Full text data of SAA4
SAA4
(CSAA)
[Confidence: low (only semi-automatic identification from reviews)]
Serum amyloid A-4 protein (Constitutively expressed serum amyloid A protein; C-SAA; Flags: Precursor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Serum amyloid A-4 protein (Constitutively expressed serum amyloid A protein; C-SAA; Flags: Precursor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
P35542
ID SAA4_HUMAN Reviewed; 130 AA.
AC P35542; Q6FHJ4;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
read moreDT 18-MAY-2010, sequence version 2.
DT 22-JAN-2014, entry version 110.
DE RecName: Full=Serum amyloid A-4 protein;
DE AltName: Full=Constitutively expressed serum amyloid A protein;
DE Short=C-SAA;
DE Flags: Precursor;
GN Name=SAA4; Synonyms=CSAA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT TYR-89.
RC TISSUE=Liver;
RX PubMed=1740433;
RA Whitehead A.S., Debeer M.C., Steel D.M., Rits M., Lelias J.M.,
RA Lane W.S., Debeer F.C.;
RT "Identification of novel members of the serum amyloid A protein
RT superfamily as constitutive apolipoproteins of high density
RT lipoprotein.";
RL J. Biol. Chem. 267:3862-3867(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT TYR-89.
RX PubMed=7686132; DOI=10.1006/geno.1993.1209;
RA Steel D.M., Sellar G.C., Uhlar C.M., Simon S., Debeer F.C.,
RA Whitehead A.S.;
RT "A constitutively expressed serum amyloid A protein gene (SAA4) is
RT closely linked to, and shares structural similarities with, an acute-
RT phase serum amyloid A protein gene (SAA2).";
RL Genomics 16:447-454(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT TYR-89.
RX PubMed=1439582; DOI=10.1111/j.1365-3083.1992.tb03131.x;
RA Watson G., Coade S., Woo P.;
RT "Analysis of the genomic and derived protein structure of a novel
RT human serum amyloid A gene, SAA4.";
RL Scand. J. Immunol. 36:703-712(1992).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT TYR-89.
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT TYR-89.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT TYR-89.
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PARTIAL PROTEIN SEQUENCE.
RX PubMed=8783012; DOI=10.1002/elps.1150170508;
RA Ducret A., Bruun C.F., Bures E.J., Marhaug G., Husby G., Aebersold R.;
RT "Characterization of human serum amyloid A protein isoforms separated
RT by two-dimensional electrophoresis by liquid
RT chromatography/electrospray ionization tandem mass spectrometry.";
RL Electrophoresis 17:866-876(1996).
RN [9]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94, AND MASS SPECTROMETRY.
RC TISSUE=Plasma;
RX PubMed=16335952; DOI=10.1021/pr0502065;
RA Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,
RA Moore R.J., Smith R.D.;
RT "Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
RT hydrazide chemistry, and mass spectrometry.";
RL J. Proteome Res. 4:2070-2080(2005).
RN [10]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94, AND MASS SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of
RT multiple enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [12]
RP VARIANT TYR-89, AND MASS SPECTROMETRY.
RX PubMed=22028381; DOI=10.1093/jmcb/mjr024;
RA Su Z.D., Sun L., Yu D.X., Li R.X., Li H.X., Yu Z.J., Sheng Q.H.,
RA Lin X., Zeng R., Wu J.R.;
RT "Quantitative detection of single amino acid polymorphisms by targeted
RT proteomics.";
RL J. Mol. Cell Biol. 3:309-315(2011).
CC -!- FUNCTION: Major acute phase reactant. Apolipoprotein of the HDL
CC complex.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma.
CC -!- INDUCTION: Constitutively expressed.
CC -!- SIMILARITY: Belongs to the SAA family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; L05920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M81349; AAA60298.1; -; mRNA.
DR EMBL; S48983; AAB24060.1; -; Genomic_DNA.
DR EMBL; S48980; AAB24060.1; JOINED; Genomic_DNA.
DR EMBL; S48981; AAB24060.1; JOINED; Genomic_DNA.
DR EMBL; CR541758; CAG46558.1; -; mRNA.
DR EMBL; AC090099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW68415.1; -; Genomic_DNA.
DR EMBL; BC007026; AAH07026.1; -; mRNA.
DR PIR; A38974; A38974.
DR RefSeq; NP_006503.2; NM_006512.3.
DR UniGene; Hs.1955; -.
DR ProteinModelPortal; P35542; -.
DR IntAct; P35542; 1.
DR MINT; MINT-1445365; -.
DR STRING; 9606.ENSP00000278222; -.
DR DMDM; 296452894; -.
DR PaxDb; P35542; -.
DR PeptideAtlas; P35542; -.
DR PRIDE; P35542; -.
DR Ensembl; ENST00000278222; ENSP00000278222; ENSG00000148965.
DR GeneID; 6291; -.
DR KEGG; hsa:6291; -.
DR UCSC; uc001mny.3; human.
DR CTD; 6291; -.
DR GeneCards; GC11M018252; -.
DR HGNC; HGNC:10516; SAA4.
DR HPA; CAB026061; -.
DR MIM; 104752; gene.
DR neXtProt; NX_P35542; -.
DR PharmGKB; PA34924; -.
DR eggNOG; NOG46739; -.
DR HOGENOM; HOG000126881; -.
DR HOVERGEN; HBG016327; -.
DR InParanoid; P35542; -.
DR KO; K17310; -.
DR OMA; FCSLVMG; -.
DR OrthoDB; EOG7QVM4V; -.
DR PhylomeDB; P35542; -.
DR GenomeRNAi; 6291; -.
DR NextBio; 24427; -.
DR PRO; PR:P35542; -.
DR Bgee; P35542; -.
DR CleanEx; HS_SAA4; -.
DR Genevestigator; P35542; -.
DR GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR InterPro; IPR000096; Serum_amyloid_A.
DR PANTHER; PTHR23424; PTHR23424; 1.
DR Pfam; PF00277; SAA; 1.
DR PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR PRINTS; PR00306; SERUMAMYLOID.
DR SMART; SM00197; SAA; 1.
DR PROSITE; PS00992; SAA; 1.
PE 1: Evidence at protein level;
KW Acute phase; Complete proteome; Direct protein sequencing;
KW Glycoprotein; HDL; Polymorphism; Reference proteome; Secreted; Signal.
FT SIGNAL 1 18
FT CHAIN 19 130 Serum amyloid A-4 protein.
FT /FTId=PRO_0000031583.
FT CARBOHYD 94 94 N-linked (GlcNAc...); partial.
FT VARIANT 89 89 C -> Y (polymorphism confirmed at protein
FT level; dbSNP:rs2460827).
FT /FTId=VAR_051893.
SQ SEQUENCE 130 AA; 14747 MW; 0F9BD50ACCF00B1C CRC64;
MRLFTGIVFC SLVMGVTSES WRSFFKEALQ GVGDMGRAYW DIMISNHQNS NRYLYARGNY
DAAQRGPGGV WAAKLISRSR VYLQGLIDCY LFGNSSTVLE DSKSNEKAEE WGRSGKDPDR
FRPDGLPKKY
//
ID SAA4_HUMAN Reviewed; 130 AA.
AC P35542; Q6FHJ4;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
read moreDT 18-MAY-2010, sequence version 2.
DT 22-JAN-2014, entry version 110.
DE RecName: Full=Serum amyloid A-4 protein;
DE AltName: Full=Constitutively expressed serum amyloid A protein;
DE Short=C-SAA;
DE Flags: Precursor;
GN Name=SAA4; Synonyms=CSAA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT TYR-89.
RC TISSUE=Liver;
RX PubMed=1740433;
RA Whitehead A.S., Debeer M.C., Steel D.M., Rits M., Lelias J.M.,
RA Lane W.S., Debeer F.C.;
RT "Identification of novel members of the serum amyloid A protein
RT superfamily as constitutive apolipoproteins of high density
RT lipoprotein.";
RL J. Biol. Chem. 267:3862-3867(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT TYR-89.
RX PubMed=7686132; DOI=10.1006/geno.1993.1209;
RA Steel D.M., Sellar G.C., Uhlar C.M., Simon S., Debeer F.C.,
RA Whitehead A.S.;
RT "A constitutively expressed serum amyloid A protein gene (SAA4) is
RT closely linked to, and shares structural similarities with, an acute-
RT phase serum amyloid A protein gene (SAA2).";
RL Genomics 16:447-454(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT TYR-89.
RX PubMed=1439582; DOI=10.1111/j.1365-3083.1992.tb03131.x;
RA Watson G., Coade S., Woo P.;
RT "Analysis of the genomic and derived protein structure of a novel
RT human serum amyloid A gene, SAA4.";
RL Scand. J. Immunol. 36:703-712(1992).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT TYR-89.
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT TYR-89.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT TYR-89.
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PARTIAL PROTEIN SEQUENCE.
RX PubMed=8783012; DOI=10.1002/elps.1150170508;
RA Ducret A., Bruun C.F., Bures E.J., Marhaug G., Husby G., Aebersold R.;
RT "Characterization of human serum amyloid A protein isoforms separated
RT by two-dimensional electrophoresis by liquid
RT chromatography/electrospray ionization tandem mass spectrometry.";
RL Electrophoresis 17:866-876(1996).
RN [9]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94, AND MASS SPECTROMETRY.
RC TISSUE=Plasma;
RX PubMed=16335952; DOI=10.1021/pr0502065;
RA Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,
RA Moore R.J., Smith R.D.;
RT "Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
RT hydrazide chemistry, and mass spectrometry.";
RL J. Proteome Res. 4:2070-2080(2005).
RN [10]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-94, AND MASS SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of
RT multiple enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [12]
RP VARIANT TYR-89, AND MASS SPECTROMETRY.
RX PubMed=22028381; DOI=10.1093/jmcb/mjr024;
RA Su Z.D., Sun L., Yu D.X., Li R.X., Li H.X., Yu Z.J., Sheng Q.H.,
RA Lin X., Zeng R., Wu J.R.;
RT "Quantitative detection of single amino acid polymorphisms by targeted
RT proteomics.";
RL J. Mol. Cell Biol. 3:309-315(2011).
CC -!- FUNCTION: Major acute phase reactant. Apolipoprotein of the HDL
CC complex.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the liver; secreted in plasma.
CC -!- INDUCTION: Constitutively expressed.
CC -!- SIMILARITY: Belongs to the SAA family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; L05920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M81349; AAA60298.1; -; mRNA.
DR EMBL; S48983; AAB24060.1; -; Genomic_DNA.
DR EMBL; S48980; AAB24060.1; JOINED; Genomic_DNA.
DR EMBL; S48981; AAB24060.1; JOINED; Genomic_DNA.
DR EMBL; CR541758; CAG46558.1; -; mRNA.
DR EMBL; AC090099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW68415.1; -; Genomic_DNA.
DR EMBL; BC007026; AAH07026.1; -; mRNA.
DR PIR; A38974; A38974.
DR RefSeq; NP_006503.2; NM_006512.3.
DR UniGene; Hs.1955; -.
DR ProteinModelPortal; P35542; -.
DR IntAct; P35542; 1.
DR MINT; MINT-1445365; -.
DR STRING; 9606.ENSP00000278222; -.
DR DMDM; 296452894; -.
DR PaxDb; P35542; -.
DR PeptideAtlas; P35542; -.
DR PRIDE; P35542; -.
DR Ensembl; ENST00000278222; ENSP00000278222; ENSG00000148965.
DR GeneID; 6291; -.
DR KEGG; hsa:6291; -.
DR UCSC; uc001mny.3; human.
DR CTD; 6291; -.
DR GeneCards; GC11M018252; -.
DR HGNC; HGNC:10516; SAA4.
DR HPA; CAB026061; -.
DR MIM; 104752; gene.
DR neXtProt; NX_P35542; -.
DR PharmGKB; PA34924; -.
DR eggNOG; NOG46739; -.
DR HOGENOM; HOG000126881; -.
DR HOVERGEN; HBG016327; -.
DR InParanoid; P35542; -.
DR KO; K17310; -.
DR OMA; FCSLVMG; -.
DR OrthoDB; EOG7QVM4V; -.
DR PhylomeDB; P35542; -.
DR GenomeRNAi; 6291; -.
DR NextBio; 24427; -.
DR PRO; PR:P35542; -.
DR Bgee; P35542; -.
DR CleanEx; HS_SAA4; -.
DR Genevestigator; P35542; -.
DR GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR InterPro; IPR000096; Serum_amyloid_A.
DR PANTHER; PTHR23424; PTHR23424; 1.
DR Pfam; PF00277; SAA; 1.
DR PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR PRINTS; PR00306; SERUMAMYLOID.
DR SMART; SM00197; SAA; 1.
DR PROSITE; PS00992; SAA; 1.
PE 1: Evidence at protein level;
KW Acute phase; Complete proteome; Direct protein sequencing;
KW Glycoprotein; HDL; Polymorphism; Reference proteome; Secreted; Signal.
FT SIGNAL 1 18
FT CHAIN 19 130 Serum amyloid A-4 protein.
FT /FTId=PRO_0000031583.
FT CARBOHYD 94 94 N-linked (GlcNAc...); partial.
FT VARIANT 89 89 C -> Y (polymorphism confirmed at protein
FT level; dbSNP:rs2460827).
FT /FTId=VAR_051893.
SQ SEQUENCE 130 AA; 14747 MW; 0F9BD50ACCF00B1C CRC64;
MRLFTGIVFC SLVMGVTSES WRSFFKEALQ GVGDMGRAYW DIMISNHQNS NRYLYARGNY
DAAQRGPGGV WAAKLISRSR VYLQGLIDCY LFGNSSTVLE DSKSNEKAEE WGRSGKDPDR
FRPDGLPKKY
//
MIM
104752
*RECORD*
*FIELD* NO
104752
*FIELD* TI
*104752 SERUM AMYLOID A4; SAA4
;;AMYLOID A, SERUM, 4;;
SERUM AMYLOID A4, CONSTITUTIVE
read more*FIELD* TX
DESCRIPTION
The acute phase reactant serum amyloid A (SAA) is a polymorphic
apolipoprotein encoded by a family of highly homologous and closely
linked genes (summary by Steel et al., 1993). For background information
on SAA, see SAA1 (104750).
CLONING
Studying protein and cDNA, Whitehead et al. (1992) identified a member
of the serum amyloid A protein superfamily, designated SAA4, as
constitutive apolipoprotein of high density lipoprotein.
Watson et al. (1992) analyzed the derived protein structure of SAA4.
GENE STRUCTURE
Watson et al. (1992) analyzed the structure of the SAA4 gene.
Steel et al. (1993) determined that the SAA4 gene shares the same
5-prime to 3-prime orientation and has the characteristic 4-exon
structure of the other members of the SAA superfamily.
MAPPING
Steel et al. (1993) demonstrated that the SAA4 gene is located 9 kb
downstream of the SAA2 gene (104751) on chromosome 11.
By fluorescence in situ hybridization using a cosmid probe carrying the
SAA2 and SAA4 genes, Sellar et al. (1994) localized these genes to
11p15.1.
De Beer et al. (1996) found that in the mouse the Saa4 gene is linked to
the serum amyloid A gene family on chromosome 7.
*FIELD* RF
1. de Beer, M. C.; de Beer, F. C.; Gerardot, C. J.; Cecil, D. R.;
Webb, N. R.; Goodson M. L.; Kindy, M. S.: Structure of the mouse
Saa4 gene and its linkage to the serum amyloid A gene family. Genomics 34:
139-142, 1996.
2. Sellar, G. C.; Jordon, S. A.; Bickmore, W. A.; Fantes, J. A.; van
Heyningen, V.; Whitehead, A. S.: The human serum amyloid A protein
(SAA) superfamily gene cluster: mapping to chromosome 11p15.1 by physical
and genetic linkage analysis. Genomics 19: 221-227, 1994.
3. Steel, D. M.; Sellar, G. C.; Uhlar, C. M.; Simon, S.; DeBeer, F.
C.; Whitehead, A. S.: A constitutively expressed serum amyloid A
protein gene (SAA4) is closely linked to, and shares structural similarities
with, an acute-phase serum amyloid A protein gene (SAA1). Genomics 16:
447-454, 1993.
4. Watson, G.; Coade, S.; Woo, P.: Analysis of the genomic and derived
protein structure of a novel human serum amyloid A gene, SAA4. Scand.
J. Immun. 36: 703-712, 1992.
5. Whitehead, A. S.; DeBeer, M. C.; Steel, D. M.; Rits, M.; Lelias,
J. M.; Lane, W. S.; DeBeer, F. C.: Identification of novel members
of the serum amyloid A protein superfamily as constitutive apolipoproteins
of high density lipoprotein. J. Biol. Chem. 267: 3862-3867, 1992.
*FIELD* CD
Victor A. McKusick: 3/9/1993
*FIELD* ED
alopez: 07/16/2012
alopez: 7/16/2012
alopez: 12/9/1998
terry: 6/5/1996
terry: 6/3/1996
mark: 8/8/1995
carol: 4/12/1994
carol: 5/21/1993
carol: 3/23/1993
carol: 3/9/1993
*RECORD*
*FIELD* NO
104752
*FIELD* TI
*104752 SERUM AMYLOID A4; SAA4
;;AMYLOID A, SERUM, 4;;
SERUM AMYLOID A4, CONSTITUTIVE
read more*FIELD* TX
DESCRIPTION
The acute phase reactant serum amyloid A (SAA) is a polymorphic
apolipoprotein encoded by a family of highly homologous and closely
linked genes (summary by Steel et al., 1993). For background information
on SAA, see SAA1 (104750).
CLONING
Studying protein and cDNA, Whitehead et al. (1992) identified a member
of the serum amyloid A protein superfamily, designated SAA4, as
constitutive apolipoprotein of high density lipoprotein.
Watson et al. (1992) analyzed the derived protein structure of SAA4.
GENE STRUCTURE
Watson et al. (1992) analyzed the structure of the SAA4 gene.
Steel et al. (1993) determined that the SAA4 gene shares the same
5-prime to 3-prime orientation and has the characteristic 4-exon
structure of the other members of the SAA superfamily.
MAPPING
Steel et al. (1993) demonstrated that the SAA4 gene is located 9 kb
downstream of the SAA2 gene (104751) on chromosome 11.
By fluorescence in situ hybridization using a cosmid probe carrying the
SAA2 and SAA4 genes, Sellar et al. (1994) localized these genes to
11p15.1.
De Beer et al. (1996) found that in the mouse the Saa4 gene is linked to
the serum amyloid A gene family on chromosome 7.
*FIELD* RF
1. de Beer, M. C.; de Beer, F. C.; Gerardot, C. J.; Cecil, D. R.;
Webb, N. R.; Goodson M. L.; Kindy, M. S.: Structure of the mouse
Saa4 gene and its linkage to the serum amyloid A gene family. Genomics 34:
139-142, 1996.
2. Sellar, G. C.; Jordon, S. A.; Bickmore, W. A.; Fantes, J. A.; van
Heyningen, V.; Whitehead, A. S.: The human serum amyloid A protein
(SAA) superfamily gene cluster: mapping to chromosome 11p15.1 by physical
and genetic linkage analysis. Genomics 19: 221-227, 1994.
3. Steel, D. M.; Sellar, G. C.; Uhlar, C. M.; Simon, S.; DeBeer, F.
C.; Whitehead, A. S.: A constitutively expressed serum amyloid A
protein gene (SAA4) is closely linked to, and shares structural similarities
with, an acute-phase serum amyloid A protein gene (SAA1). Genomics 16:
447-454, 1993.
4. Watson, G.; Coade, S.; Woo, P.: Analysis of the genomic and derived
protein structure of a novel human serum amyloid A gene, SAA4. Scand.
J. Immun. 36: 703-712, 1992.
5. Whitehead, A. S.; DeBeer, M. C.; Steel, D. M.; Rits, M.; Lelias,
J. M.; Lane, W. S.; DeBeer, F. C.: Identification of novel members
of the serum amyloid A protein superfamily as constitutive apolipoproteins
of high density lipoprotein. J. Biol. Chem. 267: 3862-3867, 1992.
*FIELD* CD
Victor A. McKusick: 3/9/1993
*FIELD* ED
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