Full text data of SCRN2
SCRN2
[Confidence: low (only semi-automatic identification from reviews)]
Secernin-2
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Secernin-2
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q96FV2
ID SCRN2_HUMAN Reviewed; 425 AA.
AC Q96FV2; A8K3N1; B7Z8S7; E9PBV5; Q96AC3; Q9BU04;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 11-JAN-2011, sequence version 3.
DT 22-JAN-2014, entry version 85.
DE RecName: Full=Secernin-2;
GN Name=SCRN2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP VAL-323.
RC TISSUE=Embryo, and Ovary;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-323.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND
RP VARIANTS ARG-103; VAL-323 AND GLY-411.
RC TISSUE=Lung, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96FV2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96FV2-2; Sequence=VSP_044566;
CC -!- SIMILARITY: Belongs to the peptidase C69 family. Secernin
CC subfamily.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH10408.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK290646; BAF83335.1; -; mRNA.
DR EMBL; AK303835; BAH14063.1; -; mRNA.
DR EMBL; AC003665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471109; EAW94791.1; -; Genomic_DNA.
DR EMBL; CH471109; EAW94792.1; -; Genomic_DNA.
DR EMBL; BC002980; AAH02980.1; -; mRNA.
DR EMBL; BC010408; AAH10408.2; ALT_INIT; mRNA.
DR EMBL; BC017317; AAH17317.1; -; mRNA.
DR RefSeq; NP_001138495.1; NM_001145023.1.
DR RefSeq; NP_612364.2; NM_138355.3.
DR RefSeq; XP_005257833.1; XM_005257776.1.
DR UniGene; Hs.239718; -.
DR ProteinModelPortal; Q96FV2; -.
DR MINT; MINT-5001860; -.
DR MEROPS; C69.004; -.
DR PhosphoSite; Q96FV2; -.
DR DMDM; 74731756; -.
DR REPRODUCTION-2DPAGE; IPI00062266; -.
DR PaxDb; Q96FV2; -.
DR PRIDE; Q96FV2; -.
DR DNASU; 90507; -.
DR Ensembl; ENST00000290216; ENSP00000290216; ENSG00000141295.
DR Ensembl; ENST00000407215; ENSP00000383935; ENSG00000141295.
DR GeneID; 90507; -.
DR KEGG; hsa:90507; -.
DR UCSC; uc002imf.3; human.
DR CTD; 90507; -.
DR GeneCards; GC17M045915; -.
DR HGNC; HGNC:30381; SCRN2.
DR HPA; HPA022934; -.
DR HPA; HPA023434; -.
DR MIM; 614966; gene.
DR neXtProt; NX_Q96FV2; -.
DR PharmGKB; PA134964266; -.
DR eggNOG; COG4690; -.
DR HOGENOM; HOG000223307; -.
DR HOVERGEN; HBG056050; -.
DR InParanoid; Q96FV2; -.
DR KO; K14358; -.
DR OrthoDB; EOG7W1545; -.
DR PhylomeDB; Q96FV2; -.
DR GenomeRNAi; 90507; -.
DR NextBio; 35480558; -.
DR PRO; PR:Q96FV2; -.
DR ArrayExpress; Q96FV2; -.
DR Bgee; Q96FV2; -.
DR CleanEx; HS_SCRN2; -.
DR Genevestigator; Q96FV2; -.
DR GO; GO:0016805; F:dipeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR InterPro; IPR005322; Peptidase_C69.
DR Pfam; PF03577; Peptidase_C69; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Polymorphism;
KW Reference proteome.
FT CHAIN 1 425 Secernin-2.
FT /FTId=PRO_0000262552.
FT ACT_SITE 12 12 Potential.
FT VAR_SEQ 374 425 DRGQQLQQKQQDLEQEGLEATQGLLAGEWAPPLWELGSLFQ
FT AFVKRESQAYA -> VSPRE (in isoform 2).
FT /FTId=VSP_044566.
FT VARIANT 103 103 K -> R (in dbSNP:rs17856536).
FT /FTId=VAR_029509.
FT VARIANT 273 273 E -> Q (in dbSNP:rs35901087).
FT /FTId=VAR_035263.
FT VARIANT 323 323 M -> V (in dbSNP:rs7350974).
FT /FTId=VAR_029510.
FT VARIANT 330 330 Q -> R (in dbSNP:rs34480825).
FT /FTId=VAR_035264.
FT VARIANT 411 411 S -> G (in dbSNP:rs17856535).
FT /FTId=VAR_029511.
SQ SEQUENCE 425 AA; 46597 MW; AA7A0290D920B359 CRC64;
MASSSPDSPC SCDCFVSVPP ASAIPAVIFA KNSDRPRDEV QEVVFVPAGT HTPGSRLQCT
YIEVEQVSKT HAVILSRPSW LWGAEMGANE HGVCIGNEAV WTKEPVGEGE ALLGMDLLRL
ALERSSSAQE ALHVITGLLE HYGQGGNCLE DAAPFSYHST FLLADRTEAW VLETAGRLWA
AQRIQEGARN ISNQLSIGTD ISAQHPELRT HAQAKGWWDG QGAFDFAQIF SLTQQPVRME
AAKARFQAGR ELLRQRQGGI TAEVMMGILR DKESGICMDS GGFRTTASMV SVLPQDPTQP
CVHFLTATPD PSRSVFKPFI FGMGVAQAPQ VLSPTFGAQD PVRTLPRFQT QVDRRHTLYR
GHQAALGLME RDQDRGQQLQ QKQQDLEQEG LEATQGLLAG EWAPPLWELG SLFQAFVKRE
SQAYA
//
ID SCRN2_HUMAN Reviewed; 425 AA.
AC Q96FV2; A8K3N1; B7Z8S7; E9PBV5; Q96AC3; Q9BU04;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 11-JAN-2011, sequence version 3.
DT 22-JAN-2014, entry version 85.
DE RecName: Full=Secernin-2;
GN Name=SCRN2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP VAL-323.
RC TISSUE=Embryo, and Ovary;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-323.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND
RP VARIANTS ARG-103; VAL-323 AND GLY-411.
RC TISSUE=Lung, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96FV2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96FV2-2; Sequence=VSP_044566;
CC -!- SIMILARITY: Belongs to the peptidase C69 family. Secernin
CC subfamily.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH10408.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK290646; BAF83335.1; -; mRNA.
DR EMBL; AK303835; BAH14063.1; -; mRNA.
DR EMBL; AC003665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471109; EAW94791.1; -; Genomic_DNA.
DR EMBL; CH471109; EAW94792.1; -; Genomic_DNA.
DR EMBL; BC002980; AAH02980.1; -; mRNA.
DR EMBL; BC010408; AAH10408.2; ALT_INIT; mRNA.
DR EMBL; BC017317; AAH17317.1; -; mRNA.
DR RefSeq; NP_001138495.1; NM_001145023.1.
DR RefSeq; NP_612364.2; NM_138355.3.
DR RefSeq; XP_005257833.1; XM_005257776.1.
DR UniGene; Hs.239718; -.
DR ProteinModelPortal; Q96FV2; -.
DR MINT; MINT-5001860; -.
DR MEROPS; C69.004; -.
DR PhosphoSite; Q96FV2; -.
DR DMDM; 74731756; -.
DR REPRODUCTION-2DPAGE; IPI00062266; -.
DR PaxDb; Q96FV2; -.
DR PRIDE; Q96FV2; -.
DR DNASU; 90507; -.
DR Ensembl; ENST00000290216; ENSP00000290216; ENSG00000141295.
DR Ensembl; ENST00000407215; ENSP00000383935; ENSG00000141295.
DR GeneID; 90507; -.
DR KEGG; hsa:90507; -.
DR UCSC; uc002imf.3; human.
DR CTD; 90507; -.
DR GeneCards; GC17M045915; -.
DR HGNC; HGNC:30381; SCRN2.
DR HPA; HPA022934; -.
DR HPA; HPA023434; -.
DR MIM; 614966; gene.
DR neXtProt; NX_Q96FV2; -.
DR PharmGKB; PA134964266; -.
DR eggNOG; COG4690; -.
DR HOGENOM; HOG000223307; -.
DR HOVERGEN; HBG056050; -.
DR InParanoid; Q96FV2; -.
DR KO; K14358; -.
DR OrthoDB; EOG7W1545; -.
DR PhylomeDB; Q96FV2; -.
DR GenomeRNAi; 90507; -.
DR NextBio; 35480558; -.
DR PRO; PR:Q96FV2; -.
DR ArrayExpress; Q96FV2; -.
DR Bgee; Q96FV2; -.
DR CleanEx; HS_SCRN2; -.
DR Genevestigator; Q96FV2; -.
DR GO; GO:0016805; F:dipeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR InterPro; IPR005322; Peptidase_C69.
DR Pfam; PF03577; Peptidase_C69; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Polymorphism;
KW Reference proteome.
FT CHAIN 1 425 Secernin-2.
FT /FTId=PRO_0000262552.
FT ACT_SITE 12 12 Potential.
FT VAR_SEQ 374 425 DRGQQLQQKQQDLEQEGLEATQGLLAGEWAPPLWELGSLFQ
FT AFVKRESQAYA -> VSPRE (in isoform 2).
FT /FTId=VSP_044566.
FT VARIANT 103 103 K -> R (in dbSNP:rs17856536).
FT /FTId=VAR_029509.
FT VARIANT 273 273 E -> Q (in dbSNP:rs35901087).
FT /FTId=VAR_035263.
FT VARIANT 323 323 M -> V (in dbSNP:rs7350974).
FT /FTId=VAR_029510.
FT VARIANT 330 330 Q -> R (in dbSNP:rs34480825).
FT /FTId=VAR_035264.
FT VARIANT 411 411 S -> G (in dbSNP:rs17856535).
FT /FTId=VAR_029511.
SQ SEQUENCE 425 AA; 46597 MW; AA7A0290D920B359 CRC64;
MASSSPDSPC SCDCFVSVPP ASAIPAVIFA KNSDRPRDEV QEVVFVPAGT HTPGSRLQCT
YIEVEQVSKT HAVILSRPSW LWGAEMGANE HGVCIGNEAV WTKEPVGEGE ALLGMDLLRL
ALERSSSAQE ALHVITGLLE HYGQGGNCLE DAAPFSYHST FLLADRTEAW VLETAGRLWA
AQRIQEGARN ISNQLSIGTD ISAQHPELRT HAQAKGWWDG QGAFDFAQIF SLTQQPVRME
AAKARFQAGR ELLRQRQGGI TAEVMMGILR DKESGICMDS GGFRTTASMV SVLPQDPTQP
CVHFLTATPD PSRSVFKPFI FGMGVAQAPQ VLSPTFGAQD PVRTLPRFQT QVDRRHTLYR
GHQAALGLME RDQDRGQQLQ QKQQDLEQEG LEATQGLLAG EWAPPLWELG SLFQAFVKRE
SQAYA
//
MIM
614966
*RECORD*
*FIELD* NO
614966
*FIELD* TI
*614966 SECERNIN 2; SCRN2
;;SES2
*FIELD* TX
CLONING
By database analysis to identify sequences similar to mouse Scrn1
read more(614965), Way et al. (2002) identified 2 splice variants of human SCRN2.
The deduced SCRN2 proteins contain 425 and 378 amino acids.
MAPPING
By genomic sequence analysis, Way et al. (2002) mapped the SCRN2 gene to
chromosome 17q21.3.
*FIELD* RF
1. Way, G.; Morrice, N.; Smythe, C.; O'Sullivan, A. J.: Purification
and identification of secernin, a novel cytosolic protein that regulates
exocytosis in mast cells. Molec. Biol. Cell 13: 3344-3354, 2002.
*FIELD* CD
Patricia A. Hartz: 12/3/2012
*FIELD* ED
mgross: 12/03/2012
*RECORD*
*FIELD* NO
614966
*FIELD* TI
*614966 SECERNIN 2; SCRN2
;;SES2
*FIELD* TX
CLONING
By database analysis to identify sequences similar to mouse Scrn1
read more(614965), Way et al. (2002) identified 2 splice variants of human SCRN2.
The deduced SCRN2 proteins contain 425 and 378 amino acids.
MAPPING
By genomic sequence analysis, Way et al. (2002) mapped the SCRN2 gene to
chromosome 17q21.3.
*FIELD* RF
1. Way, G.; Morrice, N.; Smythe, C.; O'Sullivan, A. J.: Purification
and identification of secernin, a novel cytosolic protein that regulates
exocytosis in mast cells. Molec. Biol. Cell 13: 3344-3354, 2002.
*FIELD* CD
Patricia A. Hartz: 12/3/2012
*FIELD* ED
mgross: 12/03/2012