Full text data of TSC22D2
TSC22D2
(KIAA0669, TILZ4)
[Confidence: low (only semi-automatic identification from reviews)]
TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
O75157
ID T22D2_HUMAN Reviewed; 780 AA.
AC O75157; D3DNI5; Q6PI50; Q9H2Z6; Q9H2Z7; Q9H2Z8;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 29-MAR-2005, sequence version 3.
DT 22-JAN-2014, entry version 101.
DE RecName: Full=TSC22 domain family protein 2;
DE AltName: Full=TSC22-related-inducible leucine zipper protein 4;
GN Name=TSC22D2; Synonyms=KIAA0669, TILZ4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9734811; DOI=10.1093/dnares/5.3.169;
RA Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H.,
RA Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. X.
RT The complete sequences of 100 new cDNA clones from brain which can
RT code for large proteins in vitro.";
RL DNA Res. 5:169-176(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 544-780 (ISOFORMS 1 AND 2).
RA Ershler M.A., Belyavsky A.V., Visser J.W.M.;
RT "Identification and characterization of a family of leucine zipper
RT genes related to TSC22.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=TILZ4a, TILZ4c;
CC IsoId=O75157-1; Sequence=Displayed;
CC Name=2; Synonyms=TILZ4b;
CC IsoId=O75157-2; Sequence=VSP_013202;
CC -!- SIMILARITY: Belongs to the TSC-22/Dip/Bun family.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA31644.2; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB014569; BAA31644.2; ALT_INIT; mRNA.
DR EMBL; CH471052; EAW78838.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78839.1; -; Genomic_DNA.
DR EMBL; BC044643; AAH44643.1; -; mRNA.
DR EMBL; AF201290; AAG41223.1; -; mRNA.
DR EMBL; AF201291; AAG41224.1; -; mRNA.
DR EMBL; AF201292; AAG41225.1; -; mRNA.
DR PIR; T00366; T00366.
DR RefSeq; NP_055594.1; NM_014779.2.
DR RefSeq; XP_005247977.1; XM_005247920.1.
DR UniGene; Hs.722470; -.
DR UniGene; Hs.730710; -.
DR ProteinModelPortal; O75157; -.
DR SMR; O75157; 694-748.
DR IntAct; O75157; 2.
DR STRING; 9606.ENSP00000354543; -.
DR PhosphoSite; O75157; -.
DR PaxDb; O75157; -.
DR PRIDE; O75157; -.
DR Ensembl; ENST00000361136; ENSP00000354893; ENSG00000196428.
DR Ensembl; ENST00000361875; ENSP00000354543; ENSG00000196428.
DR GeneID; 9819; -.
DR KEGG; hsa:9819; -.
DR UCSC; uc003exv.3; human.
DR CTD; 9819; -.
DR GeneCards; GC03P150126; -.
DR H-InvDB; HIX0031086; -.
DR HGNC; HGNC:29095; TSC22D2.
DR HPA; HPA004926; -.
DR neXtProt; NX_O75157; -.
DR PharmGKB; PA142670697; -.
DR eggNOG; NOG263752; -.
DR HOGENOM; HOG000121773; -.
DR HOVERGEN; HBG060969; -.
DR InParanoid; O75157; -.
DR OMA; SMQGAHG; -.
DR OrthoDB; EOG7RZ5PT; -.
DR GenomeRNAi; 9819; -.
DR NextBio; 36982; -.
DR PRO; PR:O75157; -.
DR ArrayExpress; O75157; -.
DR Bgee; O75157; -.
DR CleanEx; HS_TSC22D2; -.
DR Genevestigator; O75157; -.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006970; P:response to osmotic stress; IEA:Ensembl.
DR InterPro; IPR000580; TSC-22_Dip_Bun.
DR PANTHER; PTHR12348; PTHR12348; 1.
DR Pfam; PF01166; TSC22; 1.
DR ProDom; PD007152; TSC-22_Dip_Bun; 1.
DR PROSITE; PS01289; TSC22; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Polymorphism;
KW Reference proteome.
FT CHAIN 1 780 TSC22 domain family protein 2.
FT /FTId=PRO_0000219369.
FT VAR_SEQ 653 676 Missing (in isoform 2).
FT /FTId=VSP_013202.
FT VARIANT 419 419 A -> T (in dbSNP:rs879634).
FT /FTId=VAR_052408.
SQ SEQUENCE 780 AA; 79228 MW; 5ED799E741944A01 CRC64;
MSKMPAKKKS CFQITSVTTA QVATSITEDT ESLDDPDESR TEDVSSEIFD VSRATDYGPE
EVCERSSSEE TLNNVGDAET PGTVSPNLLL DGQLAAAAAA PANGGGVVSA RSVSGALAST
LAAAATSAPA PGAPGGPQLA GSSAGPVTAA PSQPPTTCSS RFRVIKLDHG SGEPYRRGRW
TCMEYYERDS DSSVLTRSGD CIRHSSTFDQ TAERDSGLGA TGGSVVVVVA SMQGAHGPES
GTDSSLTAVS QLPPSEKMSQ PTPAQPQSFS VGQPQPPPPP VGGAVAQSSA PLPPFPGAAT
GPQPMMAAAQ PSQPQGAGPG GQTLPPTNVT LAQPAMSLPP QPGPAVGAPA AQQPQQFAYP
QPQIPPGHLL PVQPSGQSEY LQQHVAGLQP PSPAQPSSTG AAASPATAAT LPVGTGQNAS
SVGAQLMGAS SQPSEAMAPR TGPAQGGQVA PCQPTGVPPA TVGGVVQPCL GPAGAGQPQS
VPPPQMGGSG PLSAVPGGPH AVVPGVPNVP AAVPAPSVPS VSTTSVTMPN VPAPLAQSQQ
LSSHTPVSRS SSIIQHVGLP LAPGTHSAPT SLPQSDLSQF QTQTQPLVGQ VDDTRRKSEP
LPQPPLSLIA ENKPVVKPPV ADSLANPLQL TPMNSLATSV FSIAIPVDGD EDRNPSTAFY
QAFHLNTLKE SKSLWDSASG GGVVAIDNKI EQAMDLVKSH LMYAVREEVE VLKEQIKELV
ERNSLLEREN ALLKSLSSND QLSQLPTQQA NPGSTSQQQA VIAQPPQPTQ PPQQPNVSSA
//
ID T22D2_HUMAN Reviewed; 780 AA.
AC O75157; D3DNI5; Q6PI50; Q9H2Z6; Q9H2Z7; Q9H2Z8;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 29-MAR-2005, sequence version 3.
DT 22-JAN-2014, entry version 101.
DE RecName: Full=TSC22 domain family protein 2;
DE AltName: Full=TSC22-related-inducible leucine zipper protein 4;
GN Name=TSC22D2; Synonyms=KIAA0669, TILZ4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9734811; DOI=10.1093/dnares/5.3.169;
RA Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H.,
RA Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. X.
RT The complete sequences of 100 new cDNA clones from brain which can
RT code for large proteins in vitro.";
RL DNA Res. 5:169-176(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 544-780 (ISOFORMS 1 AND 2).
RA Ershler M.A., Belyavsky A.V., Visser J.W.M.;
RT "Identification and characterization of a family of leucine zipper
RT genes related to TSC22.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=TILZ4a, TILZ4c;
CC IsoId=O75157-1; Sequence=Displayed;
CC Name=2; Synonyms=TILZ4b;
CC IsoId=O75157-2; Sequence=VSP_013202;
CC -!- SIMILARITY: Belongs to the TSC-22/Dip/Bun family.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA31644.2; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AB014569; BAA31644.2; ALT_INIT; mRNA.
DR EMBL; CH471052; EAW78838.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78839.1; -; Genomic_DNA.
DR EMBL; BC044643; AAH44643.1; -; mRNA.
DR EMBL; AF201290; AAG41223.1; -; mRNA.
DR EMBL; AF201291; AAG41224.1; -; mRNA.
DR EMBL; AF201292; AAG41225.1; -; mRNA.
DR PIR; T00366; T00366.
DR RefSeq; NP_055594.1; NM_014779.2.
DR RefSeq; XP_005247977.1; XM_005247920.1.
DR UniGene; Hs.722470; -.
DR UniGene; Hs.730710; -.
DR ProteinModelPortal; O75157; -.
DR SMR; O75157; 694-748.
DR IntAct; O75157; 2.
DR STRING; 9606.ENSP00000354543; -.
DR PhosphoSite; O75157; -.
DR PaxDb; O75157; -.
DR PRIDE; O75157; -.
DR Ensembl; ENST00000361136; ENSP00000354893; ENSG00000196428.
DR Ensembl; ENST00000361875; ENSP00000354543; ENSG00000196428.
DR GeneID; 9819; -.
DR KEGG; hsa:9819; -.
DR UCSC; uc003exv.3; human.
DR CTD; 9819; -.
DR GeneCards; GC03P150126; -.
DR H-InvDB; HIX0031086; -.
DR HGNC; HGNC:29095; TSC22D2.
DR HPA; HPA004926; -.
DR neXtProt; NX_O75157; -.
DR PharmGKB; PA142670697; -.
DR eggNOG; NOG263752; -.
DR HOGENOM; HOG000121773; -.
DR HOVERGEN; HBG060969; -.
DR InParanoid; O75157; -.
DR OMA; SMQGAHG; -.
DR OrthoDB; EOG7RZ5PT; -.
DR GenomeRNAi; 9819; -.
DR NextBio; 36982; -.
DR PRO; PR:O75157; -.
DR ArrayExpress; O75157; -.
DR Bgee; O75157; -.
DR CleanEx; HS_TSC22D2; -.
DR Genevestigator; O75157; -.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006970; P:response to osmotic stress; IEA:Ensembl.
DR InterPro; IPR000580; TSC-22_Dip_Bun.
DR PANTHER; PTHR12348; PTHR12348; 1.
DR Pfam; PF01166; TSC22; 1.
DR ProDom; PD007152; TSC-22_Dip_Bun; 1.
DR PROSITE; PS01289; TSC22; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Polymorphism;
KW Reference proteome.
FT CHAIN 1 780 TSC22 domain family protein 2.
FT /FTId=PRO_0000219369.
FT VAR_SEQ 653 676 Missing (in isoform 2).
FT /FTId=VSP_013202.
FT VARIANT 419 419 A -> T (in dbSNP:rs879634).
FT /FTId=VAR_052408.
SQ SEQUENCE 780 AA; 79228 MW; 5ED799E741944A01 CRC64;
MSKMPAKKKS CFQITSVTTA QVATSITEDT ESLDDPDESR TEDVSSEIFD VSRATDYGPE
EVCERSSSEE TLNNVGDAET PGTVSPNLLL DGQLAAAAAA PANGGGVVSA RSVSGALAST
LAAAATSAPA PGAPGGPQLA GSSAGPVTAA PSQPPTTCSS RFRVIKLDHG SGEPYRRGRW
TCMEYYERDS DSSVLTRSGD CIRHSSTFDQ TAERDSGLGA TGGSVVVVVA SMQGAHGPES
GTDSSLTAVS QLPPSEKMSQ PTPAQPQSFS VGQPQPPPPP VGGAVAQSSA PLPPFPGAAT
GPQPMMAAAQ PSQPQGAGPG GQTLPPTNVT LAQPAMSLPP QPGPAVGAPA AQQPQQFAYP
QPQIPPGHLL PVQPSGQSEY LQQHVAGLQP PSPAQPSSTG AAASPATAAT LPVGTGQNAS
SVGAQLMGAS SQPSEAMAPR TGPAQGGQVA PCQPTGVPPA TVGGVVQPCL GPAGAGQPQS
VPPPQMGGSG PLSAVPGGPH AVVPGVPNVP AAVPAPSVPS VSTTSVTMPN VPAPLAQSQQ
LSSHTPVSRS SSIIQHVGLP LAPGTHSAPT SLPQSDLSQF QTQTQPLVGQ VDDTRRKSEP
LPQPPLSLIA ENKPVVKPPV ADSLANPLQL TPMNSLATSV FSIAIPVDGD EDRNPSTAFY
QAFHLNTLKE SKSLWDSASG GGVVAIDNKI EQAMDLVKSH LMYAVREEVE VLKEQIKELV
ERNSLLEREN ALLKSLSSND QLSQLPTQQA NPGSTSQQQA VIAQPPQPTQ PPQQPNVSSA
//