Full text data of THEM6
THEM6
(C8orf55)
[Confidence: high (present in two of the MS resources)]
Protein THEM6 (Mesenchymal stem cell protein DSCD75; Thioesterase superfamily member 6; Flags: Precursor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Protein THEM6 (Mesenchymal stem cell protein DSCD75; Thioesterase superfamily member 6; Flags: Precursor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00010292
IPI00010292 Mesenchymal stem cell protein DSCD75 Mesenchymal stem cell protein DSCD75 membrane n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
IPI00010292 Mesenchymal stem cell protein DSCD75 Mesenchymal stem cell protein DSCD75 membrane n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
UniProt
Q8WUY1
ID THEM6_HUMAN Reviewed; 208 AA.
AC Q8WUY1; B2RDN6; Q8NBN2; Q9NYI2;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAY-2007, sequence version 2.
DT 22-JAN-2014, entry version 74.
DE RecName: Full=Protein THEM6;
DE AltName: Full=Mesenchymal stem cell protein DSCD75;
DE AltName: Full=Thioesterase superfamily member 6;
DE Flags: Precursor;
GN Name=THEM6; Synonyms=C8orf55; ORFNames=PSEC0098;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Mesenchymal stem cell;
RA van den Bos C., Mbalaviele G., Thiede M.;
RT "cDNA DSCD75 expressed by osteogenic human mesenchymal stem cells.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-
RT length human cDNAs encoding secretion or membrane proteins from oligo-
RT capped cDNA libraries.";
RL DNA Res. 12:117-126(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-93.
RC TISSUE=Muscle, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC -!- SIMILARITY: Belongs to the THEM6 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF242773; AAF65450.1; -; mRNA.
DR EMBL; AK315614; BAG37983.1; -; mRNA.
DR EMBL; AK075407; BAC11600.1; -; mRNA.
DR EMBL; BC001311; AAH01311.1; -; mRNA.
DR EMBL; BC019104; AAH19104.1; -; mRNA.
DR RefSeq; NP_057731.1; NM_016647.2.
DR UniGene; Hs.368402; -.
DR ProteinModelPortal; Q8WUY1; -.
DR IntAct; Q8WUY1; 4.
DR STRING; 9606.ENSP00000338607; -.
DR PhosphoSite; Q8WUY1; -.
DR DMDM; 146286068; -.
DR PaxDb; Q8WUY1; -.
DR PeptideAtlas; Q8WUY1; -.
DR PRIDE; Q8WUY1; -.
DR Ensembl; ENST00000336138; ENSP00000338607; ENSG00000130193.
DR Ensembl; ENST00000575946; ENSP00000460182; ENSG00000263194.
DR GeneID; 51337; -.
DR KEGG; hsa:51337; -.
DR UCSC; uc003yww.1; human.
DR CTD; 51337; -.
DR GeneCards; GC08P143808; -.
DR HGNC; HGNC:29656; THEM6.
DR HPA; HPA023255; -.
DR neXtProt; NX_Q8WUY1; -.
DR PharmGKB; PA142672318; -.
DR eggNOG; NOG75805; -.
DR HOGENOM; HOG000249151; -.
DR HOVERGEN; HBG059534; -.
DR InParanoid; Q8WUY1; -.
DR OMA; AASCARY; -.
DR PhylomeDB; Q8WUY1; -.
DR GenomeRNAi; 51337; -.
DR NextBio; 54766; -.
DR PRO; PR:Q8WUY1; -.
DR Bgee; Q8WUY1; -.
DR CleanEx; HS_C8orf55; -.
DR Genevestigator; Q8WUY1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Complete proteome; Polymorphism; Reference proteome; Secreted; Signal.
FT SIGNAL 1 17 Potential.
FT CHAIN 18 208 Protein THEM6.
FT /FTId=PRO_0000285636.
FT VARIANT 93 93 E -> Q (in dbSNP:rs17851711).
FT /FTId=VAR_032034.
FT CONFLICT 20 20 D -> G (in Ref. 3; BAC11600).
SQ SEQUENCE 208 AA; 23865 MW; 6F9808DB345194D5 CRC64;
MLGLLVALLA LGLAVFALLD VWYLVRLPCA VLRARLLQPR VRDLLAEQRF PGRVLPSDLD
LLLHMNNARY LREADFARVA HLTRCGVLGA LRELRAHTVL AASCARHRRS LRLLEPFEVR
TRLLGWDDRA FYLEARFVSL RDGFVCALLR FRQHLLGTSP ERVVQHLCQR RVEPPELPAD
LQHWISYNEA SSQLLRMESG LSDVTKDQ
//
ID THEM6_HUMAN Reviewed; 208 AA.
AC Q8WUY1; B2RDN6; Q8NBN2; Q9NYI2;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAY-2007, sequence version 2.
DT 22-JAN-2014, entry version 74.
DE RecName: Full=Protein THEM6;
DE AltName: Full=Mesenchymal stem cell protein DSCD75;
DE AltName: Full=Thioesterase superfamily member 6;
DE Flags: Precursor;
GN Name=THEM6; Synonyms=C8orf55; ORFNames=PSEC0098;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Mesenchymal stem cell;
RA van den Bos C., Mbalaviele G., Thiede M.;
RT "cDNA DSCD75 expressed by osteogenic human mesenchymal stem cells.";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-
RT length human cDNAs encoding secretion or membrane proteins from oligo-
RT capped cDNA libraries.";
RL DNA Res. 12:117-126(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-93.
RC TISSUE=Muscle, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC -!- SIMILARITY: Belongs to the THEM6 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF242773; AAF65450.1; -; mRNA.
DR EMBL; AK315614; BAG37983.1; -; mRNA.
DR EMBL; AK075407; BAC11600.1; -; mRNA.
DR EMBL; BC001311; AAH01311.1; -; mRNA.
DR EMBL; BC019104; AAH19104.1; -; mRNA.
DR RefSeq; NP_057731.1; NM_016647.2.
DR UniGene; Hs.368402; -.
DR ProteinModelPortal; Q8WUY1; -.
DR IntAct; Q8WUY1; 4.
DR STRING; 9606.ENSP00000338607; -.
DR PhosphoSite; Q8WUY1; -.
DR DMDM; 146286068; -.
DR PaxDb; Q8WUY1; -.
DR PeptideAtlas; Q8WUY1; -.
DR PRIDE; Q8WUY1; -.
DR Ensembl; ENST00000336138; ENSP00000338607; ENSG00000130193.
DR Ensembl; ENST00000575946; ENSP00000460182; ENSG00000263194.
DR GeneID; 51337; -.
DR KEGG; hsa:51337; -.
DR UCSC; uc003yww.1; human.
DR CTD; 51337; -.
DR GeneCards; GC08P143808; -.
DR HGNC; HGNC:29656; THEM6.
DR HPA; HPA023255; -.
DR neXtProt; NX_Q8WUY1; -.
DR PharmGKB; PA142672318; -.
DR eggNOG; NOG75805; -.
DR HOGENOM; HOG000249151; -.
DR HOVERGEN; HBG059534; -.
DR InParanoid; Q8WUY1; -.
DR OMA; AASCARY; -.
DR PhylomeDB; Q8WUY1; -.
DR GenomeRNAi; 51337; -.
DR NextBio; 54766; -.
DR PRO; PR:Q8WUY1; -.
DR Bgee; Q8WUY1; -.
DR CleanEx; HS_C8orf55; -.
DR Genevestigator; Q8WUY1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Complete proteome; Polymorphism; Reference proteome; Secreted; Signal.
FT SIGNAL 1 17 Potential.
FT CHAIN 18 208 Protein THEM6.
FT /FTId=PRO_0000285636.
FT VARIANT 93 93 E -> Q (in dbSNP:rs17851711).
FT /FTId=VAR_032034.
FT CONFLICT 20 20 D -> G (in Ref. 3; BAC11600).
SQ SEQUENCE 208 AA; 23865 MW; 6F9808DB345194D5 CRC64;
MLGLLVALLA LGLAVFALLD VWYLVRLPCA VLRARLLQPR VRDLLAEQRF PGRVLPSDLD
LLLHMNNARY LREADFARVA HLTRCGVLGA LRELRAHTVL AASCARHRRS LRLLEPFEVR
TRLLGWDDRA FYLEARFVSL RDGFVCALLR FRQHLLGTSP ERVVQHLCQR RVEPPELPAD
LQHWISYNEA SSQLLRMESG LSDVTKDQ
//