Full text data of SPRR3
SPRR3
(SPRC)
[Confidence: low (only semi-automatic identification from reviews)]
Small proline-rich protein 3 (22 kDa pancornulin; Cornifin beta; Esophagin)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Small proline-rich protein 3 (22 kDa pancornulin; Cornifin beta; Esophagin)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9UBC9
ID SPRR3_HUMAN Reviewed; 169 AA.
AC Q9UBC9; A5YKK8; B2R4G8; D3DV32; O75597; Q4ZGI7; Q5T525; Q8NET7;
read moreAC Q9UDG3;
DT 11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 11-FEB-2002, sequence version 2.
DT 22-JAN-2014, entry version 102.
DE RecName: Full=Small proline-rich protein 3;
DE AltName: Full=22 kDa pancornulin;
DE AltName: Full=Cornifin beta;
DE AltName: Full=Esophagin;
GN Name=SPRR3; Synonyms=SPRC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Peripheral blood;
RX PubMed=8325635; DOI=10.1006/geno.1993.1240;
RA Gibbs S., Fijneman R., Wiegant J., Geurts van Kessel A.,
RA van de Putte P., Backendorf C.;
RT "Molecular characterization and evolution of the SPRR family of
RT keratinocyte differentiation markers encoding small proline-rich
RT proteins.";
RL Genomics 16:630-637(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8018055; DOI=10.1016/0003-9969(94)90051-5;
RA Robinson P.A., Marley J.J., High A.S., Hume W.J.;
RT "Differential expression of protease inhibitor and small proline-rich
RT protein genes between normal human oral tissue and odontogenic
RT keratocysts.";
RL Arch. Oral Biol. 39:251-259(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8809402;
RA Abraham J.M., Wang S., Suzuki H., Jiang H.Y., Rosenblum-Vos L.S.,
RA Yin J., Meltzer S.J.;
RT "Esophagin cDNA cloning and characterization: a tissue-specific member
RT of the small proline-rich protein family that is not expressed in
RT esophageal tumors.";
RL Cell Growth Differ. 7:855-860(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11230159; DOI=10.1101/gr.114801;
RA Marenholz I., Zirra M., Fischer D.F., Backendorf C., Ziegler A.,
RA Mischke D.;
RT "Identification of human epidermal differentiation complex (EDC)-
RT encoded genes by subtractive hybridization of entire YACs to a gridded
RT keratinocyte cDNA library.";
RL Genome Res. 11:341-355(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA], MASS SPECTROMETRY, CLEAVAGE OF INITIATOR
RP METHIONINE, ACETYLATION AT SER-2, AND VARIANTS DEL 98-CYS--PRO-104 AND
RP VAL-149.
RC TISSUE=Oral mucosa, Parotid gland, Saliva, and Submandibular gland;
RX PubMed=20599699; DOI=10.1016/j.bbrc.2010.06.103;
RA Manconi B., Cabras T., Pisano E., Nemolato S., Inzitari R.,
RA Iavarone F., Fanali C., Sanna M.T., Tirone C., Vento G., Romagnoli C.,
RA Faa G., Castagnola M., Messana I.;
RT "Characterization of two isoforms of human SPRR3 from saliva of
RT preterm human newborn and autoptic fetal oral mucosa, parotid and
RT submandibular gland samples.";
RL Biochem. Biophys. Res. Commun. 398:477-481(2010).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-149.
RG NIEHS SNPs program;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-149.
RC TISSUE=Skeletal muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [12]
RP PROTEIN SEQUENCE OF 8-40 AND 140-165.
RC TISSUE=Keratinocyte;
RX PubMed=7829876; DOI=10.1111/1523-1747.ep12612759;
RA Greco M.A., Lorand L., Lane W.S., Baden H.P., Parameswaran K.N.P.,
RA Kvedar J.C.;
RT "The pancornulins: a group of small proline rich-related cornified
RT envelope precursors with bifunctional capabilities in isopeptide bond
RT formation.";
RL J. Invest. Dermatol. 104:204-210(1995).
CC -!- FUNCTION: Cross-linked envelope protein of keratinocytes.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- INDUCTION: During squamous differentiation of epidermal
CC keratinocytes.
CC -!- MASS SPECTROMETRY: Mass=17239; Method=Electrospray; Range=2-169;
CC Note=Variants Del 98-Cys--Pro-105 and Val-149;
CC Source=PubMed:20599699;
CC -!- MASS SPECTROMETRY: Mass=18065; Method=Electrospray; Range=2-169;
CC Source=PubMed:20599699;
CC -!- SIMILARITY: Belongs to the cornifin (SPRR) family.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/sprr3/";
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DR EMBL; AF077374; AAD11938.1; -; Genomic_DNA.
DR EMBL; AY118269; AAM74559.1; -; mRNA.
DR EMBL; AJ243667; CAB65098.1; -; mRNA.
DR EMBL; DQ017955; AAY26394.1; -; Genomic_DNA.
DR EMBL; AK311823; BAG34765.1; -; mRNA.
DR EMBL; EF553525; ABQ66270.1; -; mRNA.
DR EMBL; AL356867; CAI19803.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53353.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53354.1; -; Genomic_DNA.
DR EMBL; BC017802; AAH17802.1; -; mRNA.
DR RefSeq; NP_001091058.1; NM_001097589.1.
DR RefSeq; NP_005407.1; NM_005416.2.
DR UniGene; Hs.139322; -.
DR ProteinModelPortal; Q9UBC9; -.
DR STRING; 9606.ENSP00000295367; -.
DR PhosphoSite; Q9UBC9; -.
DR DMDM; 20138065; -.
DR PaxDb; Q9UBC9; -.
DR PeptideAtlas; Q9UBC9; -.
DR PRIDE; Q9UBC9; -.
DR Ensembl; ENST00000295367; ENSP00000295367; ENSG00000163209.
DR Ensembl; ENST00000331860; ENSP00000330391; ENSG00000163209.
DR GeneID; 6707; -.
DR KEGG; hsa:6707; -.
DR UCSC; uc001fax.4; human.
DR CTD; 6707; -.
DR GeneCards; GC01P152974; -.
DR H-InvDB; HIX0001078; -.
DR HGNC; HGNC:11268; SPRR3.
DR HPA; HPA044467; -.
DR MIM; 182271; gene.
DR neXtProt; NX_Q9UBC9; -.
DR PharmGKB; PA36097; -.
DR eggNOG; NOG39062; -.
DR HOVERGEN; HBG079213; -.
DR InParanoid; Q9UBC9; -.
DR OMA; PGHTKVP; -.
DR PhylomeDB; Q9UBC9; -.
DR GeneWiki; SPRR3; -.
DR GenomeRNAi; 6707; -.
DR NextBio; 26152; -.
DR PRO; PR:Q9UBC9; -.
DR ArrayExpress; Q9UBC9; -.
DR Bgee; Q9UBC9; -.
DR CleanEx; HS_SPRR3; -.
DR Genevestigator; Q9UBC9; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; TAS:UniProtKB.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0030216; P:keratinocyte differentiation; NAS:UniProtKB.
DR GO; GO:0018149; P:peptide cross-linking; IEA:InterPro.
DR GO; GO:0042060; P:wound healing; TAS:UniProtKB.
DR InterPro; IPR003302; Cornifin.
DR InterPro; IPR026075; SPRR/LCE.
DR PANTHER; PTHR23263; PTHR23263; 1.
DR Pfam; PF02389; Cornifin; 2.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing;
KW Keratinization; Polymorphism; Reference proteome; Repeat.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 169 Small proline-rich protein 3.
FT /FTId=PRO_0000150003.
FT REPEAT 43 50 1.
FT REPEAT 51 58 2.
FT REPEAT 59 66 3.
FT REPEAT 67 74 4.
FT REPEAT 75 82 5.
FT REPEAT 83 90 6.
FT REPEAT 91 98 7.
FT REPEAT 99 106 8.
FT REPEAT 107 114 9.
FT REPEAT 115 122 10.
FT REPEAT 123 130 11.
FT REPEAT 131 138 12.
FT REPEAT 139 146 13.
FT REPEAT 147 154 14.
FT REGION 43 154 14 X 8 AA approximate tandem repeats.
FT MOD_RES 2 2 N-acetylserine.
FT VARIANT 98 105 Missing.
FT /FTId=VAR_065255.
FT VARIANT 149 149 L -> V (in dbSNP:rs1055935).
FT /FTId=VAR_023377.
FT VARIANT 156 156 T -> M (in dbSNP:rs2075740).
FT /FTId=VAR_053048.
FT CONFLICT 19 19 Q -> H (in Ref. 3; AAM74559).
FT CONFLICT 61 68 Missing (in Ref. 2; no nucleotide entry,
FT 4; CAB65098 and 9; AAH17802).
SQ SEQUENCE 169 AA; 18154 MW; B8E522AF798F1ECB CRC64;
MSSYQQKQTF TPPPQLQQQQ VKQPSQPPPQ EIFVPTTKEP CHSKVPQPGN TKIPEPGCTK
VPEPGCTKVP EPGCTKVPEP GCTKVPEPGC TKVPEPGCTK VPEPGYTKVP EPGSIKVPDQ
GFIKFPEPGA IKVPEQGYTK VPVPGYTKLP EPCPSTVTPG PAQQKTKQK
//
ID SPRR3_HUMAN Reviewed; 169 AA.
AC Q9UBC9; A5YKK8; B2R4G8; D3DV32; O75597; Q4ZGI7; Q5T525; Q8NET7;
read moreAC Q9UDG3;
DT 11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 11-FEB-2002, sequence version 2.
DT 22-JAN-2014, entry version 102.
DE RecName: Full=Small proline-rich protein 3;
DE AltName: Full=22 kDa pancornulin;
DE AltName: Full=Cornifin beta;
DE AltName: Full=Esophagin;
GN Name=SPRR3; Synonyms=SPRC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Peripheral blood;
RX PubMed=8325635; DOI=10.1006/geno.1993.1240;
RA Gibbs S., Fijneman R., Wiegant J., Geurts van Kessel A.,
RA van de Putte P., Backendorf C.;
RT "Molecular characterization and evolution of the SPRR family of
RT keratinocyte differentiation markers encoding small proline-rich
RT proteins.";
RL Genomics 16:630-637(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8018055; DOI=10.1016/0003-9969(94)90051-5;
RA Robinson P.A., Marley J.J., High A.S., Hume W.J.;
RT "Differential expression of protease inhibitor and small proline-rich
RT protein genes between normal human oral tissue and odontogenic
RT keratocysts.";
RL Arch. Oral Biol. 39:251-259(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8809402;
RA Abraham J.M., Wang S., Suzuki H., Jiang H.Y., Rosenblum-Vos L.S.,
RA Yin J., Meltzer S.J.;
RT "Esophagin cDNA cloning and characterization: a tissue-specific member
RT of the small proline-rich protein family that is not expressed in
RT esophageal tumors.";
RL Cell Growth Differ. 7:855-860(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11230159; DOI=10.1101/gr.114801;
RA Marenholz I., Zirra M., Fischer D.F., Backendorf C., Ziegler A.,
RA Mischke D.;
RT "Identification of human epidermal differentiation complex (EDC)-
RT encoded genes by subtractive hybridization of entire YACs to a gridded
RT keratinocyte cDNA library.";
RL Genome Res. 11:341-355(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA], MASS SPECTROMETRY, CLEAVAGE OF INITIATOR
RP METHIONINE, ACETYLATION AT SER-2, AND VARIANTS DEL 98-CYS--PRO-104 AND
RP VAL-149.
RC TISSUE=Oral mucosa, Parotid gland, Saliva, and Submandibular gland;
RX PubMed=20599699; DOI=10.1016/j.bbrc.2010.06.103;
RA Manconi B., Cabras T., Pisano E., Nemolato S., Inzitari R.,
RA Iavarone F., Fanali C., Sanna M.T., Tirone C., Vento G., Romagnoli C.,
RA Faa G., Castagnola M., Messana I.;
RT "Characterization of two isoforms of human SPRR3 from saliva of
RT preterm human newborn and autoptic fetal oral mucosa, parotid and
RT submandibular gland samples.";
RL Biochem. Biophys. Res. Commun. 398:477-481(2010).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-149.
RG NIEHS SNPs program;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-149.
RC TISSUE=Skeletal muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [12]
RP PROTEIN SEQUENCE OF 8-40 AND 140-165.
RC TISSUE=Keratinocyte;
RX PubMed=7829876; DOI=10.1111/1523-1747.ep12612759;
RA Greco M.A., Lorand L., Lane W.S., Baden H.P., Parameswaran K.N.P.,
RA Kvedar J.C.;
RT "The pancornulins: a group of small proline rich-related cornified
RT envelope precursors with bifunctional capabilities in isopeptide bond
RT formation.";
RL J. Invest. Dermatol. 104:204-210(1995).
CC -!- FUNCTION: Cross-linked envelope protein of keratinocytes.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- INDUCTION: During squamous differentiation of epidermal
CC keratinocytes.
CC -!- MASS SPECTROMETRY: Mass=17239; Method=Electrospray; Range=2-169;
CC Note=Variants Del 98-Cys--Pro-105 and Val-149;
CC Source=PubMed:20599699;
CC -!- MASS SPECTROMETRY: Mass=18065; Method=Electrospray; Range=2-169;
CC Source=PubMed:20599699;
CC -!- SIMILARITY: Belongs to the cornifin (SPRR) family.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/sprr3/";
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DR EMBL; AF077374; AAD11938.1; -; Genomic_DNA.
DR EMBL; AY118269; AAM74559.1; -; mRNA.
DR EMBL; AJ243667; CAB65098.1; -; mRNA.
DR EMBL; DQ017955; AAY26394.1; -; Genomic_DNA.
DR EMBL; AK311823; BAG34765.1; -; mRNA.
DR EMBL; EF553525; ABQ66270.1; -; mRNA.
DR EMBL; AL356867; CAI19803.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53353.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW53354.1; -; Genomic_DNA.
DR EMBL; BC017802; AAH17802.1; -; mRNA.
DR RefSeq; NP_001091058.1; NM_001097589.1.
DR RefSeq; NP_005407.1; NM_005416.2.
DR UniGene; Hs.139322; -.
DR ProteinModelPortal; Q9UBC9; -.
DR STRING; 9606.ENSP00000295367; -.
DR PhosphoSite; Q9UBC9; -.
DR DMDM; 20138065; -.
DR PaxDb; Q9UBC9; -.
DR PeptideAtlas; Q9UBC9; -.
DR PRIDE; Q9UBC9; -.
DR Ensembl; ENST00000295367; ENSP00000295367; ENSG00000163209.
DR Ensembl; ENST00000331860; ENSP00000330391; ENSG00000163209.
DR GeneID; 6707; -.
DR KEGG; hsa:6707; -.
DR UCSC; uc001fax.4; human.
DR CTD; 6707; -.
DR GeneCards; GC01P152974; -.
DR H-InvDB; HIX0001078; -.
DR HGNC; HGNC:11268; SPRR3.
DR HPA; HPA044467; -.
DR MIM; 182271; gene.
DR neXtProt; NX_Q9UBC9; -.
DR PharmGKB; PA36097; -.
DR eggNOG; NOG39062; -.
DR HOVERGEN; HBG079213; -.
DR InParanoid; Q9UBC9; -.
DR OMA; PGHTKVP; -.
DR PhylomeDB; Q9UBC9; -.
DR GeneWiki; SPRR3; -.
DR GenomeRNAi; 6707; -.
DR NextBio; 26152; -.
DR PRO; PR:Q9UBC9; -.
DR ArrayExpress; Q9UBC9; -.
DR Bgee; Q9UBC9; -.
DR CleanEx; HS_SPRR3; -.
DR Genevestigator; Q9UBC9; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; TAS:UniProtKB.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0030216; P:keratinocyte differentiation; NAS:UniProtKB.
DR GO; GO:0018149; P:peptide cross-linking; IEA:InterPro.
DR GO; GO:0042060; P:wound healing; TAS:UniProtKB.
DR InterPro; IPR003302; Cornifin.
DR InterPro; IPR026075; SPRR/LCE.
DR PANTHER; PTHR23263; PTHR23263; 1.
DR Pfam; PF02389; Cornifin; 2.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing;
KW Keratinization; Polymorphism; Reference proteome; Repeat.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 169 Small proline-rich protein 3.
FT /FTId=PRO_0000150003.
FT REPEAT 43 50 1.
FT REPEAT 51 58 2.
FT REPEAT 59 66 3.
FT REPEAT 67 74 4.
FT REPEAT 75 82 5.
FT REPEAT 83 90 6.
FT REPEAT 91 98 7.
FT REPEAT 99 106 8.
FT REPEAT 107 114 9.
FT REPEAT 115 122 10.
FT REPEAT 123 130 11.
FT REPEAT 131 138 12.
FT REPEAT 139 146 13.
FT REPEAT 147 154 14.
FT REGION 43 154 14 X 8 AA approximate tandem repeats.
FT MOD_RES 2 2 N-acetylserine.
FT VARIANT 98 105 Missing.
FT /FTId=VAR_065255.
FT VARIANT 149 149 L -> V (in dbSNP:rs1055935).
FT /FTId=VAR_023377.
FT VARIANT 156 156 T -> M (in dbSNP:rs2075740).
FT /FTId=VAR_053048.
FT CONFLICT 19 19 Q -> H (in Ref. 3; AAM74559).
FT CONFLICT 61 68 Missing (in Ref. 2; no nucleotide entry,
FT 4; CAB65098 and 9; AAH17802).
SQ SEQUENCE 169 AA; 18154 MW; B8E522AF798F1ECB CRC64;
MSSYQQKQTF TPPPQLQQQQ VKQPSQPPPQ EIFVPTTKEP CHSKVPQPGN TKIPEPGCTK
VPEPGCTKVP EPGCTKVPEP GCTKVPEPGC TKVPEPGCTK VPEPGYTKVP EPGSIKVPDQ
GFIKFPEPGA IKVPEQGYTK VPVPGYTKLP EPCPSTVTPG PAQQKTKQK
//
MIM
182271
*RECORD*
*FIELD* NO
182271
*FIELD* TI
*182271 SMALL PROLINE-RICH PROTEIN 3; SPRR3
*FIELD* TX
See 182265. Gibbs et al. (1993) concluded that there is a single gene
read morefor the SPRR3 subfamily of small proline-rich proteins. All SPRR genes
are closely linked within a 300-kb DNA segment on 1q21-q22.
*FIELD* RF
1. Gibbs, S.; Fijneman, R.; Wiegant, J.; Geurts van Kessel, A.; van
de Putte, P.; Backendorf, C.: Molecular characterization and evolution
of the SPRR family of keratinocyte differentiation markers encoding
small proline-rich proteins. Genomics 16: 630-637, 1993.
*FIELD* CD
Victor A. McKusick: 6/18/1993
*FIELD* ED
terry: 7/11/1994
carol: 6/18/1993
*RECORD*
*FIELD* NO
182271
*FIELD* TI
*182271 SMALL PROLINE-RICH PROTEIN 3; SPRR3
*FIELD* TX
See 182265. Gibbs et al. (1993) concluded that there is a single gene
read morefor the SPRR3 subfamily of small proline-rich proteins. All SPRR genes
are closely linked within a 300-kb DNA segment on 1q21-q22.
*FIELD* RF
1. Gibbs, S.; Fijneman, R.; Wiegant, J.; Geurts van Kessel, A.; van
de Putte, P.; Backendorf, C.: Molecular characterization and evolution
of the SPRR family of keratinocyte differentiation markers encoding
small proline-rich proteins. Genomics 16: 630-637, 1993.
*FIELD* CD
Victor A. McKusick: 6/18/1993
*FIELD* ED
terry: 7/11/1994
carol: 6/18/1993