Full text data of SCFD2
SCFD2
(STXBP1L1)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Sec1 family domain-containing protein 2 (Syntaxin-binding protein 1-like 1)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Sec1 family domain-containing protein 2 (Syntaxin-binding protein 1-like 1)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8WU76
ID SCFD2_HUMAN Reviewed; 684 AA.
AC Q8WU76; Q8N5F3; Q8N8H0; Q96ED3;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2004, sequence version 2.
DT 22-JAN-2014, entry version 87.
DE RecName: Full=Sec1 family domain-containing protein 2;
DE AltName: Full=Syntaxin-binding protein 1-like 1;
GN Name=SCFD2; Synonyms=STXBP1L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Fetal brain;
RA Weber A., Glaum A., Klinkhammer B., Bergmann E., Berwanger B.,
RA Eilers M., Christiansen H.;
RT "Expression of a syntaxin binding protein 1-like gene in human
RT neuroblastoma.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Endothelial cell;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, Colon, Lung, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May be involved in protein transport.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WU76-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WU76-2; Sequence=VSP_010710;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
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DR EMBL; AY299407; AAP57259.1; -; mRNA.
DR EMBL; AK096833; BAC04872.1; -; mRNA.
DR EMBL; BC012458; AAH12458.1; -; mRNA.
DR EMBL; BC021137; AAH21137.2; -; mRNA.
DR EMBL; BC032453; AAH32453.1; -; mRNA.
DR RefSeq; NP_689753.2; NM_152540.3.
DR RefSeq; XP_005265786.1; XM_005265729.1.
DR UniGene; Hs.302287; -.
DR ProteinModelPortal; Q8WU76; -.
DR IntAct; Q8WU76; 1.
DR PhosphoSite; Q8WU76; -.
DR DMDM; 51338675; -.
DR PaxDb; Q8WU76; -.
DR PRIDE; Q8WU76; -.
DR DNASU; 152579; -.
DR Ensembl; ENST00000388940; ENSP00000373592; ENSG00000184178.
DR Ensembl; ENST00000401642; ENSP00000384182; ENSG00000184178.
DR GeneID; 152579; -.
DR KEGG; hsa:152579; -.
DR UCSC; uc003gzu.3; human.
DR CTD; 152579; -.
DR GeneCards; GC04M053739; -.
DR HGNC; HGNC:30676; SCFD2.
DR HPA; HPA036526; -.
DR neXtProt; NX_Q8WU76; -.
DR PharmGKB; PA134953686; -.
DR eggNOG; NOG75473; -.
DR HOGENOM; HOG000234008; -.
DR HOVERGEN; HBG055096; -.
DR InParanoid; Q8WU76; -.
DR OMA; LQKITGC; -.
DR OrthoDB; EOG7WX07R; -.
DR GenomeRNAi; 152579; -.
DR NextBio; 86992; -.
DR PRO; PR:Q8WU76; -.
DR ArrayExpress; Q8WU76; -.
DR Bgee; Q8WU76; -.
DR CleanEx; HS_SCFD2; -.
DR Genevestigator; Q8WU76; -.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
DR Gene3D; 3.40.50.1910; -; 2.
DR InterPro; IPR027482; Sec-1-like_dom2.
DR InterPro; IPR001619; Sec1-like.
DR PANTHER; PTHR11679; PTHR11679; 1.
DR Pfam; PF00995; Sec1; 1.
DR SUPFAM; SSF56815; SSF56815; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Polymorphism;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1 684 Sec1 family domain-containing protein 2.
FT /FTId=PRO_0000206290.
FT COMPBIAS 120 124 Poly-Ala.
FT VAR_SEQ 570 614 Missing (in isoform 2).
FT /FTId=VSP_010710.
FT VARIANT 512 512 L -> S (in dbSNP:rs7675987).
FT /FTId=VAR_024687.
SQ SEQUENCE 684 AA; 75127 MW; 8CD37FAF22801CB8 CRC64;
MSASGVLSFT QQGWEQVLAK VKRAVVYLDA ACAESLHWGC GSTRLLEAVG GPDCHLREFE
PDAIGGGAKQ PKAVFVLSCL LKGRTVEILR DIICRSHFQY CVVVTTVSHA VHLTANHVPA
AAAAEMEGQQ PVFEQLEEKL CEWMGNMNYT AEVFHVPLLL APVAPHFALT PAFASLFPLL
PQDVHLLNSA RPDKRKLGSL GDVDSTTLTP ELLLQIRCLV SGLSSLCEHL GVREECFAVG
SLSQVIAADL ANYAPAKNRK KTAAGRASVV FVDRTLDLTG AVGHHGDNLV EKIISALPQL
PGHTNDVMVN MIALTALHTE EENYNVVAPG CLSQSSDTTA KALWEALLNT KHKEAVMEVR
RHLVEAASRE NLPIKMSMGR VTPGQLMSYI QLFKNNLKAL MNHCGLLQLG LATAQTLKHP
QTAKWDNFLA FERLLLQSIG ESAMSVVLNQ LLPMIKPVTQ RTNEDYSPEE LLILLIYIYS
VTGELTVDKD LCEAEEKVKK ALAQVFCEES GLSPLLQKIT DWDSSINLTF HKSKIAVDEL
FTSLRDIAGA RSLLKQFKSV YVPGNHTHQA SYKPLLKQVV EEIFHPERPD SVDIEHMSSG
LTDLLKTGFS MFMKVSRPHP SDYPLLILFV VGGVTVSEVK MVKDLVASLK PGTQVIVLST
RLLKPLNIPE LLFATDRLHP DLGF
//
ID SCFD2_HUMAN Reviewed; 684 AA.
AC Q8WU76; Q8N5F3; Q8N8H0; Q96ED3;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2004, sequence version 2.
DT 22-JAN-2014, entry version 87.
DE RecName: Full=Sec1 family domain-containing protein 2;
DE AltName: Full=Syntaxin-binding protein 1-like 1;
GN Name=SCFD2; Synonyms=STXBP1L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Fetal brain;
RA Weber A., Glaum A., Klinkhammer B., Bergmann E., Berwanger B.,
RA Eilers M., Christiansen H.;
RT "Expression of a syntaxin binding protein 1-like gene in human
RT neuroblastoma.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Endothelial cell;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, Colon, Lung, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May be involved in protein transport.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8WU76-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WU76-2; Sequence=VSP_010710;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY299407; AAP57259.1; -; mRNA.
DR EMBL; AK096833; BAC04872.1; -; mRNA.
DR EMBL; BC012458; AAH12458.1; -; mRNA.
DR EMBL; BC021137; AAH21137.2; -; mRNA.
DR EMBL; BC032453; AAH32453.1; -; mRNA.
DR RefSeq; NP_689753.2; NM_152540.3.
DR RefSeq; XP_005265786.1; XM_005265729.1.
DR UniGene; Hs.302287; -.
DR ProteinModelPortal; Q8WU76; -.
DR IntAct; Q8WU76; 1.
DR PhosphoSite; Q8WU76; -.
DR DMDM; 51338675; -.
DR PaxDb; Q8WU76; -.
DR PRIDE; Q8WU76; -.
DR DNASU; 152579; -.
DR Ensembl; ENST00000388940; ENSP00000373592; ENSG00000184178.
DR Ensembl; ENST00000401642; ENSP00000384182; ENSG00000184178.
DR GeneID; 152579; -.
DR KEGG; hsa:152579; -.
DR UCSC; uc003gzu.3; human.
DR CTD; 152579; -.
DR GeneCards; GC04M053739; -.
DR HGNC; HGNC:30676; SCFD2.
DR HPA; HPA036526; -.
DR neXtProt; NX_Q8WU76; -.
DR PharmGKB; PA134953686; -.
DR eggNOG; NOG75473; -.
DR HOGENOM; HOG000234008; -.
DR HOVERGEN; HBG055096; -.
DR InParanoid; Q8WU76; -.
DR OMA; LQKITGC; -.
DR OrthoDB; EOG7WX07R; -.
DR GenomeRNAi; 152579; -.
DR NextBio; 86992; -.
DR PRO; PR:Q8WU76; -.
DR ArrayExpress; Q8WU76; -.
DR Bgee; Q8WU76; -.
DR CleanEx; HS_SCFD2; -.
DR Genevestigator; Q8WU76; -.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
DR Gene3D; 3.40.50.1910; -; 2.
DR InterPro; IPR027482; Sec-1-like_dom2.
DR InterPro; IPR001619; Sec1-like.
DR PANTHER; PTHR11679; PTHR11679; 1.
DR Pfam; PF00995; Sec1; 1.
DR SUPFAM; SSF56815; SSF56815; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Polymorphism;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1 684 Sec1 family domain-containing protein 2.
FT /FTId=PRO_0000206290.
FT COMPBIAS 120 124 Poly-Ala.
FT VAR_SEQ 570 614 Missing (in isoform 2).
FT /FTId=VSP_010710.
FT VARIANT 512 512 L -> S (in dbSNP:rs7675987).
FT /FTId=VAR_024687.
SQ SEQUENCE 684 AA; 75127 MW; 8CD37FAF22801CB8 CRC64;
MSASGVLSFT QQGWEQVLAK VKRAVVYLDA ACAESLHWGC GSTRLLEAVG GPDCHLREFE
PDAIGGGAKQ PKAVFVLSCL LKGRTVEILR DIICRSHFQY CVVVTTVSHA VHLTANHVPA
AAAAEMEGQQ PVFEQLEEKL CEWMGNMNYT AEVFHVPLLL APVAPHFALT PAFASLFPLL
PQDVHLLNSA RPDKRKLGSL GDVDSTTLTP ELLLQIRCLV SGLSSLCEHL GVREECFAVG
SLSQVIAADL ANYAPAKNRK KTAAGRASVV FVDRTLDLTG AVGHHGDNLV EKIISALPQL
PGHTNDVMVN MIALTALHTE EENYNVVAPG CLSQSSDTTA KALWEALLNT KHKEAVMEVR
RHLVEAASRE NLPIKMSMGR VTPGQLMSYI QLFKNNLKAL MNHCGLLQLG LATAQTLKHP
QTAKWDNFLA FERLLLQSIG ESAMSVVLNQ LLPMIKPVTQ RTNEDYSPEE LLILLIYIYS
VTGELTVDKD LCEAEEKVKK ALAQVFCEES GLSPLLQKIT DWDSSINLTF HKSKIAVDEL
FTSLRDIAGA RSLLKQFKSV YVPGNHTHQA SYKPLLKQVV EEIFHPERPD SVDIEHMSSG
LTDLLKTGFS MFMKVSRPHP SDYPLLILFV VGGVTVSEVK MVKDLVASLK PGTQVIVLST
RLLKPLNIPE LLFATDRLHP DLGF
//