Full text data of TMEM56
TMEM56
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Transmembrane protein 56
Transmembrane protein 56
hRBCD
IPI00043429
IPI00043429 Hypothetical protein FLJ31842 Hypothetical protein FLJ31842 membrane n/a 1 1 n/a 1 n/a n/a n/a 2 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a integral membrane protein n/a found at its expected molecular weight found at molecular weight
IPI00043429 Hypothetical protein FLJ31842 Hypothetical protein FLJ31842 membrane n/a 1 1 n/a 1 n/a n/a n/a 2 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a integral membrane protein n/a found at its expected molecular weight found at molecular weight
UniProt
Q96MV1
ID TMM56_HUMAN Reviewed; 263 AA.
AC Q96MV1; B2RPI2; D3DT48;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 77.
DE RecName: Full=Transmembrane protein 56;
GN Name=TMEM56;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-165, AND MASS SPECTROMETRY.
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA Walther T.C., Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- SIMILARITY: Belongs to the TMEM56 family.
CC -!- SIMILARITY: Contains 1 TLC (TRAM/LAG1/CLN8) domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK056404; BAB71177.1; -; mRNA.
DR EMBL; CH471097; EAW73024.1; -; Genomic_DNA.
DR EMBL; CH471097; EAW73025.1; -; Genomic_DNA.
DR EMBL; BC137457; AAI37458.1; -; mRNA.
DR EMBL; BC137458; AAI37459.1; -; mRNA.
DR EMBL; BC139737; AAI39738.1; -; mRNA.
DR RefSeq; NP_001186608.1; NM_001199679.1.
DR RefSeq; NP_689700.1; NM_152487.2.
DR UniGene; Hs.483512; -.
DR ProteinModelPortal; Q96MV1; -.
DR STRING; 9606.ENSP00000359222; -.
DR PhosphoSite; Q96MV1; -.
DR DMDM; 74732443; -.
DR PaxDb; Q96MV1; -.
DR PRIDE; Q96MV1; -.
DR Ensembl; ENST00000370203; ENSP00000359222; ENSG00000152078.
DR GeneID; 148534; -.
DR KEGG; hsa:148534; -.
DR UCSC; uc001drb.3; human.
DR CTD; 148534; -.
DR GeneCards; GC01P095582; -.
DR HGNC; HGNC:26477; TMEM56.
DR neXtProt; NX_Q96MV1; -.
DR PharmGKB; PA142670772; -.
DR eggNOG; NOG327998; -.
DR HOGENOM; HOG000007105; -.
DR HOVERGEN; HBG100306; -.
DR InParanoid; Q96MV1; -.
DR OMA; YWFSAKV; -.
DR OrthoDB; EOG7K9K46; -.
DR PhylomeDB; Q96MV1; -.
DR GenomeRNAi; 148534; -.
DR NextBio; 85947; -.
DR PRO; PR:Q96MV1; -.
DR ArrayExpress; Q96MV1; -.
DR Bgee; Q96MV1; -.
DR CleanEx; HS_TMEM56; -.
DR Genevestigator; Q96MV1; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR006634; TLC-dom.
DR Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR SMART; SM00724; TLC; 1.
DR PROSITE; PS50922; TLC; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 263 Transmembrane protein 56.
FT /FTId=PRO_0000286701.
FT TRANSMEM 7 27 Helical; (Potential).
FT TRANSMEM 53 73 Helical; (Potential).
FT TRANSMEM 90 110 Helical; (Potential).
FT TRANSMEM 124 144 Helical; (Potential).
FT TRANSMEM 173 193 Helical; (Potential).
FT TRANSMEM 211 231 Helical; (Potential).
FT DOMAIN 44 246 TLC.
FT MOD_RES 165 165 N6-acetyllysine.
SQ SEQUENCE 263 AA; 30041 MW; 51480330FACC8ABF CRC64;
MEINTKLLIS VTCISFFTFQ LLFYFVSYWF SAKVSPGFNS LSFKKKIEWN SRVVSTCHSL
VVGIFGLYIF LFDEATKADP LWGGPSLANV NIAIASGYLI SDLSIIILYW KVIGDKFFIM
HHCASLYAYY LVLKNGVLAY IGNFRLLAEL SSPFVNQRWF FEALKYPKFS KAIVINGILM
TVVFFIVRIA SMLPHYGFMY SVYGTEPYIR LGVLIQLSWV ISCVVLDVMN VMWMIKISKG
CIKVISHIRQ EKAKNSLQNG KLD
//
ID TMM56_HUMAN Reviewed; 263 AA.
AC Q96MV1; B2RPI2; D3DT48;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-DEC-2001, sequence version 1.
DT 22-JAN-2014, entry version 77.
DE RecName: Full=Transmembrane protein 56;
GN Name=TMEM56;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-165, AND MASS SPECTROMETRY.
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
RA Walther T.C., Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Potential).
CC -!- SIMILARITY: Belongs to the TMEM56 family.
CC -!- SIMILARITY: Contains 1 TLC (TRAM/LAG1/CLN8) domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AK056404; BAB71177.1; -; mRNA.
DR EMBL; CH471097; EAW73024.1; -; Genomic_DNA.
DR EMBL; CH471097; EAW73025.1; -; Genomic_DNA.
DR EMBL; BC137457; AAI37458.1; -; mRNA.
DR EMBL; BC137458; AAI37459.1; -; mRNA.
DR EMBL; BC139737; AAI39738.1; -; mRNA.
DR RefSeq; NP_001186608.1; NM_001199679.1.
DR RefSeq; NP_689700.1; NM_152487.2.
DR UniGene; Hs.483512; -.
DR ProteinModelPortal; Q96MV1; -.
DR STRING; 9606.ENSP00000359222; -.
DR PhosphoSite; Q96MV1; -.
DR DMDM; 74732443; -.
DR PaxDb; Q96MV1; -.
DR PRIDE; Q96MV1; -.
DR Ensembl; ENST00000370203; ENSP00000359222; ENSG00000152078.
DR GeneID; 148534; -.
DR KEGG; hsa:148534; -.
DR UCSC; uc001drb.3; human.
DR CTD; 148534; -.
DR GeneCards; GC01P095582; -.
DR HGNC; HGNC:26477; TMEM56.
DR neXtProt; NX_Q96MV1; -.
DR PharmGKB; PA142670772; -.
DR eggNOG; NOG327998; -.
DR HOGENOM; HOG000007105; -.
DR HOVERGEN; HBG100306; -.
DR InParanoid; Q96MV1; -.
DR OMA; YWFSAKV; -.
DR OrthoDB; EOG7K9K46; -.
DR PhylomeDB; Q96MV1; -.
DR GenomeRNAi; 148534; -.
DR NextBio; 85947; -.
DR PRO; PR:Q96MV1; -.
DR ArrayExpress; Q96MV1; -.
DR Bgee; Q96MV1; -.
DR CleanEx; HS_TMEM56; -.
DR Genevestigator; Q96MV1; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR006634; TLC-dom.
DR Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR SMART; SM00724; TLC; 1.
DR PROSITE; PS50922; TLC; 1.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 263 Transmembrane protein 56.
FT /FTId=PRO_0000286701.
FT TRANSMEM 7 27 Helical; (Potential).
FT TRANSMEM 53 73 Helical; (Potential).
FT TRANSMEM 90 110 Helical; (Potential).
FT TRANSMEM 124 144 Helical; (Potential).
FT TRANSMEM 173 193 Helical; (Potential).
FT TRANSMEM 211 231 Helical; (Potential).
FT DOMAIN 44 246 TLC.
FT MOD_RES 165 165 N6-acetyllysine.
SQ SEQUENCE 263 AA; 30041 MW; 51480330FACC8ABF CRC64;
MEINTKLLIS VTCISFFTFQ LLFYFVSYWF SAKVSPGFNS LSFKKKIEWN SRVVSTCHSL
VVGIFGLYIF LFDEATKADP LWGGPSLANV NIAIASGYLI SDLSIIILYW KVIGDKFFIM
HHCASLYAYY LVLKNGVLAY IGNFRLLAEL SSPFVNQRWF FEALKYPKFS KAIVINGILM
TVVFFIVRIA SMLPHYGFMY SVYGTEPYIR LGVLIQLSWV ISCVVLDVMN VMWMIKISKG
CIKVISHIRQ EKAKNSLQNG KLD
//