Full text data of S100A16
S100A16
(S100F)
[Confidence: low (only semi-automatic identification from reviews)]
Protein S100-A16 (Aging-associated gene 13 protein; Protein S100-F; S100 calcium-binding protein A16)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Protein S100-A16 (Aging-associated gene 13 protein; Protein S100-F; S100 calcium-binding protein A16)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q96FQ6
ID S10AG_HUMAN Reviewed; 103 AA.
AC Q96FQ6; A8K439; D3DV52; Q5RHS6;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 101.
DE RecName: Full=Protein S100-A16;
DE AltName: Full=Aging-associated gene 13 protein;
DE AltName: Full=Protein S100-F;
DE AltName: Full=S100 calcium-binding protein A16;
GN Name=S100A16; Synonyms=S100F; ORFNames=AAG13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Marenholz I., Heizmann C.W.;
RT "S100A16, a new EF-hand protein and potential tumor promoter in
RT human.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Keratinocyte;
RA Morita K.;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kim J.W.;
RT "Identification of a human aging related gene.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND
RP CALCIUM-BINDING.
RX PubMed=17030513; DOI=10.1074/jbc.M605798200;
RA Sturchler E., Cox J.A., Durussel I., Weibel M., Heizmann C.W.;
RT "S100A16, a novel calcium-binding protein of the EF-hand
RT superfamily.";
RL J. Biol. Chem. 281:38905-38917(2006).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [11]
RP X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS), STRUCTURE BY NMR, SUBUNIT, AND
RP CALCIUM-BINDING DOMAIN.
RX PubMed=21046186; DOI=10.1007/s00775-010-0721-3;
RA Babini E., Bertini I., Borsi V., Calderone V., Hu X., Luchinat C.,
RA Parigi G.;
RT "Structural characterization of human S100A16, a low-affinity calcium
RT binder.";
RL J. Biol. Inorg. Chem. 16:243-256(2011).
CC -!- FUNCTION: Calcium-binding protein. Binds one calcium ion per
CC monomer.
CC -!- SUBUNIT: Homodimer.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm.
CC Note=Primarily nucleolar. Translocates from the nucleolus to the
CC cytoplasm in response to an increase of intracellular calcium
CC levels.
CC -!- SIMILARITY: Belongs to the S-100 family.
CC -!- SIMILARITY: Contains 2 EF-hand domains.
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DR EMBL; AJ585980; CAE51865.1; -; Genomic_DNA.
DR EMBL; AY221961; AAP46152.1; -; mRNA.
DR EMBL; AY762098; AAW88319.1; -; mRNA.
DR EMBL; AK290804; BAF83493.1; -; mRNA.
DR EMBL; BX470102; CAI14758.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53303.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53304.1; -; Genomic_DNA.
DR EMBL; BC010541; AAH10541.1; -; mRNA.
DR EMBL; BC019099; AAH19099.1; -; mRNA.
DR EMBL; BC095462; AAH95462.1; -; mRNA.
DR RefSeq; NP_525127.1; NM_080388.1.
DR RefSeq; XP_005244962.1; XM_005244905.1.
DR RefSeq; XP_005244963.1; XM_005244906.1.
DR UniGene; Hs.515714; -.
DR PDB; 2L50; NMR; -; A/B=2-103.
DR PDB; 2L51; NMR; -; A/B=2-103.
DR PDB; 3NXA; X-ray; 2.10 A; A/B/C/D=3-102.
DR PDBsum; 2L50; -.
DR PDBsum; 2L51; -.
DR PDBsum; 3NXA; -.
DR ProteinModelPortal; Q96FQ6; -.
DR SMR; Q96FQ6; 2-103.
DR IntAct; Q96FQ6; 4.
DR MINT; MINT-1457417; -.
DR STRING; 9606.ENSP00000357692; -.
DR PhosphoSite; Q96FQ6; -.
DR DMDM; 20178113; -.
DR SWISS-2DPAGE; Q96FQ6; -.
DR PaxDb; Q96FQ6; -.
DR PeptideAtlas; Q96FQ6; -.
DR PRIDE; Q96FQ6; -.
DR DNASU; 140576; -.
DR Ensembl; ENST00000368703; ENSP00000357692; ENSG00000188643.
DR Ensembl; ENST00000368704; ENSP00000357693; ENSG00000188643.
DR Ensembl; ENST00000368705; ENSP00000357694; ENSG00000188643.
DR Ensembl; ENST00000368706; ENSP00000357695; ENSG00000188643.
DR GeneID; 140576; -.
DR KEGG; hsa:140576; -.
DR UCSC; uc001fcd.1; human.
DR CTD; 140576; -.
DR GeneCards; GC01M153579; -.
DR HGNC; HGNC:20441; S100A16.
DR HPA; HPA045841; -.
DR neXtProt; NX_Q96FQ6; -.
DR PharmGKB; PA134931606; -.
DR eggNOG; NOG41319; -.
DR HOGENOM; HOG000013071; -.
DR HOVERGEN; HBG001479; -.
DR InParanoid; Q96FQ6; -.
DR OMA; MADCYTE; -.
DR OrthoDB; EOG789CDN; -.
DR PhylomeDB; Q96FQ6; -.
DR ChiTaRS; S100A16; human.
DR EvolutionaryTrace; Q96FQ6; -.
DR GeneWiki; S100A16; -.
DR GenomeRNAi; 140576; -.
DR NextBio; 84165; -.
DR PRO; PR:Q96FQ6; -.
DR Bgee; Q96FQ6; -.
DR CleanEx; HS_S100A16; -.
DR Genevestigator; Q96FQ6; -.
DR GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0005509; F:calcium ion binding; IDA:UniProtKB.
DR GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR Gene3D; 1.10.238.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR028485; S100-A16.
DR InterPro; IPR001751; S100/CaBP-9k_CS.
DR PANTHER; PTHR11639:SF2; PTHR11639:SF2; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Calcium; Complete proteome; Cytoplasm; Metal-binding;
KW Nucleus; Reference proteome; Repeat.
FT CHAIN 1 103 Protein S100-A16.
FT /FTId=PRO_0000144023.
FT DOMAIN 12 47 EF-hand 1.
FT DOMAIN 54 89 EF-hand 2.
FT CA_BIND 23 36 1; low affinity (Potential).
FT CA_BIND 67 78 2; high affinity.
FT HELIX 7 21
FT TURN 28 30
FT HELIX 35 45
FT TURN 47 50
FT STRAND 51 53
FT HELIX 54 65
FT HELIX 66 68
FT HELIX 76 87
FT HELIX 88 90
FT HELIX 91 100
SQ SEQUENCE 103 AA; 11801 MW; 7D00C08F85697A6C CRC64;
MSDCYTELEK AVIVLVENFY KYVSKYSLVK NKISKSSFRE MLQKELNHML SDTGNRKAAD
KLIQNLDANH DGRISFDEYW TLIGGITGPI AKLIHEQEQQ SSS
//
ID S10AG_HUMAN Reviewed; 103 AA.
AC Q96FQ6; A8K439; D3DV52; Q5RHS6;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 101.
DE RecName: Full=Protein S100-A16;
DE AltName: Full=Aging-associated gene 13 protein;
DE AltName: Full=Protein S100-F;
DE AltName: Full=S100 calcium-binding protein A16;
GN Name=S100A16; Synonyms=S100F; ORFNames=AAG13;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Marenholz I., Heizmann C.W.;
RT "S100A16, a new EF-hand protein and potential tumor promoter in
RT human.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Keratinocyte;
RA Morita K.;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kim J.W.;
RT "Identification of a human aging related gene.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND
RP CALCIUM-BINDING.
RX PubMed=17030513; DOI=10.1074/jbc.M605798200;
RA Sturchler E., Cox J.A., Durussel I., Weibel M., Heizmann C.W.;
RT "S100A16, a novel calcium-binding protein of the EF-hand
RT superfamily.";
RL J. Biol. Chem. 281:38905-38917(2006).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [11]
RP X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS), STRUCTURE BY NMR, SUBUNIT, AND
RP CALCIUM-BINDING DOMAIN.
RX PubMed=21046186; DOI=10.1007/s00775-010-0721-3;
RA Babini E., Bertini I., Borsi V., Calderone V., Hu X., Luchinat C.,
RA Parigi G.;
RT "Structural characterization of human S100A16, a low-affinity calcium
RT binder.";
RL J. Biol. Inorg. Chem. 16:243-256(2011).
CC -!- FUNCTION: Calcium-binding protein. Binds one calcium ion per
CC monomer.
CC -!- SUBUNIT: Homodimer.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm.
CC Note=Primarily nucleolar. Translocates from the nucleolus to the
CC cytoplasm in response to an increase of intracellular calcium
CC levels.
CC -!- SIMILARITY: Belongs to the S-100 family.
CC -!- SIMILARITY: Contains 2 EF-hand domains.
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DR EMBL; AJ585980; CAE51865.1; -; Genomic_DNA.
DR EMBL; AY221961; AAP46152.1; -; mRNA.
DR EMBL; AY762098; AAW88319.1; -; mRNA.
DR EMBL; AK290804; BAF83493.1; -; mRNA.
DR EMBL; BX470102; CAI14758.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53303.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53304.1; -; Genomic_DNA.
DR EMBL; BC010541; AAH10541.1; -; mRNA.
DR EMBL; BC019099; AAH19099.1; -; mRNA.
DR EMBL; BC095462; AAH95462.1; -; mRNA.
DR RefSeq; NP_525127.1; NM_080388.1.
DR RefSeq; XP_005244962.1; XM_005244905.1.
DR RefSeq; XP_005244963.1; XM_005244906.1.
DR UniGene; Hs.515714; -.
DR PDB; 2L50; NMR; -; A/B=2-103.
DR PDB; 2L51; NMR; -; A/B=2-103.
DR PDB; 3NXA; X-ray; 2.10 A; A/B/C/D=3-102.
DR PDBsum; 2L50; -.
DR PDBsum; 2L51; -.
DR PDBsum; 3NXA; -.
DR ProteinModelPortal; Q96FQ6; -.
DR SMR; Q96FQ6; 2-103.
DR IntAct; Q96FQ6; 4.
DR MINT; MINT-1457417; -.
DR STRING; 9606.ENSP00000357692; -.
DR PhosphoSite; Q96FQ6; -.
DR DMDM; 20178113; -.
DR SWISS-2DPAGE; Q96FQ6; -.
DR PaxDb; Q96FQ6; -.
DR PeptideAtlas; Q96FQ6; -.
DR PRIDE; Q96FQ6; -.
DR DNASU; 140576; -.
DR Ensembl; ENST00000368703; ENSP00000357692; ENSG00000188643.
DR Ensembl; ENST00000368704; ENSP00000357693; ENSG00000188643.
DR Ensembl; ENST00000368705; ENSP00000357694; ENSG00000188643.
DR Ensembl; ENST00000368706; ENSP00000357695; ENSG00000188643.
DR GeneID; 140576; -.
DR KEGG; hsa:140576; -.
DR UCSC; uc001fcd.1; human.
DR CTD; 140576; -.
DR GeneCards; GC01M153579; -.
DR HGNC; HGNC:20441; S100A16.
DR HPA; HPA045841; -.
DR neXtProt; NX_Q96FQ6; -.
DR PharmGKB; PA134931606; -.
DR eggNOG; NOG41319; -.
DR HOGENOM; HOG000013071; -.
DR HOVERGEN; HBG001479; -.
DR InParanoid; Q96FQ6; -.
DR OMA; MADCYTE; -.
DR OrthoDB; EOG789CDN; -.
DR PhylomeDB; Q96FQ6; -.
DR ChiTaRS; S100A16; human.
DR EvolutionaryTrace; Q96FQ6; -.
DR GeneWiki; S100A16; -.
DR GenomeRNAi; 140576; -.
DR NextBio; 84165; -.
DR PRO; PR:Q96FQ6; -.
DR Bgee; Q96FQ6; -.
DR CleanEx; HS_S100A16; -.
DR Genevestigator; Q96FQ6; -.
DR GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0005509; F:calcium ion binding; IDA:UniProtKB.
DR GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR Gene3D; 1.10.238.10; -; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR028485; S100-A16.
DR InterPro; IPR001751; S100/CaBP-9k_CS.
DR PANTHER; PTHR11639:SF2; PTHR11639:SF2; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS00303; S100_CABP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Calcium; Complete proteome; Cytoplasm; Metal-binding;
KW Nucleus; Reference proteome; Repeat.
FT CHAIN 1 103 Protein S100-A16.
FT /FTId=PRO_0000144023.
FT DOMAIN 12 47 EF-hand 1.
FT DOMAIN 54 89 EF-hand 2.
FT CA_BIND 23 36 1; low affinity (Potential).
FT CA_BIND 67 78 2; high affinity.
FT HELIX 7 21
FT TURN 28 30
FT HELIX 35 45
FT TURN 47 50
FT STRAND 51 53
FT HELIX 54 65
FT HELIX 66 68
FT HELIX 76 87
FT HELIX 88 90
FT HELIX 91 100
SQ SEQUENCE 103 AA; 11801 MW; 7D00C08F85697A6C CRC64;
MSDCYTELEK AVIVLVENFY KYVSKYSLVK NKISKSSFRE MLQKELNHML SDTGNRKAAD
KLIQNLDANH DGRISFDEYW TLIGGITGPI AKLIHEQEQQ SSS
//