Full text data of TMEM50B
TMEM50B
(C21orf4)
[Confidence: low (only semi-automatic identification from reviews)]
Transmembrane protein 50B (HCV p7-trans-regulated protein 3)
Transmembrane protein 50B (HCV p7-trans-regulated protein 3)
UniProt
P56557
ID TM50B_HUMAN Reviewed; 158 AA.
AC P56557; B2R4L4; D3DSF1; O60537; Q5PY47;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2000, sequence version 2.
DT 22-JAN-2014, entry version 103.
DE RecName: Full=Transmembrane protein 50B;
DE AltName: Full=HCV p7-trans-regulated protein 3;
GN Name=TMEM50B; Synonyms=C21orf4; ORFNames=UNQ167/PRO193;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=10077530;
RA Reboul J., Gardiner K., Monneron D., Uze G., Lutfalla G.;
RT "Comparative genomic analysis of the interferon/interleukin-10
RT receptor gene cluster.";
RL Genome Res. 9:242-250(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Guo J., Cheng J., Ji D., Zhao L.-F., Zhang L.-Y.;
RT "Screening and identification of genes trans-regulated by HCV p7
RT protein with microarray assay.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- SIMILARITY: Belongs to the UPF0220 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF045606; AAC05974.2; -; mRNA.
DR EMBL; AF039906; AAC05090.1; -; Genomic_DNA.
DR EMBL; AY820138; AAV68502.1; -; mRNA.
DR EMBL; AY358634; AAQ88997.1; -; mRNA.
DR EMBL; AK311870; BAG34811.1; -; mRNA.
DR EMBL; BX537378; CAD97620.1; -; mRNA.
DR EMBL; CH471079; EAX09832.1; -; Genomic_DNA.
DR EMBL; CH471079; EAX09833.1; -; Genomic_DNA.
DR EMBL; BC000569; AAH00569.1; -; mRNA.
DR RefSeq; NP_006125.2; NM_006134.6.
DR UniGene; Hs.433668; -.
DR UniGene; Hs.655101; -.
DR ProteinModelPortal; P56557; -.
DR STRING; 9606.ENSP00000371390; -.
DR DMDM; 12643476; -.
DR PaxDb; P56557; -.
DR PRIDE; P56557; -.
DR Ensembl; ENST00000420455; ENSP00000397773; ENSG00000142188.
DR Ensembl; ENST00000542230; ENSP00000439768; ENSG00000142188.
DR Ensembl; ENST00000571778; ENSP00000458900; ENSG00000263160.
DR Ensembl; ENST00000573374; ENSP00000460121; ENSG00000263160.
DR GeneID; 757; -.
DR KEGG; hsa:757; -.
DR CTD; 757; -.
DR GeneCards; GC21M034804; -.
DR H-InvDB; HIX0175060; -.
DR HGNC; HGNC:1280; TMEM50B.
DR HPA; CAB034199; -.
DR neXtProt; NX_P56557; -.
DR PharmGKB; PA25835; -.
DR eggNOG; NOG313740; -.
DR HOGENOM; HOG000264235; -.
DR HOVERGEN; HBG000997; -.
DR InParanoid; P56557; -.
DR OMA; YSDGCLG; -.
DR ChiTaRS; TMEM50B; human.
DR GenomeRNAi; 757; -.
DR NextBio; 3060; -.
DR PRO; PR:P56557; -.
DR ArrayExpress; P56557; -.
DR Bgee; P56557; -.
DR CleanEx; HS_TMEM50B; -.
DR Genevestigator; P56557; -.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR InterPro; IPR007919; UPF0220.
DR PANTHER; PTHR13180; PTHR13180; 1.
DR Pfam; PF05255; UPF0220; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 158 Transmembrane protein 50B.
FT /FTId=PRO_0000174183.
FT TRANSMEM 28 48 Helical; (Potential).
FT TRANSMEM 56 76 Helical; (Potential).
FT TRANSMEM 98 118 Helical; (Potential).
FT TRANSMEM 128 148 Helical; (Potential).
SQ SEQUENCE 158 AA; 17936 MW; 515ABB6AAA817DEB CRC64;
MAGFLDNFRW PECECIDWSE RRNAVASVVA GILFFTGWWI MIDAAVVYPK PEQLNHAFHT
CGVFSTLAFF MINAVSNAQV RGDSYESGCL GRTGARVWLF IGFMLMFGSL IASMWILFGA
YVTQNTDVYP GLAVFFQNAL IFFSTLIYKF GRTEELWT
//
ID TM50B_HUMAN Reviewed; 158 AA.
AC P56557; B2R4L4; D3DSF1; O60537; Q5PY47;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2000, sequence version 2.
DT 22-JAN-2014, entry version 103.
DE RecName: Full=Transmembrane protein 50B;
DE AltName: Full=HCV p7-trans-regulated protein 3;
GN Name=TMEM50B; Synonyms=C21orf4; ORFNames=UNQ167/PRO193;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=10077530;
RA Reboul J., Gardiner K., Monneron D., Uze G., Lutfalla G.;
RT "Comparative genomic analysis of the interferon/interleukin-10
RT receptor gene cluster.";
RL Genome Res. 9:242-250(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Guo J., Cheng J., Ji D., Zhao L.-F., Zhang L.-Y.;
RT "Screening and identification of genes trans-regulated by HCV p7
RT protein with microarray assay.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- SIMILARITY: Belongs to the UPF0220 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF045606; AAC05974.2; -; mRNA.
DR EMBL; AF039906; AAC05090.1; -; Genomic_DNA.
DR EMBL; AY820138; AAV68502.1; -; mRNA.
DR EMBL; AY358634; AAQ88997.1; -; mRNA.
DR EMBL; AK311870; BAG34811.1; -; mRNA.
DR EMBL; BX537378; CAD97620.1; -; mRNA.
DR EMBL; CH471079; EAX09832.1; -; Genomic_DNA.
DR EMBL; CH471079; EAX09833.1; -; Genomic_DNA.
DR EMBL; BC000569; AAH00569.1; -; mRNA.
DR RefSeq; NP_006125.2; NM_006134.6.
DR UniGene; Hs.433668; -.
DR UniGene; Hs.655101; -.
DR ProteinModelPortal; P56557; -.
DR STRING; 9606.ENSP00000371390; -.
DR DMDM; 12643476; -.
DR PaxDb; P56557; -.
DR PRIDE; P56557; -.
DR Ensembl; ENST00000420455; ENSP00000397773; ENSG00000142188.
DR Ensembl; ENST00000542230; ENSP00000439768; ENSG00000142188.
DR Ensembl; ENST00000571778; ENSP00000458900; ENSG00000263160.
DR Ensembl; ENST00000573374; ENSP00000460121; ENSG00000263160.
DR GeneID; 757; -.
DR KEGG; hsa:757; -.
DR CTD; 757; -.
DR GeneCards; GC21M034804; -.
DR H-InvDB; HIX0175060; -.
DR HGNC; HGNC:1280; TMEM50B.
DR HPA; CAB034199; -.
DR neXtProt; NX_P56557; -.
DR PharmGKB; PA25835; -.
DR eggNOG; NOG313740; -.
DR HOGENOM; HOG000264235; -.
DR HOVERGEN; HBG000997; -.
DR InParanoid; P56557; -.
DR OMA; YSDGCLG; -.
DR ChiTaRS; TMEM50B; human.
DR GenomeRNAi; 757; -.
DR NextBio; 3060; -.
DR PRO; PR:P56557; -.
DR ArrayExpress; P56557; -.
DR Bgee; P56557; -.
DR CleanEx; HS_TMEM50B; -.
DR Genevestigator; P56557; -.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR InterPro; IPR007919; UPF0220.
DR PANTHER; PTHR13180; PTHR13180; 1.
DR Pfam; PF05255; UPF0220; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 158 Transmembrane protein 50B.
FT /FTId=PRO_0000174183.
FT TRANSMEM 28 48 Helical; (Potential).
FT TRANSMEM 56 76 Helical; (Potential).
FT TRANSMEM 98 118 Helical; (Potential).
FT TRANSMEM 128 148 Helical; (Potential).
SQ SEQUENCE 158 AA; 17936 MW; 515ABB6AAA817DEB CRC64;
MAGFLDNFRW PECECIDWSE RRNAVASVVA GILFFTGWWI MIDAAVVYPK PEQLNHAFHT
CGVFSTLAFF MINAVSNAQV RGDSYESGCL GRTGARVWLF IGFMLMFGSL IASMWILFGA
YVTQNTDVYP GLAVFFQNAL IFFSTLIYKF GRTEELWT
//