Full text data of SH3BGRL2
SH3BGRL2
(FASH3)
[Confidence: high (present in two of the MS resources)]
SH3 domain-binding glutamic acid-rich-like protein 2 (Fovea-associated SH3 domain-binding protein)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
SH3 domain-binding glutamic acid-rich-like protein 2 (Fovea-associated SH3 domain-binding protein)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00006812
IPI00006812 SH3 domain-binding glutamic acid-rich-like protein 3 SH3 domain-binding glutamic acid-rich-like protein 3 membrane n/a n/a n/a n/a n/a n/a n/a n/a 4 n/a n/a n/a n/a n/a n/a n/a n/a 1 1 n/a nuclear n/a found at its expected molecular weight found at molecular weight
IPI00006812 SH3 domain-binding glutamic acid-rich-like protein 3 SH3 domain-binding glutamic acid-rich-like protein 3 membrane n/a n/a n/a n/a n/a n/a n/a n/a 4 n/a n/a n/a n/a n/a n/a n/a n/a 1 1 n/a nuclear n/a found at its expected molecular weight found at molecular weight
UniProt
Q9UJC5
ID SH3L2_HUMAN Reviewed; 107 AA.
AC Q9UJC5; A8MQU2; Q2VPC2; Q5VV96; Q6NSK8; Q6P9E8; Q7Z734; Q8IWD3;
read moreAC Q9BPY5;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-2002, sequence version 2.
DT 22-JAN-2014, entry version 104.
DE RecName: Full=SH3 domain-binding glutamic acid-rich-like protein 2;
DE AltName: Full=Fovea-associated SH3 domain-binding protein;
GN Name=SH3BGRL2; Synonyms=FASH3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=12095696; DOI=10.1016/S0378-1119(02)00602-9;
RA Mazzocco M., Maffei M., Egeo A., Vergano A., Arrigo P., Di Lisi R.,
RA Ghiotto F., Scartezzini P.;
RT "The identification of a novel human homologue of the SH3 binding
RT glutamic acid-rich (SH3BGR) gene establishes a new family of highly
RT conserved small proteins related to Thioredoxin Superfamily.";
RL Gene 291:233-239(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Bowes Rickman C., Yarovinsky T.O., McKay B.S., Stone E.M., Ritter R.,
RA Rickman D.W., Edwards A.O.;
RT "Characterization of a novel candidate gene, FASH3, expressed in the
RT primate fovea and linked to the disease gene, ELOVL4, associated with
RT Stargardt-like dominant progressive macular dystrophy.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Eye, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP STRUCTURE BY NMR OF 1-98.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the SH3 domain-binding glutamic acid-rich-like
RT protein 2.";
RL Submitted (NOV-2005) to the PDB data bank.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain, placenta, liver and
CC kidney. Expressed in retina.
CC -!- SIMILARITY: Belongs to the SH3BGR family.
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DR EMBL; AJ297972; CAC35771.1; -; mRNA.
DR EMBL; AF340151; AAK37526.1; -; mRNA.
DR EMBL; AK311757; BAG34700.1; -; mRNA.
DR EMBL; AL035700; CAB55867.2; -; Genomic_DNA.
DR EMBL; AL451064; CAB55867.2; JOINED; Genomic_DNA.
DR EMBL; AL451064; CAH70932.1; -; Genomic_DNA.
DR EMBL; AL035700; CAH70932.1; JOINED; Genomic_DNA.
DR EMBL; CH471051; EAW48703.1; -; Genomic_DNA.
DR EMBL; BC040489; AAH40489.2; -; mRNA.
DR EMBL; BC052987; AAH52987.2; -; mRNA.
DR EMBL; BC060799; AAH60799.2; -; mRNA.
DR EMBL; BC070059; AAH70059.2; -; mRNA.
DR EMBL; BC109043; AAI09044.2; -; mRNA.
DR EMBL; BC109044; AAI09045.2; -; mRNA.
DR RefSeq; NP_113657.1; NM_031469.2.
DR UniGene; Hs.302772; -.
DR PDB; 2CT6; NMR; -; A=1-98.
DR PDBsum; 2CT6; -.
DR ProteinModelPortal; Q9UJC5; -.
DR SMR; Q9UJC5; 1-98.
DR IntAct; Q9UJC5; 2.
DR PhosphoSite; Q9UJC5; -.
DR DMDM; 24638476; -.
DR UCD-2DPAGE; Q9UJC5; -.
DR PaxDb; Q9UJC5; -.
DR PeptideAtlas; Q9UJC5; -.
DR PRIDE; Q9UJC5; -.
DR Ensembl; ENST00000369838; ENSP00000358853; ENSG00000198478.
DR GeneID; 83699; -.
DR KEGG; hsa:83699; -.
DR UCSC; uc003piz.1; human.
DR CTD; 83699; -.
DR GeneCards; GC06P080397; -.
DR HGNC; HGNC:15567; SH3BGRL2.
DR HPA; HPA047486; -.
DR neXtProt; NX_Q9UJC5; -.
DR PharmGKB; PA37978; -.
DR eggNOG; NOG327011; -.
DR HOVERGEN; HBG054781; -.
DR InParanoid; Q9UJC5; -.
DR OMA; VDITMLE; -.
DR OrthoDB; EOG7GTT63; -.
DR PhylomeDB; Q9UJC5; -.
DR EvolutionaryTrace; Q9UJC5; -.
DR GenomeRNAi; 83699; -.
DR NextBio; 72684; -.
DR PRO; PR:Q9UJC5; -.
DR Bgee; Q9UJC5; -.
DR CleanEx; HS_SH3BGRL2; -.
DR Genevestigator; Q9UJC5; -.
DR GO; GO:0005634; C:nucleus; IDA:HPA.
DR Gene3D; 3.40.30.10; -; 1.
DR InterPro; IPR006993; Glut_rich_SH3-bd.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR PANTHER; PTHR12232; PTHR12232; 1.
DR Pfam; PF04908; SH3BGR; 1.
DR PIRSF; PIRSF008142; SH3-bind_E-rich_L; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Nucleus; Reference proteome;
KW SH3-binding.
FT CHAIN 1 107 SH3 domain-binding glutamic acid-rich-
FT like protein 2.
FT /FTId=PRO_0000220747.
FT MOTIF 61 67 SH3-binding (Potential).
FT CONFLICT 7 7 I -> V (in Ref. 6; AAH70059).
FT CONFLICT 39 39 I -> T (in Ref. 6; AAH40489).
FT STRAND 3 7
FT HELIX 14 29
FT STRAND 34 38
FT TURN 39 41
FT HELIX 43 51
FT TURN 55 57
FT STRAND 60 63
FT STRAND 68 71
FT STRAND 74 78
FT HELIX 79 86
FT TURN 87 89
FT HELIX 91 95
SQ SEQUENCE 107 AA; 12326 MW; D160736103FA8635 CRC64;
MVIRVFIASS SGFVAIKKKQ QDVVRFLEAN KIEFEEVDIT MSEEQRQWMY KNVPPEKKPT
QGNPLPPQIF NGDRYCGDYD SFFESKESNT VFSFLGLKPR LASKAEP
//
ID SH3L2_HUMAN Reviewed; 107 AA.
AC Q9UJC5; A8MQU2; Q2VPC2; Q5VV96; Q6NSK8; Q6P9E8; Q7Z734; Q8IWD3;
read moreAC Q9BPY5;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-2002, sequence version 2.
DT 22-JAN-2014, entry version 104.
DE RecName: Full=SH3 domain-binding glutamic acid-rich-like protein 2;
DE AltName: Full=Fovea-associated SH3 domain-binding protein;
GN Name=SH3BGRL2; Synonyms=FASH3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=12095696; DOI=10.1016/S0378-1119(02)00602-9;
RA Mazzocco M., Maffei M., Egeo A., Vergano A., Arrigo P., Di Lisi R.,
RA Ghiotto F., Scartezzini P.;
RT "The identification of a novel human homologue of the SH3 binding
RT glutamic acid-rich (SH3BGR) gene establishes a new family of highly
RT conserved small proteins related to Thioredoxin Superfamily.";
RL Gene 291:233-239(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Bowes Rickman C., Yarovinsky T.O., McKay B.S., Stone E.M., Ritter R.,
RA Rickman D.W., Edwards A.O.;
RT "Characterization of a novel candidate gene, FASH3, expressed in the
RT primate fovea and linked to the disease gene, ELOVL4, associated with
RT Stargardt-like dominant progressive macular dystrophy.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Eye, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP STRUCTURE BY NMR OF 1-98.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the SH3 domain-binding glutamic acid-rich-like
RT protein 2.";
RL Submitted (NOV-2005) to the PDB data bank.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain, placenta, liver and
CC kidney. Expressed in retina.
CC -!- SIMILARITY: Belongs to the SH3BGR family.
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DR EMBL; AJ297972; CAC35771.1; -; mRNA.
DR EMBL; AF340151; AAK37526.1; -; mRNA.
DR EMBL; AK311757; BAG34700.1; -; mRNA.
DR EMBL; AL035700; CAB55867.2; -; Genomic_DNA.
DR EMBL; AL451064; CAB55867.2; JOINED; Genomic_DNA.
DR EMBL; AL451064; CAH70932.1; -; Genomic_DNA.
DR EMBL; AL035700; CAH70932.1; JOINED; Genomic_DNA.
DR EMBL; CH471051; EAW48703.1; -; Genomic_DNA.
DR EMBL; BC040489; AAH40489.2; -; mRNA.
DR EMBL; BC052987; AAH52987.2; -; mRNA.
DR EMBL; BC060799; AAH60799.2; -; mRNA.
DR EMBL; BC070059; AAH70059.2; -; mRNA.
DR EMBL; BC109043; AAI09044.2; -; mRNA.
DR EMBL; BC109044; AAI09045.2; -; mRNA.
DR RefSeq; NP_113657.1; NM_031469.2.
DR UniGene; Hs.302772; -.
DR PDB; 2CT6; NMR; -; A=1-98.
DR PDBsum; 2CT6; -.
DR ProteinModelPortal; Q9UJC5; -.
DR SMR; Q9UJC5; 1-98.
DR IntAct; Q9UJC5; 2.
DR PhosphoSite; Q9UJC5; -.
DR DMDM; 24638476; -.
DR UCD-2DPAGE; Q9UJC5; -.
DR PaxDb; Q9UJC5; -.
DR PeptideAtlas; Q9UJC5; -.
DR PRIDE; Q9UJC5; -.
DR Ensembl; ENST00000369838; ENSP00000358853; ENSG00000198478.
DR GeneID; 83699; -.
DR KEGG; hsa:83699; -.
DR UCSC; uc003piz.1; human.
DR CTD; 83699; -.
DR GeneCards; GC06P080397; -.
DR HGNC; HGNC:15567; SH3BGRL2.
DR HPA; HPA047486; -.
DR neXtProt; NX_Q9UJC5; -.
DR PharmGKB; PA37978; -.
DR eggNOG; NOG327011; -.
DR HOVERGEN; HBG054781; -.
DR InParanoid; Q9UJC5; -.
DR OMA; VDITMLE; -.
DR OrthoDB; EOG7GTT63; -.
DR PhylomeDB; Q9UJC5; -.
DR EvolutionaryTrace; Q9UJC5; -.
DR GenomeRNAi; 83699; -.
DR NextBio; 72684; -.
DR PRO; PR:Q9UJC5; -.
DR Bgee; Q9UJC5; -.
DR CleanEx; HS_SH3BGRL2; -.
DR Genevestigator; Q9UJC5; -.
DR GO; GO:0005634; C:nucleus; IDA:HPA.
DR Gene3D; 3.40.30.10; -; 1.
DR InterPro; IPR006993; Glut_rich_SH3-bd.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR PANTHER; PTHR12232; PTHR12232; 1.
DR Pfam; PF04908; SH3BGR; 1.
DR PIRSF; PIRSF008142; SH3-bind_E-rich_L; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Nucleus; Reference proteome;
KW SH3-binding.
FT CHAIN 1 107 SH3 domain-binding glutamic acid-rich-
FT like protein 2.
FT /FTId=PRO_0000220747.
FT MOTIF 61 67 SH3-binding (Potential).
FT CONFLICT 7 7 I -> V (in Ref. 6; AAH70059).
FT CONFLICT 39 39 I -> T (in Ref. 6; AAH40489).
FT STRAND 3 7
FT HELIX 14 29
FT STRAND 34 38
FT TURN 39 41
FT HELIX 43 51
FT TURN 55 57
FT STRAND 60 63
FT STRAND 68 71
FT STRAND 74 78
FT HELIX 79 86
FT TURN 87 89
FT HELIX 91 95
SQ SEQUENCE 107 AA; 12326 MW; D160736103FA8635 CRC64;
MVIRVFIASS SGFVAIKKKQ QDVVRFLEAN KIEFEEVDIT MSEEQRQWMY KNVPPEKKPT
QGNPLPPQIF NGDRYCGDYD SFFESKESNT VFSFLGLKPR LASKAEP
//