and northern blot analysis.";
RL Cancer Lett. 89:195-200(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Mammary carcinoma;
RX PubMed=7490069; DOI=10.1006/geno.1995.1163;
RA Tomasetto C.L., Regnier C.H., Moog-Lutz C., Mattei M.-G.,
RA Chenard M.-P., Lidereau R., Basset P., Rio M.-C.;
RT "Identification of four novel human genes amplified and overexpressed
RT in breast carcinoma and localized to the q11-q21.3 region of
RT chromosome 17.";
RL Genomics 28:367-376(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RA Nakatani K., Kato A., Sugimoto M., Kumano K., Komada T., Tsunoda H.,
RA Ito M., Nakano T., Shima T., Tanaka T.;
RT "Isolation and characterization of cDNA for human S100C protein and a
RT related gene.";
RL Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Fujiwara T., Kawai A., Shimizu F., Shinomiya K., Hirano H., Okuno S.,
RA Ozaki K., Katagiri T., Takeda S., Kuga Y., Shimada Y., Nagata M.,
RA Takaichi A., Watanabe T., Horie M., Nakamura Y., Takahashi E.,
RA Hirai Y.;
RT "Molecular cloning of a human homologue of the two calcium binding
RT protein, porcine S100 and rabbit calgizzarin.";
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT vector.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta, and Urinary bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PROTEIN SEQUENCE OF 4-12; 43-51 AND 56-62.
RC TISSUE=Keratinocyte;
RX PubMed=1286667; DOI=10.1002/elps.11501301199;
RA Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E.,
RA Vandekerckhove J.;
RT "Microsequences of 145 proteins recorded in the two-dimensional gel
RT protein database of normal human epidermal keratinocytes.";
RL Electrophoresis 13:960-969(1992).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-3, MASS
RP SPECTROMETRY, AND CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA Walther T.C., Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [13]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND ALA-2, AND MASS
RP SPECTROMETRY.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [14]
RP STRUCTURE BY NMR OF 1-19, DISULFIDE BOND, PHOSPHORYLATION AT THR-10,
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=18618420; DOI=10.1002/psc.1050;
RA Kouno T., Mizuguchi M., Sakaguchi M., Makino E., Mori Y., Shinoda H.,
RA Aizawa T., Demura M., Huh N.H., Kawano K.;
RT "The structure of S100A11 fragment explains a local structural change
RT induced by phosphorylation.";
RL J. Pept. Sci. 14:1129-1138(2008).
CC -!- FUNCTION: Facilitates the differentiation and the cornification of
CC keratinocytes.
CC -!- SUBUNIT: Homodimer; disulfide-linked.
CC -!- INTERACTION:
CC P04271:S100B; NbExp=5; IntAct=EBI-701862, EBI-458391;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC -!- PTM: Phosphorylation at Thr-10 by PRKCA significantly suppresses
CC homodimerization and promotes association with NCL/nucleolin which
CC induces nuclear translocation.
CC -!- MISCELLANEOUS: Binds two calcium ions per molecule with an
CC affinity similar to that of the S-100 proteins (By similarity).
CC -!- SIMILARITY: Belongs to the S-100 family.
CC -!- SIMILARITY: Contains 2 EF-hand domains.
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DR EMBL; D38583; BAA07597.1; -; mRNA.
DR EMBL; X80201; CAA56492.1; -; mRNA.
DR EMBL; D49355; BAA08354.1; -; mRNA.
DR EMBL; D50374; BAA23325.1; -; mRNA.
DR EMBL; BT009912; AAP88914.1; -; mRNA.
DR EMBL; AL591893; CAH72895.1; -; Genomic_DNA.
DR EMBL; BC001410; AAH01410.1; -; mRNA.
DR EMBL; BC014354; AAH14354.1; -; mRNA.
DR PIR; I37080; I37080.
DR RefSeq; NP_005611.1; NM_005620.1.
DR UniGene; Hs.417004; -.
DR PDB; 1V4Z; NMR; -; A=1-19.
DR PDB; 1V50; NMR; -; A=1-19.
DR PDB; 2LUC; NMR; -; A/B=1-105.
DR PDBsum; 1V4Z; -.
DR PDBsum; 1V50; -.
DR PDBsum; 2LUC; -.
DR ProteinModelPortal; P31949; -.
DR SMR; P31949; 1-105.
DR IntAct; P31949; 7.
DR MINT; MINT-5002556; -.
DR STRING; 9606.ENSP00000271638; -.
DR PhosphoSite; P31949; -.
DR DMDM; 1710818; -.
DR DOSAC-COBS-2DPAGE; P31949; -.
DR SWISS-2DPAGE; P31949; -.
DR PaxDb; P31949; -.
DR PeptideAtlas; P31949; -.
DR PRIDE; P31949; -.
DR DNASU; 6282; -.
DR Ensembl; ENST00000271638; ENSP00000271638; ENSG00000163191.
DR GeneID; 6282; -.
DR KEGG; hsa:6282; -.
DR UCSC; uc001ezn.3; human.
DR CTD; 6282; -.
DR GeneCards; GC01M152004; -.
DR HGNC; HGNC:10488; S100A11.
DR HPA; CAB034320; -.
DR HPA; HPA042745; -.
DR MIM; 603114; gene.
DR neXtProt; NX_P31949; -.
DR PharmGKB; PA34900; -.
DR eggNOG; NOG29318; -.
DR HOGENOM; HOG000246968; -.
DR HOVERGEN; HBG001479; -.
DR InParanoid; P31949; -.
DR OMA; ACHDSFM; -.
DR OrthoDB; EOG7XH6SB; -.
DR PhylomeDB; P31949; -.
DR EvolutionaryTrace; P31949; -.
DR GeneWiki; S100A11; -.
DR GenomeRNAi; 6282; -.
DR NextBio; 24385; -.
DR PRO; PR:P31949; -.
DR Bgee; P31949; -.
DR CleanEx; HS_S100A11; -.
DR Genevestigator; P31949; -.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0001726; C:ruffle; IDA:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048306; F:calcium-dependent protein binding; IDA:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
DR GO; GO:0008156; P:negative regulation of DNA replication; TAS:ProtInc.
DR GO; GO:0007165; P:signal transduction; TAS:UniProtKB.
DR Gene3D; 1.10.238.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR001751; S100/CaBP-9k_CS.
DR InterPro; IPR013787; S100_Ca-bd_sub.
DR InterPro; IPR028482; S100A11.
DR PANTHER; PTHR11639:SF7; PTHR11639:SF7; 1.
DR Pfam; PF00036; EF-hand_1; 1.
DR Pfam; PF01023; S_100; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Calcium; Complete proteome; Cytoplasm;
KW Direct protein sequencing; Disulfide bond; Metal-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1 105 Protein S100-A11.
FT /FTId=PRO_0000424465.
FT INIT_MET 1 1 Removed; alternate.
FT CHAIN 2 105 Protein S100-A11, N-terminally processed.
FT /FTId=PRO_0000144009.
FT DOMAIN 13 49 EF-hand 1.
FT DOMAIN 55 90 EF-hand 2.
FT CA_BIND 25 38 1; low affinity (Potential).
FT CA_BIND 68 79 2; high affinity (Potential).
FT MOD_RES 1 1 N-acetylmethionine.
FT MOD_RES 2 2 N-acetylalanine; in Protein S100-A11, N-
FT terminally processed.
FT MOD_RES 3 3 N6-acetyllysine.
FT MOD_RES 6 6 Phosphoserine.
FT MOD_RES 10 10 Phosphothreonine.
FT DISULFID 13 13 Interchain.
FT HELIX 7 18
FT STRAND 30 32
FT HELIX 36 45
FT HELIX 48 54
FT HELIX 58 67
FT STRAND 70 75
FT HELIX 77 96
SQ SEQUENCE 105 AA; 11740 MW; 1729ED680290CFE4 CRC64;
MAKISSPTET ERCIESLIAV FQKYAGKDGY NYTLSKTEFL SFMNTELAAF TKNQKDPGVL
DRMMKKLDTN SDGQLDFSEF LNLIGGLAMA CHDSFLKAVP SQKRT
//
MIM
603114
*RECORD*
*FIELD* NO
603114
*FIELD* TI
*603114 S100 CALCIUM-BINDING PROTEIN A11; S100A11
;;CALGIZZARIN;;
S100C
*FIELD* TX
read more
DESCRIPTION
S100 proteins, such as S100A11, are 10- to 12-kD molecules that have a
canonical EF hand at their C termini and a modified, S100-specific EF
hand at their N termini. Binding of Ca(2+) to EF-hand motifs changes the
conformation and hence the function of S100 proteins (summary by
Sakaguchi et al., 2008).
CLONING
Todoroki et al. (1991) purified an S100 protein from chicken gizzard
that they called calgizzarin. Watanabe et al. (1991) isolated a cDNA
encoding rabbit calgizzarin.
Tanaka et al. (1995) identified and sequenced a cDNA encoding a human
calgizzarin homolog. The deduced protein contains 105 amino acids.
Using Northern blot analysis, Sakaguchi et al. (2003) found that S100A11
was variably expressed in human tissues, with highest expression in
skin, followed by placenta, lung, peripheral blood leukocytes, kidney,
and heart. Other tissues showed much lower expression, and there was
little to no expression in brain. Immunohistochemical analysis of human
skin detected S100A11 in nuclei of differentiating cells in the
suprabasal layers, but not in nuclei of proliferating cells in the basal
layer.
GENE FUNCTION
Tanaka et al. (1995) found that expression of human calgizzarin was
elevated in colorectal cancers compared with normal colorectal mucosa.
Tomasetto et al. (1995) reported that calgizzarin, or MLN70, is 1 of
several genes expressed in breast cancer-derived metastatic axillary
lymph nodes, but not in normal lymph nodes or breast fibroadenomas.
High extracellular Ca(2+) concentration results in termination of cell
growth in keratinocytes and induction of terminal differentiation.
Sakaguchi et al. (2003) identified S100A11 as a key mediator of
Ca(2+)-induced growth inhibition in cultured human epidermal
keratinocytes. Elevated extracellular Ca(2+) resulted in phosphorylation
of S100A11 on thr10 and ser94. Phosphorylated and Ca(2+)-bound S100A11
interacted with nucleolin (NCL; 164035) and was translocated to the
nucleus. Binding of S100A11 to nucleolin resulted in induction of
p21(CIP1/WAF1) (CDN1A; 116899) by SP1 (189906) and SP3 (601804), leading
to inhibition of cell growth.
Sakaguchi et al. (2008) noted that both high Ca(2+) levels and TGF-beta
(TGFB1; 190180) activation suppress growth of human keratinocytes via
S100A11. However, they found that secreted S100A11 could enhance cell
growth via induction of EGF (131530) and activation of EGFR (131550)
signaling. Addition of purified S100A11 to the culture medium stimulated
growth of human keratinocytes by binding of S100A11 to the cell surface
S100 receptor RAGE (AGER; 600214). Enhanced cell growth involved
downregulation of p21(WAF1) and p27(KIP1) (CDKN1B 600778), activation of
NF-kappa-B (see 164011) and ATK (see 164730), and phosphorylation of
CREB (CREB1; 123810), culminating in AP1 (165160)-mediated activation of
the EGF promoter. Sakaguchi et al. (2008) also found that Ca(2+) induced
S100A11 phosphorylation, but not its secretion, whereas EGF enhanced
S100A11 secretion, but not its phosphorylation.
MAPPING
By in situ hybridization, Moog-Lutz et al. (1995) mapped the S100A11
gene to chromosome 1q21. By analysis of clones from this region, Wicki
et al. (1996) determined that S100A11 is part of the S100 gene cluster
and is located near S100A10 (114085).
*FIELD* RF
1. Moog-Lutz, C.; Bouillet, P.; Regnier, C. H.; Tomasetto, C.; Mattei,
M. G.; Chenard, M. P.; Anglard, P.; Rio, M. C.; Basset, P.: Comparative
expression of the psoriasin (S100A7) and S100C genes in breast carcinoma
and co-localization to human chromosome 1q21-q22. Int. J. Cancer 63:
297-303, 1995.
2. Sakaguchi, M.; Miyazaki, M.; Takaishi, M.; Sakaguchi, Y.; Makino,
E.; Kataoka, N.; Yamada, H.; Namba, M.; Huh, N.: S100C/A11 is a key
mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes. J.
Cell Biol. 163: 825-835, 2003.
3. Sakaguchi, M.; Sonegawa, H.; Murata, H.; Kitazoe, M.; Futami, J.;
Kataoka, K.; Yamada, H.; Huh, N.: S100A11, an (sic) dual mediator
for growth regulation of human keratinocytes. Molec. Biol. Cell 19:
78-85, 2008.
4. Tanaka, M.; Adzuma, K.; Iwami, M.; Yoshimoto, K.; Monden, Y.; Itakura,
M.: Human calgizzarin: one colorectal cancer-related gene selected
by a large scale random cDNA sequencing and northern blot analysis. Cancer
Lett. 89: 195-200, 1995.
5. Todoroki, H.; Kobayashi, R.; Watanabe, M.; Minami, H.; Hidaka,
H.: Purification, characterization, and partial sequence analysis
of a newly identified EF-hand type 13-kDa Ca(2+)-binding protein from
smooth muscle and non-muscle tissues. J. Biol. Chem. 266: 18668-18673,
1991.
6. Tomasetto, C.; Regnier, C.; Moog-Lutz, C.; Mattei, M. G.; Chenard,
M. P.; Lidereau, R.; Basset, P.; Rio, M. C.: Identification of four
novel human genes amplified and overexpressed in breast carcinoma
and localized to the q11-q21.3 region of chromosome 17. Genomics 28:
367-376, 1995.
7. Watanabe, M.; Ando, Y.; Todoroki, H.; Minami, H.; Hidaka, H.:
Molecular cloning and sequencing of a cDNA clone encoding a new calcium
binding protein, named calgizzarin, from rabbit lung. Biochem. Biophys.
Res. Commun. 181: 644-649, 1991.
8. Wicki, R.; Marenholz, I.; Mischke, D.; Schafer, B. W.; Heizmann,
C. W.: Characterization of the human S100A12 (calgranulin C, p6,
CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome
1q21. Cell Calcium 20: 459-464, 1996.
*FIELD* CN
Patricia A. Hartz - updated: 5/12/2010
*FIELD* CD
Rebekah S. Rasooly: 10/12/1998
*FIELD* ED
mgross: 05/13/2010
mgross: 5/12/2010
alopez: 10/12/1998
*RECORD*
*FIELD* NO
603114
*FIELD* TI
*603114 S100 CALCIUM-BINDING PROTEIN A11; S100A11
;;CALGIZZARIN;;
S100C
*FIELD* TX
read more
DESCRIPTION
S100 proteins, such as S100A11, are 10- to 12-kD molecules that have a
canonical EF hand at their C termini and a modified, S100-specific EF
hand at their N termini. Binding of Ca(2+) to EF-hand motifs changes the
conformation and hence the function of S100 proteins (summary by
Sakaguchi et al., 2008).
CLONING
Todoroki et al. (1991) purified an S100 protein from chicken gizzard
that they called calgizzarin. Watanabe et al. (1991) isolated a cDNA
encoding rabbit calgizzarin.
Tanaka et al. (1995) identified and sequenced a cDNA encoding a human
calgizzarin homolog. The deduced protein contains 105 amino acids.
Using Northern blot analysis, Sakaguchi et al. (2003) found that S100A11
was variably expressed in human tissues, with highest expression in
skin, followed by placenta, lung, peripheral blood leukocytes, kidney,
and heart. Other tissues showed much lower expression, and there was
little to no expression in brain. Immunohistochemical analysis of human
skin detected S100A11 in nuclei of differentiating cells in the
suprabasal layers, but not in nuclei of proliferating cells in the basal
layer.
GENE FUNCTION
Tanaka et al. (1995) found that expression of human calgizzarin was
elevated in colorectal cancers compared with normal colorectal mucosa.
Tomasetto et al. (1995) reported that calgizzarin, or MLN70, is 1 of
several genes expressed in breast cancer-derived metastatic axillary
lymph nodes, but not in normal lymph nodes or breast fibroadenomas.
High extracellular Ca(2+) concentration results in termination of cell
growth in keratinocytes and induction of terminal differentiation.
Sakaguchi et al. (2003) identified S100A11 as a key mediator of
Ca(2+)-induced growth inhibition in cultured human epidermal
keratinocytes. Elevated extracellular Ca(2+) resulted in phosphorylation
of S100A11 on thr10 and ser94. Phosphorylated and Ca(2+)-bound S100A11
interacted with nucleolin (NCL; 164035) and was translocated to the
nucleus. Binding of S100A11 to nucleolin resulted in induction of
p21(CIP1/WAF1) (CDN1A; 116899) by SP1 (189906) and SP3 (601804), leading
to inhibition of cell growth.
Sakaguchi et al. (2008) noted that both high Ca(2+) levels and TGF-beta
(TGFB1; 190180) activation suppress growth of human keratinocytes via
S100A11. However, they found that secreted S100A11 could enhance cell
growth via induction of EGF (131530) and activation of EGFR (131550)
signaling. Addition of purified S100A11 to the culture medium stimulated
growth of human keratinocytes by binding of S100A11 to the cell surface
S100 receptor RAGE (AGER; 600214). Enhanced cell growth involved
downregulation of p21(WAF1) and p27(KIP1) (CDKN1B 600778), activation of
NF-kappa-B (see 164011) and ATK (see 164730), and phosphorylation of
CREB (CREB1; 123810), culminating in AP1 (165160)-mediated activation of
the EGF promoter. Sakaguchi et al. (2008) also found that Ca(2+) induced
S100A11 phosphorylation, but not its secretion, whereas EGF enhanced
S100A11 secretion, but not its phosphorylation.
MAPPING
By in situ hybridization, Moog-Lutz et al. (1995) mapped the S100A11
gene to chromosome 1q21. By analysis of clones from this region, Wicki
et al. (1996) determined that S100A11 is part of the S100 gene cluster
and is located near S100A10 (114085).
*FIELD* RF
1. Moog-Lutz, C.; Bouillet, P.; Regnier, C. H.; Tomasetto, C.; Mattei,
M. G.; Chenard, M. P.; Anglard, P.; Rio, M. C.; Basset, P.: Comparative
expression of the psoriasin (S100A7) and S100C genes in breast carcinoma
and co-localization to human chromosome 1q21-q22. Int. J. Cancer 63:
297-303, 1995.
2. Sakaguchi, M.; Miyazaki, M.; Takaishi, M.; Sakaguchi, Y.; Makino,
E.; Kataoka, N.; Yamada, H.; Namba, M.; Huh, N.: S100C/A11 is a key
mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes. J.
Cell Biol. 163: 825-835, 2003.
3. Sakaguchi, M.; Sonegawa, H.; Murata, H.; Kitazoe, M.; Futami, J.;
Kataoka, K.; Yamada, H.; Huh, N.: S100A11, an (sic) dual mediator
for growth regulation of human keratinocytes. Molec. Biol. Cell 19:
78-85, 2008.
4. Tanaka, M.; Adzuma, K.; Iwami, M.; Yoshimoto, K.; Monden, Y.; Itakura,
M.: Human calgizzarin: one colorectal cancer-related gene selected
by a large scale random cDNA sequencing and northern blot analysis. Cancer
Lett. 89: 195-200, 1995.
5. Todoroki, H.; Kobayashi, R.; Watanabe, M.; Minami, H.; Hidaka,
H.: Purification, characterization, and partial sequence analysis
of a newly identified EF-hand type 13-kDa Ca(2+)-binding protein from
smooth muscle and non-muscle tissues. J. Biol. Chem. 266: 18668-18673,
1991.
6. Tomasetto, C.; Regnier, C.; Moog-Lutz, C.; Mattei, M. G.; Chenard,
M. P.; Lidereau, R.; Basset, P.; Rio, M. C.: Identification of four
novel human genes amplified and overexpressed in breast carcinoma
and localized to the q11-q21.3 region of chromosome 17. Genomics 28:
367-376, 1995.
7. Watanabe, M.; Ando, Y.; Todoroki, H.; Minami, H.; Hidaka, H.:
Molecular cloning and sequencing of a cDNA clone encoding a new calcium
binding protein, named calgizzarin, from rabbit lung. Biochem. Biophys.
Res. Commun. 181: 644-649, 1991.
8. Wicki, R.; Marenholz, I.; Mischke, D.; Schafer, B. W.; Heizmann,
C. W.: Characterization of the human S100A12 (calgranulin C, p6,
CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome
1q21. Cell Calcium 20: 459-464, 1996.
*FIELD* CN
Patricia A. Hartz - updated: 5/12/2010
*FIELD* CD
Rebekah S. Rasooly: 10/12/1998
*FIELD* ED
mgross: 05/13/2010
mgross: 5/12/2010
alopez: 10/12/1998