Full text data of SFT2D1
SFT2D1
(C6orf83)
[Confidence: low (only semi-automatic identification from reviews)]
Vesicle transport protein SFT2A (SFT2 domain-containing protein 1; pRGR1)
Vesicle transport protein SFT2A (SFT2 domain-containing protein 1; pRGR1)
UniProt
Q8WV19
ID SFT2A_HUMAN Reviewed; 159 AA.
AC Q8WV19; Q5TI64; Q9UIC7;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2002, sequence version 1.
DT 22-JAN-2014, entry version 80.
DE RecName: Full=Vesicle transport protein SFT2A;
DE AltName: Full=SFT2 domain-containing protein 1;
DE AltName: Full=pRGR1;
GN Name=SFT2D1; Synonyms=C6orf83;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hu Y.F., Mao X.H., Zhuang M., Lu C.D.;
RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Choriocarcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May be involved in fusion of retrograde transport
CC vesicles derived from an endocytic compartment with the Golgi
CC complex (By similarity).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- SIMILARITY: Belongs to the SFT2 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF18564.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF041429; AAF18564.1; ALT_INIT; mRNA.
DR EMBL; AL022069; CAI19656.2; -; Genomic_DNA.
DR EMBL; AL121956; CAI19656.2; JOINED; Genomic_DNA.
DR EMBL; AL121956; CAI22197.2; -; Genomic_DNA.
DR EMBL; AL022069; CAI22197.2; JOINED; Genomic_DNA.
DR EMBL; BC018969; AAH18969.1; -; mRNA.
DR RefSeq; NP_660152.1; NM_145169.1.
DR UniGene; Hs.487143; -.
DR ProteinModelPortal; Q8WV19; -.
DR IntAct; Q8WV19; 1.
DR STRING; 9606.ENSP00000354590; -.
DR PhosphoSite; Q8WV19; -.
DR DMDM; 74751535; -.
DR PaxDb; Q8WV19; -.
DR PRIDE; Q8WV19; -.
DR Ensembl; ENST00000361731; ENSP00000354590; ENSG00000198818.
DR GeneID; 113402; -.
DR KEGG; hsa:113402; -.
DR UCSC; uc003qux.3; human.
DR CTD; 113402; -.
DR GeneCards; GC06M166654; -.
DR H-InvDB; HIX0200841; -.
DR HGNC; HGNC:21102; SFT2D1.
DR HPA; HPA014677; -.
DR neXtProt; NX_Q8WV19; -.
DR PharmGKB; PA134962126; -.
DR eggNOG; NOG263508; -.
DR HOGENOM; HOG000017959; -.
DR HOVERGEN; HBG053306; -.
DR InParanoid; Q8WV19; -.
DR OMA; ALWWRKK; -.
DR OrthoDB; EOG71CFP3; -.
DR ChiTaRS; SFT2D1; human.
DR GenomeRNAi; 113402; -.
DR NextBio; 78828; -.
DR PRO; PR:Q8WV19; -.
DR Bgee; Q8WV19; -.
DR CleanEx; HS_SFT2D1; -.
DR Genevestigator; Q8WV19; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR007305; Vesicle_transpt_Got1/SFT2.
DR InterPro; IPR011691; Vesicle_transpt_SFT2.
DR PANTHER; PTHR23137; PTHR23137; 1.
DR Pfam; PF04178; Got1; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; Phosphoprotein; Polymorphism;
KW Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 159 Vesicle transport protein SFT2A.
FT /FTId=PRO_0000238607.
FT TOPO_DOM 1 36 Cytoplasmic (Potential).
FT TRANSMEM 37 57 Helical; Name=1; (Potential).
FT TOPO_DOM 58 62 Lumenal (Potential).
FT TRANSMEM 63 83 Helical; Name=2; (Potential).
FT TOPO_DOM 84 97 Cytoplasmic (Potential).
FT TRANSMEM 98 118 Helical; Name=3; (Potential).
FT TOPO_DOM 119 122 Lumenal (Potential).
FT TRANSMEM 123 143 Helical; Name=4; (Potential).
FT TOPO_DOM 144 159 Cytoplasmic (Potential).
FT MOD_RES 9 9 Phosphoserine (By similarity).
FT VARIANT 109 109 I -> V (in dbSNP:rs11551053).
FT /FTId=VAR_034492.
FT CONFLICT 93 93 F -> C (in Ref. 1; AAF18564).
SQ SEQUENCE 159 AA; 17804 MW; 0EC8A9CED7EF27E0 CRC64;
MEKLRRVLSG QDDEEQGLTA QVLDASSLSF NTRLKWFAIC FVCGVFFSIL GTGLLWLPGG
IKLFAVFYTL GNLAALASTC FLMGPVKQLK KMFEATRLLA TIVMLLCFIF TLCAALWWHK
KGLAVLFCIL QFLSMTWYSL SYIPYARDAV IKCCSSLLS
//
ID SFT2A_HUMAN Reviewed; 159 AA.
AC Q8WV19; Q5TI64; Q9UIC7;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2002, sequence version 1.
DT 22-JAN-2014, entry version 80.
DE RecName: Full=Vesicle transport protein SFT2A;
DE AltName: Full=SFT2 domain-containing protein 1;
DE AltName: Full=pRGR1;
GN Name=SFT2D1; Synonyms=C6orf83;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hu Y.F., Mao X.H., Zhuang M., Lu C.D.;
RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Choriocarcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May be involved in fusion of retrograde transport
CC vesicles derived from an endocytic compartment with the Golgi
CC complex (By similarity).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- SIMILARITY: Belongs to the SFT2 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF18564.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF041429; AAF18564.1; ALT_INIT; mRNA.
DR EMBL; AL022069; CAI19656.2; -; Genomic_DNA.
DR EMBL; AL121956; CAI19656.2; JOINED; Genomic_DNA.
DR EMBL; AL121956; CAI22197.2; -; Genomic_DNA.
DR EMBL; AL022069; CAI22197.2; JOINED; Genomic_DNA.
DR EMBL; BC018969; AAH18969.1; -; mRNA.
DR RefSeq; NP_660152.1; NM_145169.1.
DR UniGene; Hs.487143; -.
DR ProteinModelPortal; Q8WV19; -.
DR IntAct; Q8WV19; 1.
DR STRING; 9606.ENSP00000354590; -.
DR PhosphoSite; Q8WV19; -.
DR DMDM; 74751535; -.
DR PaxDb; Q8WV19; -.
DR PRIDE; Q8WV19; -.
DR Ensembl; ENST00000361731; ENSP00000354590; ENSG00000198818.
DR GeneID; 113402; -.
DR KEGG; hsa:113402; -.
DR UCSC; uc003qux.3; human.
DR CTD; 113402; -.
DR GeneCards; GC06M166654; -.
DR H-InvDB; HIX0200841; -.
DR HGNC; HGNC:21102; SFT2D1.
DR HPA; HPA014677; -.
DR neXtProt; NX_Q8WV19; -.
DR PharmGKB; PA134962126; -.
DR eggNOG; NOG263508; -.
DR HOGENOM; HOG000017959; -.
DR HOVERGEN; HBG053306; -.
DR InParanoid; Q8WV19; -.
DR OMA; ALWWRKK; -.
DR OrthoDB; EOG71CFP3; -.
DR ChiTaRS; SFT2D1; human.
DR GenomeRNAi; 113402; -.
DR NextBio; 78828; -.
DR PRO; PR:Q8WV19; -.
DR Bgee; Q8WV19; -.
DR CleanEx; HS_SFT2D1; -.
DR Genevestigator; Q8WV19; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR007305; Vesicle_transpt_Got1/SFT2.
DR InterPro; IPR011691; Vesicle_transpt_SFT2.
DR PANTHER; PTHR23137; PTHR23137; 1.
DR Pfam; PF04178; Got1; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; Phosphoprotein; Polymorphism;
KW Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 159 Vesicle transport protein SFT2A.
FT /FTId=PRO_0000238607.
FT TOPO_DOM 1 36 Cytoplasmic (Potential).
FT TRANSMEM 37 57 Helical; Name=1; (Potential).
FT TOPO_DOM 58 62 Lumenal (Potential).
FT TRANSMEM 63 83 Helical; Name=2; (Potential).
FT TOPO_DOM 84 97 Cytoplasmic (Potential).
FT TRANSMEM 98 118 Helical; Name=3; (Potential).
FT TOPO_DOM 119 122 Lumenal (Potential).
FT TRANSMEM 123 143 Helical; Name=4; (Potential).
FT TOPO_DOM 144 159 Cytoplasmic (Potential).
FT MOD_RES 9 9 Phosphoserine (By similarity).
FT VARIANT 109 109 I -> V (in dbSNP:rs11551053).
FT /FTId=VAR_034492.
FT CONFLICT 93 93 F -> C (in Ref. 1; AAF18564).
SQ SEQUENCE 159 AA; 17804 MW; 0EC8A9CED7EF27E0 CRC64;
MEKLRRVLSG QDDEEQGLTA QVLDASSLSF NTRLKWFAIC FVCGVFFSIL GTGLLWLPGG
IKLFAVFYTL GNLAALASTC FLMGPVKQLK KMFEATRLLA TIVMLLCFIF TLCAALWWHK
KGLAVLFCIL QFLSMTWYSL SYIPYARDAV IKCCSSLLS
//