Full text data of TMX4
TMX4
(KIAA1162, TXNDC13)
[Confidence: high (present in two of the MS resources)]
Thioredoxin-related transmembrane protein 4 (Thioredoxin domain-containing protein 13; Flags: Precursor)
Thioredoxin-related transmembrane protein 4 (Thioredoxin domain-containing protein 13; Flags: Precursor)
hRBCD
IPI00100247
IPI00100247 Thioredoxin-like protein KIAA1162 precursor Thioredoxin-like protein KIAA1162 precursor membrane n/a n/a 2 n/a 1 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a Type I membrane protein n/a found at its expected molecular weight found at molecular weight
IPI00100247 Thioredoxin-like protein KIAA1162 precursor Thioredoxin-like protein KIAA1162 precursor membrane n/a n/a 2 n/a 1 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a Type I membrane protein n/a found at its expected molecular weight found at molecular weight
UniProt
Q9H1E5
ID TMX4_HUMAN Reviewed; 349 AA.
AC Q9H1E5; Q8N4P7; Q8NCC1; Q9UJA1; Q9ULQ8;
DT 23-APR-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2001, sequence version 1.
DT 22-JAN-2014, entry version 115.
DE RecName: Full=Thioredoxin-related transmembrane protein 4;
DE AltName: Full=Thioredoxin domain-containing protein 13;
DE Flags: Precursor;
GN Name=TMX4; Synonyms=KIAA1162, TXNDC13;
GN ORFNames=PSEC0095, UNQ475/PRO938;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-
RT length human cDNAs encoding secretion or membrane proteins from oligo-
RT capped cDNA libraries.";
RL DNA Res. 12:117-126(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-303.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 88-349.
RA Stavrides G.S., Huckle E.J., Deloukas P.;
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 235-349.
RC TISSUE=Brain;
RX PubMed=10574461; DOI=10.1093/dnares/6.5.329;
RA Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.;
RT "Characterization of cDNA clones selected by the GeneMark analysis
RT from size-fractionated cDNA libraries from human brain.";
RL DNA Res. 6:329-336(1999).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251 AND SER-259, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in
RT signaling networks.";
RL Cell 127:635-648(2006).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251 AND SER-259, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC protein (Potential).
CC -!- SIMILARITY: Contains 1 thioredoxin domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB56344.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY359004; AAQ89363.1; -; mRNA.
DR EMBL; AK074838; BAC11237.1; -; mRNA.
DR EMBL; AK075404; BAC11599.1; -; mRNA.
DR EMBL; AL021396; CAC17521.1; -; Genomic_DNA.
DR EMBL; BC033787; AAH33787.1; -; mRNA.
DR EMBL; AL118494; CAB56344.1; ALT_INIT; mRNA.
DR EMBL; AB032988; BAA86476.1; -; mRNA.
DR RefSeq; NP_066979.2; NM_021156.2.
DR UniGene; Hs.169358; -.
DR ProteinModelPortal; Q9H1E5; -.
DR SMR; Q9H1E5; 39-154.
DR IntAct; Q9H1E5; 2.
DR MINT; MINT-6944233; -.
DR PhosphoSite; Q9H1E5; -.
DR DMDM; 30173124; -.
DR PaxDb; Q9H1E5; -.
DR PRIDE; Q9H1E5; -.
DR DNASU; 56255; -.
DR Ensembl; ENST00000246024; ENSP00000246024; ENSG00000125827.
DR GeneID; 56255; -.
DR KEGG; hsa:56255; -.
DR UCSC; uc002wmx.1; human.
DR CTD; 56255; -.
DR GeneCards; GC20M007908; -.
DR H-InvDB; HIX0174699; -.
DR HGNC; HGNC:25237; TMX4.
DR HPA; HPA000399; -.
DR HPA; HPA015752; -.
DR neXtProt; NX_Q9H1E5; -.
DR PharmGKB; PA164726669; -.
DR eggNOG; NOG251548; -.
DR HOGENOM; HOG000045750; -.
DR InParanoid; Q9H1E5; -.
DR OMA; IYEDLQN; -.
DR OrthoDB; EOG7KM5VC; -.
DR PhylomeDB; Q9H1E5; -.
DR GeneWiki; TMX4; -.
DR GenomeRNAi; 56255; -.
DR NextBio; 61897; -.
DR PRO; PR:Q9H1E5; -.
DR ArrayExpress; Q9H1E5; -.
DR Bgee; Q9H1E5; -.
DR CleanEx; HS_TXNDC13; -.
DR Genevestigator; Q9H1E5; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR GO; GO:0055114; P:oxidation-reduction process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.30.10; -; 1.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS00194; THIOREDOXIN_1; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Disulfide bond; Electron transport; Membrane;
KW Phosphoprotein; Polymorphism; Redox-active center; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1 23 Potential.
FT CHAIN 24 349 Thioredoxin-related transmembrane protein
FT 4.
FT /FTId=PRO_0000034191.
FT TRANSMEM 190 210 Helical; (Potential).
FT DOMAIN 30 137 Thioredoxin.
FT COMPBIAS 224 334 Glu-rich.
FT MOD_RES 251 251 Phosphoserine.
FT MOD_RES 259 259 Phosphoserine.
FT DISULFID 64 67 Redox-active (Potential).
FT VARIANT 215 215 Y -> C (in dbSNP:rs1135711).
FT /FTId=VAR_052578.
FT VARIANT 303 303 G -> R (in dbSNP:rs2076015).
FT /FTId=VAR_052579.
FT CONFLICT 289 289 V -> E (in Ref. 2; BAC11237).
SQ SEQUENCE 349 AA; 38952 MW; FE944AA2F44131F1 CRC64;
MAGGRCGPQL TALLAAWIAA VAATAGPEEA ALPPEQSRVQ PMTASNWTLV MEGEWMLKFY
APWCPSCQQT DSEWEAFAKN GEILQISVGK VDVIQEPGLS GRFFVTTLPA FFHAKDGIFR
RYRGPGIFED LQNYILEKKW QSVEPLTGWK SPASLTMSGM AGLFSISGKI WHLHNYFTVT
LGIPAWCSYV FFVIATLVFG LFMGLVLVVI SECFYVPLPR HLSERSEQNR RSEEAHRAEQ
LQDAEEEKDD SNEEENKDSL VDDEEEKEDL GDEDEAEEEE EEDNLAAGVD EERSEANDQG
PPGEDGVTRE EVEPEEAEEG ISEQPCPADT EVVEDSLRQR KSQHADKGL
//
ID TMX4_HUMAN Reviewed; 349 AA.
AC Q9H1E5; Q8N4P7; Q8NCC1; Q9UJA1; Q9ULQ8;
DT 23-APR-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-MAR-2001, sequence version 1.
DT 22-JAN-2014, entry version 115.
DE RecName: Full=Thioredoxin-related transmembrane protein 4;
DE AltName: Full=Thioredoxin domain-containing protein 13;
DE Flags: Precursor;
GN Name=TMX4; Synonyms=KIAA1162, TXNDC13;
GN ORFNames=PSEC0095, UNQ475/PRO938;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-
RT length human cDNAs encoding secretion or membrane proteins from oligo-
RT capped cDNA libraries.";
RL DNA Res. 12:117-126(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-303.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 88-349.
RA Stavrides G.S., Huckle E.J., Deloukas P.;
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 235-349.
RC TISSUE=Brain;
RX PubMed=10574461; DOI=10.1093/dnares/6.5.329;
RA Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.;
RT "Characterization of cDNA clones selected by the GeneMark analysis
RT from size-fractionated cDNA libraries from human brain.";
RL DNA Res. 6:329-336(1999).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251 AND SER-259, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in
RT signaling networks.";
RL Cell 127:635-648(2006).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-251 AND SER-259, AND
RP MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC protein (Potential).
CC -!- SIMILARITY: Contains 1 thioredoxin domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB56344.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY359004; AAQ89363.1; -; mRNA.
DR EMBL; AK074838; BAC11237.1; -; mRNA.
DR EMBL; AK075404; BAC11599.1; -; mRNA.
DR EMBL; AL021396; CAC17521.1; -; Genomic_DNA.
DR EMBL; BC033787; AAH33787.1; -; mRNA.
DR EMBL; AL118494; CAB56344.1; ALT_INIT; mRNA.
DR EMBL; AB032988; BAA86476.1; -; mRNA.
DR RefSeq; NP_066979.2; NM_021156.2.
DR UniGene; Hs.169358; -.
DR ProteinModelPortal; Q9H1E5; -.
DR SMR; Q9H1E5; 39-154.
DR IntAct; Q9H1E5; 2.
DR MINT; MINT-6944233; -.
DR PhosphoSite; Q9H1E5; -.
DR DMDM; 30173124; -.
DR PaxDb; Q9H1E5; -.
DR PRIDE; Q9H1E5; -.
DR DNASU; 56255; -.
DR Ensembl; ENST00000246024; ENSP00000246024; ENSG00000125827.
DR GeneID; 56255; -.
DR KEGG; hsa:56255; -.
DR UCSC; uc002wmx.1; human.
DR CTD; 56255; -.
DR GeneCards; GC20M007908; -.
DR H-InvDB; HIX0174699; -.
DR HGNC; HGNC:25237; TMX4.
DR HPA; HPA000399; -.
DR HPA; HPA015752; -.
DR neXtProt; NX_Q9H1E5; -.
DR PharmGKB; PA164726669; -.
DR eggNOG; NOG251548; -.
DR HOGENOM; HOG000045750; -.
DR InParanoid; Q9H1E5; -.
DR OMA; IYEDLQN; -.
DR OrthoDB; EOG7KM5VC; -.
DR PhylomeDB; Q9H1E5; -.
DR GeneWiki; TMX4; -.
DR GenomeRNAi; 56255; -.
DR NextBio; 61897; -.
DR PRO; PR:Q9H1E5; -.
DR ArrayExpress; Q9H1E5; -.
DR Bgee; Q9H1E5; -.
DR CleanEx; HS_TXNDC13; -.
DR Genevestigator; Q9H1E5; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR GO; GO:0055114; P:oxidation-reduction process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.30.10; -; 1.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS00194; THIOREDOXIN_1; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Disulfide bond; Electron transport; Membrane;
KW Phosphoprotein; Polymorphism; Redox-active center; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1 23 Potential.
FT CHAIN 24 349 Thioredoxin-related transmembrane protein
FT 4.
FT /FTId=PRO_0000034191.
FT TRANSMEM 190 210 Helical; (Potential).
FT DOMAIN 30 137 Thioredoxin.
FT COMPBIAS 224 334 Glu-rich.
FT MOD_RES 251 251 Phosphoserine.
FT MOD_RES 259 259 Phosphoserine.
FT DISULFID 64 67 Redox-active (Potential).
FT VARIANT 215 215 Y -> C (in dbSNP:rs1135711).
FT /FTId=VAR_052578.
FT VARIANT 303 303 G -> R (in dbSNP:rs2076015).
FT /FTId=VAR_052579.
FT CONFLICT 289 289 V -> E (in Ref. 2; BAC11237).
SQ SEQUENCE 349 AA; 38952 MW; FE944AA2F44131F1 CRC64;
MAGGRCGPQL TALLAAWIAA VAATAGPEEA ALPPEQSRVQ PMTASNWTLV MEGEWMLKFY
APWCPSCQQT DSEWEAFAKN GEILQISVGK VDVIQEPGLS GRFFVTTLPA FFHAKDGIFR
RYRGPGIFED LQNYILEKKW QSVEPLTGWK SPASLTMSGM AGLFSISGKI WHLHNYFTVT
LGIPAWCSYV FFVIATLVFG LFMGLVLVVI SECFYVPLPR HLSERSEQNR RSEEAHRAEQ
LQDAEEEKDD SNEEENKDSL VDDEEEKEDL GDEDEAEEEE EEDNLAAGVD EERSEANDQG
PPGEDGVTRE EVEPEEAEEG ISEQPCPADT EVVEDSLRQR KSQHADKGL
//