Full text data of SNX22
SNX22
[Confidence: low (only semi-automatic identification from reviews)]
Sorting nexin-22
Sorting nexin-22
UniProt
Q96L94
ID SNX22_HUMAN Reviewed; 193 AA.
AC Q96L94; Q9H844;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 99.
DE RecName: Full=Sorting nexin-22;
GN Name=SNX22;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hong W.;
RT "A novel member (SNX22) of the sorting nexin family.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP STRUCTURE BY NMR OF 2-120, DOMAIN, SUBCELLULAR LOCATION, AND
RP PHOSPHATIDYLINOSITOL 3-PHOSPHATE BINDING.
RX PubMed=17400918; DOI=10.1110/ps.072752407;
RA Song J., Zhao K.Q., Newman C.L., Vinarov D.A., Markley J.L.;
RT "Solution structure of human sorting nexin 22.";
RL Protein Sci. 16:807-814(2007).
CC -!- FUNCTION: May be involved in several stages of intracellular
CC trafficking (By similarity). Interacts with membranes containing
CC phosphatidylinositol 3-phosphate (PtdIns(3P)).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Peripheral
CC membrane protein; Cytoplasmic side (By similarity).
CC -!- DOMAIN: The PX domain mediates specific binding to membranes
CC enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC -!- SIMILARITY: Contains 1 PX (phox homology) domain.
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DR EMBL; AY044653; AAK98767.1; -; mRNA.
DR EMBL; AK024014; BAB14776.1; -; mRNA.
DR RefSeq; NP_079074.2; NM_024798.2.
DR UniGene; Hs.744250; -.
DR PDB; 2ETT; NMR; -; A=2-120.
DR PDBsum; 2ETT; -.
DR ProteinModelPortal; Q96L94; -.
DR SMR; Q96L94; 2-120.
DR IntAct; Q96L94; 4.
DR PhosphoSite; Q96L94; -.
DR DMDM; 20140142; -.
DR PaxDb; Q96L94; -.
DR PRIDE; Q96L94; -.
DR Ensembl; ENST00000325881; ENSP00000323435; ENSG00000157734.
DR GeneID; 79856; -.
DR KEGG; hsa:79856; -.
DR UCSC; uc002anc.1; human.
DR CTD; 79856; -.
DR GeneCards; GC15P064443; -.
DR HGNC; HGNC:16315; SNX22.
DR HPA; HPA038470; -.
DR neXtProt; NX_Q96L94; -.
DR PharmGKB; PA134897329; -.
DR eggNOG; NOG302319; -.
DR HOGENOM; HOG000253944; -.
DR HOVERGEN; HBG064936; -.
DR InParanoid; Q96L94; -.
DR OMA; WGTLGEF; -.
DR OrthoDB; EOG7QVM42; -.
DR PhylomeDB; Q96L94; -.
DR ChiTaRS; SNX22; human.
DR EvolutionaryTrace; Q96L94; -.
DR GenomeRNAi; 79856; -.
DR NextBio; 69574; -.
DR PRO; PR:Q96L94; -.
DR ArrayExpress; Q96L94; -.
DR Bgee; Q96L94; -.
DR CleanEx; HS_SNX22; -.
DR Genevestigator; Q96L94; -.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR001683; Phox.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Cytoplasmic vesicle; Lipid-binding;
KW Membrane; Protein transport; Reference proteome; Transport.
FT CHAIN 1 193 Sorting nexin-22.
FT /FTId=PRO_0000213871.
FT DOMAIN 1 118 PX.
FT BINDING 43 43 Phosphatidylinositol 3-phosphate.
FT BINDING 45 45 Phosphatidylinositol 3-phosphate; via
FT amide nitrogen and carbonyl oxygen.
FT BINDING 66 66 Phosphatidylinositol 3-phosphate.
FT BINDING 79 79 Phosphatidylinositol 3-phosphate.
FT CONFLICT 191 191 P -> L (in Ref. 2; BAB14776).
FT STRAND 2 11
FT STRAND 26 33
FT STRAND 36 43
FT HELIX 44 55
FT STRAND 71 74
FT HELIX 76 93
FT STRAND 94 97
FT HELIX 99 105
SQ SEQUENCE 193 AA; 22068 MW; B57D8F8B737F429E CRC64;
MLEVHIPSVG PEAEGPRQSP EKSHMVFRVE VLCSGRRHTV PRRYSEFHAL HKRIKKLYKV
PDFPSKRLPN WRTRGLEQRR QGLEAYIQGI LYLNQEVPKE LLEFLRLRHF PTDPKASNWG
TLREFLPGDS SSQQHQRPVL SFHVDPYVCN PSPESLPNVV VNGVLQGLYS FSISPDKAQP
KAACHPAPLP PMP
//
ID SNX22_HUMAN Reviewed; 193 AA.
AC Q96L94; Q9H844;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 99.
DE RecName: Full=Sorting nexin-22;
GN Name=SNX22;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hong W.;
RT "A novel member (SNX22) of the sorting nexin family.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP STRUCTURE BY NMR OF 2-120, DOMAIN, SUBCELLULAR LOCATION, AND
RP PHOSPHATIDYLINOSITOL 3-PHOSPHATE BINDING.
RX PubMed=17400918; DOI=10.1110/ps.072752407;
RA Song J., Zhao K.Q., Newman C.L., Vinarov D.A., Markley J.L.;
RT "Solution structure of human sorting nexin 22.";
RL Protein Sci. 16:807-814(2007).
CC -!- FUNCTION: May be involved in several stages of intracellular
CC trafficking (By similarity). Interacts with membranes containing
CC phosphatidylinositol 3-phosphate (PtdIns(3P)).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Peripheral
CC membrane protein; Cytoplasmic side (By similarity).
CC -!- DOMAIN: The PX domain mediates specific binding to membranes
CC enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC -!- SIMILARITY: Contains 1 PX (phox homology) domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY044653; AAK98767.1; -; mRNA.
DR EMBL; AK024014; BAB14776.1; -; mRNA.
DR RefSeq; NP_079074.2; NM_024798.2.
DR UniGene; Hs.744250; -.
DR PDB; 2ETT; NMR; -; A=2-120.
DR PDBsum; 2ETT; -.
DR ProteinModelPortal; Q96L94; -.
DR SMR; Q96L94; 2-120.
DR IntAct; Q96L94; 4.
DR PhosphoSite; Q96L94; -.
DR DMDM; 20140142; -.
DR PaxDb; Q96L94; -.
DR PRIDE; Q96L94; -.
DR Ensembl; ENST00000325881; ENSP00000323435; ENSG00000157734.
DR GeneID; 79856; -.
DR KEGG; hsa:79856; -.
DR UCSC; uc002anc.1; human.
DR CTD; 79856; -.
DR GeneCards; GC15P064443; -.
DR HGNC; HGNC:16315; SNX22.
DR HPA; HPA038470; -.
DR neXtProt; NX_Q96L94; -.
DR PharmGKB; PA134897329; -.
DR eggNOG; NOG302319; -.
DR HOGENOM; HOG000253944; -.
DR HOVERGEN; HBG064936; -.
DR InParanoid; Q96L94; -.
DR OMA; WGTLGEF; -.
DR OrthoDB; EOG7QVM42; -.
DR PhylomeDB; Q96L94; -.
DR ChiTaRS; SNX22; human.
DR EvolutionaryTrace; Q96L94; -.
DR GenomeRNAi; 79856; -.
DR NextBio; 69574; -.
DR PRO; PR:Q96L94; -.
DR ArrayExpress; Q96L94; -.
DR Bgee; Q96L94; -.
DR CleanEx; HS_SNX22; -.
DR Genevestigator; Q96L94; -.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR001683; Phox.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Cytoplasmic vesicle; Lipid-binding;
KW Membrane; Protein transport; Reference proteome; Transport.
FT CHAIN 1 193 Sorting nexin-22.
FT /FTId=PRO_0000213871.
FT DOMAIN 1 118 PX.
FT BINDING 43 43 Phosphatidylinositol 3-phosphate.
FT BINDING 45 45 Phosphatidylinositol 3-phosphate; via
FT amide nitrogen and carbonyl oxygen.
FT BINDING 66 66 Phosphatidylinositol 3-phosphate.
FT BINDING 79 79 Phosphatidylinositol 3-phosphate.
FT CONFLICT 191 191 P -> L (in Ref. 2; BAB14776).
FT STRAND 2 11
FT STRAND 26 33
FT STRAND 36 43
FT HELIX 44 55
FT STRAND 71 74
FT HELIX 76 93
FT STRAND 94 97
FT HELIX 99 105
SQ SEQUENCE 193 AA; 22068 MW; B57D8F8B737F429E CRC64;
MLEVHIPSVG PEAEGPRQSP EKSHMVFRVE VLCSGRRHTV PRRYSEFHAL HKRIKKLYKV
PDFPSKRLPN WRTRGLEQRR QGLEAYIQGI LYLNQEVPKE LLEFLRLRHF PTDPKASNWG
TLREFLPGDS SSQQHQRPVL SFHVDPYVCN PSPESLPNVV VNGVLQGLYS FSISPDKAQP
KAACHPAPLP PMP
//