Full text data of SAAL1
SAAL1
[Confidence: low (only semi-automatic identification from reviews)]
Protein SAAL1
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Protein SAAL1
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q96ER3
ID SAAL1_HUMAN Reviewed; 474 AA.
AC Q96ER3; A6NH05;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 14-OCT-2008, sequence version 2.
DT 22-JAN-2014, entry version 84.
DE RecName: Full=Protein SAAL1;
GN Name=SAAL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-387, AND MASS
RP SPECTROMETRY.
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,
RA Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,
RA Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SIMILARITY: Belongs to the SAAL1 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC090099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW68419.1; -; Genomic_DNA.
DR EMBL; BC012010; AAH12010.1; -; mRNA.
DR RefSeq; NP_612430.2; NM_138421.2.
DR UniGene; Hs.591998; -.
DR ProteinModelPortal; Q96ER3; -.
DR IntAct; Q96ER3; 4.
DR MINT; MINT-1430177; -.
DR STRING; 9606.ENSP00000300013; -.
DR PhosphoSite; Q96ER3; -.
DR DMDM; 209572677; -.
DR PaxDb; Q96ER3; -.
DR PRIDE; Q96ER3; -.
DR Ensembl; ENST00000524803; ENSP00000432487; ENSG00000166788.
DR GeneID; 113174; -.
DR KEGG; hsa:113174; -.
DR UCSC; uc001mnq.3; human.
DR CTD; 113174; -.
DR GeneCards; GC11M018059; -.
DR H-InvDB; HIX0009481; -.
DR HGNC; HGNC:25158; SAAL1.
DR HPA; HPA039004; -.
DR neXtProt; NX_Q96ER3; -.
DR PharmGKB; PA142670959; -.
DR eggNOG; NOG69884; -.
DR HOGENOM; HOG000154242; -.
DR HOVERGEN; HBG061166; -.
DR InParanoid; Q96ER3; -.
DR OrthoDB; EOG7M98GZ; -.
DR GenomeRNAi; 113174; -.
DR NextBio; 78763; -.
DR PRO; PR:Q96ER3; -.
DR ArrayExpress; Q96ER3; -.
DR Bgee; Q96ER3; -.
DR CleanEx; HS_SAAL1; -.
DR Genevestigator; Q96ER3; -.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0006953; P:acute-phase response; IEA:InterPro.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000096; Serum_amyloid_A.
DR PANTHER; PTHR23424; PTHR23424; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Phosphoprotein; Polymorphism; Reference proteome.
FT CHAIN 1 474 Protein SAAL1.
FT /FTId=PRO_0000279540.
FT MOD_RES 6 6 Phosphoserine (By similarity).
FT MOD_RES 387 387 Phosphothreonine.
FT VARIANT 315 315 I -> V (in dbSNP:rs35525096).
FT /FTId=VAR_053846.
FT VARIANT 426 426 S -> G (in dbSNP:rs28930681).
FT /FTId=VAR_053847.
FT CONFLICT 10 10 P -> PP (in Ref. 3; AAH12010).
SQ SEQUENCE 474 AA; 53558 MW; C206C80827F49681 CRC64;
MDRNPSPPPP GRDKEEEEEV AGGDCIGSTV YSKHWLFGVL SGLIQIVSPE NTKSSSDDEE
QLTELDEEME NEICRVWDMS MDEDVALFLQ EFNAPDIFMG VLAKSKCPRL REICVGILGN
MACFQEICVS ISSDKNLGQV LLHCLYDSDP PTLLETSRLL LTCLSQAEVA SVWVERIQEH
PAIYDSICFI MSSSTNVDLL VKVGEVVDKL FDLDEKLMLE WVRNGAAQPL DQPQEESEEQ
PVFRLVPCIL EAAKQVRSEN PEWLDVYMHI LQLLTTVDDG IQAIVHCPDT GKDIWNLLFD
LVCHEFCQSD DPPIILQEQK TVLASVFSVL SAIYASQTEQ EYLKIEKVDL PLIDSLIRVL
QNMEQCQKKP ENSAESNTEE TKRTDLTQDD FHLKILKDIL CEFLSNIFQA LTKETVAQGV
KEGQLSKQKC SSAFQNLLPF YSPVVEDFIK ILREVDKALA DDLEKNFPSL KVQT
//
ID SAAL1_HUMAN Reviewed; 474 AA.
AC Q96ER3; A6NH05;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 14-OCT-2008, sequence version 2.
DT 22-JAN-2014, entry version 84.
DE RecName: Full=Protein SAAL1;
GN Name=SAAL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-387, AND MASS
RP SPECTROMETRY.
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,
RA Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,
RA Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SIMILARITY: Belongs to the SAAL1 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC090099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW68419.1; -; Genomic_DNA.
DR EMBL; BC012010; AAH12010.1; -; mRNA.
DR RefSeq; NP_612430.2; NM_138421.2.
DR UniGene; Hs.591998; -.
DR ProteinModelPortal; Q96ER3; -.
DR IntAct; Q96ER3; 4.
DR MINT; MINT-1430177; -.
DR STRING; 9606.ENSP00000300013; -.
DR PhosphoSite; Q96ER3; -.
DR DMDM; 209572677; -.
DR PaxDb; Q96ER3; -.
DR PRIDE; Q96ER3; -.
DR Ensembl; ENST00000524803; ENSP00000432487; ENSG00000166788.
DR GeneID; 113174; -.
DR KEGG; hsa:113174; -.
DR UCSC; uc001mnq.3; human.
DR CTD; 113174; -.
DR GeneCards; GC11M018059; -.
DR H-InvDB; HIX0009481; -.
DR HGNC; HGNC:25158; SAAL1.
DR HPA; HPA039004; -.
DR neXtProt; NX_Q96ER3; -.
DR PharmGKB; PA142670959; -.
DR eggNOG; NOG69884; -.
DR HOGENOM; HOG000154242; -.
DR HOVERGEN; HBG061166; -.
DR InParanoid; Q96ER3; -.
DR OrthoDB; EOG7M98GZ; -.
DR GenomeRNAi; 113174; -.
DR NextBio; 78763; -.
DR PRO; PR:Q96ER3; -.
DR ArrayExpress; Q96ER3; -.
DR Bgee; Q96ER3; -.
DR CleanEx; HS_SAAL1; -.
DR Genevestigator; Q96ER3; -.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0006953; P:acute-phase response; IEA:InterPro.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000096; Serum_amyloid_A.
DR PANTHER; PTHR23424; PTHR23424; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Phosphoprotein; Polymorphism; Reference proteome.
FT CHAIN 1 474 Protein SAAL1.
FT /FTId=PRO_0000279540.
FT MOD_RES 6 6 Phosphoserine (By similarity).
FT MOD_RES 387 387 Phosphothreonine.
FT VARIANT 315 315 I -> V (in dbSNP:rs35525096).
FT /FTId=VAR_053846.
FT VARIANT 426 426 S -> G (in dbSNP:rs28930681).
FT /FTId=VAR_053847.
FT CONFLICT 10 10 P -> PP (in Ref. 3; AAH12010).
SQ SEQUENCE 474 AA; 53558 MW; C206C80827F49681 CRC64;
MDRNPSPPPP GRDKEEEEEV AGGDCIGSTV YSKHWLFGVL SGLIQIVSPE NTKSSSDDEE
QLTELDEEME NEICRVWDMS MDEDVALFLQ EFNAPDIFMG VLAKSKCPRL REICVGILGN
MACFQEICVS ISSDKNLGQV LLHCLYDSDP PTLLETSRLL LTCLSQAEVA SVWVERIQEH
PAIYDSICFI MSSSTNVDLL VKVGEVVDKL FDLDEKLMLE WVRNGAAQPL DQPQEESEEQ
PVFRLVPCIL EAAKQVRSEN PEWLDVYMHI LQLLTTVDDG IQAIVHCPDT GKDIWNLLFD
LVCHEFCQSD DPPIILQEQK TVLASVFSVL SAIYASQTEQ EYLKIEKVDL PLIDSLIRVL
QNMEQCQKKP ENSAESNTEE TKRTDLTQDD FHLKILKDIL CEFLSNIFQA LTKETVAQGV
KEGQLSKQKC SSAFQNLLPF YSPVVEDFIK ILREVDKALA DDLEKNFPSL KVQT
//