Full text data of SLC22A23
SLC22A23
(C6orf85)
[Confidence: low (only semi-automatic identification from reviews)]
Solute carrier family 22 member 23
Solute carrier family 22 member 23
UniProt
A1A5C7
ID S22AN_HUMAN Reviewed; 686 AA.
AC A1A5C7; A1A5C8; Q5T8B8; Q6ZMH3; Q8IW73;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-OCT-2007, sequence version 2.
DT 22-JAN-2014, entry version 63.
DE RecName: Full=Solute carrier family 22 member 23;
GN Name=SLC22A23; Synonyms=C6orf85;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-686 (ISOFORM 4).
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 303-686.
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=17714910; DOI=10.1016/j.ygeno.2007.03.017;
RA Jacobsson J.A., Haitina T., Lindblom J., Fredriksson R.;
RT "Identification of six putative human transporters with structural
RT similarity to the drug transporter SLC22 family.";
RL Genomics 90:595-609(2007).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=A1A5C7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A1A5C7-2; Sequence=VSP_028954;
CC Name=3;
CC IsoId=A1A5C7-3; Sequence=VSP_028955;
CC Note=No experimental confirmation available;
CC Name=4;
CC IsoId=A1A5C7-4; Sequence=VSP_028956;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1)
CC superfamily. Organic cation transporter (TC 2.A.1.19) family.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD18753.1; Type=Erroneous initiation;
CC Sequence=CAI12303.1; Type=Erroneous gene model prediction;
CC Sequence=CAI40959.1; Type=Erroneous gene model prediction;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL160398; CAI12303.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL445309; CAI12303.1; JOINED; Genomic_DNA.
DR EMBL; AL445309; CAI40959.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL160398; CAI40959.1; JOINED; Genomic_DNA.
DR EMBL; BC040876; AAH40876.1; -; mRNA.
DR EMBL; BC128580; AAI28581.1; -; mRNA.
DR EMBL; BC128581; AAI28582.1; -; mRNA.
DR EMBL; AK172770; BAD18753.1; ALT_INIT; mRNA.
DR RefSeq; NP_001273384.1; NM_001286455.1.
DR RefSeq; NP_001273385.1; NM_001286456.1.
DR RefSeq; NP_056297.1; NM_015482.1.
DR RefSeq; NP_068764.3; NM_021945.6.
DR UniGene; Hs.713588; -.
DR ProteinModelPortal; A1A5C7; -.
DR SMR; A1A5C7; 552-588.
DR TCDB; 2.A.1.19.28; the major facilitator superfamily (mfs).
DR PhosphoSite; A1A5C7; -.
DR PaxDb; A1A5C7; -.
DR PRIDE; A1A5C7; -.
DR Ensembl; ENST00000380298; ENSP00000369653; ENSG00000137266.
DR Ensembl; ENST00000380302; ENSP00000369657; ENSG00000137266.
DR Ensembl; ENST00000406686; ENSP00000385028; ENSG00000137266.
DR Ensembl; ENST00000490273; ENSP00000419463; ENSG00000137266.
DR GeneID; 63027; -.
DR KEGG; hsa:63027; -.
DR UCSC; uc003mvm.3; human.
DR CTD; 63027; -.
DR GeneCards; GC06M003269; -.
DR H-InvDB; HIX0005541; -.
DR H-InvDB; HIX0005544; -.
DR HGNC; HGNC:21106; SLC22A23.
DR HPA; HPA014697; -.
DR MIM; 611697; gene.
DR neXtProt; NX_A1A5C7; -.
DR PharmGKB; PA162403516; -.
DR eggNOG; NOG275019; -.
DR HOGENOM; HOG000124569; -.
DR HOVERGEN; HBG108437; -.
DR InParanoid; A1A5C7; -.
DR KO; K08215; -.
DR GenomeRNAi; 63027; -.
DR NextBio; 65527; -.
DR PRO; PR:A1A5C7; -.
DR ArrayExpress; A1A5C7; -.
DR Bgee; A1A5C7; -.
DR CleanEx; HS_SLC22A23; -.
DR Genevestigator; A1A5C7; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR InterPro; IPR005828; Sub_transporter.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Glycoprotein; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1 686 Solute carrier family 22 member 23.
FT /FTId=PRO_0000308315.
FT TRANSMEM 234 254 Helical; (Potential).
FT TRANSMEM 258 278 Helical; (Potential).
FT TRANSMEM 288 308 Helical; (Potential).
FT TRANSMEM 315 335 Helical; (Potential).
FT TRANSMEM 344 364 Helical; (Potential).
FT TRANSMEM 467 487 Helical; (Potential).
FT TRANSMEM 494 514 Helical; (Potential).
FT TRANSMEM 538 558 Helical; (Potential).
FT TRANSMEM 569 589 Helical; (Potential).
FT TRANSMEM 598 618 Helical; (Potential).
FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 279 279 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 1 370 Missing (in isoform 3).
FT /FTId=VSP_028955.
FT VAR_SEQ 1 281 Missing (in isoform 2).
FT /FTId=VSP_028954.
FT VAR_SEQ 362 686 Missing (in isoform 4).
FT /FTId=VSP_028956.
FT CONFLICT 685 685 A -> G (in Ref. 3; BAD18753).
SQ SEQUENCE 686 AA; 73748 MW; 035E53BA5FEDF8F0 CRC64;
MAIDRRREAA GGGPGRQPAP AEENGSLPPG DAAASAPLGG RAGPGGGAEI QPLPPLHPGG
GPHPSCCSAA AAPSLLLLDY DGSVLPFLGG LGGGYQKTLV LLTWIPALFI GFSQFSDSFL
LDQPNFWCRG AGKGTELAGV TTTGRGGDMG NWTSLPTTPF ATAPWEAAGN RSNSSGADGG
DTPPLPSPPD KGDNASNCDC RAWDYGIRAG LVQNVVSKWD LVCDNAWKVH IAKFSLLVGL
IFGYLITGCI ADWVGRRPVL LFSIIFILIF GLTVALSVNV TMFSTLRFFE GFCLAGIILT
LYALRIELCP PGKRFMITMV ASFVAMAGQF LMPGLAALCR DWQVLQALII CPFLLMLLYW
SIFPESLRWL MATQQFESAK RLILHFTQKN RMNPEGDIKG VIPELEKELS RRPKKVCIVK
VVGTRNLWKN IVVLCVNSLT GYGIHHCFAR SMMGHEVKVP LLENFYADYY TTASIALVSC
LAMCVVVRFL GRRGGLLLFM ILTALASLLQ LGLLNLIGKY SQHPDSGMSD SVKDKFSIAF
SIVGMFASHA VGSLSVFFCA EITPTVIRCG GLGLVLASAG FGMLTAPIIE LHNQKGYFLH
HIIFACCTLI CIICILLLPE SRDQNLPENI SNGEHYTRQP LLPHKKGEQP LLLTNAELKD
YSGLHDAAAA GDTLPEGATA NGMKAM
//
ID S22AN_HUMAN Reviewed; 686 AA.
AC A1A5C7; A1A5C8; Q5T8B8; Q6ZMH3; Q8IW73;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-OCT-2007, sequence version 2.
DT 22-JAN-2014, entry version 63.
DE RecName: Full=Solute carrier family 22 member 23;
GN Name=SLC22A23; Synonyms=C6orf85;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-686 (ISOFORM 4).
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 303-686.
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=17714910; DOI=10.1016/j.ygeno.2007.03.017;
RA Jacobsson J.A., Haitina T., Lindblom J., Fredriksson R.;
RT "Identification of six putative human transporters with structural
RT similarity to the drug transporter SLC22 family.";
RL Genomics 90:595-609(2007).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=A1A5C7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A1A5C7-2; Sequence=VSP_028954;
CC Name=3;
CC IsoId=A1A5C7-3; Sequence=VSP_028955;
CC Note=No experimental confirmation available;
CC Name=4;
CC IsoId=A1A5C7-4; Sequence=VSP_028956;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the major facilitator (TC 2.A.1)
CC superfamily. Organic cation transporter (TC 2.A.1.19) family.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD18753.1; Type=Erroneous initiation;
CC Sequence=CAI12303.1; Type=Erroneous gene model prediction;
CC Sequence=CAI40959.1; Type=Erroneous gene model prediction;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL160398; CAI12303.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL445309; CAI12303.1; JOINED; Genomic_DNA.
DR EMBL; AL445309; CAI40959.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL160398; CAI40959.1; JOINED; Genomic_DNA.
DR EMBL; BC040876; AAH40876.1; -; mRNA.
DR EMBL; BC128580; AAI28581.1; -; mRNA.
DR EMBL; BC128581; AAI28582.1; -; mRNA.
DR EMBL; AK172770; BAD18753.1; ALT_INIT; mRNA.
DR RefSeq; NP_001273384.1; NM_001286455.1.
DR RefSeq; NP_001273385.1; NM_001286456.1.
DR RefSeq; NP_056297.1; NM_015482.1.
DR RefSeq; NP_068764.3; NM_021945.6.
DR UniGene; Hs.713588; -.
DR ProteinModelPortal; A1A5C7; -.
DR SMR; A1A5C7; 552-588.
DR TCDB; 2.A.1.19.28; the major facilitator superfamily (mfs).
DR PhosphoSite; A1A5C7; -.
DR PaxDb; A1A5C7; -.
DR PRIDE; A1A5C7; -.
DR Ensembl; ENST00000380298; ENSP00000369653; ENSG00000137266.
DR Ensembl; ENST00000380302; ENSP00000369657; ENSG00000137266.
DR Ensembl; ENST00000406686; ENSP00000385028; ENSG00000137266.
DR Ensembl; ENST00000490273; ENSP00000419463; ENSG00000137266.
DR GeneID; 63027; -.
DR KEGG; hsa:63027; -.
DR UCSC; uc003mvm.3; human.
DR CTD; 63027; -.
DR GeneCards; GC06M003269; -.
DR H-InvDB; HIX0005541; -.
DR H-InvDB; HIX0005544; -.
DR HGNC; HGNC:21106; SLC22A23.
DR HPA; HPA014697; -.
DR MIM; 611697; gene.
DR neXtProt; NX_A1A5C7; -.
DR PharmGKB; PA162403516; -.
DR eggNOG; NOG275019; -.
DR HOGENOM; HOG000124569; -.
DR HOVERGEN; HBG108437; -.
DR InParanoid; A1A5C7; -.
DR KO; K08215; -.
DR GenomeRNAi; 63027; -.
DR NextBio; 65527; -.
DR PRO; PR:A1A5C7; -.
DR ArrayExpress; A1A5C7; -.
DR Bgee; A1A5C7; -.
DR CleanEx; HS_SLC22A23; -.
DR Genevestigator; A1A5C7; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR InterPro; IPR005828; Sub_transporter.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Glycoprotein; Ion transport;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1 686 Solute carrier family 22 member 23.
FT /FTId=PRO_0000308315.
FT TRANSMEM 234 254 Helical; (Potential).
FT TRANSMEM 258 278 Helical; (Potential).
FT TRANSMEM 288 308 Helical; (Potential).
FT TRANSMEM 315 335 Helical; (Potential).
FT TRANSMEM 344 364 Helical; (Potential).
FT TRANSMEM 467 487 Helical; (Potential).
FT TRANSMEM 494 514 Helical; (Potential).
FT TRANSMEM 538 558 Helical; (Potential).
FT TRANSMEM 569 589 Helical; (Potential).
FT TRANSMEM 598 618 Helical; (Potential).
FT CARBOHYD 24 24 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 279 279 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 1 370 Missing (in isoform 3).
FT /FTId=VSP_028955.
FT VAR_SEQ 1 281 Missing (in isoform 2).
FT /FTId=VSP_028954.
FT VAR_SEQ 362 686 Missing (in isoform 4).
FT /FTId=VSP_028956.
FT CONFLICT 685 685 A -> G (in Ref. 3; BAD18753).
SQ SEQUENCE 686 AA; 73748 MW; 035E53BA5FEDF8F0 CRC64;
MAIDRRREAA GGGPGRQPAP AEENGSLPPG DAAASAPLGG RAGPGGGAEI QPLPPLHPGG
GPHPSCCSAA AAPSLLLLDY DGSVLPFLGG LGGGYQKTLV LLTWIPALFI GFSQFSDSFL
LDQPNFWCRG AGKGTELAGV TTTGRGGDMG NWTSLPTTPF ATAPWEAAGN RSNSSGADGG
DTPPLPSPPD KGDNASNCDC RAWDYGIRAG LVQNVVSKWD LVCDNAWKVH IAKFSLLVGL
IFGYLITGCI ADWVGRRPVL LFSIIFILIF GLTVALSVNV TMFSTLRFFE GFCLAGIILT
LYALRIELCP PGKRFMITMV ASFVAMAGQF LMPGLAALCR DWQVLQALII CPFLLMLLYW
SIFPESLRWL MATQQFESAK RLILHFTQKN RMNPEGDIKG VIPELEKELS RRPKKVCIVK
VVGTRNLWKN IVVLCVNSLT GYGIHHCFAR SMMGHEVKVP LLENFYADYY TTASIALVSC
LAMCVVVRFL GRRGGLLLFM ILTALASLLQ LGLLNLIGKY SQHPDSGMSD SVKDKFSIAF
SIVGMFASHA VGSLSVFFCA EITPTVIRCG GLGLVLASAG FGMLTAPIIE LHNQKGYFLH
HIIFACCTLI CIICILLLPE SRDQNLPENI SNGEHYTRQP LLPHKKGEQP LLLTNAELKD
YSGLHDAAAA GDTLPEGATA NGMKAM
//
MIM
611697
*RECORD*
*FIELD* NO
611697
*FIELD* TI
*611697 CHROMOSOME 6 OPEN READING FRAME 85; C6ORF85
;;SOLUTE CARRIER FAMILY 22, MEMBER 23; SLC22A23
read more*FIELD* TX
DESCRIPTION
SLC22A23 belongs to a large family of transmembrane proteins that
function as uniporters, symporters, and antiporters to transport organic
ions across cell membranes (Jacobsson et al., 2007).
CLONING
By searching a human database for SLC22 family members, Jacobsson et al.
(2007) identified SLC22A23. The deduced 405-amino acid protein has 12
putative transmembrane domains. Quantitative real-time PCR detected high
expression of rat Slc22a23 in several brain regions and spinal cord, and
in liver, skeletal muscle, and kidney. Moderate expression was detected
in adipose tissue, lung, epididymis, and heart, and weaker expression
was detected in several other tissues.
GENE STRUCTURE
Jacobsson et al. (2007) determined that the SLC22A23 gene contains 7
exons.
MAPPING
Jacobsson et al. (2007) stated that the SLC22A23 gene maps to chromosome
6p25.2; the mouse Slc22a23 gene maps to chromosome 19qA3.3.
*FIELD* RF
1. Jacobsson, J. A.; Haitina, T.; Lindblom, J.; Fredriksson, R.:
Identification of six putative human transporters with structural
similarity to the drug transporter SLC22 family. Genomics 90: 595-609,
2007.
*FIELD* CD
Patricia A. Hartz: 12/21/2007
*FIELD* ED
carol: 12/21/2007
*RECORD*
*FIELD* NO
611697
*FIELD* TI
*611697 CHROMOSOME 6 OPEN READING FRAME 85; C6ORF85
;;SOLUTE CARRIER FAMILY 22, MEMBER 23; SLC22A23
read more*FIELD* TX
DESCRIPTION
SLC22A23 belongs to a large family of transmembrane proteins that
function as uniporters, symporters, and antiporters to transport organic
ions across cell membranes (Jacobsson et al., 2007).
CLONING
By searching a human database for SLC22 family members, Jacobsson et al.
(2007) identified SLC22A23. The deduced 405-amino acid protein has 12
putative transmembrane domains. Quantitative real-time PCR detected high
expression of rat Slc22a23 in several brain regions and spinal cord, and
in liver, skeletal muscle, and kidney. Moderate expression was detected
in adipose tissue, lung, epididymis, and heart, and weaker expression
was detected in several other tissues.
GENE STRUCTURE
Jacobsson et al. (2007) determined that the SLC22A23 gene contains 7
exons.
MAPPING
Jacobsson et al. (2007) stated that the SLC22A23 gene maps to chromosome
6p25.2; the mouse Slc22a23 gene maps to chromosome 19qA3.3.
*FIELD* RF
1. Jacobsson, J. A.; Haitina, T.; Lindblom, J.; Fredriksson, R.:
Identification of six putative human transporters with structural
similarity to the drug transporter SLC22 family. Genomics 90: 595-609,
2007.
*FIELD* CD
Patricia A. Hartz: 12/21/2007
*FIELD* ED
carol: 12/21/2007