Full text data of SFXN1
SFXN1
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Sideroflexin-1 (Tricarboxylate carrier protein; TCC)
Sideroflexin-1 (Tricarboxylate carrier protein; TCC)
UniProt
Q9H9B4
ID SFXN1_HUMAN Reviewed; 322 AA.
AC Q9H9B4; B3KPW3; D3DQN2; Q9HA53;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 4.
DT 22-JAN-2014, entry version 110.
DE RecName: Full=Sideroflexin-1;
DE AltName: Full=Tricarboxylate carrier protein;
DE Short=TCC;
GN Name=SFXN1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Li N., Chen T., Wan T., Zhang W., Cao X.;
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland, Prostate, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 2-12; 16-48; 56-70; 73-86; 137-170; 203-214;
RP 224-233 AND 291-314, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT
RP SER-2, AND MASS SPECTROMETRY.
RC TISSUE=B-cell lymphoma;
RA Bienvenut W.V.;
RL Submitted (JUN-2005) to UniProtKB.
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASS SPECTROMETRY.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASS SPECTROMETRY.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Might be involved in the transport of a component
CC required for iron utilization into or out of the mitochondria.
CC -!- INTERACTION:
CC O00264:PGRMC1; NbExp=1; IntAct=EBI-355861, EBI-1045534;
CC Q15714:TSC22D1; NbExp=1; IntAct=EBI-355861, EBI-712609;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane
CC protein (By similarity).
CC -!- SIMILARITY: Belongs to the sideroflexin family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH20517.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=BAB14003.1; Type=Miscellaneous discrepancy; Note=Cloning artifact;
CC Sequence=BAB14318.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF327346; AAL56007.1; -; mRNA.
DR EMBL; AK022287; BAB14003.1; ALT_SEQ; mRNA.
DR EMBL; AK022938; BAB14318.1; ALT_INIT; mRNA.
DR EMBL; AK056915; BAG51825.1; -; mRNA.
DR EMBL; BX648188; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC091393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471062; EAW61370.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW61372.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW61374.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW61375.1; -; Genomic_DNA.
DR EMBL; BC020517; AAH20517.1; ALT_INIT; mRNA.
DR EMBL; BC063241; AAH63241.1; -; mRNA.
DR RefSeq; NP_073591.2; NM_022754.5.
DR UniGene; Hs.369440; -.
DR ProteinModelPortal; Q9H9B4; -.
DR IntAct; Q9H9B4; 6.
DR MINT; MINT-1151298; -.
DR STRING; 9606.ENSP00000316905; -.
DR PhosphoSite; Q9H9B4; -.
DR DMDM; 20140250; -.
DR PaxDb; Q9H9B4; -.
DR PeptideAtlas; Q9H9B4; -.
DR PRIDE; Q9H9B4; -.
DR DNASU; 94081; -.
DR Ensembl; ENST00000321442; ENSP00000316905; ENSG00000164466.
DR GeneID; 94081; -.
DR KEGG; hsa:94081; -.
DR UCSC; uc003mda.2; human.
DR CTD; 94081; -.
DR GeneCards; GC05P174838; -.
DR HGNC; HGNC:16085; SFXN1.
DR HPA; HPA019543; -.
DR neXtProt; NX_Q9H9B4; -.
DR PharmGKB; PA38090; -.
DR eggNOG; NOG283056; -.
DR HOGENOM; HOG000203440; -.
DR HOVERGEN; HBG056083; -.
DR InParanoid; Q9H9B4; -.
DR OMA; CMMTFYK; -.
DR PhylomeDB; Q9H9B4; -.
DR ChiTaRS; SFXN1; human.
DR GeneWiki; SFXN1; -.
DR GenomeRNAi; 94081; -.
DR NextBio; 78363; -.
DR PRO; PR:Q9H9B4; -.
DR ArrayExpress; Q9H9B4; -.
DR Bgee; Q9H9B4; -.
DR CleanEx; HS_SFXN1; -.
DR Genevestigator; Q9H9B4; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0006826; P:iron ion transport; IEA:Ensembl.
DR InterPro; IPR004686; Mtc.
DR PANTHER; PTHR11153; PTHR11153; 1.
DR Pfam; PF03820; Mtc; 1.
DR TIGRFAMs; TIGR00798; mtc; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Direct protein sequencing;
KW Ion transport; Iron; Iron transport; Membrane; Mitochondrion;
KW Polymorphism; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 322 Sideroflexin-1.
FT /FTId=PRO_0000177032.
FT TRANSMEM 103 120 Helical; (Potential).
FT TRANSMEM 147 167 Helical; (Potential).
FT TRANSMEM 175 195 Helical; (Potential).
FT TRANSMEM 229 249 Helical; (Potential).
FT TRANSMEM 267 287 Helical; (Potential).
FT MOD_RES 2 2 N-acetylserine.
FT VARIANT 26 26 N -> S (in dbSNP:rs17065105).
FT /FTId=VAR_051966.
FT VARIANT 266 266 P -> S (in dbSNP:rs34907038).
FT /FTId=VAR_051967.
FT CONFLICT 73 73 Y -> K (in Ref. 2; BAB14318).
SQ SEQUENCE 322 AA; 35619 MW; 47E03172F27990DB CRC64;
MSGELPPNIN IKEPRWDQST FIGRANHFFT VTDPRNILLT NEQLESARKI VHDYRQGIVP
PGLTENELWR AKYIYDSAFH PDTGEKMILI GRMSAQVPMN MTITGCMMTF YRTTPAVLFW
QWINQSFNAV VNYTNRSGDA PLTVNELGTA YVSATTGAVA TALGLNALTK HVSPLIGRFV
PFAAVAAANC INIPLMRQRE LKVGIPVTDE NGNRLGESAN AAKQAITQVV VSRILMAAPG
MAIPPFIMNT LEKKAFLKRF PWMSAPIQVG LVGFCLVFAT PLCCALFPQK SSMSVTSLEA
ELQAKIQESH PELRRVYFNK GL
//
ID SFXN1_HUMAN Reviewed; 322 AA.
AC Q9H9B4; B3KPW3; D3DQN2; Q9HA53;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 4.
DT 22-JAN-2014, entry version 110.
DE RecName: Full=Sideroflexin-1;
DE AltName: Full=Tricarboxylate carrier protein;
DE Short=TCC;
GN Name=SFXN1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Li N., Chen T., Wan T., Zhang W., Cao X.;
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland, Prostate, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung, and PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 2-12; 16-48; 56-70; 73-86; 137-170; 203-214;
RP 224-233 AND 291-314, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT
RP SER-2, AND MASS SPECTROMETRY.
RC TISSUE=B-cell lymphoma;
RA Bienvenut W.V.;
RL Submitted (JUN-2005) to UniProtKB.
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASS SPECTROMETRY.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASS SPECTROMETRY.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Might be involved in the transport of a component
CC required for iron utilization into or out of the mitochondria.
CC -!- INTERACTION:
CC O00264:PGRMC1; NbExp=1; IntAct=EBI-355861, EBI-1045534;
CC Q15714:TSC22D1; NbExp=1; IntAct=EBI-355861, EBI-712609;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane
CC protein (By similarity).
CC -!- SIMILARITY: Belongs to the sideroflexin family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH20517.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=BAB14003.1; Type=Miscellaneous discrepancy; Note=Cloning artifact;
CC Sequence=BAB14318.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF327346; AAL56007.1; -; mRNA.
DR EMBL; AK022287; BAB14003.1; ALT_SEQ; mRNA.
DR EMBL; AK022938; BAB14318.1; ALT_INIT; mRNA.
DR EMBL; AK056915; BAG51825.1; -; mRNA.
DR EMBL; BX648188; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC091393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471062; EAW61370.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW61372.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW61374.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW61375.1; -; Genomic_DNA.
DR EMBL; BC020517; AAH20517.1; ALT_INIT; mRNA.
DR EMBL; BC063241; AAH63241.1; -; mRNA.
DR RefSeq; NP_073591.2; NM_022754.5.
DR UniGene; Hs.369440; -.
DR ProteinModelPortal; Q9H9B4; -.
DR IntAct; Q9H9B4; 6.
DR MINT; MINT-1151298; -.
DR STRING; 9606.ENSP00000316905; -.
DR PhosphoSite; Q9H9B4; -.
DR DMDM; 20140250; -.
DR PaxDb; Q9H9B4; -.
DR PeptideAtlas; Q9H9B4; -.
DR PRIDE; Q9H9B4; -.
DR DNASU; 94081; -.
DR Ensembl; ENST00000321442; ENSP00000316905; ENSG00000164466.
DR GeneID; 94081; -.
DR KEGG; hsa:94081; -.
DR UCSC; uc003mda.2; human.
DR CTD; 94081; -.
DR GeneCards; GC05P174838; -.
DR HGNC; HGNC:16085; SFXN1.
DR HPA; HPA019543; -.
DR neXtProt; NX_Q9H9B4; -.
DR PharmGKB; PA38090; -.
DR eggNOG; NOG283056; -.
DR HOGENOM; HOG000203440; -.
DR HOVERGEN; HBG056083; -.
DR InParanoid; Q9H9B4; -.
DR OMA; CMMTFYK; -.
DR PhylomeDB; Q9H9B4; -.
DR ChiTaRS; SFXN1; human.
DR GeneWiki; SFXN1; -.
DR GenomeRNAi; 94081; -.
DR NextBio; 78363; -.
DR PRO; PR:Q9H9B4; -.
DR ArrayExpress; Q9H9B4; -.
DR Bgee; Q9H9B4; -.
DR CleanEx; HS_SFXN1; -.
DR Genevestigator; Q9H9B4; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0006826; P:iron ion transport; IEA:Ensembl.
DR InterPro; IPR004686; Mtc.
DR PANTHER; PTHR11153; PTHR11153; 1.
DR Pfam; PF03820; Mtc; 1.
DR TIGRFAMs; TIGR00798; mtc; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Direct protein sequencing;
KW Ion transport; Iron; Iron transport; Membrane; Mitochondrion;
KW Polymorphism; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 322 Sideroflexin-1.
FT /FTId=PRO_0000177032.
FT TRANSMEM 103 120 Helical; (Potential).
FT TRANSMEM 147 167 Helical; (Potential).
FT TRANSMEM 175 195 Helical; (Potential).
FT TRANSMEM 229 249 Helical; (Potential).
FT TRANSMEM 267 287 Helical; (Potential).
FT MOD_RES 2 2 N-acetylserine.
FT VARIANT 26 26 N -> S (in dbSNP:rs17065105).
FT /FTId=VAR_051966.
FT VARIANT 266 266 P -> S (in dbSNP:rs34907038).
FT /FTId=VAR_051967.
FT CONFLICT 73 73 Y -> K (in Ref. 2; BAB14318).
SQ SEQUENCE 322 AA; 35619 MW; 47E03172F27990DB CRC64;
MSGELPPNIN IKEPRWDQST FIGRANHFFT VTDPRNILLT NEQLESARKI VHDYRQGIVP
PGLTENELWR AKYIYDSAFH PDTGEKMILI GRMSAQVPMN MTITGCMMTF YRTTPAVLFW
QWINQSFNAV VNYTNRSGDA PLTVNELGTA YVSATTGAVA TALGLNALTK HVSPLIGRFV
PFAAVAAANC INIPLMRQRE LKVGIPVTDE NGNRLGESAN AAKQAITQVV VSRILMAAPG
MAIPPFIMNT LEKKAFLKRF PWMSAPIQVG LVGFCLVFAT PLCCALFPQK SSMSVTSLEA
ELQAKIQESH PELRRVYFNK GL
//