Full text data of SBSN
SBSN
[Confidence: low (only semi-automatic identification from reviews)]
Suprabasin; Flags: Precursor
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Suprabasin; Flags: Precursor
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q6UWP8
ID SBSN_HUMAN Reviewed; 590 AA.
AC Q6UWP8; A8K5J0; E9PBV3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 06-FEB-2013, sequence version 2.
DT 22-JAN-2014, entry version 70.
DE RecName: Full=Suprabasin;
DE Flags: Precursor;
GN Name=SBSN; ORFNames=UNQ698/PRO1343;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP GLY-419.
RC TISSUE=Cervix;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=12228223; DOI=10.1074/jbc.M205380200;
RA Park G.T., Lim S.E., Jang S.-I., Morasso M.I.;
RT "Suprabasin, a novel epidermal differentiation marker and potential
RT cornified envelope precursor.";
RL J. Biol. Chem. 277:45195-45202(2002).
CC -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UWP8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UWP8-2; Sequence=VSP_044973;
CC -!- TISSUE SPECIFICITY: Detected in thymus, uterus and esophagus.
CC -!- INDUCTION: Up-regulated in differentiating keratinocytes.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY358701; AAQ89064.1; -; mRNA.
DR EMBL; AK291305; BAF83994.1; -; mRNA.
DR EMBL; BX648076; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC002389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC063640; AAH63640.1; -; mRNA.
DR RefSeq; NP_001159506.1; NM_001166034.1.
DR RefSeq; NP_001159507.1; NM_001166035.1.
DR RefSeq; NP_940940.1; NM_198538.3.
DR UniGene; Hs.433484; -.
DR ProteinModelPortal; Q6UWP8; -.
DR PhosphoSite; Q6UWP8; -.
DR DMDM; 74738122; -.
DR PRIDE; Q6UWP8; -.
DR Ensembl; ENST00000452271; ENSP00000430242; ENSG00000189001.
DR Ensembl; ENST00000518157; ENSP00000428771; ENSG00000189001.
DR GeneID; 374897; -.
DR KEGG; hsa:374897; -.
DR UCSC; uc002oad.2; human.
DR CTD; 374897; -.
DR GeneCards; GC19M036014; -.
DR HGNC; HGNC:24950; SBSN.
DR MIM; 609969; gene.
DR neXtProt; NX_Q6UWP8; -.
DR PharmGKB; PA144596385; -.
DR HOGENOM; HOG000130803; -.
DR InParanoid; Q6UWP8; -.
DR OMA; FGQGAHH; -.
DR OrthoDB; EOG72JWG8; -.
DR ChiTaRS; SBSN; human.
DR GenomeRNAi; 374897; -.
DR NextBio; 100318; -.
DR PRO; PR:Q6UWP8; -.
DR ArrayExpress; Q6UWP8; -.
DR Bgee; Q6UWP8; -.
DR CleanEx; HS_SBSN; -.
DR Genevestigator; Q6UWP8; -.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR024153; Suprabasin.
DR PANTHER; PTHR23243; PTHR23243; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Polymorphism;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1 25 Potential.
FT CHAIN 26 590 Suprabasin.
FT /FTId=PRO_0000317120.
FT COMPBIAS 48 524 Ala/Gly/His-rich.
FT VAR_SEQ 125 467 Missing (in isoform 2).
FT /FTId=VSP_044973.
FT VARIANT 419 419 A -> G (in dbSNP:rs10775583).
FT /FTId=VAR_069027.
FT CONFLICT 298 298 Q -> L (in Ref. 3; BX648076).
FT CONFLICT 372 372 V -> A (in Ref. 3; BX648076).
FT CONFLICT 406 406 Q -> R (in Ref. 3; BX648076).
FT CONFLICT 533 533 G -> W (in Ref. 2; BAF83994).
SQ SEQUENCE 590 AA; 60541 MW; CC3391C48A409DEA CRC64;
MHLARLVGSC SLLLLLGALS GWAASDDPIE KVIEGINRGL SNAEREVGKA LDGINSGITH
AGREVEKVFN GLSNMGSHTG KELDKGVQGL NHGMDKVAHE INHGIGQAGK EAEKLGHGVN
NAAGQVGKEA DKLIHHGVHH GANQAGSEAG KFGQGVDNAA GQAGNEAGRF GQGVHHAAGQ
AGNEAGRFGQ GVHHAAGQAG NEAGRFGQGA HHGLSEGWKE TEKFGQGIHH AAGQVGKEAE
KFGQGAHHAA GQAGNEAGRF GQGVHHGLSE GWKETEKFGQ GVHHTAGQVG KEAEKFGQGA
HHAAGQAGNE AGRFGQGAHH AAGQAGNEAG RFGQGVHHGL SEGWKETEKF GQGVHHAASQ
FGKETEKLGH GVHHGVNEAW KEAEKFGQGV HHAASQVGKE EDRVVQGLHH GVSQAGREAG
QFGHDIHHTA GQAGKEGDIA VHGVQPGVHE AGKEAGQFGQ GVHHTLEQAG KEADKAVQGF
HTGVHQAGKE AEKLGQGVNH AADQAGKEVE KLGQGAHHAA GQAGKELQNA HNGVNQASKE
ANQLLNGNHQ SGSSSHQGGA TTTPLASGAS VNTPFINLPA LWRSVANIMP
//
ID SBSN_HUMAN Reviewed; 590 AA.
AC Q6UWP8; A8K5J0; E9PBV3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 06-FEB-2013, sequence version 2.
DT 22-JAN-2014, entry version 70.
DE RecName: Full=Suprabasin;
DE Flags: Precursor;
GN Name=SBSN; ORFNames=UNQ698/PRO1343;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
RP GLY-419.
RC TISSUE=Cervix;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=12228223; DOI=10.1074/jbc.M205380200;
RA Park G.T., Lim S.E., Jang S.-I., Morasso M.I.;
RT "Suprabasin, a novel epidermal differentiation marker and potential
RT cornified envelope precursor.";
RL J. Biol. Chem. 277:45195-45202(2002).
CC -!- SUBCELLULAR LOCATION: Secreted (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UWP8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UWP8-2; Sequence=VSP_044973;
CC -!- TISSUE SPECIFICITY: Detected in thymus, uterus and esophagus.
CC -!- INDUCTION: Up-regulated in differentiating keratinocytes.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY358701; AAQ89064.1; -; mRNA.
DR EMBL; AK291305; BAF83994.1; -; mRNA.
DR EMBL; BX648076; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC002389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC063640; AAH63640.1; -; mRNA.
DR RefSeq; NP_001159506.1; NM_001166034.1.
DR RefSeq; NP_001159507.1; NM_001166035.1.
DR RefSeq; NP_940940.1; NM_198538.3.
DR UniGene; Hs.433484; -.
DR ProteinModelPortal; Q6UWP8; -.
DR PhosphoSite; Q6UWP8; -.
DR DMDM; 74738122; -.
DR PRIDE; Q6UWP8; -.
DR Ensembl; ENST00000452271; ENSP00000430242; ENSG00000189001.
DR Ensembl; ENST00000518157; ENSP00000428771; ENSG00000189001.
DR GeneID; 374897; -.
DR KEGG; hsa:374897; -.
DR UCSC; uc002oad.2; human.
DR CTD; 374897; -.
DR GeneCards; GC19M036014; -.
DR HGNC; HGNC:24950; SBSN.
DR MIM; 609969; gene.
DR neXtProt; NX_Q6UWP8; -.
DR PharmGKB; PA144596385; -.
DR HOGENOM; HOG000130803; -.
DR InParanoid; Q6UWP8; -.
DR OMA; FGQGAHH; -.
DR OrthoDB; EOG72JWG8; -.
DR ChiTaRS; SBSN; human.
DR GenomeRNAi; 374897; -.
DR NextBio; 100318; -.
DR PRO; PR:Q6UWP8; -.
DR ArrayExpress; Q6UWP8; -.
DR Bgee; Q6UWP8; -.
DR CleanEx; HS_SBSN; -.
DR Genevestigator; Q6UWP8; -.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR024153; Suprabasin.
DR PANTHER; PTHR23243; PTHR23243; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Polymorphism;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1 25 Potential.
FT CHAIN 26 590 Suprabasin.
FT /FTId=PRO_0000317120.
FT COMPBIAS 48 524 Ala/Gly/His-rich.
FT VAR_SEQ 125 467 Missing (in isoform 2).
FT /FTId=VSP_044973.
FT VARIANT 419 419 A -> G (in dbSNP:rs10775583).
FT /FTId=VAR_069027.
FT CONFLICT 298 298 Q -> L (in Ref. 3; BX648076).
FT CONFLICT 372 372 V -> A (in Ref. 3; BX648076).
FT CONFLICT 406 406 Q -> R (in Ref. 3; BX648076).
FT CONFLICT 533 533 G -> W (in Ref. 2; BAF83994).
SQ SEQUENCE 590 AA; 60541 MW; CC3391C48A409DEA CRC64;
MHLARLVGSC SLLLLLGALS GWAASDDPIE KVIEGINRGL SNAEREVGKA LDGINSGITH
AGREVEKVFN GLSNMGSHTG KELDKGVQGL NHGMDKVAHE INHGIGQAGK EAEKLGHGVN
NAAGQVGKEA DKLIHHGVHH GANQAGSEAG KFGQGVDNAA GQAGNEAGRF GQGVHHAAGQ
AGNEAGRFGQ GVHHAAGQAG NEAGRFGQGA HHGLSEGWKE TEKFGQGIHH AAGQVGKEAE
KFGQGAHHAA GQAGNEAGRF GQGVHHGLSE GWKETEKFGQ GVHHTAGQVG KEAEKFGQGA
HHAAGQAGNE AGRFGQGAHH AAGQAGNEAG RFGQGVHHGL SEGWKETEKF GQGVHHAASQ
FGKETEKLGH GVHHGVNEAW KEAEKFGQGV HHAASQVGKE EDRVVQGLHH GVSQAGREAG
QFGHDIHHTA GQAGKEGDIA VHGVQPGVHE AGKEAGQFGQ GVHHTLEQAG KEADKAVQGF
HTGVHQAGKE AEKLGQGVNH AADQAGKEVE KLGQGAHHAA GQAGKELQNA HNGVNQASKE
ANQLLNGNHQ SGSSSHQGGA TTTPLASGAS VNTPFINLPA LWRSVANIMP
//
MIM
609969
*RECORD*
*FIELD* NO
609969
*FIELD* TI
*609969 SUPRABASIN
;;SBSN
*FIELD* TX
CLONING
By subtractive hybridization to identify genes expressed in
read moredifferentiated mouse keratinocytes, Park et al. (2002) cloned Sbsn. The
deduced 700-amino acid protein has a calculated molecular mass of 72 kD.
Sbsn contains an N-terminal transmembrane domain, a central domain with
glycine-, alanine-, and histidine-rich short tandem repeats, and several
phosphorylation and myristoylation sites. An alternatively spliced
transcript encodes a protein lacking the central repetitive region. By
RT-PCR of skin RNA, Park et al. (2002) cloned a partial human SBSN cDNA.
Northern blot analysis of human tissues detected 2.2- and 1.1-kb SBSN
transcripts in skin, esophagus, uterus, thymus, and a keratinocyte cell
line. Northern blot analysis detected 2 Sbsn transcripts at embryonic
day 15.5 in mice, coinciding with epidermal stratification. In situ
hybridization of embryonic and adult mice showed Sbsn expression in the
suprabasal layers of the epithelia in tongue, stomach, and epidermis.
Northern and RNA dot blot analyses of adult mouse tissues revealed
expression in uterus and thyroid, but not in heart, brain, spleen, lung,
liver, smooth muscle, and kidney. Fluorescence-tagged Sbsn showed a
punctate cytoplasmic distribution in transfected mouse keratinocytes
that did not overlap with lysosomal or mitochondrial markers.
GENE FUNCTION
Park et al. (2002) found that expression of Sbsn in primary mouse
epidermal keratinocytes was induced by calcium and phorbol esters and
inhibited by a PKC (see PRKCA; 176960) inhibitor. Monomeric recombinant
Sbsn was cross-linked into a high molecular mass form by the
transglutaminases Tgm2 (190196) and Tgm3 (600238). Park et al. (2002)
concluded that SBSN may have a role in epidermal differentiation.
GENE STRUCTURE
Park et al. (2002) determined that the mouse Sbsn gene contains 4 exons.
MAPPING
By genomic sequence analysis, Park et al. (2002) mapped the SBSN gene to
chromosome 19q13.1. They mapped the mouse Sbsn gene to a region of
chromosome 7B2-B3 that shares homology of synteny with human chromosome
19q13.1.
*FIELD* RF
1. Park, G. T.; Lim, S. E.; Jang, S.-I.; Morasso, M. I.: Suprabasin,
a novel epidermal differentiation marker and potential cornified envelope
precursor. J. Biol. Chem. 277: 45195-45202, 2002.
*FIELD* CD
Patricia A. Hartz: 3/16/2006
*FIELD* ED
mgross: 03/16/2006
*RECORD*
*FIELD* NO
609969
*FIELD* TI
*609969 SUPRABASIN
;;SBSN
*FIELD* TX
CLONING
By subtractive hybridization to identify genes expressed in
read moredifferentiated mouse keratinocytes, Park et al. (2002) cloned Sbsn. The
deduced 700-amino acid protein has a calculated molecular mass of 72 kD.
Sbsn contains an N-terminal transmembrane domain, a central domain with
glycine-, alanine-, and histidine-rich short tandem repeats, and several
phosphorylation and myristoylation sites. An alternatively spliced
transcript encodes a protein lacking the central repetitive region. By
RT-PCR of skin RNA, Park et al. (2002) cloned a partial human SBSN cDNA.
Northern blot analysis of human tissues detected 2.2- and 1.1-kb SBSN
transcripts in skin, esophagus, uterus, thymus, and a keratinocyte cell
line. Northern blot analysis detected 2 Sbsn transcripts at embryonic
day 15.5 in mice, coinciding with epidermal stratification. In situ
hybridization of embryonic and adult mice showed Sbsn expression in the
suprabasal layers of the epithelia in tongue, stomach, and epidermis.
Northern and RNA dot blot analyses of adult mouse tissues revealed
expression in uterus and thyroid, but not in heart, brain, spleen, lung,
liver, smooth muscle, and kidney. Fluorescence-tagged Sbsn showed a
punctate cytoplasmic distribution in transfected mouse keratinocytes
that did not overlap with lysosomal or mitochondrial markers.
GENE FUNCTION
Park et al. (2002) found that expression of Sbsn in primary mouse
epidermal keratinocytes was induced by calcium and phorbol esters and
inhibited by a PKC (see PRKCA; 176960) inhibitor. Monomeric recombinant
Sbsn was cross-linked into a high molecular mass form by the
transglutaminases Tgm2 (190196) and Tgm3 (600238). Park et al. (2002)
concluded that SBSN may have a role in epidermal differentiation.
GENE STRUCTURE
Park et al. (2002) determined that the mouse Sbsn gene contains 4 exons.
MAPPING
By genomic sequence analysis, Park et al. (2002) mapped the SBSN gene to
chromosome 19q13.1. They mapped the mouse Sbsn gene to a region of
chromosome 7B2-B3 that shares homology of synteny with human chromosome
19q13.1.
*FIELD* RF
1. Park, G. T.; Lim, S. E.; Jang, S.-I.; Morasso, M. I.: Suprabasin,
a novel epidermal differentiation marker and potential cornified envelope
precursor. J. Biol. Chem. 277: 45195-45202, 2002.
*FIELD* CD
Patricia A. Hartz: 3/16/2006
*FIELD* ED
mgross: 03/16/2006