Full text data of NAPG
NAPG
(SNAPG)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Gamma-soluble NSF attachment protein; SNAP-gamma (N-ethylmaleimide-sensitive factor attachment protein gamma)
Gamma-soluble NSF attachment protein; SNAP-gamma (N-ethylmaleimide-sensitive factor attachment protein gamma)
UniProt
Q99747
ID SNAG_HUMAN Reviewed; 312 AA.
AC Q99747; Q9BUV1;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAY-1997, sequence version 1.
DT 22-JAN-2014, entry version 121.
DE RecName: Full=Gamma-soluble NSF attachment protein;
DE Short=SNAP-gamma;
DE AltName: Full=N-ethylmaleimide-sensitive factor attachment protein gamma;
GN Name=NAPG; Synonyms=SNAPG;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9269766;
RA Lemons P.P., Chen D., Bernstein A.M., Bennett M.K., Whiteheart S.W.;
RT "Regulated secretion in platelets: identification of elements of the
RT platelet exocytosis machinery.";
RL Blood 90:1490-1500(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INTERACTION WITH RIP11.
RX PubMed=11278501; DOI=10.1074/jbc.M009424200;
RA Chen D., Xu W., He P., Medrano E.E., Whiteheart S.W.;
RT "Gaf-1, a gamma-SNAP-binding protein associated with the
RT mitochondria.";
RL J. Biol. Chem. 276:13127-13135(2001).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=15592455; DOI=10.1038/nbt1046;
RA Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
RA Zha X.-M., Polakiewicz R.D., Comb M.J.;
RT "Immunoaffinity profiling of tyrosine phosphorylation in cancer
RT cells.";
RL Nat. Biotechnol. 23:94-101(2005).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Required for vesicular transport between the endoplasmic
CC reticulum and the Golgi apparatus.
CC -!- SUBUNIT: Binds RIP11. Interacts with VTI1A (By similarity).
CC -!- SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein (By
CC similarity).
CC -!- SIMILARITY: Belongs to the SNAP family.
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DR EMBL; U78107; AAB69753.1; -; mRNA.
DR EMBL; BC001889; AAH01889.1; -; mRNA.
DR RefSeq; NP_003817.1; NM_003826.2.
DR UniGene; Hs.464622; -.
DR ProteinModelPortal; Q99747; -.
DR SMR; Q99747; 2-276.
DR IntAct; Q99747; 2.
DR STRING; 9606.ENSP00000324628; -.
DR PhosphoSite; Q99747; -.
DR DMDM; 3024632; -.
DR OGP; Q99747; -.
DR PaxDb; Q99747; -.
DR PRIDE; Q99747; -.
DR DNASU; 8774; -.
DR Ensembl; ENST00000322897; ENSP00000324628; ENSG00000134265.
DR GeneID; 8774; -.
DR KEGG; hsa:8774; -.
DR UCSC; uc002kon.3; human.
DR CTD; 8774; -.
DR GeneCards; GC18P010516; -.
DR HGNC; HGNC:7642; NAPG.
DR HPA; HPA008208; -.
DR HPA; HPA011389; -.
DR MIM; 603216; gene.
DR neXtProt; NX_Q99747; -.
DR PharmGKB; PA31445; -.
DR eggNOG; NOG296973; -.
DR HOGENOM; HOG000007747; -.
DR HOVERGEN; HBG001648; -.
DR InParanoid; Q99747; -.
DR OMA; AVCFKNA; -.
DR ChiTaRS; NAPG; human.
DR GeneWiki; NAPG; -.
DR GenomeRNAi; 8774; -.
DR NextBio; 32900; -.
DR PRO; PR:Q99747; -.
DR ArrayExpress; Q99747; -.
DR Bgee; Q99747; -.
DR CleanEx; HS_NAPG; -.
DR Genevestigator; Q99747; -.
DR GO; GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; TAS:ProtInc.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0061025; P:membrane fusion; TAS:ProtInc.
DR GO; GO:0006461; P:protein complex assembly; NAS:UniProtKB.
DR GO; GO:0050821; P:protein stabilization; NAS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR000744; NSF_attach.
DR InterPro; IPR011990; TPR-like_helical.
DR PANTHER; PTHR13768; PTHR13768; 1.
PE 1: Evidence at protein level;
KW Complete proteome; ER-Golgi transport; Membrane; Polymorphism;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1 312 Gamma-soluble NSF attachment protein.
FT /FTId=PRO_0000219063.
FT VARIANT 92 92 P -> S (in dbSNP:rs16974765).
FT /FTId=VAR_052027.
FT VARIANT 281 281 K -> N (in dbSNP:rs2305370).
FT /FTId=VAR_020129.
FT CONFLICT 147 147 E -> D (in Ref. 2; AAH01889).
SQ SEQUENCE 312 AA; 34746 MW; C37D73C1AEFD48C8 CRC64;
MAAQKINEGL EHLAKAEKYL KTGFLKWKPD YDSAASEYGK AAVAFKNAKQ FEQAKDACLR
EAVAHENNRA LFHAAKAYEQ AGMMLKEMQK LPEAVQLIEK ASMMYLENGT PDTAAMALER
AGKLIENVDP EKAVQLYQQT ANVFENEERL RQAVELLGKA SRLLVRGRRF DEAALSIQKE
KNIYKEIENY PTCYKKTIAQ VLVHLHRNDY VAAERCVRES YSIPGFNGSE DCAALEQLLE
GYDQQDQDQV SDVCNSPLFK YMDNDYAKLG LSLVVPGGGI KKKSPATPQA KPDGVTATAA
DEEEDEYSGG LC
//
ID SNAG_HUMAN Reviewed; 312 AA.
AC Q99747; Q9BUV1;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAY-1997, sequence version 1.
DT 22-JAN-2014, entry version 121.
DE RecName: Full=Gamma-soluble NSF attachment protein;
DE Short=SNAP-gamma;
DE AltName: Full=N-ethylmaleimide-sensitive factor attachment protein gamma;
GN Name=NAPG; Synonyms=SNAPG;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9269766;
RA Lemons P.P., Chen D., Bernstein A.M., Bennett M.K., Whiteheart S.W.;
RT "Regulated secretion in platelets: identification of elements of the
RT platelet exocytosis machinery.";
RL Blood 90:1490-1500(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INTERACTION WITH RIP11.
RX PubMed=11278501; DOI=10.1074/jbc.M009424200;
RA Chen D., Xu W., He P., Medrano E.E., Whiteheart S.W.;
RT "Gaf-1, a gamma-SNAP-binding protein associated with the
RT mitochondria.";
RL J. Biol. Chem. 276:13127-13135(2001).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=15592455; DOI=10.1038/nbt1046;
RA Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
RA Zha X.-M., Polakiewicz R.D., Comb M.J.;
RT "Immunoaffinity profiling of tyrosine phosphorylation in cancer
RT cells.";
RL Nat. Biotechnol. 23:94-101(2005).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Required for vesicular transport between the endoplasmic
CC reticulum and the Golgi apparatus.
CC -!- SUBUNIT: Binds RIP11. Interacts with VTI1A (By similarity).
CC -!- SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein (By
CC similarity).
CC -!- SIMILARITY: Belongs to the SNAP family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; U78107; AAB69753.1; -; mRNA.
DR EMBL; BC001889; AAH01889.1; -; mRNA.
DR RefSeq; NP_003817.1; NM_003826.2.
DR UniGene; Hs.464622; -.
DR ProteinModelPortal; Q99747; -.
DR SMR; Q99747; 2-276.
DR IntAct; Q99747; 2.
DR STRING; 9606.ENSP00000324628; -.
DR PhosphoSite; Q99747; -.
DR DMDM; 3024632; -.
DR OGP; Q99747; -.
DR PaxDb; Q99747; -.
DR PRIDE; Q99747; -.
DR DNASU; 8774; -.
DR Ensembl; ENST00000322897; ENSP00000324628; ENSG00000134265.
DR GeneID; 8774; -.
DR KEGG; hsa:8774; -.
DR UCSC; uc002kon.3; human.
DR CTD; 8774; -.
DR GeneCards; GC18P010516; -.
DR HGNC; HGNC:7642; NAPG.
DR HPA; HPA008208; -.
DR HPA; HPA011389; -.
DR MIM; 603216; gene.
DR neXtProt; NX_Q99747; -.
DR PharmGKB; PA31445; -.
DR eggNOG; NOG296973; -.
DR HOGENOM; HOG000007747; -.
DR HOVERGEN; HBG001648; -.
DR InParanoid; Q99747; -.
DR OMA; AVCFKNA; -.
DR ChiTaRS; NAPG; human.
DR GeneWiki; NAPG; -.
DR GenomeRNAi; 8774; -.
DR NextBio; 32900; -.
DR PRO; PR:Q99747; -.
DR ArrayExpress; Q99747; -.
DR Bgee; Q99747; -.
DR CleanEx; HS_NAPG; -.
DR Genevestigator; Q99747; -.
DR GO; GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; TAS:ProtInc.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0061025; P:membrane fusion; TAS:ProtInc.
DR GO; GO:0006461; P:protein complex assembly; NAS:UniProtKB.
DR GO; GO:0050821; P:protein stabilization; NAS:UniProtKB.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR000744; NSF_attach.
DR InterPro; IPR011990; TPR-like_helical.
DR PANTHER; PTHR13768; PTHR13768; 1.
PE 1: Evidence at protein level;
KW Complete proteome; ER-Golgi transport; Membrane; Polymorphism;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1 312 Gamma-soluble NSF attachment protein.
FT /FTId=PRO_0000219063.
FT VARIANT 92 92 P -> S (in dbSNP:rs16974765).
FT /FTId=VAR_052027.
FT VARIANT 281 281 K -> N (in dbSNP:rs2305370).
FT /FTId=VAR_020129.
FT CONFLICT 147 147 E -> D (in Ref. 2; AAH01889).
SQ SEQUENCE 312 AA; 34746 MW; C37D73C1AEFD48C8 CRC64;
MAAQKINEGL EHLAKAEKYL KTGFLKWKPD YDSAASEYGK AAVAFKNAKQ FEQAKDACLR
EAVAHENNRA LFHAAKAYEQ AGMMLKEMQK LPEAVQLIEK ASMMYLENGT PDTAAMALER
AGKLIENVDP EKAVQLYQQT ANVFENEERL RQAVELLGKA SRLLVRGRRF DEAALSIQKE
KNIYKEIENY PTCYKKTIAQ VLVHLHRNDY VAAERCVRES YSIPGFNGSE DCAALEQLLE
GYDQQDQDQV SDVCNSPLFK YMDNDYAKLG LSLVVPGGGI KKKSPATPQA KPDGVTATAA
DEEEDEYSGG LC
//
MIM
603216
*RECORD*
*FIELD* NO
603216
*FIELD* TI
*603216 SOLUBLE NSF-ATTACHMENT PROTEIN, GAMMA; NAPG
;;SNAP, GAMMA
*FIELD* TX
NSF (601633) and SNAPs are general elements of the cellular membrane
read moretransport apparatus. See alpha-SNAP (603215) for additional information.
Whiteheart et al. (1993) cloned bovine cDNAs encoding alpha-, beta-, and
gamma-SNAP. By searching a human EST database for homologs of bovine
gamma-SNAP, Lemons et al. (1997) identified a melanocyte cell cDNA
encoding human gamma-SNAP. The sequence of the predicted 312-amino acid
human protein is 95% identical to that of bovine gamma-SNAP. These
authors characterized gamma-SNAP and some of the other proteins that
mediate platelet exocytosis and proposed a mechanism for controlling the
membrane fusion events of this process.
*FIELD* RF
1. Lemons, P. P.; Chen, D.; Bernstein, A. M.; Bennett, M. K.; Whiteheart,
S. W.: Regulated secretion in platelets: identification of elements
of the platelet exocytosis machinery. Blood 90: 1490-1500, 1997.
2. Whiteheart, S. W.; Griff, I. C.; Brunner, M.; Clary, D. O.; Mayer,
T.; Buhrow, S. A.; Rothman, J. E.: SNAP family of NSF attachment
proteins includes a brain-specific isoform. Nature 362: 353-355,
1993.
*FIELD* CD
Rebekah S. Rasooly: 10/27/1998
*FIELD* ED
alopez: 01/02/2007
carol: 5/18/2000
psherman: 10/28/1998
psherman: 10/27/1998
*RECORD*
*FIELD* NO
603216
*FIELD* TI
*603216 SOLUBLE NSF-ATTACHMENT PROTEIN, GAMMA; NAPG
;;SNAP, GAMMA
*FIELD* TX
NSF (601633) and SNAPs are general elements of the cellular membrane
read moretransport apparatus. See alpha-SNAP (603215) for additional information.
Whiteheart et al. (1993) cloned bovine cDNAs encoding alpha-, beta-, and
gamma-SNAP. By searching a human EST database for homologs of bovine
gamma-SNAP, Lemons et al. (1997) identified a melanocyte cell cDNA
encoding human gamma-SNAP. The sequence of the predicted 312-amino acid
human protein is 95% identical to that of bovine gamma-SNAP. These
authors characterized gamma-SNAP and some of the other proteins that
mediate platelet exocytosis and proposed a mechanism for controlling the
membrane fusion events of this process.
*FIELD* RF
1. Lemons, P. P.; Chen, D.; Bernstein, A. M.; Bennett, M. K.; Whiteheart,
S. W.: Regulated secretion in platelets: identification of elements
of the platelet exocytosis machinery. Blood 90: 1490-1500, 1997.
2. Whiteheart, S. W.; Griff, I. C.; Brunner, M.; Clary, D. O.; Mayer,
T.; Buhrow, S. A.; Rothman, J. E.: SNAP family of NSF attachment
proteins includes a brain-specific isoform. Nature 362: 353-355,
1993.
*FIELD* CD
Rebekah S. Rasooly: 10/27/1998
*FIELD* ED
alopez: 01/02/2007
carol: 5/18/2000
psherman: 10/28/1998
psherman: 10/27/1998