Full text data of SPRR2D
SPRR2D
[Confidence: low (only semi-automatic identification from reviews)]
Small proline-rich protein 2D; SPR-2D (Small proline-rich protein II; SPR-II)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Small proline-rich protein 2D; SPR-2D (Small proline-rich protein II; SPR-II)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
P22532
ID SPR2D_HUMAN Reviewed; 72 AA.
AC P22532; A4QN03; A8K5K2; D3DV33; Q5T523; Q96RM3;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
read moreDT 15-MAR-2004, sequence version 2.
DT 22-JAN-2014, entry version 98.
DE RecName: Full=Small proline-rich protein 2D;
DE Short=SPR-2D;
DE AltName: Full=Small proline-rich protein II;
DE Short=SPR-II;
GN Name=SPRR2D;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Keratinocyte;
RX PubMed=3133554;
RA Kartasova T., van de Putte P.;
RT "Isolation, characterization, and UV-stimulated expression of two
RT families of genes encoding polypeptides of related structure in human
RT epidermal keratinocytes.";
RL Mol. Cell. Biol. 8:2195-2203(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11279051; DOI=10.1074/jbc.M100336200;
RA Cabral A., Voskamp P., Cleton-Jansen A.-M., South A., Nizetic D.,
RA Backendorf C.;
RT "Structural organization and regulation of the small proline-rich
RT family of cornified envelope precursors suggest a role in adaptive
RT barrier function.";
RL J. Biol. Chem. 276:19231-19237(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-20.
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Cross-linked envelope protein of keratinocytes. It is a
CC keratinocyte protein that first appears in the cell cytosol, but
CC ultimately becomes cross-linked to membrane proteins by
CC transglutaminase. All that results in the formation of an
CC insoluble envelope beneath the plasma membrane.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- INDUCTION: During squamous differentiation of epidermal
CC keratinocytes.
CC -!- SIMILARITY: Belongs to the cornifin (SPRR) family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; M21302; AAA36640.1; -; mRNA.
DR EMBL; AF333954; AAK70941.1; -; Genomic_DNA.
DR EMBL; AK291317; BAF84006.1; -; mRNA.
DR EMBL; AL356867; CAI19806.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53348.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53349.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53350.1; -; Genomic_DNA.
DR EMBL; BC120938; AAI20939.1; -; mRNA.
DR RefSeq; NP_008876.3; NM_006945.4.
DR UniGene; Hs.505327; -.
DR ProteinModelPortal; P22532; -.
DR IntAct; P22532; 4.
DR MINT; MINT-8247553; -.
DR STRING; 9606.ENSP00000353542; -.
DR DMDM; 45644953; -.
DR PaxDb; P22532; -.
DR PRIDE; P22532; -.
DR Ensembl; ENST00000360379; ENSP00000353542; ENSG00000163216.
DR Ensembl; ENST00000368756; ENSP00000357745; ENSG00000163216.
DR Ensembl; ENST00000368757; ENSP00000357746; ENSG00000163216.
DR Ensembl; ENST00000368758; ENSP00000357747; ENSG00000163216.
DR GeneID; 6703; -.
DR KEGG; hsa:6703; -.
DR UCSC; uc001fbb.2; human.
DR CTD; 6703; -.
DR GeneCards; GC01M153012; -.
DR HGNC; HGNC:11264; SPRR2D.
DR neXtProt; NX_P22532; -.
DR PharmGKB; PA36093; -.
DR HOVERGEN; HBG095432; -.
DR OMA; PPPKCIV; -.
DR GenomeRNAi; 6703; -.
DR NextBio; 26136; -.
DR PRO; PR:P22532; -.
DR Bgee; P22532; -.
DR CleanEx; HS_SPRR2D; -.
DR Genevestigator; P22532; -.
DR GO; GO:0001533; C:cornified envelope; NAS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0030216; P:keratinocyte differentiation; NAS:UniProtKB.
DR InterPro; IPR026075; SPRR/LCE.
DR PANTHER; PTHR23263; PTHR23263; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Cytoplasm; Keratinization; Polymorphism;
KW Reference proteome; Repeat.
FT CHAIN 1 72 Small proline-rich protein 2D.
FT /FTId=PRO_0000150010.
FT REPEAT 21 29 1.
FT REPEAT 30 38 2.
FT REPEAT 39 47 3.
FT REGION 21 47 3 X 9 AA tandem repeats of P-K-C-P-[EQ]-
FT P-C-P-[PS].
FT VARIANT 20 20 T -> A (in dbSNP:rs1846857).
FT /FTId=VAR_053049.
FT CONFLICT 22 22 K -> N (in Ref. 1; AAA36640).
FT CONFLICT 32 32 C -> S (in Ref. 1; AAA36640).
FT CONFLICT 38 39 SP -> PS (in Ref. 1; AAA36640).
SQ SEQUENCE 72 AA; 7905 MW; 87B4502DD773D448 CRC64;
MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPSPK CPQPCPPQQC QQKYPPVTPS
PPCQPKCPPK SK
//
ID SPR2D_HUMAN Reviewed; 72 AA.
AC P22532; A4QN03; A8K5K2; D3DV33; Q5T523; Q96RM3;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
read moreDT 15-MAR-2004, sequence version 2.
DT 22-JAN-2014, entry version 98.
DE RecName: Full=Small proline-rich protein 2D;
DE Short=SPR-2D;
DE AltName: Full=Small proline-rich protein II;
DE Short=SPR-II;
GN Name=SPRR2D;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Keratinocyte;
RX PubMed=3133554;
RA Kartasova T., van de Putte P.;
RT "Isolation, characterization, and UV-stimulated expression of two
RT families of genes encoding polypeptides of related structure in human
RT epidermal keratinocytes.";
RL Mol. Cell. Biol. 8:2195-2203(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11279051; DOI=10.1074/jbc.M100336200;
RA Cabral A., Voskamp P., Cleton-Jansen A.-M., South A., Nizetic D.,
RA Backendorf C.;
RT "Structural organization and regulation of the small proline-rich
RT family of cornified envelope precursors suggest a role in adaptive
RT barrier function.";
RL J. Biol. Chem. 276:19231-19237(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-20.
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Cross-linked envelope protein of keratinocytes. It is a
CC keratinocyte protein that first appears in the cell cytosol, but
CC ultimately becomes cross-linked to membrane proteins by
CC transglutaminase. All that results in the formation of an
CC insoluble envelope beneath the plasma membrane.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- INDUCTION: During squamous differentiation of epidermal
CC keratinocytes.
CC -!- SIMILARITY: Belongs to the cornifin (SPRR) family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; M21302; AAA36640.1; -; mRNA.
DR EMBL; AF333954; AAK70941.1; -; Genomic_DNA.
DR EMBL; AK291317; BAF84006.1; -; mRNA.
DR EMBL; AL356867; CAI19806.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53348.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53349.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53350.1; -; Genomic_DNA.
DR EMBL; BC120938; AAI20939.1; -; mRNA.
DR RefSeq; NP_008876.3; NM_006945.4.
DR UniGene; Hs.505327; -.
DR ProteinModelPortal; P22532; -.
DR IntAct; P22532; 4.
DR MINT; MINT-8247553; -.
DR STRING; 9606.ENSP00000353542; -.
DR DMDM; 45644953; -.
DR PaxDb; P22532; -.
DR PRIDE; P22532; -.
DR Ensembl; ENST00000360379; ENSP00000353542; ENSG00000163216.
DR Ensembl; ENST00000368756; ENSP00000357745; ENSG00000163216.
DR Ensembl; ENST00000368757; ENSP00000357746; ENSG00000163216.
DR Ensembl; ENST00000368758; ENSP00000357747; ENSG00000163216.
DR GeneID; 6703; -.
DR KEGG; hsa:6703; -.
DR UCSC; uc001fbb.2; human.
DR CTD; 6703; -.
DR GeneCards; GC01M153012; -.
DR HGNC; HGNC:11264; SPRR2D.
DR neXtProt; NX_P22532; -.
DR PharmGKB; PA36093; -.
DR HOVERGEN; HBG095432; -.
DR OMA; PPPKCIV; -.
DR GenomeRNAi; 6703; -.
DR NextBio; 26136; -.
DR PRO; PR:P22532; -.
DR Bgee; P22532; -.
DR CleanEx; HS_SPRR2D; -.
DR Genevestigator; P22532; -.
DR GO; GO:0001533; C:cornified envelope; NAS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0030216; P:keratinocyte differentiation; NAS:UniProtKB.
DR InterPro; IPR026075; SPRR/LCE.
DR PANTHER; PTHR23263; PTHR23263; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Cytoplasm; Keratinization; Polymorphism;
KW Reference proteome; Repeat.
FT CHAIN 1 72 Small proline-rich protein 2D.
FT /FTId=PRO_0000150010.
FT REPEAT 21 29 1.
FT REPEAT 30 38 2.
FT REPEAT 39 47 3.
FT REGION 21 47 3 X 9 AA tandem repeats of P-K-C-P-[EQ]-
FT P-C-P-[PS].
FT VARIANT 20 20 T -> A (in dbSNP:rs1846857).
FT /FTId=VAR_053049.
FT CONFLICT 22 22 K -> N (in Ref. 1; AAA36640).
FT CONFLICT 32 32 C -> S (in Ref. 1; AAA36640).
FT CONFLICT 38 39 SP -> PS (in Ref. 1; AAA36640).
SQ SEQUENCE 72 AA; 7905 MW; 87B4502DD773D448 CRC64;
MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPSPK CPQPCPPQQC QQKYPPVTPS
PPCQPKCPPK SK
//