Full text data of TM9SF3
TM9SF3
(SMBP)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Transmembrane 9 superfamily member 3 (EP70-P-iso; SM-11044-binding protein; Flags: Precursor)
Transmembrane 9 superfamily member 3 (EP70-P-iso; SM-11044-binding protein; Flags: Precursor)
UniProt
Q9HD45
ID TM9S3_HUMAN Reviewed; 589 AA.
AC Q9HD45; Q5TB57; Q6UWE7; Q9NWL8; Q9P0G9; Q9UHW8;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
read moreDT 27-APR-2001, sequence version 2.
DT 22-JAN-2014, entry version 106.
DE RecName: Full=Transmembrane 9 superfamily member 3;
DE AltName: Full=EP70-P-iso;
DE AltName: Full=SM-11044-binding protein;
DE Flags: Precursor;
GN Name=TM9SF3; Synonyms=SMBP; ORFNames=UNQ245/PRO282;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Warner S.J., Lomax M.I.;
RT "Evolution of the TM9 super family of membrane spanning proteins.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Adrenal gland;
RA Gu Y., Peng Y., Li Y., Fu S., Gu J., Gu W., Jiang C., Yu Y., Han Z.,
RA Wang Y., Chen Z., Fu G.;
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 12-589.
RC TISSUE=Skeletal muscle;
RA Sugasawa T., Lenzen G., Simon S., Hidaka J., Cahen A., Guillaume J.L.,
RA Camoin L., Nahmias C., Strosberg A.D.;
RT "The iodocyanopindolol and SM-11044 binding protein (SMBP) belongs to
RT the emerging family of MP70 multispanning membrane proteins.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-589.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 128-589.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [9]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-174, AND MASS
RP SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of
RT multiple enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [10]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-174, AND MASS
RP SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-
RT linked cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Probable).
CC -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF67014.1; Type=Frameshift; Positions=184, 198, 370, 446;
CC Sequence=AAQ89178.1; Type=Frameshift; Positions=70;
CC Sequence=BAA91362.1; Type=Erroneous initiation;
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DR EMBL; AF269150; AAF98159.1; -; mRNA.
DR EMBL; AF160213; AAF67014.1; ALT_FRAME; mRNA.
DR EMBL; AL138765; CAI13584.1; -; Genomic_DNA.
DR EMBL; CH471066; EAW49972.1; -; Genomic_DNA.
DR EMBL; CH471066; EAW49974.1; -; Genomic_DNA.
DR EMBL; BC136788; AAI36789.1; -; mRNA.
DR EMBL; BC136789; AAI36790.1; -; mRNA.
DR EMBL; AF116347; AAF21983.1; -; mRNA.
DR EMBL; AY358819; AAQ89178.1; ALT_FRAME; mRNA.
DR EMBL; AK000756; BAA91362.1; ALT_INIT; mRNA.
DR RefSeq; NP_064508.3; NM_020123.3.
DR UniGene; Hs.500674; -.
DR ProteinModelPortal; Q9HD45; -.
DR IntAct; Q9HD45; 6.
DR MINT; MINT-5005017; -.
DR STRING; 9606.ENSP00000360184; -.
DR PhosphoSite; Q9HD45; -.
DR DMDM; 13878808; -.
DR PaxDb; Q9HD45; -.
DR PeptideAtlas; Q9HD45; -.
DR PRIDE; Q9HD45; -.
DR Ensembl; ENST00000371142; ENSP00000360184; ENSG00000077147.
DR GeneID; 56889; -.
DR KEGG; hsa:56889; -.
DR UCSC; uc001kmm.4; human.
DR CTD; 56889; -.
DR GeneCards; GC10M098267; -.
DR H-InvDB; HIX0009076; -.
DR HGNC; HGNC:21529; TM9SF3.
DR HPA; HPA039609; -.
DR neXtProt; NX_Q9HD45; -.
DR PharmGKB; PA144596264; -.
DR eggNOG; NOG251394; -.
DR HOGENOM; HOG000216680; -.
DR HOVERGEN; HBG054197; -.
DR InParanoid; Q9HD45; -.
DR KO; K17087; -.
DR OMA; YLYSFYY; -.
DR OrthoDB; EOG7PZRWX; -.
DR PhylomeDB; Q9HD45; -.
DR ChiTaRS; TM9SF3; human.
DR GenomeRNAi; 56889; -.
DR NextBio; 62295; -.
DR PRO; PR:Q9HD45; -.
DR ArrayExpress; Q9HD45; -.
DR Bgee; Q9HD45; -.
DR CleanEx; HS_TM9SF3; -.
DR Genevestigator; Q9HD45; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR004240; EMP70.
DR PANTHER; PTHR10766; PTHR10766; 1.
DR Pfam; PF02990; EMP70; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1 28 Potential.
FT CHAIN 29 589 Transmembrane 9 superfamily member 3.
FT /FTId=PRO_0000034369.
FT TRANSMEM 224 244 Helical; (Potential).
FT TRANSMEM 294 314 Helical; (Potential).
FT TRANSMEM 328 348 Helical; (Potential).
FT TRANSMEM 360 380 Helical; (Potential).
FT TRANSMEM 389 409 Helical; (Potential).
FT TRANSMEM 449 469 Helical; (Potential).
FT TRANSMEM 482 502 Helical; (Potential).
FT TRANSMEM 519 539 Helical; (Potential).
FT TRANSMEM 551 571 Helical; (Potential).
FT CARBOHYD 174 174 N-linked (GlcNAc...).
FT CARBOHYD 419 419 N-linked (GlcNAc...) (Potential).
FT CONFLICT 15 15 Missing (in Ref. 2; AAF67014).
FT CONFLICT 191 191 M -> I (in Ref. 1; AAF98159).
FT CONFLICT 210 218 KYLDPSFFQ -> NILIVLFS (in Ref. 2;
FT AAF67014).
FT CONFLICT 232 232 M -> T (in Ref. 8; BAA91362).
FT CONFLICT 398 398 V -> R (in Ref. 7; AAQ89178).
FT CONFLICT 547 547 F -> S (in Ref. 8; BAA91362).
SQ SEQUENCE 589 AA; 67888 MW; E673D547A35BC4A7 CRC64;
MRPLPGALGV AAAAALWLLL LLLPRTRADE HEHTYQDKEE VVLWMNTVGP YHNRQETYKY
FSLPFCVGSK KSISHYHETL GEALQGVELE FSGLDIKFKD DVMPATYCEI DLDKEKRDAF
VYAIKNHYWY QMYIDDLPIW GIVGEADENG EDYYLWTYKK LEIGFNGNRI VDVNLTSEGK
VKLVPNTKIQ MSYSVKWKKS DVKFEDRFDK YLDPSFFQHR IHWFSIFNSF MMVIFLVGLV
SMILMRTLRK DYARYSKEEE MDDMDRDLGD EYGWKQVHGD VFRPSSHPLI FSSLIGSGCQ
IFAVSLIVII VAMIEDLYTE RGSMLSTAIF VYAATSPVNG YFGGSLYARQ GGRRWIKQMF
IGAFLIPAMV CGTAFFINFI AIYYHASRAI PFGTMVAVCC ICFFVILPLN LVGTILGRNL
SGQPNFPCRV NAVPRPIPEK KWFMEPAVIV CLGGILPFGS IFIEMYFIFT SFWAYKIYYV
YGFMMLVLVI LCIVTVCVTI VCTYFLLNAE DYRWQWTSFL SAASTAIYVY MYSFYYYFFK
TKMYGLFQTS FYFGYMAVFS TALGIMCGAI GYMGTSAFVR KIYTNVKID
//
ID TM9S3_HUMAN Reviewed; 589 AA.
AC Q9HD45; Q5TB57; Q6UWE7; Q9NWL8; Q9P0G9; Q9UHW8;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
read moreDT 27-APR-2001, sequence version 2.
DT 22-JAN-2014, entry version 106.
DE RecName: Full=Transmembrane 9 superfamily member 3;
DE AltName: Full=EP70-P-iso;
DE AltName: Full=SM-11044-binding protein;
DE Flags: Precursor;
GN Name=TM9SF3; Synonyms=SMBP; ORFNames=UNQ245/PRO282;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Warner S.J., Lomax M.I.;
RT "Evolution of the TM9 super family of membrane spanning proteins.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Adrenal gland;
RA Gu Y., Peng Y., Li Y., Fu S., Gu J., Gu W., Jiang C., Yu Y., Han Z.,
RA Wang Y., Chen Z., Fu G.;
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 12-589.
RC TISSUE=Skeletal muscle;
RA Sugasawa T., Lenzen G., Simon S., Hidaka J., Cahen A., Guillaume J.L.,
RA Camoin L., Nahmias C., Strosberg A.D.;
RT "The iodocyanopindolol and SM-11044 binding protein (SMBP) belongs to
RT the emerging family of MP70 multispanning membrane proteins.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-589.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 128-589.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [9]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-174, AND MASS
RP SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of
RT multiple enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [10]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-174, AND MASS
RP SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-
RT linked cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Probable).
CC -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF67014.1; Type=Frameshift; Positions=184, 198, 370, 446;
CC Sequence=AAQ89178.1; Type=Frameshift; Positions=70;
CC Sequence=BAA91362.1; Type=Erroneous initiation;
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DR EMBL; AF269150; AAF98159.1; -; mRNA.
DR EMBL; AF160213; AAF67014.1; ALT_FRAME; mRNA.
DR EMBL; AL138765; CAI13584.1; -; Genomic_DNA.
DR EMBL; CH471066; EAW49972.1; -; Genomic_DNA.
DR EMBL; CH471066; EAW49974.1; -; Genomic_DNA.
DR EMBL; BC136788; AAI36789.1; -; mRNA.
DR EMBL; BC136789; AAI36790.1; -; mRNA.
DR EMBL; AF116347; AAF21983.1; -; mRNA.
DR EMBL; AY358819; AAQ89178.1; ALT_FRAME; mRNA.
DR EMBL; AK000756; BAA91362.1; ALT_INIT; mRNA.
DR RefSeq; NP_064508.3; NM_020123.3.
DR UniGene; Hs.500674; -.
DR ProteinModelPortal; Q9HD45; -.
DR IntAct; Q9HD45; 6.
DR MINT; MINT-5005017; -.
DR STRING; 9606.ENSP00000360184; -.
DR PhosphoSite; Q9HD45; -.
DR DMDM; 13878808; -.
DR PaxDb; Q9HD45; -.
DR PeptideAtlas; Q9HD45; -.
DR PRIDE; Q9HD45; -.
DR Ensembl; ENST00000371142; ENSP00000360184; ENSG00000077147.
DR GeneID; 56889; -.
DR KEGG; hsa:56889; -.
DR UCSC; uc001kmm.4; human.
DR CTD; 56889; -.
DR GeneCards; GC10M098267; -.
DR H-InvDB; HIX0009076; -.
DR HGNC; HGNC:21529; TM9SF3.
DR HPA; HPA039609; -.
DR neXtProt; NX_Q9HD45; -.
DR PharmGKB; PA144596264; -.
DR eggNOG; NOG251394; -.
DR HOGENOM; HOG000216680; -.
DR HOVERGEN; HBG054197; -.
DR InParanoid; Q9HD45; -.
DR KO; K17087; -.
DR OMA; YLYSFYY; -.
DR OrthoDB; EOG7PZRWX; -.
DR PhylomeDB; Q9HD45; -.
DR ChiTaRS; TM9SF3; human.
DR GenomeRNAi; 56889; -.
DR NextBio; 62295; -.
DR PRO; PR:Q9HD45; -.
DR ArrayExpress; Q9HD45; -.
DR Bgee; Q9HD45; -.
DR CleanEx; HS_TM9SF3; -.
DR Genevestigator; Q9HD45; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR004240; EMP70.
DR PANTHER; PTHR10766; PTHR10766; 1.
DR Pfam; PF02990; EMP70; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1 28 Potential.
FT CHAIN 29 589 Transmembrane 9 superfamily member 3.
FT /FTId=PRO_0000034369.
FT TRANSMEM 224 244 Helical; (Potential).
FT TRANSMEM 294 314 Helical; (Potential).
FT TRANSMEM 328 348 Helical; (Potential).
FT TRANSMEM 360 380 Helical; (Potential).
FT TRANSMEM 389 409 Helical; (Potential).
FT TRANSMEM 449 469 Helical; (Potential).
FT TRANSMEM 482 502 Helical; (Potential).
FT TRANSMEM 519 539 Helical; (Potential).
FT TRANSMEM 551 571 Helical; (Potential).
FT CARBOHYD 174 174 N-linked (GlcNAc...).
FT CARBOHYD 419 419 N-linked (GlcNAc...) (Potential).
FT CONFLICT 15 15 Missing (in Ref. 2; AAF67014).
FT CONFLICT 191 191 M -> I (in Ref. 1; AAF98159).
FT CONFLICT 210 218 KYLDPSFFQ -> NILIVLFS (in Ref. 2;
FT AAF67014).
FT CONFLICT 232 232 M -> T (in Ref. 8; BAA91362).
FT CONFLICT 398 398 V -> R (in Ref. 7; AAQ89178).
FT CONFLICT 547 547 F -> S (in Ref. 8; BAA91362).
SQ SEQUENCE 589 AA; 67888 MW; E673D547A35BC4A7 CRC64;
MRPLPGALGV AAAAALWLLL LLLPRTRADE HEHTYQDKEE VVLWMNTVGP YHNRQETYKY
FSLPFCVGSK KSISHYHETL GEALQGVELE FSGLDIKFKD DVMPATYCEI DLDKEKRDAF
VYAIKNHYWY QMYIDDLPIW GIVGEADENG EDYYLWTYKK LEIGFNGNRI VDVNLTSEGK
VKLVPNTKIQ MSYSVKWKKS DVKFEDRFDK YLDPSFFQHR IHWFSIFNSF MMVIFLVGLV
SMILMRTLRK DYARYSKEEE MDDMDRDLGD EYGWKQVHGD VFRPSSHPLI FSSLIGSGCQ
IFAVSLIVII VAMIEDLYTE RGSMLSTAIF VYAATSPVNG YFGGSLYARQ GGRRWIKQMF
IGAFLIPAMV CGTAFFINFI AIYYHASRAI PFGTMVAVCC ICFFVILPLN LVGTILGRNL
SGQPNFPCRV NAVPRPIPEK KWFMEPAVIV CLGGILPFGS IFIEMYFIFT SFWAYKIYYV
YGFMMLVLVI LCIVTVCVTI VCTYFLLNAE DYRWQWTSFL SAASTAIYVY MYSFYYYFFK
TKMYGLFQTS FYFGYMAVFS TALGIMCGAI GYMGTSAFVR KIYTNVKID
//