Full text data of TMEM33
TMEM33
(DB83)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Transmembrane protein 33 (Protein DB83)
Transmembrane protein 33 (Protein DB83)
UniProt
P57088
ID TMM33_HUMAN Reviewed; 247 AA.
AC P57088; B3KSS8; Q9H953;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
read moreDT 19-SEP-2002, sequence version 2.
DT 22-JAN-2014, entry version 103.
DE RecName: Full=Transmembrane protein 33;
DE AltName: Full=Protein DB83;
GN Name=TMEM33; Synonyms=DB83;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
RC TISSUE=Melanoma;
RX PubMed=17081065; DOI=10.1021/pr060363j;
RA Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H.,
RA Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R.,
RA Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E.,
RA Hunt D.F.;
RT "Proteomic and bioinformatic characterization of the biogenesis and
RT function of melanosomes.";
RL J. Proteome Res. 5:3135-3144(2006).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential). Melanosome. Note=Identified by mass spectrometry in
CC melanosome fractions from stage I to stage IV.
CC -!- SIMILARITY: Belongs to the PER33/POM33 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK001387; BAA91665.1; -; mRNA.
DR EMBL; AK023062; BAB14384.1; -; mRNA.
DR EMBL; AK094190; BAG52840.1; -; mRNA.
DR EMBL; CR457260; CAG33541.1; -; mRNA.
DR EMBL; CH471069; EAW92991.1; -; Genomic_DNA.
DR EMBL; BC000948; AAH00948.2; -; mRNA.
DR RefSeq; NP_060596.2; NM_018126.2.
DR RefSeq; XP_005248173.1; XM_005248116.1.
DR RefSeq; XP_005248174.1; XM_005248117.1.
DR UniGene; Hs.31082; -.
DR ProteinModelPortal; P57088; -.
DR IntAct; P57088; 11.
DR MINT; MINT-3021719; -.
DR STRING; 9606.ENSP00000264452; -.
DR PhosphoSite; P57088; -.
DR DMDM; 23503056; -.
DR PaxDb; P57088; -.
DR PeptideAtlas; P57088; -.
DR PRIDE; P57088; -.
DR DNASU; 55161; -.
DR Ensembl; ENST00000325094; ENSP00000441455; ENSG00000109133.
DR Ensembl; ENST00000504986; ENSP00000422473; ENSG00000109133.
DR Ensembl; ENST00000513702; ENSP00000427006; ENSG00000109133.
DR GeneID; 55161; -.
DR KEGG; hsa:55161; -.
DR UCSC; uc003gwi.2; human.
DR CTD; 55161; -.
DR GeneCards; GC04P041937; -.
DR HGNC; HGNC:25541; TMEM33.
DR neXtProt; NX_P57088; -.
DR PharmGKB; PA134963055; -.
DR eggNOG; NOG236583; -.
DR HOVERGEN; HBG054225; -.
DR InParanoid; P57088; -.
DR OMA; IMKPSCP; -.
DR OrthoDB; EOG78SQJW; -.
DR PhylomeDB; P57088; -.
DR ChiTaRS; TMEM33; human.
DR GenomeRNAi; 55161; -.
DR NextBio; 58921; -.
DR PRO; PR:P57088; -.
DR ArrayExpress; P57088; -.
DR Bgee; P57088; -.
DR CleanEx; HS_TMEM33; -.
DR Genevestigator; P57088; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0042470; C:melanosome; IDA:UniProtKB.
DR InterPro; IPR005344; UPF0121.
DR Pfam; PF03661; UPF0121; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 247 Transmembrane protein 33.
FT /FTId=PRO_0000220899.
FT TRANSMEM 32 52 Helical; (Potential).
FT TRANSMEM 101 121 Helical; (Potential).
FT TRANSMEM 156 176 Helical; (Potential).
FT CONFLICT 7 7 N -> S (in Ref. 1; BAA91665).
SQ SEQUENCE 247 AA; 27978 MW; 392A53377511A6A0 CRC64;
MADTTPNGPQ GAGAVQFMMT NKLDTAMWLS RLFTVYCSAL FVLPLLGLHE AASFYQRALL
ANALTSALRL HQRLPHFQLS RAFLAQALLE DSCHYLLYSL IFVNSYPVTM SIFPVLLFSL
LHAATYTKKV LDARGSNSLP LLRSVLDKLS ANQQNILKFI ACNEIFLMPA TVFMLFSGQG
SLLQPFIYYR FLTLRYSSRR NPYCRTLFNE LRIVVEHIIM KPACPLFVRR LCLQSIAFIS
RLAPTVP
//
ID TMM33_HUMAN Reviewed; 247 AA.
AC P57088; B3KSS8; Q9H953;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
read moreDT 19-SEP-2002, sequence version 2.
DT 22-JAN-2014, entry version 103.
DE RecName: Full=Transmembrane protein 33;
DE AltName: Full=Protein DB83;
GN Name=TMEM33; Synonyms=DB83;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
RC TISSUE=Melanoma;
RX PubMed=17081065; DOI=10.1021/pr060363j;
RA Chi A., Valencia J.C., Hu Z.-Z., Watabe H., Yamaguchi H.,
RA Mangini N.J., Huang H., Canfield V.A., Cheng K.C., Yang F., Abe R.,
RA Yamagishi S., Shabanowitz J., Hearing V.J., Wu C., Appella E.,
RA Hunt D.F.;
RT "Proteomic and bioinformatic characterization of the biogenesis and
RT function of melanosomes.";
RL J. Proteome Res. 5:3135-3144(2006).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential). Melanosome. Note=Identified by mass spectrometry in
CC melanosome fractions from stage I to stage IV.
CC -!- SIMILARITY: Belongs to the PER33/POM33 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK001387; BAA91665.1; -; mRNA.
DR EMBL; AK023062; BAB14384.1; -; mRNA.
DR EMBL; AK094190; BAG52840.1; -; mRNA.
DR EMBL; CR457260; CAG33541.1; -; mRNA.
DR EMBL; CH471069; EAW92991.1; -; Genomic_DNA.
DR EMBL; BC000948; AAH00948.2; -; mRNA.
DR RefSeq; NP_060596.2; NM_018126.2.
DR RefSeq; XP_005248173.1; XM_005248116.1.
DR RefSeq; XP_005248174.1; XM_005248117.1.
DR UniGene; Hs.31082; -.
DR ProteinModelPortal; P57088; -.
DR IntAct; P57088; 11.
DR MINT; MINT-3021719; -.
DR STRING; 9606.ENSP00000264452; -.
DR PhosphoSite; P57088; -.
DR DMDM; 23503056; -.
DR PaxDb; P57088; -.
DR PeptideAtlas; P57088; -.
DR PRIDE; P57088; -.
DR DNASU; 55161; -.
DR Ensembl; ENST00000325094; ENSP00000441455; ENSG00000109133.
DR Ensembl; ENST00000504986; ENSP00000422473; ENSG00000109133.
DR Ensembl; ENST00000513702; ENSP00000427006; ENSG00000109133.
DR GeneID; 55161; -.
DR KEGG; hsa:55161; -.
DR UCSC; uc003gwi.2; human.
DR CTD; 55161; -.
DR GeneCards; GC04P041937; -.
DR HGNC; HGNC:25541; TMEM33.
DR neXtProt; NX_P57088; -.
DR PharmGKB; PA134963055; -.
DR eggNOG; NOG236583; -.
DR HOVERGEN; HBG054225; -.
DR InParanoid; P57088; -.
DR OMA; IMKPSCP; -.
DR OrthoDB; EOG78SQJW; -.
DR PhylomeDB; P57088; -.
DR ChiTaRS; TMEM33; human.
DR GenomeRNAi; 55161; -.
DR NextBio; 58921; -.
DR PRO; PR:P57088; -.
DR ArrayExpress; P57088; -.
DR Bgee; P57088; -.
DR CleanEx; HS_TMEM33; -.
DR Genevestigator; P57088; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0042470; C:melanosome; IDA:UniProtKB.
DR InterPro; IPR005344; UPF0121.
DR Pfam; PF03661; UPF0121; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 247 Transmembrane protein 33.
FT /FTId=PRO_0000220899.
FT TRANSMEM 32 52 Helical; (Potential).
FT TRANSMEM 101 121 Helical; (Potential).
FT TRANSMEM 156 176 Helical; (Potential).
FT CONFLICT 7 7 N -> S (in Ref. 1; BAA91665).
SQ SEQUENCE 247 AA; 27978 MW; 392A53377511A6A0 CRC64;
MADTTPNGPQ GAGAVQFMMT NKLDTAMWLS RLFTVYCSAL FVLPLLGLHE AASFYQRALL
ANALTSALRL HQRLPHFQLS RAFLAQALLE DSCHYLLYSL IFVNSYPVTM SIFPVLLFSL
LHAATYTKKV LDARGSNSLP LLRSVLDKLS ANQQNILKFI ACNEIFLMPA TVFMLFSGQG
SLLQPFIYYR FLTLRYSSRR NPYCRTLFNE LRIVVEHIIM KPACPLFVRR LCLQSIAFIS
RLAPTVP
//