Full text data of SMYD5
SMYD5
(RAI15)
[Confidence: low (only semi-automatic identification from reviews)]
SET and MYND domain-containing protein 5; 2.1.1.- (Protein NN8-4AG; Retinoic acid-induced protein 15)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
SET and MYND domain-containing protein 5; 2.1.1.- (Protein NN8-4AG; Retinoic acid-induced protein 15)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q6GMV2
ID SMYD5_HUMAN Reviewed; 418 AA.
AC Q6GMV2; D6W5H3; Q13558;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 21-MAR-2006, sequence version 2.
DT 22-JAN-2014, entry version 79.
DE RecName: Full=SET and MYND domain-containing protein 5;
DE EC=2.1.1.-;
DE AltName: Full=Protein NN8-4AG;
DE AltName: Full=Retinoic acid-induced protein 15;
GN Name=SMYD5; Synonyms=RAI15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 7-418.
RC TISSUE=Brain;
RX PubMed=8754834;
RA Shago M., Giguere V.;
RT "Isolation of a novel retinoic acid-responsive gene by selection of
RT genomic fragments derived from CpG-island-enriched DNA.";
RL Mol. Cell. Biol. 16:4337-4348(1996).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC methyltransferase superfamily.
CC -!- SIMILARITY: Contains 1 MYND-type zinc finger.
CC -!- SIMILARITY: Contains 1 SET domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH73806.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
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DR EMBL; CH471053; EAW99744.1; -; Genomic_DNA.
DR EMBL; CH471053; EAW99745.1; -; Genomic_DNA.
DR EMBL; BC073806; AAH73806.1; ALT_INIT; mRNA.
DR EMBL; U50383; AAB38131.1; -; mRNA.
DR PIR; G02453; G02453.
DR RefSeq; NP_006053.2; NM_006062.2.
DR UniGene; Hs.631882; -.
DR ProteinModelPortal; Q6GMV2; -.
DR SMR; Q6GMV2; 26-381.
DR PhosphoSite; Q6GMV2; -.
DR DMDM; 90101758; -.
DR PaxDb; Q6GMV2; -.
DR PRIDE; Q6GMV2; -.
DR DNASU; 10322; -.
DR Ensembl; ENST00000389501; ENSP00000374152; ENSG00000135632.
DR GeneID; 10322; -.
DR KEGG; hsa:10322; -.
DR UCSC; uc002siw.2; human.
DR CTD; 10322; -.
DR GeneCards; GC02P073441; -.
DR HGNC; HGNC:16258; SMYD5.
DR HPA; HPA015514; -.
DR neXtProt; NX_Q6GMV2; -.
DR PharmGKB; PA34190; -.
DR eggNOG; NOG241303; -.
DR HOGENOM; HOG000007877; -.
DR HOVERGEN; HBG060385; -.
DR InParanoid; Q6GMV2; -.
DR OMA; HPELCTV; -.
DR ChiTaRS; SMYD5; human.
DR GenomeRNAi; 10322; -.
DR NextBio; 39131; -.
DR PRO; PR:Q6GMV2; -.
DR ArrayExpress; Q6GMV2; -.
DR Bgee; Q6GMV2; -.
DR CleanEx; HS_SMYD5; -.
DR Genevestigator; Q6GMV2; -.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR InterPro; IPR001214; SET_dom.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01360; ZF_MYND_1; FALSE_NEG.
DR PROSITE; PS50865; ZF_MYND_2; FALSE_NEG.
PE 1: Evidence at protein level;
KW Complete proteome; Metal-binding; Methyltransferase;
KW Reference proteome; S-adenosyl-L-methionine; Transferase; Zinc;
KW Zinc-finger.
FT CHAIN 1 418 SET and MYND domain-containing protein 5.
FT /FTId=PRO_0000227788.
FT DOMAIN 21 352 SET.
FT ZN_FING 98 136 MYND-type.
FT COMPBIAS 200 203 Poly-Glu.
FT COMPBIAS 384 414 Glu-rich.
FT CONFLICT 7 7 D -> A (in Ref. 3; AAB38131).
FT CONFLICT 280 281 QL -> HV (in Ref. 3; AAB38131).
SQ SEQUENCE 418 AA; 47341 MW; 11073818FF5EEB83 CRC64;
MAASMCDVFS FCVGVAGRAR VSVEVRFVSS AKGKGLFATQ LIRKGETIFV ERPLVAAQFL
WNALYRYRAC DHCLRALEKA EENAQRLTGK PGQVLPHPEL CTVRKDLHQN CPHCQVMYCS
AECRLAATEQ YHQVLCPGPS QDDPLHPLNK LQEAWRSIHY PPETASIMLM ARMVATVKQA
KDKDRWIRLF SQFCNKTANE EEEIVHKLLG DKFKGQLELL RRLFTEALYE EAVSQWFTPD
GFRSLFALVG TNGQGIGTSS LSQWVHACDT LELKPQDREQ LDAFIDQLYK DIEAATGEFL
NCEGSGLFVL QSCCNHSCVP NAETSFPENN FLLHVTALED IKPGEEICIS YLDCCQRERS
RHSRHKILRE NYLFVCSCPK CLAEADEPNV TSEEEEEEEE EEEGEPEDAE LGDEMTDV
//
ID SMYD5_HUMAN Reviewed; 418 AA.
AC Q6GMV2; D6W5H3; Q13558;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 21-MAR-2006, sequence version 2.
DT 22-JAN-2014, entry version 79.
DE RecName: Full=SET and MYND domain-containing protein 5;
DE EC=2.1.1.-;
DE AltName: Full=Protein NN8-4AG;
DE AltName: Full=Retinoic acid-induced protein 15;
GN Name=SMYD5; Synonyms=RAI15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 7-418.
RC TISSUE=Brain;
RX PubMed=8754834;
RA Shago M., Giguere V.;
RT "Isolation of a novel retinoic acid-responsive gene by selection of
RT genomic fragments derived from CpG-island-enriched DNA.";
RL Mol. Cell. Biol. 16:4337-4348(1996).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC methyltransferase superfamily.
CC -!- SIMILARITY: Contains 1 MYND-type zinc finger.
CC -!- SIMILARITY: Contains 1 SET domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH73806.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; CH471053; EAW99744.1; -; Genomic_DNA.
DR EMBL; CH471053; EAW99745.1; -; Genomic_DNA.
DR EMBL; BC073806; AAH73806.1; ALT_INIT; mRNA.
DR EMBL; U50383; AAB38131.1; -; mRNA.
DR PIR; G02453; G02453.
DR RefSeq; NP_006053.2; NM_006062.2.
DR UniGene; Hs.631882; -.
DR ProteinModelPortal; Q6GMV2; -.
DR SMR; Q6GMV2; 26-381.
DR PhosphoSite; Q6GMV2; -.
DR DMDM; 90101758; -.
DR PaxDb; Q6GMV2; -.
DR PRIDE; Q6GMV2; -.
DR DNASU; 10322; -.
DR Ensembl; ENST00000389501; ENSP00000374152; ENSG00000135632.
DR GeneID; 10322; -.
DR KEGG; hsa:10322; -.
DR UCSC; uc002siw.2; human.
DR CTD; 10322; -.
DR GeneCards; GC02P073441; -.
DR HGNC; HGNC:16258; SMYD5.
DR HPA; HPA015514; -.
DR neXtProt; NX_Q6GMV2; -.
DR PharmGKB; PA34190; -.
DR eggNOG; NOG241303; -.
DR HOGENOM; HOG000007877; -.
DR HOVERGEN; HBG060385; -.
DR InParanoid; Q6GMV2; -.
DR OMA; HPELCTV; -.
DR ChiTaRS; SMYD5; human.
DR GenomeRNAi; 10322; -.
DR NextBio; 39131; -.
DR PRO; PR:Q6GMV2; -.
DR ArrayExpress; Q6GMV2; -.
DR Bgee; Q6GMV2; -.
DR CleanEx; HS_SMYD5; -.
DR Genevestigator; Q6GMV2; -.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR InterPro; IPR001214; SET_dom.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01360; ZF_MYND_1; FALSE_NEG.
DR PROSITE; PS50865; ZF_MYND_2; FALSE_NEG.
PE 1: Evidence at protein level;
KW Complete proteome; Metal-binding; Methyltransferase;
KW Reference proteome; S-adenosyl-L-methionine; Transferase; Zinc;
KW Zinc-finger.
FT CHAIN 1 418 SET and MYND domain-containing protein 5.
FT /FTId=PRO_0000227788.
FT DOMAIN 21 352 SET.
FT ZN_FING 98 136 MYND-type.
FT COMPBIAS 200 203 Poly-Glu.
FT COMPBIAS 384 414 Glu-rich.
FT CONFLICT 7 7 D -> A (in Ref. 3; AAB38131).
FT CONFLICT 280 281 QL -> HV (in Ref. 3; AAB38131).
SQ SEQUENCE 418 AA; 47341 MW; 11073818FF5EEB83 CRC64;
MAASMCDVFS FCVGVAGRAR VSVEVRFVSS AKGKGLFATQ LIRKGETIFV ERPLVAAQFL
WNALYRYRAC DHCLRALEKA EENAQRLTGK PGQVLPHPEL CTVRKDLHQN CPHCQVMYCS
AECRLAATEQ YHQVLCPGPS QDDPLHPLNK LQEAWRSIHY PPETASIMLM ARMVATVKQA
KDKDRWIRLF SQFCNKTANE EEEIVHKLLG DKFKGQLELL RRLFTEALYE EAVSQWFTPD
GFRSLFALVG TNGQGIGTSS LSQWVHACDT LELKPQDREQ LDAFIDQLYK DIEAATGEFL
NCEGSGLFVL QSCCNHSCVP NAETSFPENN FLLHVTALED IKPGEEICIS YLDCCQRERS
RHSRHKILRE NYLFVCSCPK CLAEADEPNV TSEEEEEEEE EEEGEPEDAE LGDEMTDV
//