Full text data of TRIM58
TRIM58
[Confidence: low (only semi-automatic identification from reviews)]
Tripartite motif-containing protein 58 (Protein BIA2)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Tripartite motif-containing protein 58 (Protein BIA2)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8NG06
ID TRI58_HUMAN Reviewed; 486 AA.
AC Q8NG06; Q6B0H9;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 78.
DE RecName: Full=Tripartite motif-containing protein 58;
DE AltName: Full=Protein BIA2;
GN Name=TRIM58;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS SER-3 AND MET-374.
RC TISSUE=Placenta;
RA Piecha D., Petersohn D., Eckes B., Krieg T.;
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-342.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family.
CC -!- SIMILARITY: Contains 1 B box-type zinc finger.
CC -!- SIMILARITY: Contains 1 B30.2/SPRY domain.
CC -!- SIMILARITY: Contains 1 RING-type zinc finger.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM63958.1; Type=Erroneous initiation;
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DR EMBL; AF327057; AAM63958.1; ALT_INIT; mRNA.
DR EMBL; BC074748; AAH74748.1; -; mRNA.
DR RefSeq; NP_056246.3; NM_015431.3.
DR UniGene; Hs.269151; -.
DR ProteinModelPortal; Q8NG06; -.
DR SMR; Q8NG06; 9-60, 90-131, 291-448.
DR PhosphoSite; Q8NG06; -.
DR DMDM; 124053416; -.
DR PaxDb; Q8NG06; -.
DR PRIDE; Q8NG06; -.
DR Ensembl; ENST00000366481; ENSP00000355437; ENSG00000162722.
DR GeneID; 25893; -.
DR KEGG; hsa:25893; -.
DR UCSC; uc001ido.3; human.
DR CTD; 25893; -.
DR GeneCards; GC01P248020; -.
DR HGNC; HGNC:24150; TRIM58.
DR HPA; HPA023637; -.
DR neXtProt; NX_Q8NG06; -.
DR PharmGKB; PA134942549; -.
DR eggNOG; NOG269716; -.
DR HOGENOM; HOG000234133; -.
DR HOVERGEN; HBG001357; -.
DR InParanoid; Q8NG06; -.
DR KO; K12027; -.
DR OMA; GPEHRTH; -.
DR OrthoDB; EOG7FNC77; -.
DR PhylomeDB; Q8NG06; -.
DR ChiTaRS; TRIM58; human.
DR GenomeRNAi; 25893; -.
DR NextBio; 47327; -.
DR PRO; PR:Q8NG06; -.
DR Bgee; Q8NG06; -.
DR CleanEx; HS_TRIM58; -.
DR Genevestigator; Q8NG06; -.
DR GO; GO:0005622; C:intracellular; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR Gene3D; 4.10.45.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR003879; Butyrophylin.
DR InterPro; IPR008985; ConA-like_lec_gl_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR018355; SPla/RYanodine_receptor_subgr.
DR InterPro; IPR003877; SPRY_rcpt.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Complete proteome; Metal-binding; Polymorphism;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1 486 Tripartite motif-containing protein 58.
FT /FTId=PRO_0000272301.
FT DOMAIN 273 463 B30.2/SPRY.
FT ZN_FING 16 61 RING-type.
FT ZN_FING 91 132 B box-type.
FT COILED 193 242 Potential.
FT VARIANT 3 3 W -> S (in dbSNP:rs11204523).
FT /FTId=VAR_030036.
FT VARIANT 322 322 V -> I (in dbSNP:rs1339847).
FT /FTId=VAR_030037.
FT VARIANT 374 374 T -> M (in dbSNP:rs3811444).
FT /FTId=VAR_030038.
FT CONFLICT 292 292 D -> G (in Ref. 1; AAM63958).
SQ SEQUENCE 486 AA; 54766 MW; 3A536C529A850063 CRC64;
MAWAPPGERL REDARCPVCL DFLQEPVSVD CGHSFCLRCI SEFCEKSDGA QGGVYACPQC
RGPFRPSGFR PNRQLAGLVE SVRRLGLGAG PGARRCARHG EDLSRFCEED EAALCWVCDA
GPEHRTHRTA PLQEAAGSYQ VKLQMALELM RKELEDALTQ EANVGKKTVI WKEKVEMQRQ
RFRLEFEKHR GFLAQEEQRQ LRRLEAEERA TLQRLRESKS RLVQQSKALK ELADELQERC
QRPALGLLEG VRGVLSRSKA VTRLEAENIP MELKTACCIP GRRELLRKFQ VDVKLDPATA
HPSLLLTADL RSVQDGEPWR DVPNNPERFD TWPCILGLQS FSSGRHYWEV LVGEGAEWGL
GVCQDTLPRK GETTPSPENG VWALWLLKGN EYMVLASPSV PLLQLESPRC IGIFLDYEAG
EISFYNVTDG SYIYTFNQLF SGLLRPYFFI CDATPLILPP TTIAGSGNWA SRDHLDPASD
VRDDHL
//
ID TRI58_HUMAN Reviewed; 486 AA.
AC Q8NG06; Q6B0H9;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
read moreDT 23-JAN-2007, sequence version 2.
DT 22-JAN-2014, entry version 78.
DE RecName: Full=Tripartite motif-containing protein 58;
DE AltName: Full=Protein BIA2;
GN Name=TRIM58;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS SER-3 AND MET-374.
RC TISSUE=Placenta;
RA Piecha D., Petersohn D., Eckes B., Krieg T.;
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-342.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family.
CC -!- SIMILARITY: Contains 1 B box-type zinc finger.
CC -!- SIMILARITY: Contains 1 B30.2/SPRY domain.
CC -!- SIMILARITY: Contains 1 RING-type zinc finger.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM63958.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF327057; AAM63958.1; ALT_INIT; mRNA.
DR EMBL; BC074748; AAH74748.1; -; mRNA.
DR RefSeq; NP_056246.3; NM_015431.3.
DR UniGene; Hs.269151; -.
DR ProteinModelPortal; Q8NG06; -.
DR SMR; Q8NG06; 9-60, 90-131, 291-448.
DR PhosphoSite; Q8NG06; -.
DR DMDM; 124053416; -.
DR PaxDb; Q8NG06; -.
DR PRIDE; Q8NG06; -.
DR Ensembl; ENST00000366481; ENSP00000355437; ENSG00000162722.
DR GeneID; 25893; -.
DR KEGG; hsa:25893; -.
DR UCSC; uc001ido.3; human.
DR CTD; 25893; -.
DR GeneCards; GC01P248020; -.
DR HGNC; HGNC:24150; TRIM58.
DR HPA; HPA023637; -.
DR neXtProt; NX_Q8NG06; -.
DR PharmGKB; PA134942549; -.
DR eggNOG; NOG269716; -.
DR HOGENOM; HOG000234133; -.
DR HOVERGEN; HBG001357; -.
DR InParanoid; Q8NG06; -.
DR KO; K12027; -.
DR OMA; GPEHRTH; -.
DR OrthoDB; EOG7FNC77; -.
DR PhylomeDB; Q8NG06; -.
DR ChiTaRS; TRIM58; human.
DR GenomeRNAi; 25893; -.
DR NextBio; 47327; -.
DR PRO; PR:Q8NG06; -.
DR Bgee; Q8NG06; -.
DR CleanEx; HS_TRIM58; -.
DR Genevestigator; Q8NG06; -.
DR GO; GO:0005622; C:intracellular; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR Gene3D; 4.10.45.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR003879; Butyrophylin.
DR InterPro; IPR008985; ConA-like_lec_gl_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR018355; SPla/RYanodine_receptor_subgr.
DR InterPro; IPR003877; SPRY_rcpt.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Complete proteome; Metal-binding; Polymorphism;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1 486 Tripartite motif-containing protein 58.
FT /FTId=PRO_0000272301.
FT DOMAIN 273 463 B30.2/SPRY.
FT ZN_FING 16 61 RING-type.
FT ZN_FING 91 132 B box-type.
FT COILED 193 242 Potential.
FT VARIANT 3 3 W -> S (in dbSNP:rs11204523).
FT /FTId=VAR_030036.
FT VARIANT 322 322 V -> I (in dbSNP:rs1339847).
FT /FTId=VAR_030037.
FT VARIANT 374 374 T -> M (in dbSNP:rs3811444).
FT /FTId=VAR_030038.
FT CONFLICT 292 292 D -> G (in Ref. 1; AAM63958).
SQ SEQUENCE 486 AA; 54766 MW; 3A536C529A850063 CRC64;
MAWAPPGERL REDARCPVCL DFLQEPVSVD CGHSFCLRCI SEFCEKSDGA QGGVYACPQC
RGPFRPSGFR PNRQLAGLVE SVRRLGLGAG PGARRCARHG EDLSRFCEED EAALCWVCDA
GPEHRTHRTA PLQEAAGSYQ VKLQMALELM RKELEDALTQ EANVGKKTVI WKEKVEMQRQ
RFRLEFEKHR GFLAQEEQRQ LRRLEAEERA TLQRLRESKS RLVQQSKALK ELADELQERC
QRPALGLLEG VRGVLSRSKA VTRLEAENIP MELKTACCIP GRRELLRKFQ VDVKLDPATA
HPSLLLTADL RSVQDGEPWR DVPNNPERFD TWPCILGLQS FSSGRHYWEV LVGEGAEWGL
GVCQDTLPRK GETTPSPENG VWALWLLKGN EYMVLASPSV PLLQLESPRC IGIFLDYEAG
EISFYNVTDG SYIYTFNQLF SGLLRPYFFI CDATPLILPP TTIAGSGNWA SRDHLDPASD
VRDDHL
//