RBCC

Full text data of TMCC2

TMCC2 (KIAA0481) [Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11)

UniProt O75069
ID TMCC2_HUMAN Reviewed; 709 AA.
AC O75069; A2RRH3; B7Z1P7; Q6ZN09;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
read moreDT 12-APR-2005, sequence version 3.
DT 22-JAN-2014, entry version 99.
DE RecName: Full=Transmembrane and coiled-coil domains protein 2;
DE AltName: Full=Cerebral protein 11;
GN Name=TMCC2; Synonyms=KIAA0481; ORFNames=hucep-11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9455484; DOI=10.1093/dnares/4.5.345;
RA Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D.,
RA Nomura N., Ohara O.;
RT "Characterization of cDNA clones in size-fractionated cDNA libraries
RT from human brain.";
RL DNA Res. 4:345-349(1997).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT "Construction of expression-ready cDNA clones for KIAA genes: manual
RT curation of 330 KIAA cDNA clones.";
RL DNA Res. 9:99-106(2002).
RN [3]
RP SEQUENCE REVISION.
RA Ohara O., Nagase T., Kikuno R.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 226-709 (ISOFORMS 1/2).
RC TISSUE=Brain;
RA Yoshimoto M., Yazaki M., Takayama K., Matsumoto K., Tsuritani K.;
RT "Molecular cloning of a gene specifically expressed in human central
RT nervous system.";
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC P02649:APOE; NbExp=5; IntAct=EBI-726731, EBI-1222467;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O75069-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O75069-2; Sequence=VSP_046245;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the TEX28 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA32326.3; Type=Erroneous initiation;
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DR EMBL; AB007950; BAA32326.3; ALT_INIT; mRNA.
DR EMBL; AK131419; BAD18566.1; -; mRNA.
DR EMBL; AK293734; BAH11583.1; -; mRNA.
DR EMBL; BC131629; AAI31630.1; -; mRNA.
DR EMBL; AC093422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471067; EAW91548.1; -; Genomic_DNA.
DR EMBL; AB001596; BAB46924.1; -; mRNA.
DR RefSeq; NP_001229854.1; NM_001242925.1.
DR RefSeq; NP_055673.2; NM_014858.3.
DR RefSeq; XP_005245741.1; XM_005245684.1.
DR RefSeq; XP_005245742.1; XM_005245685.1.
DR RefSeq; XP_005245745.1; XM_005245688.1.
DR UniGene; Hs.6360; -.
DR ProteinModelPortal; O75069; -.
DR IntAct; O75069; 4.
DR STRING; 9606.ENSP00000350718; -.
DR PhosphoSite; O75069; -.
DR PaxDb; O75069; -.
DR PRIDE; O75069; -.
DR DNASU; 9911; -.
DR Ensembl; ENST00000330675; ENSP00000331842; ENSG00000133069.
DR Ensembl; ENST00000358024; ENSP00000350718; ENSG00000133069.
DR Ensembl; ENST00000545499; ENSP00000437943; ENSG00000133069.
DR GeneID; 9911; -.
DR KEGG; hsa:9911; -.
DR UCSC; uc001hca.3; human.
DR CTD; 9911; -.
DR GeneCards; GC01P205197; -.
DR H-InvDB; HIX0160023; -.
DR HGNC; HGNC:24239; TMCC2.
DR HPA; HPA014254; -.
DR neXtProt; NX_O75069; -.
DR PharmGKB; PA134963344; -.
DR eggNOG; NOG319116; -.
DR HOGENOM; HOG000294160; -.
DR HOVERGEN; HBG057342; -.
DR InParanoid; O75069; -.
DR OMA; SKPPDLK; -.
DR OrthoDB; EOG7W6WKN; -.
DR ChiTaRS; TMCC2; human.
DR GenomeRNAi; 9911; -.
DR NextBio; 37387; -.
DR PRO; PR:O75069; -.
DR ArrayExpress; O75069; -.
DR Bgee; O75069; -.
DR CleanEx; HS_TMCC2; -.
DR Genevestigator; O75069; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR019394; Predicted_TM_coiled-coil_2.
DR Pfam; PF10267; Tmemb_cc2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Complete proteome; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 709 Transmembrane and coiled-coil domains
FT protein 2.
FT /FTId=PRO_0000184597.
FT TRANSMEM 649 669 Helical; (Potential).
FT TRANSMEM 682 702 Helical; (Potential).
FT COILED 333 368 Potential.
FT COILED 514 633 Potential.
FT VAR_SEQ 1 78 Missing (in isoform 2).
FT /FTId=VSP_046245.
FT CONFLICT 226 249 TALLLADGSNVYLLAEEAEGIGDK -> MNQVVQPLMSRHS
FT ACRGSQAHLSW (in Ref. 8; BAB46924).
SQ SEQUENCE 709 AA; 77449 MW; 002993EA6B0E4546 CRC64;
MKRCRSDELQ QQQGEEDGAG LEDAASHLPG ADLRPGETTG ANSAGGPTSD AGAAAAPNPG
PRSKPPDLKK IQQLSEGSMF GHGLKHLFHS RRRSREREHQ TSQDSQQHQQ QQGMSDHDSP
DEKERSPEMH RVSYAMSLHD LPARPTAFNR VLQQIRSRPS IKRGASLHSS SGGGSSGSSS
RRTKSSSLEP QRGSPHLLRK APQDSSLAAI LHQHQCRPRS SSTTDTALLL ADGSNVYLLA
EEAEGIGDKV DKGDLVALSL PAGHGDTDGP ISLDVPDGAP DPQRTKAAID HLHQKILKIT
EQIKIEQEAR DDNVAEYLKL ANNADKQQVS RIKQVFEKKN QKSAQTIAQL HKKLEHYRRR
LKEIEQNGPS RQPKDVLRDM QQGLKDVGAN VRAGISGFGG GVVEGVKGSL SGLSQATHTA
VVSKPREFAS LIRNKFGSAD NIAHLKDPLE DGPPEEAARA LSGSATLVSS PKYGSDDECS
SASASSAGAG SNSGAGPGGA LGSPKSNALY GAPGNLDALL EELREIKEGQ SHLEDSMEDL
KTQLQRDYTY MTQCLQEERY RYERLEEQLN DLTELHQNEM TNLKQELASM EEKVAYQSYE
RARDIQEAVE SCLTRVTKLE LQQQQQQVVQ LEGVENANAR ALLGKFINVI LALMAVLLVF
VSTIANFITP LMKTRLRITS TTLLVLVLFL LWKHWDSLTY LLEHVLLPS
//

RBCC Red Blood Cell Collection

Full text data of TMCC2