Full text data of TMEM63B
TMEM63B
(C6orf110)
[Confidence: high (present in two of the MS resources)]
Transmembrane protein 63B
Transmembrane protein 63B
UniProt
Q5T3F8
ID TM63B_HUMAN Reviewed; 832 AA.
AC Q5T3F8; B9EGU3; Q5T3F9; Q6AHX4; Q6P5A0; Q8N219; Q8NDE1; Q9NSG5;
read moreDT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 22-JAN-2014, entry version 72.
DE RecName: Full=Transmembrane protein 63B;
GN Name=TMEM63B; Synonyms=C6orf110;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 186-832 (ISOFORM 3), AND VARIANT
RP MET-307.
RC TISSUE=Endometrial adenocarcinoma, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- INTERACTION:
CC Q3TWI9:Tmem63b (xeno); NbExp=1; IntAct=EBI-2553509, EBI-2553501;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5T3F8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T3F8-2; Sequence=VSP_023889, VSP_023890;
CC Note=No experimental confirmation available;
CC Name=3;
CC IsoId=Q5T3F8-3; Sequence=VSP_023891, VSP_023892;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the SPO75/TMEM63 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAH10540.1; Type=Frameshift; Positions=647;
CC Sequence=CAI20530.1; Type=Erroneous gene model prediction;
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DR EMBL; AK093629; BAC04207.1; -; mRNA.
DR EMBL; AL353957; CAB89257.1; -; mRNA.
DR EMBL; AL834238; CAD38916.1; -; mRNA.
DR EMBL; CR627460; CAH10540.1; ALT_FRAME; mRNA.
DR EMBL; AL365192; CAI20530.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL365192; CAI20531.1; -; Genomic_DNA.
DR EMBL; BC062989; AAH62989.1; -; mRNA.
DR EMBL; BC136769; AAI36770.1; -; mRNA.
DR PIR; T48692; T48692.
DR RefSeq; NP_060896.1; NM_018426.1.
DR RefSeq; XP_005249269.1; XM_005249212.1.
DR RefSeq; XP_005249270.1; XM_005249213.1.
DR RefSeq; XP_005249274.1; XM_005249217.1.
DR UniGene; Hs.414473; -.
DR ProteinModelPortal; Q5T3F8; -.
DR IntAct; Q5T3F8; 2.
DR STRING; 9606.ENSP00000327154; -.
DR TCDB; 1.A.17.5.3; the calcium-dependent chloride channel (ca-clc) family.
DR PhosphoSite; Q5T3F8; -.
DR DMDM; 74744754; -.
DR PaxDb; Q5T3F8; -.
DR PRIDE; Q5T3F8; -.
DR Ensembl; ENST00000259746; ENSP00000259746; ENSG00000137216.
DR Ensembl; ENST00000323267; ENSP00000327154; ENSG00000137216.
DR GeneID; 55362; -.
DR KEGG; hsa:55362; -.
DR UCSC; uc003owr.3; human.
DR CTD; 55362; -.
DR GeneCards; GC06P044095; -.
DR H-InvDB; HIX0005919; -.
DR HGNC; HGNC:17735; TMEM63B.
DR HPA; HPA029249; -.
DR HPA; HPA029251; -.
DR neXtProt; NX_Q5T3F8; -.
DR PharmGKB; PA134911221; -.
DR eggNOG; NOG249731; -.
DR HOVERGEN; HBG056752; -.
DR InParanoid; Q5T3F8; -.
DR OMA; RLKEDYR; -.
DR OrthoDB; EOG7HTHG9; -.
DR GenomeRNAi; 55362; -.
DR NextBio; 59735; -.
DR PRO; PR:Q5T3F8; -.
DR ArrayExpress; Q5T3F8; -.
DR Bgee; Q5T3F8; -.
DR CleanEx; HS_TMEM63B; -.
DR Genevestigator; Q5T3F8; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR003864; DUF221.
DR InterPro; IPR027815; DUF4463.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR InterPro; IPR026957; TMEM63.
DR PANTHER; PTHR13018:SF9; PTHR13018:SF9; 1.
DR Pfam; PF02714; DUF221; 1.
DR Pfam; PF14703; DUF4463; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Glycoprotein; Membrane;
KW Phosphoprotein; Polymorphism; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 832 Transmembrane protein 63B.
FT /FTId=PRO_0000280728.
FT TRANSMEM 41 61 Helical; (Potential).
FT TRANSMEM 158 178 Helical; (Potential).
FT TRANSMEM 203 223 Helical; (Potential).
FT TRANSMEM 435 455 Helical; (Potential).
FT TRANSMEM 481 501 Helical; (Potential).
FT TRANSMEM 521 541 Helical; (Potential).
FT TRANSMEM 560 580 Helical; (Potential).
FT TRANSMEM 615 629 Helical; (Potential).
FT TRANSMEM 630 650 Helical; (Potential).
FT TRANSMEM 678 698 Helical; (Potential).
FT TRANSMEM 711 731 Helical; (Potential).
FT MOD_RES 111 111 Phosphoserine (By similarity).
FT MOD_RES 114 114 Phosphoserine.
FT MOD_RES 115 115 Phosphoserine (By similarity).
FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 266 266 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 462 462 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 472 491 NPIITQFFPTLLLWCFSALL -> VRPHAPVTFHAGSQHTD
FT TRP (in isoform 2).
FT /FTId=VSP_023889.
FT VAR_SEQ 492 832 Missing (in isoform 2).
FT /FTId=VSP_023890.
FT VAR_SEQ 704 704 G -> D (in isoform 3).
FT /FTId=VSP_023891.
FT VAR_SEQ 705 832 Missing (in isoform 3).
FT /FTId=VSP_023892.
FT VARIANT 307 307 V -> M (in dbSNP:rs4714759).
FT /FTId=VAR_031192.
FT CONFLICT 298 298 F -> L (in Ref. 1; BAC04207).
SQ SEQUENCE 832 AA; 94958 MW; 8F28F9DBBA1A6A62 CRC64;
MLPFLLATLG TTALNNSNPK DYCYSARIRS TVLQGLPFGG VPTVLALDFM CFLALLFLFS
ILRKVAWDYG RLALVTDADR LRRQERDRVE QEYVASAMHG DSHDRYERLT SVSSSVDFDQ
RDNGFCSWLT AIFRIKDDEI RDKCGGDAVH YLSFQRHIIG LLVVVGVLSV GIVLPVNFSG
DLLENNAYSF GRTTIANLKS GNNLLWLHTS FAFLYLLLTV YSMRRHTSKM RYKEDDLVKR
TLFINGISKY AESEKIKKHF EEAYPNCTVL EARPCYNVAR LMFLDAERKK AERGKLYFTN
LQSKENVPTM INPKPCGHLC CCVVRGCEQV EAIEYYTKLE QKLKEDYKRE KEKVNEKPLG
MAFVTFHNET ITAIILKDFN VCKCQGCTCR GEPRPSSCSE SLHISNWTVS YAPDPQNIYW
EHLSIRGFIW WLRCLVINVV LFILLFFLTT PAIIITTMDK FNVTKPVEYL NNPIITQFFP
TLLLWCFSAL LPTIVYYSAF FEAHWTRSGE NRTTMHKCYT FLIFMVLLLP SLGLSSLDLF
FRWLFDKKFL AEAAIRFECV FLPDNGAFFV NYVIASAFIG NAMDLLRIPG LLMYMIRLCL
ARSAAERRNV KRHQAYEFQF GAAYAWMMCV FTVVMTYSIT CPIIVPFGLM YMLLKHLVDR
YNLYYAYLPA KLDKKIHSGA VNQVVAAPIL CLFWLLFFST MRTGFLAPTS MFTFVVLVIT
IVICLCHVCF GHFKYLSAHN YKIEHTETDT VDPRSNGRPP TAAAVPKSAK YIAQVLQDSE
VDGDGDGAPG SSGDEPPSSS SQDEELLMPP DALTDTDFQS CEDSLIENEI HQ
//
ID TM63B_HUMAN Reviewed; 832 AA.
AC Q5T3F8; B9EGU3; Q5T3F9; Q6AHX4; Q6P5A0; Q8N219; Q8NDE1; Q9NSG5;
read moreDT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 22-JAN-2014, entry version 72.
DE RecName: Full=Transmembrane protein 63B;
GN Name=TMEM63B; Synonyms=C6orf110;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 186-832 (ISOFORM 3), AND VARIANT
RP MET-307.
RC TISSUE=Endometrial adenocarcinoma, and Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- INTERACTION:
CC Q3TWI9:Tmem63b (xeno); NbExp=1; IntAct=EBI-2553509, EBI-2553501;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5T3F8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T3F8-2; Sequence=VSP_023889, VSP_023890;
CC Note=No experimental confirmation available;
CC Name=3;
CC IsoId=Q5T3F8-3; Sequence=VSP_023891, VSP_023892;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the SPO75/TMEM63 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAH10540.1; Type=Frameshift; Positions=647;
CC Sequence=CAI20530.1; Type=Erroneous gene model prediction;
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DR EMBL; AK093629; BAC04207.1; -; mRNA.
DR EMBL; AL353957; CAB89257.1; -; mRNA.
DR EMBL; AL834238; CAD38916.1; -; mRNA.
DR EMBL; CR627460; CAH10540.1; ALT_FRAME; mRNA.
DR EMBL; AL365192; CAI20530.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL365192; CAI20531.1; -; Genomic_DNA.
DR EMBL; BC062989; AAH62989.1; -; mRNA.
DR EMBL; BC136769; AAI36770.1; -; mRNA.
DR PIR; T48692; T48692.
DR RefSeq; NP_060896.1; NM_018426.1.
DR RefSeq; XP_005249269.1; XM_005249212.1.
DR RefSeq; XP_005249270.1; XM_005249213.1.
DR RefSeq; XP_005249274.1; XM_005249217.1.
DR UniGene; Hs.414473; -.
DR ProteinModelPortal; Q5T3F8; -.
DR IntAct; Q5T3F8; 2.
DR STRING; 9606.ENSP00000327154; -.
DR TCDB; 1.A.17.5.3; the calcium-dependent chloride channel (ca-clc) family.
DR PhosphoSite; Q5T3F8; -.
DR DMDM; 74744754; -.
DR PaxDb; Q5T3F8; -.
DR PRIDE; Q5T3F8; -.
DR Ensembl; ENST00000259746; ENSP00000259746; ENSG00000137216.
DR Ensembl; ENST00000323267; ENSP00000327154; ENSG00000137216.
DR GeneID; 55362; -.
DR KEGG; hsa:55362; -.
DR UCSC; uc003owr.3; human.
DR CTD; 55362; -.
DR GeneCards; GC06P044095; -.
DR H-InvDB; HIX0005919; -.
DR HGNC; HGNC:17735; TMEM63B.
DR HPA; HPA029249; -.
DR HPA; HPA029251; -.
DR neXtProt; NX_Q5T3F8; -.
DR PharmGKB; PA134911221; -.
DR eggNOG; NOG249731; -.
DR HOVERGEN; HBG056752; -.
DR InParanoid; Q5T3F8; -.
DR OMA; RLKEDYR; -.
DR OrthoDB; EOG7HTHG9; -.
DR GenomeRNAi; 55362; -.
DR NextBio; 59735; -.
DR PRO; PR:Q5T3F8; -.
DR ArrayExpress; Q5T3F8; -.
DR Bgee; Q5T3F8; -.
DR CleanEx; HS_TMEM63B; -.
DR Genevestigator; Q5T3F8; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR003864; DUF221.
DR InterPro; IPR027815; DUF4463.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR InterPro; IPR026957; TMEM63.
DR PANTHER; PTHR13018:SF9; PTHR13018:SF9; 1.
DR Pfam; PF02714; DUF221; 1.
DR Pfam; PF14703; DUF4463; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Glycoprotein; Membrane;
KW Phosphoprotein; Polymorphism; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 832 Transmembrane protein 63B.
FT /FTId=PRO_0000280728.
FT TRANSMEM 41 61 Helical; (Potential).
FT TRANSMEM 158 178 Helical; (Potential).
FT TRANSMEM 203 223 Helical; (Potential).
FT TRANSMEM 435 455 Helical; (Potential).
FT TRANSMEM 481 501 Helical; (Potential).
FT TRANSMEM 521 541 Helical; (Potential).
FT TRANSMEM 560 580 Helical; (Potential).
FT TRANSMEM 615 629 Helical; (Potential).
FT TRANSMEM 630 650 Helical; (Potential).
FT TRANSMEM 678 698 Helical; (Potential).
FT TRANSMEM 711 731 Helical; (Potential).
FT MOD_RES 111 111 Phosphoserine (By similarity).
FT MOD_RES 114 114 Phosphoserine.
FT MOD_RES 115 115 Phosphoserine (By similarity).
FT CARBOHYD 15 15 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 266 266 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 462 462 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 472 491 NPIITQFFPTLLLWCFSALL -> VRPHAPVTFHAGSQHTD
FT TRP (in isoform 2).
FT /FTId=VSP_023889.
FT VAR_SEQ 492 832 Missing (in isoform 2).
FT /FTId=VSP_023890.
FT VAR_SEQ 704 704 G -> D (in isoform 3).
FT /FTId=VSP_023891.
FT VAR_SEQ 705 832 Missing (in isoform 3).
FT /FTId=VSP_023892.
FT VARIANT 307 307 V -> M (in dbSNP:rs4714759).
FT /FTId=VAR_031192.
FT CONFLICT 298 298 F -> L (in Ref. 1; BAC04207).
SQ SEQUENCE 832 AA; 94958 MW; 8F28F9DBBA1A6A62 CRC64;
MLPFLLATLG TTALNNSNPK DYCYSARIRS TVLQGLPFGG VPTVLALDFM CFLALLFLFS
ILRKVAWDYG RLALVTDADR LRRQERDRVE QEYVASAMHG DSHDRYERLT SVSSSVDFDQ
RDNGFCSWLT AIFRIKDDEI RDKCGGDAVH YLSFQRHIIG LLVVVGVLSV GIVLPVNFSG
DLLENNAYSF GRTTIANLKS GNNLLWLHTS FAFLYLLLTV YSMRRHTSKM RYKEDDLVKR
TLFINGISKY AESEKIKKHF EEAYPNCTVL EARPCYNVAR LMFLDAERKK AERGKLYFTN
LQSKENVPTM INPKPCGHLC CCVVRGCEQV EAIEYYTKLE QKLKEDYKRE KEKVNEKPLG
MAFVTFHNET ITAIILKDFN VCKCQGCTCR GEPRPSSCSE SLHISNWTVS YAPDPQNIYW
EHLSIRGFIW WLRCLVINVV LFILLFFLTT PAIIITTMDK FNVTKPVEYL NNPIITQFFP
TLLLWCFSAL LPTIVYYSAF FEAHWTRSGE NRTTMHKCYT FLIFMVLLLP SLGLSSLDLF
FRWLFDKKFL AEAAIRFECV FLPDNGAFFV NYVIASAFIG NAMDLLRIPG LLMYMIRLCL
ARSAAERRNV KRHQAYEFQF GAAYAWMMCV FTVVMTYSIT CPIIVPFGLM YMLLKHLVDR
YNLYYAYLPA KLDKKIHSGA VNQVVAAPIL CLFWLLFFST MRTGFLAPTS MFTFVVLVIT
IVICLCHVCF GHFKYLSAHN YKIEHTETDT VDPRSNGRPP TAAAVPKSAK YIAQVLQDSE
VDGDGDGAPG SSGDEPPSSS SQDEELLMPP DALTDTDFQS CEDSLIENEI HQ
//