Full text data of SP2
SP2
(KIAA0048)
[Confidence: low (only semi-automatic identification from reviews)]
Transcription factor Sp2
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Transcription factor Sp2
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q02086
ID SP2_HUMAN Reviewed; 613 AA.
AC Q02086; A6NK74;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
read moreDT 12-DEC-2006, sequence version 3.
DT 22-JAN-2014, entry version 125.
DE RecName: Full=Transcription factor Sp2;
GN Name=SP2; Synonyms=KIAA0048;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Bone marrow;
RX PubMed=7584044; DOI=10.1093/dnares/1.5.223;
RA Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S.,
RA Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.;
RT "Prediction of the coding sequences of unidentified human genes. II.
RT The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by
RT analysis of cDNA clones from human cell line KG-1.";
RL DNA Res. 1:223-229(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung, Lymph, and Spleen;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 119-613.
RX PubMed=1341900;
RA Kingsley C., Winoto A.;
RT "Cloning of GT box-binding proteins: a novel Sp1 multigene family
RT regulating T-cell receptor gene expression.";
RL Mol. Cell. Biol. 12:4251-4261(1992).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
CC -!- FUNCTION: Binds to GC box promoters elements and selectively
CC activates mRNA synthesis from genes that contain functional
CC recognition sites.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q02086-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q02086-2; Sequence=VSP_022021;
CC -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein
CC family.
CC -!- SIMILARITY: Contains 3 C2H2-type zinc fingers.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH16680.1; Type=Erroneous initiation;
CC Sequence=AAH33814.1; Type=Erroneous initiation;
CC Sequence=BAA05923.2; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; D28588; BAA05923.2; ALT_INIT; mRNA.
DR EMBL; AC018521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471109; EAW94785.1; -; Genomic_DNA.
DR EMBL; BC016680; AAH16680.1; ALT_INIT; mRNA.
DR EMBL; BC033814; AAH33814.1; ALT_INIT; mRNA.
DR EMBL; M97190; AAA36629.1; -; mRNA.
DR PIR; A44489; A44489.
DR RefSeq; NP_003101.3; NM_003110.5.
DR RefSeq; XP_005257668.1; XM_005257611.1.
DR RefSeq; XP_005257669.1; XM_005257612.1.
DR UniGene; Hs.514276; -.
DR ProteinModelPortal; Q02086; -.
DR SMR; Q02086; 494-608.
DR IntAct; Q02086; 1.
DR STRING; 9606.ENSP00000365931; -.
DR PhosphoSite; Q02086; -.
DR DMDM; 119370531; -.
DR PaxDb; Q02086; -.
DR PRIDE; Q02086; -.
DR DNASU; 6668; -.
DR Ensembl; ENST00000376741; ENSP00000365931; ENSG00000167182.
DR GeneID; 6668; -.
DR KEGG; hsa:6668; -.
DR UCSC; uc002imk.3; human.
DR CTD; 6668; -.
DR GeneCards; GC17P045973; -.
DR HGNC; HGNC:11207; SP2.
DR HPA; CAB010245; -.
DR HPA; HPA003357; -.
DR MIM; 601801; gene.
DR neXtProt; NX_Q02086; -.
DR PharmGKB; PA36044; -.
DR eggNOG; COG5048; -.
DR HOGENOM; HOG000234295; -.
DR HOVERGEN; HBG008933; -.
DR InParanoid; Q02086; -.
DR KO; K09192; -.
DR OMA; NCKDGDK; -.
DR OrthoDB; EOG7JQBMX; -.
DR SignaLink; Q02086; -.
DR GeneWiki; Sp2_transcription_factor; -.
DR GenomeRNAi; 6668; -.
DR NextBio; 25999; -.
DR PRO; PR:Q02086; -.
DR Bgee; Q02086; -.
DR CleanEx; HS_SP2; -.
DR Genevestigator; Q02086; -.
DR GO; GO:0005634; C:nucleus; IDA:HPA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0072358; P:cardiovascular system development; IEA:Ensembl.
DR GO; GO:0048568; P:embryonic organ development; IEA:Ensembl.
DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; TAS:ProtInc.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 3.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR SMART; SM00355; ZnF_C2H2; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Complete proteome; DNA-binding;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 613 Transcription factor Sp2.
FT /FTId=PRO_0000047140.
FT ZN_FING 525 549 C2H2-type 1.
FT ZN_FING 555 579 C2H2-type 2.
FT ZN_FING 585 607 C2H2-type 3.
FT MOD_RES 78 78 Phosphoserine.
FT VAR_SEQ 1 7 Missing (in isoform 2).
FT /FTId=VSP_022021.
SQ SEQUENCE 613 AA; 64900 MW; DEE6BFCAE3405793 CRC64;
MSDPQTSMAA TAAVSPSDYL QPAASTTQDS QPSPLALLAA TCSKIGPPAV EAAVTPPAPP
QPTPRKLVPI KPAPLPLSPG KNSFGILSSK GNILQIQGSQ LSASYPGGQL VFAIQNPTMI
NKGTRSNANI QYQAVPQIQA SNSQTIQVQP NLTNQIQIIP GTNQAIITPS PSSHKPVPIK
PAPIQKSSTT TTPVQSGANV VKLTGGGGNV TLTLPVNNLV NASDTGAPTQ LLTESPPTPL
SKTNKKARKK SLPASQPPVA VAEQVETVLI ETTADNIIQA GNNLLIVQSP GGGQPAVVQQ
VQVVPPKAEQ QQVVQIPQQA LRVVQAASAT LPTVPQKPSQ NFQIQAAEPT PTQVYIRTPS
GEVQTVLVQD SPPATAAATS NTTCSSPASR APHLSGTSKK HSAAILRKER PLPKIAPAGS
IISLNAAQLA AAAQAMQTIN INGVQVQGVP VTITNTGGQQ QLTVQNVSGN NLTISGLSPT
QIQLQMEQAL AGETQPGEKR RRMACTCPNC KDGEKRSGEQ GKKKHVCHIP DCGKTFRKTS
LLRAHVRLHT GERPFVCNWF FCGKRFTRSD ELQRHARTHT GDKRFECAQC QKRFMRSDHL
TKHYKTHLVT KNL
//
ID SP2_HUMAN Reviewed; 613 AA.
AC Q02086; A6NK74;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
read moreDT 12-DEC-2006, sequence version 3.
DT 22-JAN-2014, entry version 125.
DE RecName: Full=Transcription factor Sp2;
GN Name=SP2; Synonyms=KIAA0048;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Bone marrow;
RX PubMed=7584044; DOI=10.1093/dnares/1.5.223;
RA Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S.,
RA Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.;
RT "Prediction of the coding sequences of unidentified human genes. II.
RT The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by
RT analysis of cDNA clones from human cell line KG-1.";
RL DNA Res. 1:223-229(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT the human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung, Lymph, and Spleen;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 119-613.
RX PubMed=1341900;
RA Kingsley C., Winoto A.;
RT "Cloning of GT box-binding proteins: a novel Sp1 multigene family
RT regulating T-cell receptor gene expression.";
RL Mol. Cell. Biol. 12:4251-4261(1992).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
CC -!- FUNCTION: Binds to GC box promoters elements and selectively
CC activates mRNA synthesis from genes that contain functional
CC recognition sites.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q02086-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q02086-2; Sequence=VSP_022021;
CC -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein
CC family.
CC -!- SIMILARITY: Contains 3 C2H2-type zinc fingers.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH16680.1; Type=Erroneous initiation;
CC Sequence=AAH33814.1; Type=Erroneous initiation;
CC Sequence=BAA05923.2; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; D28588; BAA05923.2; ALT_INIT; mRNA.
DR EMBL; AC018521; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471109; EAW94785.1; -; Genomic_DNA.
DR EMBL; BC016680; AAH16680.1; ALT_INIT; mRNA.
DR EMBL; BC033814; AAH33814.1; ALT_INIT; mRNA.
DR EMBL; M97190; AAA36629.1; -; mRNA.
DR PIR; A44489; A44489.
DR RefSeq; NP_003101.3; NM_003110.5.
DR RefSeq; XP_005257668.1; XM_005257611.1.
DR RefSeq; XP_005257669.1; XM_005257612.1.
DR UniGene; Hs.514276; -.
DR ProteinModelPortal; Q02086; -.
DR SMR; Q02086; 494-608.
DR IntAct; Q02086; 1.
DR STRING; 9606.ENSP00000365931; -.
DR PhosphoSite; Q02086; -.
DR DMDM; 119370531; -.
DR PaxDb; Q02086; -.
DR PRIDE; Q02086; -.
DR DNASU; 6668; -.
DR Ensembl; ENST00000376741; ENSP00000365931; ENSG00000167182.
DR GeneID; 6668; -.
DR KEGG; hsa:6668; -.
DR UCSC; uc002imk.3; human.
DR CTD; 6668; -.
DR GeneCards; GC17P045973; -.
DR HGNC; HGNC:11207; SP2.
DR HPA; CAB010245; -.
DR HPA; HPA003357; -.
DR MIM; 601801; gene.
DR neXtProt; NX_Q02086; -.
DR PharmGKB; PA36044; -.
DR eggNOG; COG5048; -.
DR HOGENOM; HOG000234295; -.
DR HOVERGEN; HBG008933; -.
DR InParanoid; Q02086; -.
DR KO; K09192; -.
DR OMA; NCKDGDK; -.
DR OrthoDB; EOG7JQBMX; -.
DR SignaLink; Q02086; -.
DR GeneWiki; Sp2_transcription_factor; -.
DR GenomeRNAi; 6668; -.
DR NextBio; 25999; -.
DR PRO; PR:Q02086; -.
DR Bgee; Q02086; -.
DR CleanEx; HS_SP2; -.
DR Genevestigator; Q02086; -.
DR GO; GO:0005634; C:nucleus; IDA:HPA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0072358; P:cardiovascular system development; IEA:Ensembl.
DR GO; GO:0048568; P:embryonic organ development; IEA:Ensembl.
DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; TAS:ProtInc.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 3.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR SMART; SM00355; ZnF_C2H2; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Complete proteome; DNA-binding;
KW Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1 613 Transcription factor Sp2.
FT /FTId=PRO_0000047140.
FT ZN_FING 525 549 C2H2-type 1.
FT ZN_FING 555 579 C2H2-type 2.
FT ZN_FING 585 607 C2H2-type 3.
FT MOD_RES 78 78 Phosphoserine.
FT VAR_SEQ 1 7 Missing (in isoform 2).
FT /FTId=VSP_022021.
SQ SEQUENCE 613 AA; 64900 MW; DEE6BFCAE3405793 CRC64;
MSDPQTSMAA TAAVSPSDYL QPAASTTQDS QPSPLALLAA TCSKIGPPAV EAAVTPPAPP
QPTPRKLVPI KPAPLPLSPG KNSFGILSSK GNILQIQGSQ LSASYPGGQL VFAIQNPTMI
NKGTRSNANI QYQAVPQIQA SNSQTIQVQP NLTNQIQIIP GTNQAIITPS PSSHKPVPIK
PAPIQKSSTT TTPVQSGANV VKLTGGGGNV TLTLPVNNLV NASDTGAPTQ LLTESPPTPL
SKTNKKARKK SLPASQPPVA VAEQVETVLI ETTADNIIQA GNNLLIVQSP GGGQPAVVQQ
VQVVPPKAEQ QQVVQIPQQA LRVVQAASAT LPTVPQKPSQ NFQIQAAEPT PTQVYIRTPS
GEVQTVLVQD SPPATAAATS NTTCSSPASR APHLSGTSKK HSAAILRKER PLPKIAPAGS
IISLNAAQLA AAAQAMQTIN INGVQVQGVP VTITNTGGQQ QLTVQNVSGN NLTISGLSPT
QIQLQMEQAL AGETQPGEKR RRMACTCPNC KDGEKRSGEQ GKKKHVCHIP DCGKTFRKTS
LLRAHVRLHT GERPFVCNWF FCGKRFTRSD ELQRHARTHT GDKRFECAQC QKRFMRSDHL
TKHYKTHLVT KNL
//
MIM
601801
*RECORD*
*FIELD* NO
601801
*FIELD* TI
*601801 TRANSCRIPTION FACTOR Sp2; SP2
;;SPECIFICITY PROTEIN 2
*FIELD* TX
CLONING
read moreKingsley and Winoto (1992) investigated transcription factors which bind
to the GT box, a T-cell transcriptional regulatory element which is
similar to the GC box, the classical binding site for SP1 (189906). Gel
shift assays showed that SP1 and 2 additional DNA-protein complexes
bound to the GT box. The authors then cloned 2 novel GT box-binding
cDNAs from a human cDNA expression library. They termed these new
transcription factors SP2 and SP3 (601804). These genes encode proteins
with several transactivation domains and a zinc finger DNA-binding
domain with homology to SP1. Kingsley and Winoto (1992) reported that
the SP2 cDNA encodes a 495-amino acid polypeptide which is 72% identical
to SP1 within the zinc finger domain. However, they noted that SP2,
unlike SP3, has limited homology to SP1. Northern blot analysis shows
that the SP2 gene produces a 3.2-kb message expressed in several cell
lines. When expressed in vitro, SP2 binds the GT box weakly but does not
bind the GC box.
MAPPING
Suske et al. (2005) stated that the human SP2 gene maps to chromosome
17q21.32, and the mouse Sp2 gene to chromosome 11D.
*FIELD* RF
1. Kingsley, C; Winoto, A.: Cloning of GT box-binding proteins: a
novel SP1 multigene family regulating T-cell receptor gene expression. Molec.
Cell Biol. 12: 4251-4261, 1992.
2. Suske, G.; Bruford, E.; Philipsen, S.: Mammalian SP/KLF transcription
factors: bring in the family. Genomics 85: 551-556, 2005.
*FIELD* CN
Patricia A. Hartz - updated: 5/31/2005
*FIELD* CD
Jennifer P. Macke: 5/15/1997
*FIELD* ED
carol: 10/29/2008
wwang: 5/31/2005
alopez: 5/27/1997
*RECORD*
*FIELD* NO
601801
*FIELD* TI
*601801 TRANSCRIPTION FACTOR Sp2; SP2
;;SPECIFICITY PROTEIN 2
*FIELD* TX
CLONING
read moreKingsley and Winoto (1992) investigated transcription factors which bind
to the GT box, a T-cell transcriptional regulatory element which is
similar to the GC box, the classical binding site for SP1 (189906). Gel
shift assays showed that SP1 and 2 additional DNA-protein complexes
bound to the GT box. The authors then cloned 2 novel GT box-binding
cDNAs from a human cDNA expression library. They termed these new
transcription factors SP2 and SP3 (601804). These genes encode proteins
with several transactivation domains and a zinc finger DNA-binding
domain with homology to SP1. Kingsley and Winoto (1992) reported that
the SP2 cDNA encodes a 495-amino acid polypeptide which is 72% identical
to SP1 within the zinc finger domain. However, they noted that SP2,
unlike SP3, has limited homology to SP1. Northern blot analysis shows
that the SP2 gene produces a 3.2-kb message expressed in several cell
lines. When expressed in vitro, SP2 binds the GT box weakly but does not
bind the GC box.
MAPPING
Suske et al. (2005) stated that the human SP2 gene maps to chromosome
17q21.32, and the mouse Sp2 gene to chromosome 11D.
*FIELD* RF
1. Kingsley, C; Winoto, A.: Cloning of GT box-binding proteins: a
novel SP1 multigene family regulating T-cell receptor gene expression. Molec.
Cell Biol. 12: 4251-4261, 1992.
2. Suske, G.; Bruford, E.; Philipsen, S.: Mammalian SP/KLF transcription
factors: bring in the family. Genomics 85: 551-556, 2005.
*FIELD* CN
Patricia A. Hartz - updated: 5/31/2005
*FIELD* CD
Jennifer P. Macke: 5/15/1997
*FIELD* ED
carol: 10/29/2008
wwang: 5/31/2005
alopez: 5/27/1997