Full text data of TSPAN14
TSPAN14
(TM4SF14)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Tetraspanin-14; Tspan-14 (DC-TM4F2; Transmembrane 4 superfamily member 14)
Tetraspanin-14; Tspan-14 (DC-TM4F2; Transmembrane 4 superfamily member 14)
hRBCD
IPI00165394
IPI00165394 DC-TM4F2 protein DC-TM4F2 protein membrane n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a Integral membrane protein n/a found at its expected molecular weight found at molecular weight
IPI00165394 DC-TM4F2 protein DC-TM4F2 protein membrane n/a n/a n/a n/a n/a n/a n/a n/a 1 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a Integral membrane protein n/a found at its expected molecular weight found at molecular weight
UniProt
Q8NG11
ID TSN14_HUMAN Reviewed; 270 AA.
AC Q8NG11; A6NHE1; B4DHY6; D3DWD7; D3DWD8; Q567U7; Q9BU34; Q9H0U1;
read moreDT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 22-JAN-2014, entry version 89.
DE RecName: Full=Tetraspanin-14;
DE Short=Tspan-14;
DE AltName: Full=DC-TM4F2;
DE AltName: Full=Transmembrane 4 superfamily member 14;
GN Name=TSPAN14; Synonyms=TM4SF14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Zhang W., Li N., Wan T., Cao X.;
RT "Identification of novel membrane proteins.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Placenta, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Probable).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8NG11-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NG11-2; Sequence=VSP_011878;
CC Name=3;
CC IsoId=Q8NG11-3; Sequence=VSP_043194;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
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DR EMBL; AF311903; AAM94899.1; -; mRNA.
DR EMBL; AL136638; CAB66573.1; -; mRNA.
DR EMBL; AK295321; BAG58298.1; -; mRNA.
DR EMBL; AC021028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471142; EAW80384.1; -; Genomic_DNA.
DR EMBL; CH471142; EAW80385.1; -; Genomic_DNA.
DR EMBL; CH471142; EAW80386.1; -; Genomic_DNA.
DR EMBL; CH471142; EAW80388.1; -; Genomic_DNA.
DR EMBL; CH471142; EAW80389.1; -; Genomic_DNA.
DR EMBL; BC002920; AAH02920.1; -; mRNA.
DR EMBL; BC093016; AAH93016.1; -; mRNA.
DR RefSeq; NP_001121781.1; NM_001128309.1.
DR RefSeq; NP_112189.2; NM_030927.2.
DR RefSeq; XP_005270249.1; XM_005270192.1.
DR UniGene; Hs.718943; -.
DR ProteinModelPortal; Q8NG11; -.
DR IntAct; Q8NG11; 2.
DR MINT; MINT-6941206; -.
DR STRING; 9606.ENSP00000361229; -.
DR PhosphoSite; Q8NG11; -.
DR DMDM; 55976537; -.
DR PaxDb; Q8NG11; -.
DR PRIDE; Q8NG11; -.
DR DNASU; 81619; -.
DR Ensembl; ENST00000372156; ENSP00000361229; ENSG00000108219.
DR Ensembl; ENST00000372158; ENSP00000361231; ENSG00000108219.
DR Ensembl; ENST00000372164; ENSP00000361237; ENSG00000108219.
DR Ensembl; ENST00000429989; ENSP00000396270; ENSG00000108219.
DR Ensembl; ENST00000481124; ENSP00000418195; ENSG00000108219.
DR GeneID; 81619; -.
DR KEGG; hsa:81619; -.
DR UCSC; uc001kcj.4; human.
DR CTD; 81619; -.
DR GeneCards; GC10P082205; -.
DR HGNC; HGNC:23303; TSPAN14.
DR HPA; HPA014773; -.
DR neXtProt; NX_Q8NG11; -.
DR PharmGKB; PA128394731; -.
DR eggNOG; NOG312878; -.
DR HOGENOM; HOG000230652; -.
DR HOVERGEN; HBG108605; -.
DR InParanoid; Q8NG11; -.
DR KO; K17296; -.
DR OMA; EDWLPRN; -.
DR OrthoDB; EOG73FQNF; -.
DR PhylomeDB; Q8NG11; -.
DR ChiTaRS; TSPAN14; human.
DR GenomeRNAi; 81619; -.
DR NextBio; 71976; -.
DR PRO; PR:Q8NG11; -.
DR ArrayExpress; Q8NG11; -.
DR Bgee; Q8NG11; -.
DR CleanEx; HS_TSPAN14; -.
DR Genevestigator; Q8NG11; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR000301; Tetraspanin.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2.
DR Pfam; PF00335; Tetraspannin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR PRINTS; PR00259; TMFOUR.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 270 Tetraspanin-14.
FT /FTId=PRO_0000219261.
FT TRANSMEM 18 38 Helical; (Potential).
FT TRANSMEM 62 82 Helical; (Potential).
FT TRANSMEM 93 113 Helical; (Potential).
FT TRANSMEM 233 253 Helical; (Potential).
FT CARBOHYD 169 169 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 28 150 Missing (in isoform 3).
FT /FTId=VSP_043194.
FT VAR_SEQ 28 44 Missing (in isoform 2).
FT /FTId=VSP_011878.
FT CONFLICT 143 143 L -> V (in Ref. 2; CAB66573).
FT CONFLICT 268 268 H -> R (in Ref. 2; CAB66573).
SQ SEQUENCE 270 AA; 30691 MW; C74D64CDC52DF107 CRC64;
MHYYRYSNAK VSCWYKYLLF SYNIIFWLAG VVFLGVGLWA WSEKGVLSDL TKVTRMHGID
PVVLVLMVGV VMFTLGFAGC VGALRENICL LNFFCGTIVL IFFLELAVAV LAFLFQDWVR
DRFREFFESN IKSYRDDIDL QNLIDSLQKA NQCCGAYGPE DWDLNVYFNC SGASYSREKC
GVPFSCCVPD PAQKVVNTQC GYDVRIQLKS KWDESIFTKG CIQALESWLP RNIYIVAGVF
IAISLLQIFG IFLARTLISD IEAVKAGHHF
//
ID TSN14_HUMAN Reviewed; 270 AA.
AC Q8NG11; A6NHE1; B4DHY6; D3DWD7; D3DWD8; Q567U7; Q9BU34; Q9H0U1;
read moreDT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 22-JAN-2014, entry version 89.
DE RecName: Full=Tetraspanin-14;
DE Short=Tspan-14;
DE AltName: Full=DC-TM4F2;
DE AltName: Full=Transmembrane 4 superfamily member 14;
GN Name=TSPAN14; Synonyms=TM4SF14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Zhang W., Li N., Wan T., Cao X.;
RT "Identification of novel membrane proteins.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA Wambutt R., Korn B., Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and
RT analysis of 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Placenta, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC (Probable).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8NG11-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NG11-2; Sequence=VSP_011878;
CC Name=3;
CC IsoId=Q8NG11-3; Sequence=VSP_043194;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC -----------------------------------------------------------------------
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CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF311903; AAM94899.1; -; mRNA.
DR EMBL; AL136638; CAB66573.1; -; mRNA.
DR EMBL; AK295321; BAG58298.1; -; mRNA.
DR EMBL; AC021028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471142; EAW80384.1; -; Genomic_DNA.
DR EMBL; CH471142; EAW80385.1; -; Genomic_DNA.
DR EMBL; CH471142; EAW80386.1; -; Genomic_DNA.
DR EMBL; CH471142; EAW80388.1; -; Genomic_DNA.
DR EMBL; CH471142; EAW80389.1; -; Genomic_DNA.
DR EMBL; BC002920; AAH02920.1; -; mRNA.
DR EMBL; BC093016; AAH93016.1; -; mRNA.
DR RefSeq; NP_001121781.1; NM_001128309.1.
DR RefSeq; NP_112189.2; NM_030927.2.
DR RefSeq; XP_005270249.1; XM_005270192.1.
DR UniGene; Hs.718943; -.
DR ProteinModelPortal; Q8NG11; -.
DR IntAct; Q8NG11; 2.
DR MINT; MINT-6941206; -.
DR STRING; 9606.ENSP00000361229; -.
DR PhosphoSite; Q8NG11; -.
DR DMDM; 55976537; -.
DR PaxDb; Q8NG11; -.
DR PRIDE; Q8NG11; -.
DR DNASU; 81619; -.
DR Ensembl; ENST00000372156; ENSP00000361229; ENSG00000108219.
DR Ensembl; ENST00000372158; ENSP00000361231; ENSG00000108219.
DR Ensembl; ENST00000372164; ENSP00000361237; ENSG00000108219.
DR Ensembl; ENST00000429989; ENSP00000396270; ENSG00000108219.
DR Ensembl; ENST00000481124; ENSP00000418195; ENSG00000108219.
DR GeneID; 81619; -.
DR KEGG; hsa:81619; -.
DR UCSC; uc001kcj.4; human.
DR CTD; 81619; -.
DR GeneCards; GC10P082205; -.
DR HGNC; HGNC:23303; TSPAN14.
DR HPA; HPA014773; -.
DR neXtProt; NX_Q8NG11; -.
DR PharmGKB; PA128394731; -.
DR eggNOG; NOG312878; -.
DR HOGENOM; HOG000230652; -.
DR HOVERGEN; HBG108605; -.
DR InParanoid; Q8NG11; -.
DR KO; K17296; -.
DR OMA; EDWLPRN; -.
DR OrthoDB; EOG73FQNF; -.
DR PhylomeDB; Q8NG11; -.
DR ChiTaRS; TSPAN14; human.
DR GenomeRNAi; 81619; -.
DR NextBio; 71976; -.
DR PRO; PR:Q8NG11; -.
DR ArrayExpress; Q8NG11; -.
DR Bgee; Q8NG11; -.
DR CleanEx; HS_TSPAN14; -.
DR Genevestigator; Q8NG11; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR000301; Tetraspanin.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2.
DR Pfam; PF00335; Tetraspannin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR PRINTS; PR00259; TMFOUR.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1 270 Tetraspanin-14.
FT /FTId=PRO_0000219261.
FT TRANSMEM 18 38 Helical; (Potential).
FT TRANSMEM 62 82 Helical; (Potential).
FT TRANSMEM 93 113 Helical; (Potential).
FT TRANSMEM 233 253 Helical; (Potential).
FT CARBOHYD 169 169 N-linked (GlcNAc...) (Potential).
FT VAR_SEQ 28 150 Missing (in isoform 3).
FT /FTId=VSP_043194.
FT VAR_SEQ 28 44 Missing (in isoform 2).
FT /FTId=VSP_011878.
FT CONFLICT 143 143 L -> V (in Ref. 2; CAB66573).
FT CONFLICT 268 268 H -> R (in Ref. 2; CAB66573).
SQ SEQUENCE 270 AA; 30691 MW; C74D64CDC52DF107 CRC64;
MHYYRYSNAK VSCWYKYLLF SYNIIFWLAG VVFLGVGLWA WSEKGVLSDL TKVTRMHGID
PVVLVLMVGV VMFTLGFAGC VGALRENICL LNFFCGTIVL IFFLELAVAV LAFLFQDWVR
DRFREFFESN IKSYRDDIDL QNLIDSLQKA NQCCGAYGPE DWDLNVYFNC SGASYSREKC
GVPFSCCVPD PAQKVVNTQC GYDVRIQLKS KWDESIFTKG CIQALESWLP RNIYIVAGVF
IAISLLQIFG IFLARTLISD IEAVKAGHHF
//