Full text data of TATDN1
TATDN1
[Confidence: low (only semi-automatic identification from reviews)]
Putative deoxyribonuclease TATDN1; 3.1.21.- (Hepatocarcinoma high expression protein)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Putative deoxyribonuclease TATDN1; 3.1.21.- (Hepatocarcinoma high expression protein)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q6P1N9
ID TATD1_HUMAN Reviewed; 297 AA.
AC Q6P1N9; B2R5J0; Q8TD02; Q9BY40;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 15-JAN-2008, sequence version 2.
DT 22-JAN-2014, entry version 71.
DE RecName: Full=Putative deoxyribonuclease TATDN1;
DE EC=3.1.21.-;
DE AltName: Full=Hepatocarcinoma high expression protein;
GN Name=TATDN1; ORFNames=CDA11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pheochromocytoma;
RA Li Y., Huang Q., Peng Y., Song H., Yu Y., Xu S., Ren S., Chen Z.,
RA Han Z.;
RT "A novel gene expressed in human pheochromocytoma.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Xu Y., Wu C., He G., Huang Y., Cao Y., Ying K., Xie Y., Mao Y.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skeletal muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS) OF 5-295.
RG Structural genomics consortium (SGC);
RT "Structure of putative deoxyribonuclease TATDN1 isoform A.";
RL Submitted (JUL-2010) to the PDB data bank.
CC -!- FUNCTION: Putative deoxyribonuclease (By similarity).
CC -!- COFACTOR: Binds 2 divalent metal cations per subunit (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6P1N9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P1N9-2; Sequence=VSP_030045;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the TatD DNase family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF212250; AAK14933.1; -; mRNA.
DR EMBL; AY071865; AAL61823.1; -; mRNA.
DR EMBL; AK312204; BAG35137.1; -; mRNA.
DR EMBL; CH471060; EAW92066.1; -; Genomic_DNA.
DR EMBL; CH471060; EAW92067.1; -; Genomic_DNA.
DR EMBL; BC064964; AAH64964.1; -; mRNA.
DR RefSeq; NP_001139632.1; NM_001146160.1.
DR RefSeq; NP_114415.1; NM_032026.3.
DR UniGene; Hs.170568; -.
DR PDB; 2XIO; X-ray; 1.19 A; A=5-295.
DR PDBsum; 2XIO; -.
DR ProteinModelPortal; Q6P1N9; -.
DR SMR; Q6P1N9; 5-295.
DR STRING; 9606.ENSP00000276692; -.
DR PhosphoSite; Q6P1N9; -.
DR DMDM; 166227295; -.
DR PaxDb; Q6P1N9; -.
DR PRIDE; Q6P1N9; -.
DR Ensembl; ENST00000276692; ENSP00000276692; ENSG00000147687.
DR Ensembl; ENST00000519548; ENSP00000428336; ENSG00000147687.
DR GeneID; 83940; -.
DR KEGG; hsa:83940; -.
DR UCSC; uc003yrd.2; human.
DR CTD; 83940; -.
DR GeneCards; GC08M125500; -.
DR HGNC; HGNC:24220; TATDN1.
DR HPA; HPA023634; -.
DR neXtProt; NX_Q6P1N9; -.
DR PharmGKB; PA134971804; -.
DR eggNOG; COG0084; -.
DR HOGENOM; HOG000201523; -.
DR HOVERGEN; HBG097580; -.
DR InParanoid; Q6P1N9; -.
DR KO; K03424; -.
DR PhylomeDB; Q6P1N9; -.
DR EvolutionaryTrace; Q6P1N9; -.
DR GenomeRNAi; 83940; -.
DR NextBio; 73073; -.
DR PRO; PR:Q6P1N9; -.
DR ArrayExpress; Q6P1N9; -.
DR Bgee; Q6P1N9; -.
DR CleanEx; HS_TATDN1; -.
DR Genevestigator; Q6P1N9; -.
DR GO; GO:0005737; C:cytoplasm; IBA:RefGenome.
DR GO; GO:0005634; C:nucleus; IBA:RefGenome.
DR GO; GO:0004536; F:deoxyribonuclease activity; IBA:RefGenome.
DR GO; GO:0016888; F:endodeoxyribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006309; P:apoptotic DNA fragmentation; IBA:RefGenome.
DR InterPro; IPR018228; DNase_TatD-rel_CS.
DR InterPro; IPR001130; TatD_family.
DR PANTHER; PTHR10060; PTHR10060; 1.
DR Pfam; PF01026; TatD_DNase; 1.
DR PIRSF; PIRSF005902; DNase_TatD; 1.
DR PROSITE; PS01090; TATD_2; FALSE_NEG.
DR PROSITE; PS01091; TATD_3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Complete proteome; Hydrolase;
KW Metal-binding; Nuclease; Nucleus; Reference proteome.
FT CHAIN 1 297 Putative deoxyribonuclease TATDN1.
FT /FTId=PRO_0000313590.
FT METAL 112 112 Divalent metal cation 1 (By similarity).
FT METAL 112 112 Divalent metal cation 2 (By similarity).
FT METAL 149 149 Divalent metal cation 2 (By similarity).
FT METAL 174 174 Divalent metal cation 2 (By similarity).
FT METAL 222 222 Divalent metal cation 1 (By similarity).
FT VAR_SEQ 1 47 Missing (in isoform 2).
FT /FTId=VSP_030045.
FT CONFLICT 161 161 M -> T (in Ref. 5; AAH64964).
FT STRAND 6 11
FT HELIX 16 19
FT HELIX 32 42
FT STRAND 44 49
FT HELIX 54 64
FT STRAND 70 74
FT HELIX 78 82
FT HELIX 83 87
FT HELIX 89 101
FT TURN 104 106
FT STRAND 107 116
FT TURN 120 122
FT HELIX 125 134
FT HELIX 136 142
FT STRAND 146 152
FT HELIX 154 163
FT HELIX 165 167
FT STRAND 171 173
FT HELIX 180 188
FT STRAND 192 195
FT HELIX 197 199
FT STRAND 200 202
FT HELIX 203 210
FT HELIX 214 216
FT STRAND 217 219
FT HELIX 235 237
FT STRAND 244 247
FT STRAND 252 254
FT HELIX 260 262
FT HELIX 263 274
FT HELIX 278 293
SQ SEQUENCE 297 AA; 33602 MW; D8671A4A50E5D9B5 CRC64;
MSRFKFIDIG INLTDPMFRG IYRGVQKHQD DLQDVIGRAV EIGVKKFMIT GGNLQDSKDA
LHLAQTNGMF FSTVGCHPTR CGEFEKNNPD LYLKELLNLA ENNKGKVVAI GECGLDFDRL
QFCPKDTQLK YFEKQFELSE QTKLPMFLHC RNSHAEFLDI MKRNRDRCVG GVVHSFDGTK
EAAAALIDLD LYIGFNGCSL KTEANLEVLK SIPSEKLMIE TDAPWCGVKS THAGSKYIRT
AFPTKKKWES GHCLKDRNEP CHIIQILEIM SAVRDEDPLE LANTLYNNTI KVFFPGI
//
ID TATD1_HUMAN Reviewed; 297 AA.
AC Q6P1N9; B2R5J0; Q8TD02; Q9BY40;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 15-JAN-2008, sequence version 2.
DT 22-JAN-2014, entry version 71.
DE RecName: Full=Putative deoxyribonuclease TATDN1;
DE EC=3.1.21.-;
DE AltName: Full=Hepatocarcinoma high expression protein;
GN Name=TATDN1; ORFNames=CDA11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pheochromocytoma;
RA Li Y., Huang Q., Peng Y., Song H., Yu Y., Xu S., Ren S., Chen Z.,
RA Han Z.;
RT "A novel gene expressed in human pheochromocytoma.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Xu Y., Wu C., He G., Huang Y., Cao Y., Ying K., Xie Y., Mao Y.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skeletal muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS) OF 5-295.
RG Structural genomics consortium (SGC);
RT "Structure of putative deoxyribonuclease TATDN1 isoform A.";
RL Submitted (JUL-2010) to the PDB data bank.
CC -!- FUNCTION: Putative deoxyribonuclease (By similarity).
CC -!- COFACTOR: Binds 2 divalent metal cations per subunit (By
CC similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6P1N9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P1N9-2; Sequence=VSP_030045;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the TatD DNase family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF212250; AAK14933.1; -; mRNA.
DR EMBL; AY071865; AAL61823.1; -; mRNA.
DR EMBL; AK312204; BAG35137.1; -; mRNA.
DR EMBL; CH471060; EAW92066.1; -; Genomic_DNA.
DR EMBL; CH471060; EAW92067.1; -; Genomic_DNA.
DR EMBL; BC064964; AAH64964.1; -; mRNA.
DR RefSeq; NP_001139632.1; NM_001146160.1.
DR RefSeq; NP_114415.1; NM_032026.3.
DR UniGene; Hs.170568; -.
DR PDB; 2XIO; X-ray; 1.19 A; A=5-295.
DR PDBsum; 2XIO; -.
DR ProteinModelPortal; Q6P1N9; -.
DR SMR; Q6P1N9; 5-295.
DR STRING; 9606.ENSP00000276692; -.
DR PhosphoSite; Q6P1N9; -.
DR DMDM; 166227295; -.
DR PaxDb; Q6P1N9; -.
DR PRIDE; Q6P1N9; -.
DR Ensembl; ENST00000276692; ENSP00000276692; ENSG00000147687.
DR Ensembl; ENST00000519548; ENSP00000428336; ENSG00000147687.
DR GeneID; 83940; -.
DR KEGG; hsa:83940; -.
DR UCSC; uc003yrd.2; human.
DR CTD; 83940; -.
DR GeneCards; GC08M125500; -.
DR HGNC; HGNC:24220; TATDN1.
DR HPA; HPA023634; -.
DR neXtProt; NX_Q6P1N9; -.
DR PharmGKB; PA134971804; -.
DR eggNOG; COG0084; -.
DR HOGENOM; HOG000201523; -.
DR HOVERGEN; HBG097580; -.
DR InParanoid; Q6P1N9; -.
DR KO; K03424; -.
DR PhylomeDB; Q6P1N9; -.
DR EvolutionaryTrace; Q6P1N9; -.
DR GenomeRNAi; 83940; -.
DR NextBio; 73073; -.
DR PRO; PR:Q6P1N9; -.
DR ArrayExpress; Q6P1N9; -.
DR Bgee; Q6P1N9; -.
DR CleanEx; HS_TATDN1; -.
DR Genevestigator; Q6P1N9; -.
DR GO; GO:0005737; C:cytoplasm; IBA:RefGenome.
DR GO; GO:0005634; C:nucleus; IBA:RefGenome.
DR GO; GO:0004536; F:deoxyribonuclease activity; IBA:RefGenome.
DR GO; GO:0016888; F:endodeoxyribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006309; P:apoptotic DNA fragmentation; IBA:RefGenome.
DR InterPro; IPR018228; DNase_TatD-rel_CS.
DR InterPro; IPR001130; TatD_family.
DR PANTHER; PTHR10060; PTHR10060; 1.
DR Pfam; PF01026; TatD_DNase; 1.
DR PIRSF; PIRSF005902; DNase_TatD; 1.
DR PROSITE; PS01090; TATD_2; FALSE_NEG.
DR PROSITE; PS01091; TATD_3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Complete proteome; Hydrolase;
KW Metal-binding; Nuclease; Nucleus; Reference proteome.
FT CHAIN 1 297 Putative deoxyribonuclease TATDN1.
FT /FTId=PRO_0000313590.
FT METAL 112 112 Divalent metal cation 1 (By similarity).
FT METAL 112 112 Divalent metal cation 2 (By similarity).
FT METAL 149 149 Divalent metal cation 2 (By similarity).
FT METAL 174 174 Divalent metal cation 2 (By similarity).
FT METAL 222 222 Divalent metal cation 1 (By similarity).
FT VAR_SEQ 1 47 Missing (in isoform 2).
FT /FTId=VSP_030045.
FT CONFLICT 161 161 M -> T (in Ref. 5; AAH64964).
FT STRAND 6 11
FT HELIX 16 19
FT HELIX 32 42
FT STRAND 44 49
FT HELIX 54 64
FT STRAND 70 74
FT HELIX 78 82
FT HELIX 83 87
FT HELIX 89 101
FT TURN 104 106
FT STRAND 107 116
FT TURN 120 122
FT HELIX 125 134
FT HELIX 136 142
FT STRAND 146 152
FT HELIX 154 163
FT HELIX 165 167
FT STRAND 171 173
FT HELIX 180 188
FT STRAND 192 195
FT HELIX 197 199
FT STRAND 200 202
FT HELIX 203 210
FT HELIX 214 216
FT STRAND 217 219
FT HELIX 235 237
FT STRAND 244 247
FT STRAND 252 254
FT HELIX 260 262
FT HELIX 263 274
FT HELIX 278 293
SQ SEQUENCE 297 AA; 33602 MW; D8671A4A50E5D9B5 CRC64;
MSRFKFIDIG INLTDPMFRG IYRGVQKHQD DLQDVIGRAV EIGVKKFMIT GGNLQDSKDA
LHLAQTNGMF FSTVGCHPTR CGEFEKNNPD LYLKELLNLA ENNKGKVVAI GECGLDFDRL
QFCPKDTQLK YFEKQFELSE QTKLPMFLHC RNSHAEFLDI MKRNRDRCVG GVVHSFDGTK
EAAAALIDLD LYIGFNGCSL KTEANLEVLK SIPSEKLMIE TDAPWCGVKS THAGSKYIRT
AFPTKKKWES GHCLKDRNEP CHIIQILEIM SAVRDEDPLE LANTLYNNTI KVFFPGI
//