Full text data of STX8
STX8
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Syntaxin-8
Syntaxin-8
UniProt
Q9UNK0
ID STX8_HUMAN Reviewed; 236 AA.
AC Q9UNK0; O60712; Q53XT8;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2000, sequence version 2.
DT 22-JAN-2014, entry version 122.
DE RecName: Full=Syntaxin-8;
GN Name=STX8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9852078; DOI=10.1074/jbc.273.51.34171;
RA Steegmaier M., Yang B., Yoo J.-S., Huang B., Shen M., Yu S., Luo Y.,
RA Scheller R.H.;
RT "Three novel proteins of the syntaxin/SNAP-25 family.";
RL J. Biol. Chem. 273:34171-34179(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RX PubMed=10198254; DOI=10.1006/bbrc.1999.0503;
RA Thoreau V., Berges T., Callebaut I., Guillier-Gencik Z., Gressin L.,
RA Bernheim A., Karst F., Mornon J.-P., Kitzis A., Chomel J.-C.;
RT "Molecular cloning, expression analysis, and chromosomal localization
RT of human syntaxin 8 (STX8).";
RL Biochem. Biophys. Res. Commun. 257:577-583(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Subramaniam V.N., Loh E., Hong W.;
RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Vesicle trafficking protein that functions in the early
CC secretory pathway, possibly by mediating retrograde transport from
CC cis-Golgi membranes to the ER.
CC -!- SUBUNIT: Forms a SNARE complex with STX7, VTI1B and VAMP8 which
CC functions in the homotypic fusion of late endosomes. Part of the
CC SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts
CC with VAMP8 (By similarity). Interacts with HECTD3 (By similarity).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane
CC protein (By similarity). Note=Preferentially associated with the
CC early endosome. To lesser extends, also present in late endosome,
CC the plasma membrane and coated pits (By similarity).
CC -!- TISSUE SPECIFICITY: Highly expressed in heart. Also found in
CC brain, kidney, liver, lung, placenta, skeletal muscle, spleen and
CC pancreas.
CC -!- PTM: Ubiquitinated by HECTD3 (By similarity).
CC -!- SIMILARITY: Belongs to the syntaxin family.
CC -!- SIMILARITY: Contains 1 t-SNARE coiled-coil homology domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF115323; AAD20831.1; -; mRNA.
DR EMBL; AF062077; AAC36466.1; -; mRNA.
DR EMBL; AF036715; AAC95285.1; -; mRNA.
DR EMBL; BT007319; AAP35983.1; -; mRNA.
DR EMBL; CH471108; EAW90029.1; -; Genomic_DNA.
DR EMBL; BC009713; AAH09713.1; -; mRNA.
DR RefSeq; NP_004844.1; NM_004853.2.
DR UniGene; Hs.431109; -.
DR ProteinModelPortal; Q9UNK0; -.
DR SMR; Q9UNK0; 152-204.
DR DIP; DIP-47274N; -.
DR IntAct; Q9UNK0; 15.
DR MINT; MINT-1396123; -.
DR STRING; 9606.ENSP00000305255; -.
DR PhosphoSite; Q9UNK0; -.
DR DMDM; 9297054; -.
DR PaxDb; Q9UNK0; -.
DR PRIDE; Q9UNK0; -.
DR DNASU; 9482; -.
DR Ensembl; ENST00000306357; ENSP00000305255; ENSG00000170310.
DR GeneID; 9482; -.
DR KEGG; hsa:9482; -.
DR UCSC; uc002glx.3; human.
DR CTD; 9482; -.
DR GeneCards; GC17M009153; -.
DR HGNC; HGNC:11443; STX8.
DR HPA; HPA001540; -.
DR MIM; 604203; gene.
DR neXtProt; NX_Q9UNK0; -.
DR PharmGKB; PA36240; -.
DR eggNOG; NOG259218; -.
DR HOGENOM; HOG000031515; -.
DR HOVERGEN; HBG007572; -.
DR InParanoid; Q9UNK0; -.
DR KO; K08501; -.
DR OMA; NQYERNG; -.
DR PhylomeDB; Q9UNK0; -.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_13685; Neuronal System.
DR ChiTaRS; STX8; human.
DR GeneWiki; STX8; -.
DR GenomeRNAi; 9482; -.
DR NextBio; 35540; -.
DR PRO; PR:Q9UNK0; -.
DR ArrayExpress; Q9UNK0; -.
DR Bgee; Q9UNK0; -.
DR CleanEx; HS_STX8; -.
DR Genevestigator; Q9UNK0; -.
DR GO; GO:0005783; C:endoplasmic reticulum; TAS:ProtInc.
DR GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR GO; GO:0031902; C:late endosome membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0031201; C:SNARE complex; IBA:RefGenome.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:RefGenome.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IBA:RefGenome.
DR GO; GO:0006906; P:vesicle fusion; IBA:RefGenome.
DR InterPro; IPR015640; Syntax_8.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR12380:SF6; PTHR12380:SF6; 1.
DR Pfam; PF05739; SNARE; 1.
DR SMART; SM00397; t_SNARE; 1.
DR PROSITE; PS00914; SYNTAXIN; FALSE_NEG.
DR PROSITE; PS50192; T_SNARE; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Complete proteome; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW Ubl conjugation.
FT CHAIN 1 236 Syntaxin-8.
FT /FTId=PRO_0000210217.
FT TOPO_DOM 1 215 Cytoplasmic (Potential).
FT TRANSMEM 216 232 Helical; Anchor for type IV membrane
FT protein; (Potential).
FT TOPO_DOM 233 236 Vesicular (Potential).
FT DOMAIN 145 207 t-SNARE coiled-coil homology.
FT COILED 42 65 Potential.
FT MOD_RES 160 160 Phosphoserine (By similarity).
FT CONFLICT 78 78 R -> Q (in Ref. 1; AAD20831).
SQ SEQUENCE 236 AA; 26907 MW; 1E64A0DA77584CC4 CRC64;
MAPDPWFSTY DSTCQIAQEI AEKIQQRNQY ERKGEKAPKL TVTIRALLQN LKEKIALLKD
LLLRAVSTHQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE GAEPDLIRSS LMSEEAKRGA
PNPWLFEEPE ETRGLGFDEI RQQQQKIIQE QDAGLDALSS IISRQKQMGQ EIGNELDEQN
EIIDDLANLV ENTDEKLRNE TRRVNMVDRK SASCGMIMVI LLLLVAIVVV AVWPTN
//
ID STX8_HUMAN Reviewed; 236 AA.
AC Q9UNK0; O60712; Q53XT8;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2000, sequence version 2.
DT 22-JAN-2014, entry version 122.
DE RecName: Full=Syntaxin-8;
GN Name=STX8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9852078; DOI=10.1074/jbc.273.51.34171;
RA Steegmaier M., Yang B., Yoo J.-S., Huang B., Shen M., Yu S., Luo Y.,
RA Scheller R.H.;
RT "Three novel proteins of the syntaxin/SNAP-25 family.";
RL J. Biol. Chem. 273:34171-34179(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lung;
RX PubMed=10198254; DOI=10.1006/bbrc.1999.0503;
RA Thoreau V., Berges T., Callebaut I., Guillier-Gencik Z., Gressin L.,
RA Bernheim A., Karst F., Mornon J.-P., Kitzis A., Chomel J.-C.;
RT "Molecular cloning, expression analysis, and chromosomal localization
RT of human syntaxin 8 (STX8).";
RL Biochem. Biophys. Res. Commun. 257:577-583(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Subramaniam V.N., Loh E., Hong W.;
RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Vesicle trafficking protein that functions in the early
CC secretory pathway, possibly by mediating retrograde transport from
CC cis-Golgi membranes to the ER.
CC -!- SUBUNIT: Forms a SNARE complex with STX7, VTI1B and VAMP8 which
CC functions in the homotypic fusion of late endosomes. Part of the
CC SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts
CC with VAMP8 (By similarity). Interacts with HECTD3 (By similarity).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane
CC protein (By similarity). Note=Preferentially associated with the
CC early endosome. To lesser extends, also present in late endosome,
CC the plasma membrane and coated pits (By similarity).
CC -!- TISSUE SPECIFICITY: Highly expressed in heart. Also found in
CC brain, kidney, liver, lung, placenta, skeletal muscle, spleen and
CC pancreas.
CC -!- PTM: Ubiquitinated by HECTD3 (By similarity).
CC -!- SIMILARITY: Belongs to the syntaxin family.
CC -!- SIMILARITY: Contains 1 t-SNARE coiled-coil homology domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF115323; AAD20831.1; -; mRNA.
DR EMBL; AF062077; AAC36466.1; -; mRNA.
DR EMBL; AF036715; AAC95285.1; -; mRNA.
DR EMBL; BT007319; AAP35983.1; -; mRNA.
DR EMBL; CH471108; EAW90029.1; -; Genomic_DNA.
DR EMBL; BC009713; AAH09713.1; -; mRNA.
DR RefSeq; NP_004844.1; NM_004853.2.
DR UniGene; Hs.431109; -.
DR ProteinModelPortal; Q9UNK0; -.
DR SMR; Q9UNK0; 152-204.
DR DIP; DIP-47274N; -.
DR IntAct; Q9UNK0; 15.
DR MINT; MINT-1396123; -.
DR STRING; 9606.ENSP00000305255; -.
DR PhosphoSite; Q9UNK0; -.
DR DMDM; 9297054; -.
DR PaxDb; Q9UNK0; -.
DR PRIDE; Q9UNK0; -.
DR DNASU; 9482; -.
DR Ensembl; ENST00000306357; ENSP00000305255; ENSG00000170310.
DR GeneID; 9482; -.
DR KEGG; hsa:9482; -.
DR UCSC; uc002glx.3; human.
DR CTD; 9482; -.
DR GeneCards; GC17M009153; -.
DR HGNC; HGNC:11443; STX8.
DR HPA; HPA001540; -.
DR MIM; 604203; gene.
DR neXtProt; NX_Q9UNK0; -.
DR PharmGKB; PA36240; -.
DR eggNOG; NOG259218; -.
DR HOGENOM; HOG000031515; -.
DR HOVERGEN; HBG007572; -.
DR InParanoid; Q9UNK0; -.
DR KO; K08501; -.
DR OMA; NQYERNG; -.
DR PhylomeDB; Q9UNK0; -.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_13685; Neuronal System.
DR ChiTaRS; STX8; human.
DR GeneWiki; STX8; -.
DR GenomeRNAi; 9482; -.
DR NextBio; 35540; -.
DR PRO; PR:Q9UNK0; -.
DR ArrayExpress; Q9UNK0; -.
DR Bgee; Q9UNK0; -.
DR CleanEx; HS_STX8; -.
DR Genevestigator; Q9UNK0; -.
DR GO; GO:0005783; C:endoplasmic reticulum; TAS:ProtInc.
DR GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
DR GO; GO:0031902; C:late endosome membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0031201; C:SNARE complex; IBA:RefGenome.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:RefGenome.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IBA:RefGenome.
DR GO; GO:0006906; P:vesicle fusion; IBA:RefGenome.
DR InterPro; IPR015640; Syntax_8.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR12380:SF6; PTHR12380:SF6; 1.
DR Pfam; PF05739; SNARE; 1.
DR SMART; SM00397; t_SNARE; 1.
DR PROSITE; PS00914; SYNTAXIN; FALSE_NEG.
DR PROSITE; PS50192; T_SNARE; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Complete proteome; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW Ubl conjugation.
FT CHAIN 1 236 Syntaxin-8.
FT /FTId=PRO_0000210217.
FT TOPO_DOM 1 215 Cytoplasmic (Potential).
FT TRANSMEM 216 232 Helical; Anchor for type IV membrane
FT protein; (Potential).
FT TOPO_DOM 233 236 Vesicular (Potential).
FT DOMAIN 145 207 t-SNARE coiled-coil homology.
FT COILED 42 65 Potential.
FT MOD_RES 160 160 Phosphoserine (By similarity).
FT CONFLICT 78 78 R -> Q (in Ref. 1; AAD20831).
SQ SEQUENCE 236 AA; 26907 MW; 1E64A0DA77584CC4 CRC64;
MAPDPWFSTY DSTCQIAQEI AEKIQQRNQY ERKGEKAPKL TVTIRALLQN LKEKIALLKD
LLLRAVSTHQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE GAEPDLIRSS LMSEEAKRGA
PNPWLFEEPE ETRGLGFDEI RQQQQKIIQE QDAGLDALSS IISRQKQMGQ EIGNELDEQN
EIIDDLANLV ENTDEKLRNE TRRVNMVDRK SASCGMIMVI LLLLVAIVVV AVWPTN
//
MIM
604203
*RECORD*
*FIELD* NO
604203
*FIELD* TI
*604203 SYNTAXIN 8; STX8
*FIELD* TX
Most membrane fusion events in eukaryotic cells are mediated by SNARE
read moreproteins on the vesicle (v-SNAREs) and on the target membrane (t-SNAREs
or syntaxins). See alpha-SNAP (603215). By searching an EST database,
Steegmaier et al. (1998) identified mouse and human cDNAs encoding
syntaxin-8. The predicted 236-amino acid human protein shares 23%
identity with syntaxin-6 (603944). Like other syntaxins, syntaxin-8 is
anchored to membranes by a C-terminal hydrophobic domain and appears to
contain a helical domain involved in the formation of a SNARE complex
(see SNAP29, 604202). Northern blot analysis revealed that syntaxin-8
was expressed as a 1.3-kb mRNA in all human tissues tested, with the
highest levels in heart. When expressed in mammalian cells, syntaxin-8
colocalized with markers of the endoplasmic reticulum (ER). Steegmaier
et al. (1998) concluded that syntaxin-8 functions as a vesicle
trafficking protein in the early secretory pathway, possibly mediating
retrograde transport from cis-Golgi membranes to the ER. Independently,
Thoreau et al. (1999) isolated syntaxin-8 as a protein that interacted
with the regulatory (R) domain of the CFTR (602421) protein in a yeast
2-hybrid screen.
By analysis of somatic cell hybrids and by fluorescence in situ
hybridization, Thoreau et al. (1999) mapped the syntaxin-8 gene to
17p12.
*FIELD* RF
1. Steegmaier, M.; Yang, B.; Yoo, J.-S.; Huang, B.; Shen, M.; Yu,
S.; Luo, Y.; Scheller, R. H.: Three novel proteins of the syntaxin/SNAP-25
family. J. Biol. Chem. 273: 34171-34179, 1998.
2. Thoreau, V.; Berges, T.; Callebaut, I.; Guillier-Gencik, Z.; Gressin,
L.; Bernheim, A.; Karst, F.; Mornon, J.-P.; Kitzis, A.; Chomel, J.-C.
: Molecular cloning, expression analysis, and chromosomal localization
of human syntaxin 8 (STX8). Biochem. Biophys. Res. Commun. 257:
577-583, 1999.
*FIELD* CD
Rebekah S. Rasooly: 9/29/1999
*FIELD* ED
alopez: 09/29/1999
*RECORD*
*FIELD* NO
604203
*FIELD* TI
*604203 SYNTAXIN 8; STX8
*FIELD* TX
Most membrane fusion events in eukaryotic cells are mediated by SNARE
read moreproteins on the vesicle (v-SNAREs) and on the target membrane (t-SNAREs
or syntaxins). See alpha-SNAP (603215). By searching an EST database,
Steegmaier et al. (1998) identified mouse and human cDNAs encoding
syntaxin-8. The predicted 236-amino acid human protein shares 23%
identity with syntaxin-6 (603944). Like other syntaxins, syntaxin-8 is
anchored to membranes by a C-terminal hydrophobic domain and appears to
contain a helical domain involved in the formation of a SNARE complex
(see SNAP29, 604202). Northern blot analysis revealed that syntaxin-8
was expressed as a 1.3-kb mRNA in all human tissues tested, with the
highest levels in heart. When expressed in mammalian cells, syntaxin-8
colocalized with markers of the endoplasmic reticulum (ER). Steegmaier
et al. (1998) concluded that syntaxin-8 functions as a vesicle
trafficking protein in the early secretory pathway, possibly mediating
retrograde transport from cis-Golgi membranes to the ER. Independently,
Thoreau et al. (1999) isolated syntaxin-8 as a protein that interacted
with the regulatory (R) domain of the CFTR (602421) protein in a yeast
2-hybrid screen.
By analysis of somatic cell hybrids and by fluorescence in situ
hybridization, Thoreau et al. (1999) mapped the syntaxin-8 gene to
17p12.
*FIELD* RF
1. Steegmaier, M.; Yang, B.; Yoo, J.-S.; Huang, B.; Shen, M.; Yu,
S.; Luo, Y.; Scheller, R. H.: Three novel proteins of the syntaxin/SNAP-25
family. J. Biol. Chem. 273: 34171-34179, 1998.
2. Thoreau, V.; Berges, T.; Callebaut, I.; Guillier-Gencik, Z.; Gressin,
L.; Bernheim, A.; Karst, F.; Mornon, J.-P.; Kitzis, A.; Chomel, J.-C.
: Molecular cloning, expression analysis, and chromosomal localization
of human syntaxin 8 (STX8). Biochem. Biophys. Res. Commun. 257:
577-583, 1999.
*FIELD* CD
Rebekah S. Rasooly: 9/29/1999
*FIELD* ED
alopez: 09/29/1999