Full text data of TANGO2
TANGO2
(C22orf25)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Transport and Golgi organization protein 2 homolog
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Transport and Golgi organization protein 2 homolog
Note: presumably soluble (membrane word is not in UniProt keywords or features)
hRBCD
IPI00168034
IPI00168034 Similar to Ser/Thr-rich protein T10 in DGCR region no information available soluble n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
IPI00168034 Similar to Ser/Thr-rich protein T10 in DGCR region no information available soluble n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a not mentioned n/a found at its expected molecular weight found at molecular weight
UniProt
Q6ICL3
ID TNG2_HUMAN Reviewed; 276 AA.
AC Q6ICL3; A8MUE9; D3DX23; Q8IW05; Q8NAL0; Q8TCS0; Q96M16;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 05-JUL-2004, sequence version 1.
DT 22-JAN-2014, entry version 68.
DE RecName: Full=Transport and Golgi organization protein 2 homolog;
GN Name=TANGO2; Synonyms=C22orf25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Placenta, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M.,
RA Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K.,
RA Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J.,
RA Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G.,
RA Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R.,
RA Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E.,
RA Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G.,
RA Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S.,
RA Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A.,
RA Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M.,
RA Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T.,
RA Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J.,
RA Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T.,
RA Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T.,
RA Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L.,
RA Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M.,
RA Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J.,
RA Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S.,
RA Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T.,
RA Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I.,
RA Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H.,
RA Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L.,
RA Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z.,
RA Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P.,
RA Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S.,
RA Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J.,
RA Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T.,
RA Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J.,
RA Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S.,
RA Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E.,
RA Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P.,
RA Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E.,
RA O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X.,
RA Khan A.S., Lane L., Tilahun Y., Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS
RP ASN-125 AND LYS-200.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-276 (ISOFORM 1).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6ICL3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ICL3-2; Sequence=VSP_021139;
CC Name=3;
CC IsoId=Q6ICL3-3; Sequence=VSP_021137, VSP_021138;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the Tango2 family.
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DR EMBL; AK057461; BAB71498.1; -; mRNA.
DR EMBL; AK092484; BAC03902.1; -; mRNA.
DR EMBL; CR456355; CAG30241.1; -; mRNA.
DR EMBL; AC005663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471176; EAX03001.1; -; Genomic_DNA.
DR EMBL; CH471176; EAX03005.1; -; Genomic_DNA.
DR EMBL; BC041339; AAH41339.1; -; mRNA.
DR EMBL; AL713640; CAD28454.1; -; mRNA.
DR RefSeq; NP_001270035.1; NM_001283106.1.
DR RefSeq; NP_001270045.1; NM_001283116.1.
DR RefSeq; NP_001270058.1; NM_001283129.1.
DR RefSeq; NP_001270077.1; NM_001283148.1.
DR RefSeq; NP_001270083.1; NM_001283154.1.
DR RefSeq; NP_001270108.1; NM_001283179.1.
DR RefSeq; NP_001270115.1; NM_001283186.1.
DR RefSeq; NP_001270128.1; NM_001283199.1.
DR RefSeq; NP_001270144.1; NM_001283215.1.
DR RefSeq; NP_001270164.1; NM_001283235.1.
DR RefSeq; NP_001270177.1; NM_001283248.1.
DR RefSeq; NP_690870.3; NM_152906.5.
DR RefSeq; XP_005261280.1; XM_005261223.1.
DR UniGene; Hs.474233; -.
DR ProteinModelPortal; Q6ICL3; -.
DR STRING; 9606.ENSP00000332721; -.
DR PhosphoSite; Q6ICL3; -.
DR DMDM; 74709518; -.
DR PaxDb; Q6ICL3; -.
DR PRIDE; Q6ICL3; -.
DR DNASU; 128989; -.
DR Ensembl; ENST00000327374; ENSP00000332721; ENSG00000183597.
DR Ensembl; ENST00000398042; ENSP00000381122; ENSG00000183597.
DR Ensembl; ENST00000401886; ENSP00000385662; ENSG00000183597.
DR Ensembl; ENST00000432883; ENSP00000402926; ENSG00000183597.
DR Ensembl; ENST00000447208; ENSP00000389797; ENSG00000183597.
DR GeneID; 128989; -.
DR KEGG; hsa:128989; -.
DR UCSC; uc002zrc.1; human.
DR CTD; 128989; -.
DR GeneCards; GC22P020005; -.
DR H-InvDB; HIX0016248; -.
DR HGNC; HGNC:25439; TANGO2.
DR HPA; HPA003080; -.
DR neXtProt; NX_Q6ICL3; -.
DR PharmGKB; PA143485406; -.
DR eggNOG; COG3332; -.
DR HOVERGEN; HBG017881; -.
DR OrthoDB; EOG7S2208; -.
DR PhylomeDB; Q6ICL3; -.
DR ChiTaRS; C22orf25; human.
DR GeneWiki; C22orf25; -.
DR GenomeRNAi; 128989; -.
DR NextBio; 82526; -.
DR PRO; PR:Q6ICL3; -.
DR ArrayExpress; Q6ICL3; -.
DR Bgee; Q6ICL3; -.
DR CleanEx; HS_C22orf25; -.
DR Genevestigator; Q6ICL3; -.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR InterPro; IPR008551; DUF833.
DR PANTHER; PTHR17985; PTHR17985; 1.
DR Pfam; PF05742; NRDE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Polymorphism;
KW Reference proteome.
FT CHAIN 1 276 Transport and Golgi organization protein
FT 2 homolog.
FT /FTId=PRO_0000253891.
FT VAR_SEQ 1 48 MCIIFFKFDPRPVSKNAYRLILAANRDEFYSRPSKLADFWG
FT NNNEILS -> MPLGAGTPVNVQRREDSATEGSHRLILAAN
FT RDEFYSRPSKLADFWGNNNEILS (in isoform 3).
FT /FTId=VSP_021137.
FT VAR_SEQ 90 151 Missing (in isoform 2).
FT /FTId=VSP_021139.
FT VAR_SEQ 190 197 Missing (in isoform 3).
FT /FTId=VSP_021138.
FT VARIANT 125 125 D -> N (in dbSNP:rs17855650).
FT /FTId=VAR_028742.
FT VARIANT 200 200 E -> K (in dbSNP:rs17854107).
FT /FTId=VAR_028743.
FT VARIANT 245 245 D -> E (in dbSNP:rs16982614).
FT /FTId=VAR_028744.
SQ SEQUENCE 276 AA; 30937 MW; 99D55353FD1B74E4 CRC64;
MCIIFFKFDP RPVSKNAYRL ILAANRDEFY SRPSKLADFW GNNNEILSGL DMEEGKEGGT
WLGISTRGKL AALTNYLQPQ LDWQARGRGE LVTHFLTTDV DSLSYLKKVS MEGHLYNGFN
LIAADLSTAK GDVICYYGNR GEPDPIVLTP GTYGLSNALL ETPWRKLCFG KQLFLEAVER
SQALPKDVLI ASLLDVLNNE EAQLPDPAIE DQGGEYVQPM LSKYAAVCVR CPGYGTRTNT
IILVDADGHV TFTERSMMDK DLSHWETRTY EFTLQS
//
ID TNG2_HUMAN Reviewed; 276 AA.
AC Q6ICL3; A8MUE9; D3DX23; Q8IW05; Q8NAL0; Q8TCS0; Q96M16;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 05-JUL-2004, sequence version 1.
DT 22-JAN-2014, entry version 68.
DE RecName: Full=Transport and Golgi organization protein 2 homolog;
GN Name=TANGO2; Synonyms=C22orf25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Placenta, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M.,
RA Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K.,
RA Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Buck D., Burgess J.,
RA Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G.,
RA Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R.,
RA Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E.,
RA Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G.,
RA Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S.,
RA Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A.,
RA Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M.,
RA Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T.,
RA Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J.,
RA Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T.,
RA Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T.,
RA Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L.,
RA Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M.,
RA Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J.,
RA Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S.,
RA Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T.,
RA Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I.,
RA Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H.,
RA Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L.,
RA Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z.,
RA Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P.,
RA Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S.,
RA Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J.,
RA Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T.,
RA Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J.,
RA Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S.,
RA Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E.,
RA Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P.,
RA Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E.,
RA O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X.,
RA Khan A.S., Lane L., Tilahun Y., Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS
RP ASN-125 AND LYS-200.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 53-276 (ISOFORM 1).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6ICL3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ICL3-2; Sequence=VSP_021139;
CC Name=3;
CC IsoId=Q6ICL3-3; Sequence=VSP_021137, VSP_021138;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the Tango2 family.
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DR EMBL; AK057461; BAB71498.1; -; mRNA.
DR EMBL; AK092484; BAC03902.1; -; mRNA.
DR EMBL; CR456355; CAG30241.1; -; mRNA.
DR EMBL; AC005663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471176; EAX03001.1; -; Genomic_DNA.
DR EMBL; CH471176; EAX03005.1; -; Genomic_DNA.
DR EMBL; BC041339; AAH41339.1; -; mRNA.
DR EMBL; AL713640; CAD28454.1; -; mRNA.
DR RefSeq; NP_001270035.1; NM_001283106.1.
DR RefSeq; NP_001270045.1; NM_001283116.1.
DR RefSeq; NP_001270058.1; NM_001283129.1.
DR RefSeq; NP_001270077.1; NM_001283148.1.
DR RefSeq; NP_001270083.1; NM_001283154.1.
DR RefSeq; NP_001270108.1; NM_001283179.1.
DR RefSeq; NP_001270115.1; NM_001283186.1.
DR RefSeq; NP_001270128.1; NM_001283199.1.
DR RefSeq; NP_001270144.1; NM_001283215.1.
DR RefSeq; NP_001270164.1; NM_001283235.1.
DR RefSeq; NP_001270177.1; NM_001283248.1.
DR RefSeq; NP_690870.3; NM_152906.5.
DR RefSeq; XP_005261280.1; XM_005261223.1.
DR UniGene; Hs.474233; -.
DR ProteinModelPortal; Q6ICL3; -.
DR STRING; 9606.ENSP00000332721; -.
DR PhosphoSite; Q6ICL3; -.
DR DMDM; 74709518; -.
DR PaxDb; Q6ICL3; -.
DR PRIDE; Q6ICL3; -.
DR DNASU; 128989; -.
DR Ensembl; ENST00000327374; ENSP00000332721; ENSG00000183597.
DR Ensembl; ENST00000398042; ENSP00000381122; ENSG00000183597.
DR Ensembl; ENST00000401886; ENSP00000385662; ENSG00000183597.
DR Ensembl; ENST00000432883; ENSP00000402926; ENSG00000183597.
DR Ensembl; ENST00000447208; ENSP00000389797; ENSG00000183597.
DR GeneID; 128989; -.
DR KEGG; hsa:128989; -.
DR UCSC; uc002zrc.1; human.
DR CTD; 128989; -.
DR GeneCards; GC22P020005; -.
DR H-InvDB; HIX0016248; -.
DR HGNC; HGNC:25439; TANGO2.
DR HPA; HPA003080; -.
DR neXtProt; NX_Q6ICL3; -.
DR PharmGKB; PA143485406; -.
DR eggNOG; COG3332; -.
DR HOVERGEN; HBG017881; -.
DR OrthoDB; EOG7S2208; -.
DR PhylomeDB; Q6ICL3; -.
DR ChiTaRS; C22orf25; human.
DR GeneWiki; C22orf25; -.
DR GenomeRNAi; 128989; -.
DR NextBio; 82526; -.
DR PRO; PR:Q6ICL3; -.
DR ArrayExpress; Q6ICL3; -.
DR Bgee; Q6ICL3; -.
DR CleanEx; HS_C22orf25; -.
DR Genevestigator; Q6ICL3; -.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR InterPro; IPR008551; DUF833.
DR PANTHER; PTHR17985; PTHR17985; 1.
DR Pfam; PF05742; NRDE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Complete proteome; Polymorphism;
KW Reference proteome.
FT CHAIN 1 276 Transport and Golgi organization protein
FT 2 homolog.
FT /FTId=PRO_0000253891.
FT VAR_SEQ 1 48 MCIIFFKFDPRPVSKNAYRLILAANRDEFYSRPSKLADFWG
FT NNNEILS -> MPLGAGTPVNVQRREDSATEGSHRLILAAN
FT RDEFYSRPSKLADFWGNNNEILS (in isoform 3).
FT /FTId=VSP_021137.
FT VAR_SEQ 90 151 Missing (in isoform 2).
FT /FTId=VSP_021139.
FT VAR_SEQ 190 197 Missing (in isoform 3).
FT /FTId=VSP_021138.
FT VARIANT 125 125 D -> N (in dbSNP:rs17855650).
FT /FTId=VAR_028742.
FT VARIANT 200 200 E -> K (in dbSNP:rs17854107).
FT /FTId=VAR_028743.
FT VARIANT 245 245 D -> E (in dbSNP:rs16982614).
FT /FTId=VAR_028744.
SQ SEQUENCE 276 AA; 30937 MW; 99D55353FD1B74E4 CRC64;
MCIIFFKFDP RPVSKNAYRL ILAANRDEFY SRPSKLADFW GNNNEILSGL DMEEGKEGGT
WLGISTRGKL AALTNYLQPQ LDWQARGRGE LVTHFLTTDV DSLSYLKKVS MEGHLYNGFN
LIAADLSTAK GDVICYYGNR GEPDPIVLTP GTYGLSNALL ETPWRKLCFG KQLFLEAVER
SQALPKDVLI ASLLDVLNNE EAQLPDPAIE DQGGEYVQPM LSKYAAVCVR CPGYGTRTNT
IILVDADGHV TFTERSMMDK DLSHWETRTY EFTLQS
//