Full text data of TAGLN2
TAGLN2
(KIAA0120)
[Confidence: low (only semi-automatic identification from reviews)]
Transgelin-2 (Epididymis tissue protein Li 7e; SM22-alpha homolog)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Transgelin-2 (Epididymis tissue protein Li 7e; SM22-alpha homolog)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
P37802
ID TAGL2_HUMAN Reviewed; 199 AA.
AC P37802; E9KL39; Q5JRQ6; Q5JRQ7; Q6FGI1; Q9BUH5; Q9H4P0;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 3.
DT 22-JAN-2014, entry version 142.
DE RecName: Full=Transgelin-2;
DE AltName: Full=Epididymis tissue protein Li 7e;
DE AltName: Full=SM22-alpha homolog;
GN Name=TAGLN2; Synonyms=KIAA0120; ORFNames=CDABP0035;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Leukemia;
RA Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A.,
RA Margolin J.F.;
RT "Pediatric leukemia cDNA sequencing project.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow;
RX PubMed=7788527; DOI=10.1093/dnares/2.1.37;
RA Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S.,
RA Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.;
RT "Prediction of the coding sequences of unidentified human genes. III.
RT The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by
RT analysis of cDNA clones from human cell line KG-1.";
RL DNA Res. 2:37-43(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Epididymis;
RX PubMed=20736409; DOI=10.1074/mcp.M110.001719;
RA Li J., Liu F., Wang H., Liu X., Liu J., Li N., Wan F., Wang W.,
RA Zhang C., Jin S., Liu J., Zhu P., Liu Y.;
RT "Systematic mapping and functional analysis of a family of human
RT epididymal secretory sperm-located proteins.";
RL Mol. Cell. Proteomics 9:2517-2528(2010).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
RA Korn B., Zuo D., Hu Y., LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-69.
RC TISSUE=Lymph, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP PROTEIN SEQUENCE OF 2-12.
RC TISSUE=Platelet;
RX PubMed=12665801; DOI=10.1038/nbt810;
RA Gevaert K., Goethals M., Martens L., Van Damme J., Staes A.,
RA Thomas G.R., Vandekerckhove J.;
RT "Exploring proteomes and analyzing protein processing by mass
RT spectrometric identification of sorted N-terminal peptides.";
RL Nat. Biotechnol. 21:566-569(2003).
RN [10]
RP PROTEIN SEQUENCE OF 2-12; 41-57; 79-154 AND 161-196, CLEAVAGE OF
RP INITIATOR METHIONINE, ACETYLATION AT ALA-2, AND MASS SPECTROMETRY.
RC TISSUE=Platelet;
RA Bienvenut W.V., Claeys D.;
RL Submitted (FEB-2006) to UniProtKB.
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, AND MASS
RP SPECTROMETRY.
RC TISSUE=Platelet;
RX PubMed=18088087; DOI=10.1021/pr0704130;
RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
RA Schuetz C., Walter U., Gambaryan S., Sickmann A.;
RT "Phosphoproteome of resting human platelets.";
RL J. Proteome Res. 7:526-534(2008).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [13]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [14]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, AND MASS
RP SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [15]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-17 AND LYS-20, AND MASS
RP SPECTROMETRY.
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA Walther T.C., Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [16]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [17]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [18]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, AND MASS
RP SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [19]
RP STRUCTURE BY NMR OF 16-157.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the CH domain of human transgelin-2.";
RL Submitted (AUG-2005) to the PDB data bank.
CC -!- INTERACTION:
CC P60709:ACTB; NbExp=3; IntAct=EBI-1056740, EBI-353944;
CC -!- TISSUE SPECIFICITY: Expressed in epididymis (at protein level).
CC -!- SIMILARITY: Belongs to the calponin family.
CC -!- SIMILARITY: Contains 1 calponin-like repeat.
CC -!- SIMILARITY: Contains 1 CH (calponin-homology) domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG01993.1; Type=Erroneous initiation;
CC Sequence=BAA04802.2; Type=Erroneous initiation;
CC Sequence=CAI14604.1; Type=Erroneous initiation;
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DR EMBL; AY007127; AAG01993.1; ALT_INIT; mRNA.
DR EMBL; D21261; BAA04802.2; ALT_INIT; mRNA.
DR EMBL; GU727636; ADU87638.1; -; mRNA.
DR EMBL; AK291562; BAF84251.1; -; mRNA.
DR EMBL; CR542126; CAG46923.1; -; mRNA.
DR EMBL; CR542136; CAG46933.1; -; mRNA.
DR EMBL; AL513485; CAI14603.1; -; Genomic_DNA.
DR EMBL; AL513485; CAI14604.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL513485; CAI14602.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW52760.1; -; Genomic_DNA.
DR EMBL; BC002616; AAH02616.1; -; mRNA.
DR EMBL; BC009357; AAH09357.1; -; mRNA.
DR RefSeq; NP_001264152.1; NM_001277223.1.
DR RefSeq; NP_001264153.1; NM_001277224.1.
DR RefSeq; NP_003555.1; NM_003564.2.
DR RefSeq; XP_005245590.1; XM_005245533.1.
DR RefSeq; XP_005245591.1; XM_005245534.1.
DR UniGene; Hs.517168; -.
DR PDB; 1WYM; NMR; -; A=16-157.
DR PDBsum; 1WYM; -.
DR ProteinModelPortal; P37802; -.
DR SMR; P37802; 9-158.
DR IntAct; P37802; 12.
DR MINT; MINT-5001664; -.
DR STRING; 9606.ENSP00000357075; -.
DR PhosphoSite; P37802; -.
DR DMDM; 586000; -.
DR DOSAC-COBS-2DPAGE; P37802; -.
DR OGP; P37802; -.
DR REPRODUCTION-2DPAGE; P37802; -.
DR PaxDb; P37802; -.
DR PRIDE; P37802; -.
DR DNASU; 8407; -.
DR Ensembl; ENST00000320307; ENSP00000357075; ENSG00000158710.
DR Ensembl; ENST00000368096; ENSP00000357076; ENSG00000158710.
DR Ensembl; ENST00000368097; ENSP00000357077; ENSG00000158710.
DR GeneID; 8407; -.
DR KEGG; hsa:8407; -.
DR UCSC; uc001fun.2; human.
DR CTD; 8407; -.
DR GeneCards; GC01M159887; -.
DR HGNC; HGNC:11554; TAGLN2.
DR HPA; HPA001925; -.
DR MIM; 604634; gene.
DR neXtProt; NX_P37802; -.
DR PharmGKB; PA36325; -.
DR eggNOG; COG5199; -.
DR HOGENOM; HOG000232113; -.
DR HOVERGEN; HBG005186; -.
DR InParanoid; P37802; -.
DR OrthoDB; EOG718KD9; -.
DR PhylomeDB; P37802; -.
DR ChiTaRS; TAGLN2; human.
DR EvolutionaryTrace; P37802; -.
DR GeneWiki; TAGLN2; -.
DR GenomeRNAi; 8407; -.
DR NextBio; 31472; -.
DR PRO; PR:P37802; -.
DR Bgee; P37802; -.
DR CleanEx; HS_TAGLN2; -.
DR Genevestigator; P37802; -.
DR GO; GO:0007517; P:muscle organ development; IEA:InterPro.
DR Gene3D; 1.10.418.10; -; 1.
DR InterPro; IPR000557; Calponin_repeat.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR003096; SM22_calponin.
DR InterPro; IPR001061; TAGLN.
DR PANTHER; PTHR18959:SF5; PTHR18959:SF5; 1.
DR Pfam; PF00402; Calponin; 1.
DR Pfam; PF00307; CH; 1.
DR PRINTS; PR00888; SM22CALPONIN.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR PROSITE; PS01052; CALPONIN_1; 1.
DR PROSITE; PS51122; CALPONIN_2; 1.
DR PROSITE; PS50021; CH; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Complete proteome;
KW Direct protein sequencing; Phosphoprotein; Polymorphism;
KW Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 199 Transgelin-2.
FT /FTId=PRO_0000204786.
FT DOMAIN 24 136 CH.
FT REPEAT 174 199 Calponin-like.
FT MOD_RES 2 2 N-acetylalanine.
FT MOD_RES 17 17 N6-acetyllysine.
FT MOD_RES 20 20 N6-acetyllysine.
FT MOD_RES 163 163 Phosphoserine.
FT VARIANT 69 69 L -> Q (in dbSNP:rs17849636).
FT /FTId=VAR_047903.
FT HELIX 24 37
FT STRAND 38 40
FT HELIX 49 57
FT HELIX 60 69
FT TURN 72 74
FT HELIX 86 103
FT TURN 107 109
FT HELIX 113 117
FT HELIX 122 136
FT STRAND 140 142
FT STRAND 148 151
SQ SEQUENCE 199 AA; 22391 MW; 07DFC1652CE2383D CRC64;
MANRGPAYGL SREVQQKIEK QYDADLEQIL IQWITTQCRK DVGRPQPGRE NFQNWLKDGT
VLCELINALY PEGQAPVKKI QASTMAFKQM EQISQFLQAA ERYGINTTDI FQTVDLWEGK
NMACVQRTLM NLGGLAVARD DGLFSGDPNW FPKKSKENPR NFSDNQLQEG KNVIGLQMGT
NRGASQAGMT GYGMPRQIL
//
ID TAGL2_HUMAN Reviewed; 199 AA.
AC P37802; E9KL39; Q5JRQ6; Q5JRQ7; Q6FGI1; Q9BUH5; Q9H4P0;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 3.
DT 22-JAN-2014, entry version 142.
DE RecName: Full=Transgelin-2;
DE AltName: Full=Epididymis tissue protein Li 7e;
DE AltName: Full=SM22-alpha homolog;
GN Name=TAGLN2; Synonyms=KIAA0120; ORFNames=CDABP0035;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Leukemia;
RA Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A.,
RA Margolin J.F.;
RT "Pediatric leukemia cDNA sequencing project.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow;
RX PubMed=7788527; DOI=10.1093/dnares/2.1.37;
RA Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S.,
RA Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.;
RT "Prediction of the coding sequences of unidentified human genes. III.
RT The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by
RT analysis of cDNA clones from human cell line KG-1.";
RL DNA Res. 2:37-43(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Epididymis;
RX PubMed=20736409; DOI=10.1074/mcp.M110.001719;
RA Li J., Liu F., Wang H., Liu X., Liu J., Li N., Wan F., Wang W.,
RA Zhang C., Jin S., Liu J., Zhu P., Liu Y.;
RT "Systematic mapping and functional analysis of a family of human
RT epididymal secretory sperm-located proteins.";
RL Mol. Cell. Proteomics 9:2517-2528(2010).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
RA Korn B., Zuo D., Hu Y., LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-69.
RC TISSUE=Lymph, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP PROTEIN SEQUENCE OF 2-12.
RC TISSUE=Platelet;
RX PubMed=12665801; DOI=10.1038/nbt810;
RA Gevaert K., Goethals M., Martens L., Van Damme J., Staes A.,
RA Thomas G.R., Vandekerckhove J.;
RT "Exploring proteomes and analyzing protein processing by mass
RT spectrometric identification of sorted N-terminal peptides.";
RL Nat. Biotechnol. 21:566-569(2003).
RN [10]
RP PROTEIN SEQUENCE OF 2-12; 41-57; 79-154 AND 161-196, CLEAVAGE OF
RP INITIATOR METHIONINE, ACETYLATION AT ALA-2, AND MASS SPECTROMETRY.
RC TISSUE=Platelet;
RA Bienvenut W.V., Claeys D.;
RL Submitted (FEB-2006) to UniProtKB.
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, AND MASS
RP SPECTROMETRY.
RC TISSUE=Platelet;
RX PubMed=18088087; DOI=10.1021/pr0704130;
RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
RA Schuetz C., Walter U., Gambaryan S., Sickmann A.;
RT "Phosphoproteome of resting human platelets.";
RL J. Proteome Res. 7:526-534(2008).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [13]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [14]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, AND MASS
RP SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [15]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-17 AND LYS-20, AND MASS
RP SPECTROMETRY.
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA Walther T.C., Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [16]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [17]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [18]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, AND MASS
RP SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [19]
RP STRUCTURE BY NMR OF 16-157.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the CH domain of human transgelin-2.";
RL Submitted (AUG-2005) to the PDB data bank.
CC -!- INTERACTION:
CC P60709:ACTB; NbExp=3; IntAct=EBI-1056740, EBI-353944;
CC -!- TISSUE SPECIFICITY: Expressed in epididymis (at protein level).
CC -!- SIMILARITY: Belongs to the calponin family.
CC -!- SIMILARITY: Contains 1 calponin-like repeat.
CC -!- SIMILARITY: Contains 1 CH (calponin-homology) domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG01993.1; Type=Erroneous initiation;
CC Sequence=BAA04802.2; Type=Erroneous initiation;
CC Sequence=CAI14604.1; Type=Erroneous initiation;
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DR EMBL; AY007127; AAG01993.1; ALT_INIT; mRNA.
DR EMBL; D21261; BAA04802.2; ALT_INIT; mRNA.
DR EMBL; GU727636; ADU87638.1; -; mRNA.
DR EMBL; AK291562; BAF84251.1; -; mRNA.
DR EMBL; CR542126; CAG46923.1; -; mRNA.
DR EMBL; CR542136; CAG46933.1; -; mRNA.
DR EMBL; AL513485; CAI14603.1; -; Genomic_DNA.
DR EMBL; AL513485; CAI14604.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL513485; CAI14602.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW52760.1; -; Genomic_DNA.
DR EMBL; BC002616; AAH02616.1; -; mRNA.
DR EMBL; BC009357; AAH09357.1; -; mRNA.
DR RefSeq; NP_001264152.1; NM_001277223.1.
DR RefSeq; NP_001264153.1; NM_001277224.1.
DR RefSeq; NP_003555.1; NM_003564.2.
DR RefSeq; XP_005245590.1; XM_005245533.1.
DR RefSeq; XP_005245591.1; XM_005245534.1.
DR UniGene; Hs.517168; -.
DR PDB; 1WYM; NMR; -; A=16-157.
DR PDBsum; 1WYM; -.
DR ProteinModelPortal; P37802; -.
DR SMR; P37802; 9-158.
DR IntAct; P37802; 12.
DR MINT; MINT-5001664; -.
DR STRING; 9606.ENSP00000357075; -.
DR PhosphoSite; P37802; -.
DR DMDM; 586000; -.
DR DOSAC-COBS-2DPAGE; P37802; -.
DR OGP; P37802; -.
DR REPRODUCTION-2DPAGE; P37802; -.
DR PaxDb; P37802; -.
DR PRIDE; P37802; -.
DR DNASU; 8407; -.
DR Ensembl; ENST00000320307; ENSP00000357075; ENSG00000158710.
DR Ensembl; ENST00000368096; ENSP00000357076; ENSG00000158710.
DR Ensembl; ENST00000368097; ENSP00000357077; ENSG00000158710.
DR GeneID; 8407; -.
DR KEGG; hsa:8407; -.
DR UCSC; uc001fun.2; human.
DR CTD; 8407; -.
DR GeneCards; GC01M159887; -.
DR HGNC; HGNC:11554; TAGLN2.
DR HPA; HPA001925; -.
DR MIM; 604634; gene.
DR neXtProt; NX_P37802; -.
DR PharmGKB; PA36325; -.
DR eggNOG; COG5199; -.
DR HOGENOM; HOG000232113; -.
DR HOVERGEN; HBG005186; -.
DR InParanoid; P37802; -.
DR OrthoDB; EOG718KD9; -.
DR PhylomeDB; P37802; -.
DR ChiTaRS; TAGLN2; human.
DR EvolutionaryTrace; P37802; -.
DR GeneWiki; TAGLN2; -.
DR GenomeRNAi; 8407; -.
DR NextBio; 31472; -.
DR PRO; PR:P37802; -.
DR Bgee; P37802; -.
DR CleanEx; HS_TAGLN2; -.
DR Genevestigator; P37802; -.
DR GO; GO:0007517; P:muscle organ development; IEA:InterPro.
DR Gene3D; 1.10.418.10; -; 1.
DR InterPro; IPR000557; Calponin_repeat.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR003096; SM22_calponin.
DR InterPro; IPR001061; TAGLN.
DR PANTHER; PTHR18959:SF5; PTHR18959:SF5; 1.
DR Pfam; PF00402; Calponin; 1.
DR Pfam; PF00307; CH; 1.
DR PRINTS; PR00888; SM22CALPONIN.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR PROSITE; PS01052; CALPONIN_1; 1.
DR PROSITE; PS51122; CALPONIN_2; 1.
DR PROSITE; PS50021; CH; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Complete proteome;
KW Direct protein sequencing; Phosphoprotein; Polymorphism;
KW Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 199 Transgelin-2.
FT /FTId=PRO_0000204786.
FT DOMAIN 24 136 CH.
FT REPEAT 174 199 Calponin-like.
FT MOD_RES 2 2 N-acetylalanine.
FT MOD_RES 17 17 N6-acetyllysine.
FT MOD_RES 20 20 N6-acetyllysine.
FT MOD_RES 163 163 Phosphoserine.
FT VARIANT 69 69 L -> Q (in dbSNP:rs17849636).
FT /FTId=VAR_047903.
FT HELIX 24 37
FT STRAND 38 40
FT HELIX 49 57
FT HELIX 60 69
FT TURN 72 74
FT HELIX 86 103
FT TURN 107 109
FT HELIX 113 117
FT HELIX 122 136
FT STRAND 140 142
FT STRAND 148 151
SQ SEQUENCE 199 AA; 22391 MW; 07DFC1652CE2383D CRC64;
MANRGPAYGL SREVQQKIEK QYDADLEQIL IQWITTQCRK DVGRPQPGRE NFQNWLKDGT
VLCELINALY PEGQAPVKKI QASTMAFKQM EQISQFLQAA ERYGINTTDI FQTVDLWEGK
NMACVQRTLM NLGGLAVARD DGLFSGDPNW FPKKSKENPR NFSDNQLQEG KNVIGLQMGT
NRGASQAGMT GYGMPRQIL
//
MIM
604634
*RECORD*
*FIELD* NO
604634
*FIELD* TI
*604634 TRANSGELIN 2; TAGLN2
*FIELD* TX
By sequencing cDNAs randomly selected from a cDNA library derived from a
read morehuman immature myeloid cell line, Nagase et al. (1995) isolated a cDNA
encoding TAGLN2, which they called KIAA0120. The deduced 199-amino acid
TAGLN2 protein shares 69.7% amino acid sequence identity with rat
neuronal protein NP25 (607953) over 195 amino acids. Northern blot
analysis detected TAGLN2 expression in all 16 human tissues examined,
with high expression in lung, liver, kidney, spleen, thymus, small
intestine, colon, prostate, testis, ovary, placenta, and peripheral
blood leukocytes, lower expression in skeletal muscle, pancreas, and
heart, and lowest expression in brain.
Stanier et al. (1998) cloned mouse Tagln2 cDNAs. They found that mouse
and human TAGLN2 share 95% amino acid sequence identity.
Using a somatic cell hybrid mapping panel, Nagase et al. (1995)
determined that the TAGLN2 gene maps to either chromosome 1 or 8.
Stanier et al. (1998) noted that an EST cluster representing the TAGLN2
gene had been mapped to 1q21-q25. By linkage analysis, Stanier et al.
(1998) mapped the mouse Tagln2 gene to distal chromosome 1, between the
Fcgr2 gene (146790) and marker D1Mit149. Distal mouse chromosome 1 shows
homology of synteny with human 1q21-q25.
*FIELD* RF
1. Nagase, T.; Miyajima, N.; Tanaka, A.; Sazuka, T.; Seki, N.; Sato,
S.; Tabata, S.; Ishikawa, K.; Kawarabayasi, Y.; Kotani, H.; Nomura,
N.: Prediction of the coding sequences of unidentified human genes.
III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced
by analysis of cDNA clones from human cell line KG-1. DNA Res. 2:
37-43, 1995.
2. Stanier, P.; Abu-Hayyeh, S.; Murdoch, J. N.; Eddleston, J.; Copp,
A. J.: Paralogous Sm22-alpha (Tagln) genes map to mouse chromosomes
1 and 9: further evidence for a paralogous relationship. Genomics 51:
144-147, 1998.
*FIELD* CD
Patti M. Sherman: 2/29/2000
*FIELD* ED
mgross: 07/17/2003
carol: 3/7/2000
mgross: 3/2/2000
mgross: 3/1/2000
psherman: 2/29/2000
*RECORD*
*FIELD* NO
604634
*FIELD* TI
*604634 TRANSGELIN 2; TAGLN2
*FIELD* TX
By sequencing cDNAs randomly selected from a cDNA library derived from a
read morehuman immature myeloid cell line, Nagase et al. (1995) isolated a cDNA
encoding TAGLN2, which they called KIAA0120. The deduced 199-amino acid
TAGLN2 protein shares 69.7% amino acid sequence identity with rat
neuronal protein NP25 (607953) over 195 amino acids. Northern blot
analysis detected TAGLN2 expression in all 16 human tissues examined,
with high expression in lung, liver, kidney, spleen, thymus, small
intestine, colon, prostate, testis, ovary, placenta, and peripheral
blood leukocytes, lower expression in skeletal muscle, pancreas, and
heart, and lowest expression in brain.
Stanier et al. (1998) cloned mouse Tagln2 cDNAs. They found that mouse
and human TAGLN2 share 95% amino acid sequence identity.
Using a somatic cell hybrid mapping panel, Nagase et al. (1995)
determined that the TAGLN2 gene maps to either chromosome 1 or 8.
Stanier et al. (1998) noted that an EST cluster representing the TAGLN2
gene had been mapped to 1q21-q25. By linkage analysis, Stanier et al.
(1998) mapped the mouse Tagln2 gene to distal chromosome 1, between the
Fcgr2 gene (146790) and marker D1Mit149. Distal mouse chromosome 1 shows
homology of synteny with human 1q21-q25.
*FIELD* RF
1. Nagase, T.; Miyajima, N.; Tanaka, A.; Sazuka, T.; Seki, N.; Sato,
S.; Tabata, S.; Ishikawa, K.; Kawarabayasi, Y.; Kotani, H.; Nomura,
N.: Prediction of the coding sequences of unidentified human genes.
III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced
by analysis of cDNA clones from human cell line KG-1. DNA Res. 2:
37-43, 1995.
2. Stanier, P.; Abu-Hayyeh, S.; Murdoch, J. N.; Eddleston, J.; Copp,
A. J.: Paralogous Sm22-alpha (Tagln) genes map to mouse chromosomes
1 and 9: further evidence for a paralogous relationship. Genomics 51:
144-147, 1998.
*FIELD* CD
Patti M. Sherman: 2/29/2000
*FIELD* ED
mgross: 07/17/2003
carol: 3/7/2000
mgross: 3/2/2000
mgross: 3/1/2000
psherman: 2/29/2000