Full text data of TMED4
TMED4
(ERS25)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25; ERS25; GMP25iso; Putative NF-kappa-B-activating protein 156; p24 family protein alpha-3; p24alpha3; Flags: Precursor)
Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25; ERS25; GMP25iso; Putative NF-kappa-B-activating protein 156; p24 family protein alpha-3; p24alpha3; Flags: Precursor)
Comments
Isoform Q7Z7H5-2 was detected.
Isoform Q7Z7H5-2 was detected.
UniProt
Q7Z7H5
ID TMED4_HUMAN Reviewed; 227 AA.
AC Q7Z7H5; A4D2K8; B4DFJ4; Q56VW3; Q7Z432; Q8N2P6;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2003, sequence version 1.
DT 22-JAN-2014, entry version 88.
DE RecName: Full=Transmembrane emp24 domain-containing protein 4;
DE AltName: Full=Endoplasmic reticulum stress-response protein 25;
DE Short=ERS25;
DE AltName: Full=GMP25iso;
DE AltName: Full=Putative NF-kappa-B-activating protein 156;
DE AltName: Full=p24 family protein alpha-3;
DE Short=p24alpha3;
DE Flags: Precursor;
GN Name=TMED4; Synonyms=ERS25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Brain cortex, Embryo, and Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Endometrium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA Mural R.J., Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 6-227 (ISOFORM 3).
RA Kim J.W.;
RT "Identification of human transforming gene.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 119-227 (ISOFORMS 1/2).
RC TISSUE=Lung fibroblast;
RX PubMed=12761501; DOI=10.1038/sj.onc.1206406;
RA Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O.,
RA Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H.,
RA Sugano S.;
RT "Large-scale identification and characterization of human genes that
RT activate NF-kappaB and MAPK signaling pathways.";
RL Oncogene 22:3307-3318(2003).
RN [8]
RP IDENTIFICATION.
RX PubMed=18326488; DOI=10.1074/jbc.M709656200;
RA Hwang S.O., Boswell S.A., Seo J.-S., Lee S.W.;
RT "Novel oxidative stress-responsive gene ERS25 functions as a regulator
RT of the heat-shock and cell death response.";
RL J. Biol. Chem. 283:13063-13069(2008).
RN [9]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-117, AND MASS
RP SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of
RT multiple enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Involved in vesicular protein trafficking, mainly in the
CC early secretory pathway. targeting. Involved in the maintenance of
CC the Golgi apparatus. Appears to play a role in the biosynthesis of
CC secreted cargo including processing. Involved in endoplasmic
CC reticulum stress response. May play a role in the regulation of
CC heat-shock response and apoptosis (By similarity).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC type I membrane protein (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q7Z7H5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z7H5-2; Sequence=VSP_035698;
CC Note=No experimental confirmation available;
CC Name=3;
CC IsoId=Q7Z7H5-3; Sequence=VSP_035699, VSP_035700;
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family.
CC -!- SIMILARITY: Contains 1 GOLD domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP20105.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=BAC77362.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
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DR EMBL; AK074557; BAC11058.1; -; mRNA.
DR EMBL; AK290125; BAF82814.1; -; mRNA.
DR EMBL; AK294122; BAG57455.1; -; mRNA.
DR EMBL; BX647965; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CH236960; EAL23751.1; -; Genomic_DNA.
DR EMBL; CH471128; EAW61090.1; -; Genomic_DNA.
DR EMBL; CH471128; EAW61091.1; -; Genomic_DNA.
DR EMBL; BC052641; AAH52641.1; -; mRNA.
DR EMBL; BC057851; AAH57851.1; -; mRNA.
DR EMBL; AY191223; AAP20105.1; ALT_INIT; mRNA.
DR EMBL; AB097009; BAC77362.1; ALT_INIT; mRNA.
DR RefSeq; NP_872353.2; NM_182547.2.
DR UniGene; Hs.598832; -.
DR UniGene; Hs.715273; -.
DR ProteinModelPortal; Q7Z7H5; -.
DR IntAct; Q7Z7H5; 2.
DR STRING; 9606.ENSP00000404042; -.
DR PhosphoSite; Q7Z7H5; -.
DR DMDM; 62287892; -.
DR PaxDb; Q7Z7H5; -.
DR PRIDE; Q7Z7H5; -.
DR DNASU; 222068; -.
DR Ensembl; ENST00000457408; ENSP00000404042; ENSG00000158604.
DR Ensembl; ENST00000481238; ENSP00000417443; ENSG00000158604.
DR GeneID; 222068; -.
DR KEGG; hsa:222068; -.
DR UCSC; uc003tli.3; human.
DR CTD; 222068; -.
DR GeneCards; GC07M044584; -.
DR HGNC; HGNC:22301; TMED4.
DR HPA; HPA014650; -.
DR MIM; 612038; gene.
DR neXtProt; NX_Q7Z7H5; -.
DR PharmGKB; PA134983854; -.
DR eggNOG; NOG323830; -.
DR HOGENOM; HOG000160228; -.
DR HOVERGEN; HBG105357; -.
DR InParanoid; Q7Z7H5; -.
DR OMA; MGRQALL; -.
DR OrthoDB; EOG74BJT2; -.
DR PhylomeDB; Q7Z7H5; -.
DR ChiTaRS; TMED4; human.
DR GeneWiki; TMED4; -.
DR GenomeRNAi; 222068; -.
DR NextBio; 91548; -.
DR PRO; PR:Q7Z7H5; -.
DR ArrayExpress; Q7Z7H5; -.
DR Bgee; Q7Z7H5; -.
DR CleanEx; HS_TMED4; -.
DR Genevestigator; Q7Z7H5; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0004871; F:signal transducer activity; IMP:UniProtKB.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR009038; GOLD.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Complete proteome;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Protein transport;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1 29 Potential.
FT CHAIN 30 227 Transmembrane emp24 domain-containing
FT protein 4.
FT /FTId=PRO_0000010387.
FT TOPO_DOM 30 194 Lumenal (Potential).
FT TRANSMEM 195 212 Helical; (Potential).
FT TOPO_DOM 213 227 Cytoplasmic (Potential).
FT DOMAIN 39 137 GOLD.
FT COILED 147 176 Potential.
FT MOTIF 220 227 COPI vesicle coat-binding (Potential).
FT MOTIF 220 221 COPII vesicle coat-binding (Potential).
FT CARBOHYD 117 117 N-linked (GlcNAc...).
FT VAR_SEQ 59 74 Missing (in isoform 2).
FT /FTId=VSP_035698.
FT VAR_SEQ 179 186 YREERFRL -> ASAYLLVI (in isoform 3).
FT /FTId=VSP_035699.
FT VAR_SEQ 187 227 Missing (in isoform 3).
FT /FTId=VSP_035700.
SQ SEQUENCE 227 AA; 25943 MW; 3C650402F472A051 CRC64;
MAGVGAGPLR AMGRQALLLL ALCATGAQGL YFHIGETEKR CFIEEIPDET MVIGNYRTQM
WDKQKEVFLP STPGLGMHVE VKDPDGKVVL SRQYGSEGRF TFTSHTPGDH QICLHSNSTR
MALFAGGKLR VHLDIQVGEH ANNYPEIAAK DKLTELQLRA RQLLDQVEQI QKEQDYQRYR
EERFRLTSES TNQRVLWWSI AQTVILILTG IWQMRHLKSF FEAKKLV
//
ID TMED4_HUMAN Reviewed; 227 AA.
AC Q7Z7H5; A4D2K8; B4DFJ4; Q56VW3; Q7Z432; Q8N2P6;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2003, sequence version 1.
DT 22-JAN-2014, entry version 88.
DE RecName: Full=Transmembrane emp24 domain-containing protein 4;
DE AltName: Full=Endoplasmic reticulum stress-response protein 25;
DE Short=ERS25;
DE AltName: Full=GMP25iso;
DE AltName: Full=Putative NF-kappa-B-activating protein 156;
DE AltName: Full=p24 family protein alpha-3;
DE Short=p24alpha3;
DE Flags: Precursor;
GN Name=TMED4; Synonyms=ERS25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Brain cortex, Embryo, and Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Endometrium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S.,
RA Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z.,
RA Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C.,
RA Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J.,
RA Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F.,
RA Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F.,
RA Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H.,
RA Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G.,
RA Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P.,
RA Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J.,
RA Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F.,
RA Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B.,
RA Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W.,
RA Mural R.J., Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 6-227 (ISOFORM 3).
RA Kim J.W.;
RT "Identification of human transforming gene.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 119-227 (ISOFORMS 1/2).
RC TISSUE=Lung fibroblast;
RX PubMed=12761501; DOI=10.1038/sj.onc.1206406;
RA Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O.,
RA Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H.,
RA Sugano S.;
RT "Large-scale identification and characterization of human genes that
RT activate NF-kappaB and MAPK signaling pathways.";
RL Oncogene 22:3307-3318(2003).
RN [8]
RP IDENTIFICATION.
RX PubMed=18326488; DOI=10.1074/jbc.M709656200;
RA Hwang S.O., Boswell S.A., Seo J.-S., Lee S.W.;
RT "Novel oxidative stress-responsive gene ERS25 functions as a regulator
RT of the heat-shock and cell death response.";
RL J. Biol. Chem. 283:13063-13069(2008).
RN [9]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-117, AND MASS
RP SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of
RT multiple enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Involved in vesicular protein trafficking, mainly in the
CC early secretory pathway. targeting. Involved in the maintenance of
CC the Golgi apparatus. Appears to play a role in the biosynthesis of
CC secreted cargo including processing. Involved in endoplasmic
CC reticulum stress response. May play a role in the regulation of
CC heat-shock response and apoptosis (By similarity).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC type I membrane protein (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q7Z7H5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z7H5-2; Sequence=VSP_035698;
CC Note=No experimental confirmation available;
CC Name=3;
CC IsoId=Q7Z7H5-3; Sequence=VSP_035699, VSP_035700;
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family.
CC -!- SIMILARITY: Contains 1 GOLD domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP20105.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=BAC77362.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
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DR EMBL; AK074557; BAC11058.1; -; mRNA.
DR EMBL; AK290125; BAF82814.1; -; mRNA.
DR EMBL; AK294122; BAG57455.1; -; mRNA.
DR EMBL; BX647965; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CH236960; EAL23751.1; -; Genomic_DNA.
DR EMBL; CH471128; EAW61090.1; -; Genomic_DNA.
DR EMBL; CH471128; EAW61091.1; -; Genomic_DNA.
DR EMBL; BC052641; AAH52641.1; -; mRNA.
DR EMBL; BC057851; AAH57851.1; -; mRNA.
DR EMBL; AY191223; AAP20105.1; ALT_INIT; mRNA.
DR EMBL; AB097009; BAC77362.1; ALT_INIT; mRNA.
DR RefSeq; NP_872353.2; NM_182547.2.
DR UniGene; Hs.598832; -.
DR UniGene; Hs.715273; -.
DR ProteinModelPortal; Q7Z7H5; -.
DR IntAct; Q7Z7H5; 2.
DR STRING; 9606.ENSP00000404042; -.
DR PhosphoSite; Q7Z7H5; -.
DR DMDM; 62287892; -.
DR PaxDb; Q7Z7H5; -.
DR PRIDE; Q7Z7H5; -.
DR DNASU; 222068; -.
DR Ensembl; ENST00000457408; ENSP00000404042; ENSG00000158604.
DR Ensembl; ENST00000481238; ENSP00000417443; ENSG00000158604.
DR GeneID; 222068; -.
DR KEGG; hsa:222068; -.
DR UCSC; uc003tli.3; human.
DR CTD; 222068; -.
DR GeneCards; GC07M044584; -.
DR HGNC; HGNC:22301; TMED4.
DR HPA; HPA014650; -.
DR MIM; 612038; gene.
DR neXtProt; NX_Q7Z7H5; -.
DR PharmGKB; PA134983854; -.
DR eggNOG; NOG323830; -.
DR HOGENOM; HOG000160228; -.
DR HOVERGEN; HBG105357; -.
DR InParanoid; Q7Z7H5; -.
DR OMA; MGRQALL; -.
DR OrthoDB; EOG74BJT2; -.
DR PhylomeDB; Q7Z7H5; -.
DR ChiTaRS; TMED4; human.
DR GeneWiki; TMED4; -.
DR GenomeRNAi; 222068; -.
DR NextBio; 91548; -.
DR PRO; PR:Q7Z7H5; -.
DR ArrayExpress; Q7Z7H5; -.
DR Bgee; Q7Z7H5; -.
DR CleanEx; HS_TMED4; -.
DR Genevestigator; Q7Z7H5; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0004871; F:signal transducer activity; IMP:UniProtKB.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR009038; GOLD.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Complete proteome;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Protein transport;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1 29 Potential.
FT CHAIN 30 227 Transmembrane emp24 domain-containing
FT protein 4.
FT /FTId=PRO_0000010387.
FT TOPO_DOM 30 194 Lumenal (Potential).
FT TRANSMEM 195 212 Helical; (Potential).
FT TOPO_DOM 213 227 Cytoplasmic (Potential).
FT DOMAIN 39 137 GOLD.
FT COILED 147 176 Potential.
FT MOTIF 220 227 COPI vesicle coat-binding (Potential).
FT MOTIF 220 221 COPII vesicle coat-binding (Potential).
FT CARBOHYD 117 117 N-linked (GlcNAc...).
FT VAR_SEQ 59 74 Missing (in isoform 2).
FT /FTId=VSP_035698.
FT VAR_SEQ 179 186 YREERFRL -> ASAYLLVI (in isoform 3).
FT /FTId=VSP_035699.
FT VAR_SEQ 187 227 Missing (in isoform 3).
FT /FTId=VSP_035700.
SQ SEQUENCE 227 AA; 25943 MW; 3C650402F472A051 CRC64;
MAGVGAGPLR AMGRQALLLL ALCATGAQGL YFHIGETEKR CFIEEIPDET MVIGNYRTQM
WDKQKEVFLP STPGLGMHVE VKDPDGKVVL SRQYGSEGRF TFTSHTPGDH QICLHSNSTR
MALFAGGKLR VHLDIQVGEH ANNYPEIAAK DKLTELQLRA RQLLDQVEQI QKEQDYQRYR
EERFRLTSES TNQRVLWWSI AQTVILILTG IWQMRHLKSF FEAKKLV
//
MIM
612038
*RECORD*
*FIELD* NO
612038
*FIELD* TI
*612038 TRANSMEMBRANE EMP24 PROTEIN TRANSPORT DOMAIN-CONTAINING PROTEIN 4;
TMED4
*FIELD* TX
read more
CLONING
Matsuda et al. (2003) cloned TMED4, which they called clone-156, from a
human lung fibroblast cDNA library. The deduced protein contains 107
amino acids.
GENE FUNCTION
Matsuda et al. (2003) found that TMED4 induced NF-kappa-B (see 164011)
signaling 7-fold following expression in human embryonic kidney cells.
MAPPING
By genomic sequence analysis, Matsuda et al. (2003) mapped the TMED4
gene to chromosome 7p22.2.
*FIELD* RF
1. Matsuda, A.; Suzuki, Y.; Honda, G.; Muramatsu, S.; Matsuzaki, O.;
Nagano, Y.; Doi, T.; Shimotohno, K.; Harada, T.; Nishida, E.; Hayashi,
H.; Sugano, S.: Large-scale identification and characterization of
human genes that activate NF-kappa-B and MAPK signaling pathways. Oncogene 22:
3307-3318, 2003.
*FIELD* CD
Patricia A. Hartz: 5/8/2008
*FIELD* ED
mgross: 05/08/2008
*RECORD*
*FIELD* NO
612038
*FIELD* TI
*612038 TRANSMEMBRANE EMP24 PROTEIN TRANSPORT DOMAIN-CONTAINING PROTEIN 4;
TMED4
*FIELD* TX
read more
CLONING
Matsuda et al. (2003) cloned TMED4, which they called clone-156, from a
human lung fibroblast cDNA library. The deduced protein contains 107
amino acids.
GENE FUNCTION
Matsuda et al. (2003) found that TMED4 induced NF-kappa-B (see 164011)
signaling 7-fold following expression in human embryonic kidney cells.
MAPPING
By genomic sequence analysis, Matsuda et al. (2003) mapped the TMED4
gene to chromosome 7p22.2.
*FIELD* RF
1. Matsuda, A.; Suzuki, Y.; Honda, G.; Muramatsu, S.; Matsuzaki, O.;
Nagano, Y.; Doi, T.; Shimotohno, K.; Harada, T.; Nishida, E.; Hayashi,
H.; Sugano, S.: Large-scale identification and characterization of
human genes that activate NF-kappa-B and MAPK signaling pathways. Oncogene 22:
3307-3318, 2003.
*FIELD* CD
Patricia A. Hartz: 5/8/2008
*FIELD* ED
mgross: 05/08/2008