Full text data of TXNDC5
TXNDC5
(TLP46)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Thioredoxin domain-containing protein 5 (Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Thioredoxin-like protein p46; Flags: Precursor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Thioredoxin domain-containing protein 5 (Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Thioredoxin-like protein p46; Flags: Precursor)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q8NBS9
ID TXND5_HUMAN Reviewed; 432 AA.
AC Q8NBS9; B2RDM2; Q5TCQ0; Q8ND33; Q8TCT2; Q9BVH9;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 11-APR-2003, sequence version 2.
DT 22-JAN-2014, entry version 121.
DE RecName: Full=Thioredoxin domain-containing protein 5;
DE AltName: Full=Endoplasmic reticulum resident protein 46;
DE Short=ER protein 46;
DE Short=ERp46;
DE AltName: Full=Thioredoxin-like protein p46;
DE Flags: Precursor;
GN Name=TXNDC5; Synonyms=TLP46; ORFNames=UNQ364/PRO700;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 70-432 (ISOFORM 1).
RC TISSUE=Liver;
RA Lo S.L., Nissom P.M., Ong S.E., Choong M.L., Ng S.S., Lim J.W.E.,
RA Liang R.C.M.Y., Ou K., Seow T.K., Chung M.C.M.;
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 82-432 (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 189-432 (ISOFORMS 1/2).
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [8]
RP STRUCTURE BY NMR OF 322-432.
RG RIKEN structural genomics initiative (RSGI);
RT "The solution structure of the third thioredoxin domain of human
RT thioredoxin domain-containing protein 5.";
RL Submitted (SEP-2006) to the PDB data bank.
CC -!- FUNCTION: Possesses thioredoxin activity. Has been shown to reduce
CC insulin disulfide bonds. Also complements protein disulfide-
CC isomerase deficiency in yeast (By similarity).
CC -!- INTERACTION:
CC Q13162:PRDX4; NbExp=2; IntAct=EBI-2510815, EBI-2211957;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NBS9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NBS9-2; Sequence=VSP_045181;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC -!- SIMILARITY: Contains 3 thioredoxin domains.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH01199.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY358646; AAQ89009.1; -; mRNA.
DR EMBL; AK075291; BAC11526.1; -; mRNA.
DR EMBL; AK315598; BAG37969.1; -; mRNA.
DR EMBL; AL023694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL096800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL133541; CAI19473.1; -; Genomic_DNA.
DR EMBL; CH471087; EAW55221.1; -; Genomic_DNA.
DR EMBL; AJ440721; CAD29430.1; -; mRNA.
DR EMBL; BC001199; AAH01199.1; ALT_INIT; mRNA.
DR EMBL; AL834423; CAD39084.1; -; mRNA.
DR RefSeq; NP_001139021.1; NM_001145549.2.
DR RefSeq; NP_110437.2; NM_030810.3.
DR UniGene; Hs.150837; -.
DR PDB; 2DIZ; NMR; -; A=322-432.
DR PDB; 3UJ1; X-ray; 2.65 A; A=323-432.
DR PDB; 3UVT; X-ray; 2.00 A; A/B/C/D/E=323-428.
DR PDBsum; 2DIZ; -.
DR PDBsum; 3UJ1; -.
DR PDBsum; 3UVT; -.
DR ProteinModelPortal; Q8NBS9; -.
DR SMR; Q8NBS9; 55-428.
DR IntAct; Q8NBS9; 7.
DR MINT; MINT-5006305; -.
DR STRING; 9606.ENSP00000369081; -.
DR PhosphoSite; Q8NBS9; -.
DR DMDM; 29839560; -.
DR PaxDb; Q8NBS9; -.
DR PRIDE; Q8NBS9; -.
DR Ensembl; ENST00000379757; ENSP00000369081; ENSG00000239264.
DR Ensembl; ENST00000473453; ENSP00000420784; ENSG00000239264.
DR GeneID; 81567; -.
DR KEGG; hsa:81567; -.
DR UCSC; uc010joa.2; human.
DR CTD; 81567; -.
DR GeneCards; GC06M007826; -.
DR HGNC; HGNC:21073; TXNDC5.
DR HPA; HPA034677; -.
DR HPA; HPA034678; -.
DR neXtProt; NX_Q8NBS9; -.
DR PharmGKB; PA134992492; -.
DR eggNOG; COG0526; -.
DR HOGENOM; HOG000007899; -.
DR HOVERGEN; HBG058611; -.
DR InParanoid; Q8NBS9; -.
DR KO; K13984; -.
DR OMA; HFVKFFA; -.
DR OrthoDB; EOG75F4DK; -.
DR PhylomeDB; Q8NBS9; -.
DR Reactome; REACT_11123; Membrane Trafficking.
DR ChiTaRS; TXNDC5; human.
DR EvolutionaryTrace; Q8NBS9; -.
DR GeneWiki; TXNDC5; -.
DR GenomeRNAi; 81567; -.
DR NextBio; 71856; -.
DR PRO; PR:Q8NBS9; -.
DR ArrayExpress; Q8NBS9; -.
DR Bgee; Q8NBS9; -.
DR CleanEx; HS_TXNDC5; -.
DR Genevestigator; Q8NBS9; -.
DR GO; GO:0005783; C:endoplasmic reticulum; TAS:UniProtKB.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0043202; C:lysosomal lumen; TAS:Reactome.
DR GO; GO:0016853; F:isomerase activity; IEA:InterPro.
DR GO; GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
DR GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR GO; GO:0006662; P:glycerol ether metabolic process; IEA:InterPro.
DR GO; GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB.
DR GO; GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome.
DR Gene3D; 3.40.30.10; -; 3.
DR InterPro; IPR005788; Disulphide_isomerase.
DR InterPro; IPR005746; Thioredoxin.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF00085; Thioredoxin; 3.
DR PRINTS; PR00421; THIOREDOXIN.
DR SUPFAM; SSF52833; SSF52833; 3.
DR TIGRFAMs; TIGR01126; pdi_dom; 1.
DR PROSITE; PS00014; ER_TARGET; 1.
DR PROSITE; PS00194; THIOREDOXIN_1; 3.
DR PROSITE; PS51352; THIOREDOXIN_2; 3.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Complete proteome; Disulfide bond;
KW Endoplasmic reticulum; Redox-active center; Reference proteome;
KW Repeat; Signal.
FT SIGNAL 1 32 Potential.
FT CHAIN 33 432 Thioredoxin domain-containing protein 5.
FT /FTId=PRO_0000034183.
FT DOMAIN 36 169 Thioredoxin 1.
FT DOMAIN 170 295 Thioredoxin 2.
FT DOMAIN 304 429 Thioredoxin 3.
FT MOTIF 429 432 Prevents secretion from ER (Potential).
FT DISULFID 89 92 Redox-active (Potential).
FT DISULFID 217 220 Redox-active (Potential).
FT DISULFID 350 353 Redox-active (Potential).
FT VAR_SEQ 1 108 Missing (in isoform 2).
FT /FTId=VSP_045181.
FT CONFLICT 354 354 K -> R (in Ref. 2; BAC11526).
FT STRAND 324 326
FT TURN 329 331
FT HELIX 332 336
FT STRAND 337 346
FT HELIX 351 364
FT STRAND 374 380
FT TURN 381 383
FT HELIX 385 390
FT STRAND 395 403
FT STRAND 406 411
FT HELIX 417 427
SQ SEQUENCE 432 AA; 47629 MW; 85E398008D6DB98C CRC64;
MPARPGRLLP LLARPAALTA LLLLLLGHGG GGRWGARAQE AAAAAADGPP AADGEDGQDP
HSKHLYTADM FTHGIQSAAH FVMFFAPWCG HCQRLQPTWN DLGDKYNSME DAKVYVAKVD
CTAHSDVCSA QGVRGYPTLK LFKPGQEAVK YQGPRDFQTL ENWMLQTLNE EPVTPEPEVE
PPSAPELKQG LYELSASNFE LHVAQGDHFI KFFAPWCGHC KALAPTWEQL ALGLEHSETV
KIGKVDCTQH YELCSGNQVR GYPTLLWFRD GKKVDQYKGK RDLESLREYV ESQLQRTETG
ATETVTPSEA PVLAAEPEAD KGTVLALTEN NFDDTIAEGI TFIKFYAPWC GHCKTLAPTW
EELSKKEFPG LAGVKIAEVD CTAERNICSK YSVRGYPTLL LFRGGKKVSE HSGGRDLDSL
HRFVLSQAKD EL
//
ID TXND5_HUMAN Reviewed; 432 AA.
AC Q8NBS9; B2RDM2; Q5TCQ0; Q8ND33; Q8TCT2; Q9BVH9;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 11-APR-2003, sequence version 2.
DT 22-JAN-2014, entry version 121.
DE RecName: Full=Thioredoxin domain-containing protein 5;
DE AltName: Full=Endoplasmic reticulum resident protein 46;
DE Short=ER protein 46;
DE Short=ERp46;
DE AltName: Full=Thioredoxin-like protein p46;
DE Flags: Precursor;
GN Name=TXNDC5; Synonyms=TLP46; ORFNames=UNQ364/PRO700;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 70-432 (ISOFORM 1).
RC TISSUE=Liver;
RA Lo S.L., Nissom P.M., Ong S.E., Choong M.L., Ng S.S., Lim J.W.E.,
RA Liang R.C.M.Y., Ou K., Seow T.K., Chung M.C.M.;
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 82-432 (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 189-432 (ISOFORMS 1/2).
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [8]
RP STRUCTURE BY NMR OF 322-432.
RG RIKEN structural genomics initiative (RSGI);
RT "The solution structure of the third thioredoxin domain of human
RT thioredoxin domain-containing protein 5.";
RL Submitted (SEP-2006) to the PDB data bank.
CC -!- FUNCTION: Possesses thioredoxin activity. Has been shown to reduce
CC insulin disulfide bonds. Also complements protein disulfide-
CC isomerase deficiency in yeast (By similarity).
CC -!- INTERACTION:
CC Q13162:PRDX4; NbExp=2; IntAct=EBI-2510815, EBI-2211957;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NBS9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NBS9-2; Sequence=VSP_045181;
CC Note=No experimental confirmation available;
CC -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC -!- SIMILARITY: Contains 3 thioredoxin domains.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH01199.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY358646; AAQ89009.1; -; mRNA.
DR EMBL; AK075291; BAC11526.1; -; mRNA.
DR EMBL; AK315598; BAG37969.1; -; mRNA.
DR EMBL; AL023694; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL096800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL133541; CAI19473.1; -; Genomic_DNA.
DR EMBL; CH471087; EAW55221.1; -; Genomic_DNA.
DR EMBL; AJ440721; CAD29430.1; -; mRNA.
DR EMBL; BC001199; AAH01199.1; ALT_INIT; mRNA.
DR EMBL; AL834423; CAD39084.1; -; mRNA.
DR RefSeq; NP_001139021.1; NM_001145549.2.
DR RefSeq; NP_110437.2; NM_030810.3.
DR UniGene; Hs.150837; -.
DR PDB; 2DIZ; NMR; -; A=322-432.
DR PDB; 3UJ1; X-ray; 2.65 A; A=323-432.
DR PDB; 3UVT; X-ray; 2.00 A; A/B/C/D/E=323-428.
DR PDBsum; 2DIZ; -.
DR PDBsum; 3UJ1; -.
DR PDBsum; 3UVT; -.
DR ProteinModelPortal; Q8NBS9; -.
DR SMR; Q8NBS9; 55-428.
DR IntAct; Q8NBS9; 7.
DR MINT; MINT-5006305; -.
DR STRING; 9606.ENSP00000369081; -.
DR PhosphoSite; Q8NBS9; -.
DR DMDM; 29839560; -.
DR PaxDb; Q8NBS9; -.
DR PRIDE; Q8NBS9; -.
DR Ensembl; ENST00000379757; ENSP00000369081; ENSG00000239264.
DR Ensembl; ENST00000473453; ENSP00000420784; ENSG00000239264.
DR GeneID; 81567; -.
DR KEGG; hsa:81567; -.
DR UCSC; uc010joa.2; human.
DR CTD; 81567; -.
DR GeneCards; GC06M007826; -.
DR HGNC; HGNC:21073; TXNDC5.
DR HPA; HPA034677; -.
DR HPA; HPA034678; -.
DR neXtProt; NX_Q8NBS9; -.
DR PharmGKB; PA134992492; -.
DR eggNOG; COG0526; -.
DR HOGENOM; HOG000007899; -.
DR HOVERGEN; HBG058611; -.
DR InParanoid; Q8NBS9; -.
DR KO; K13984; -.
DR OMA; HFVKFFA; -.
DR OrthoDB; EOG75F4DK; -.
DR PhylomeDB; Q8NBS9; -.
DR Reactome; REACT_11123; Membrane Trafficking.
DR ChiTaRS; TXNDC5; human.
DR EvolutionaryTrace; Q8NBS9; -.
DR GeneWiki; TXNDC5; -.
DR GenomeRNAi; 81567; -.
DR NextBio; 71856; -.
DR PRO; PR:Q8NBS9; -.
DR ArrayExpress; Q8NBS9; -.
DR Bgee; Q8NBS9; -.
DR CleanEx; HS_TXNDC5; -.
DR Genevestigator; Q8NBS9; -.
DR GO; GO:0005783; C:endoplasmic reticulum; TAS:UniProtKB.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0043202; C:lysosomal lumen; TAS:Reactome.
DR GO; GO:0016853; F:isomerase activity; IEA:InterPro.
DR GO; GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
DR GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR GO; GO:0006662; P:glycerol ether metabolic process; IEA:InterPro.
DR GO; GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB.
DR GO; GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome.
DR Gene3D; 3.40.30.10; -; 3.
DR InterPro; IPR005788; Disulphide_isomerase.
DR InterPro; IPR005746; Thioredoxin.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR017937; Thioredoxin_CS.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF00085; Thioredoxin; 3.
DR PRINTS; PR00421; THIOREDOXIN.
DR SUPFAM; SSF52833; SSF52833; 3.
DR TIGRFAMs; TIGR01126; pdi_dom; 1.
DR PROSITE; PS00014; ER_TARGET; 1.
DR PROSITE; PS00194; THIOREDOXIN_1; 3.
DR PROSITE; PS51352; THIOREDOXIN_2; 3.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Complete proteome; Disulfide bond;
KW Endoplasmic reticulum; Redox-active center; Reference proteome;
KW Repeat; Signal.
FT SIGNAL 1 32 Potential.
FT CHAIN 33 432 Thioredoxin domain-containing protein 5.
FT /FTId=PRO_0000034183.
FT DOMAIN 36 169 Thioredoxin 1.
FT DOMAIN 170 295 Thioredoxin 2.
FT DOMAIN 304 429 Thioredoxin 3.
FT MOTIF 429 432 Prevents secretion from ER (Potential).
FT DISULFID 89 92 Redox-active (Potential).
FT DISULFID 217 220 Redox-active (Potential).
FT DISULFID 350 353 Redox-active (Potential).
FT VAR_SEQ 1 108 Missing (in isoform 2).
FT /FTId=VSP_045181.
FT CONFLICT 354 354 K -> R (in Ref. 2; BAC11526).
FT STRAND 324 326
FT TURN 329 331
FT HELIX 332 336
FT STRAND 337 346
FT HELIX 351 364
FT STRAND 374 380
FT TURN 381 383
FT HELIX 385 390
FT STRAND 395 403
FT STRAND 406 411
FT HELIX 417 427
SQ SEQUENCE 432 AA; 47629 MW; 85E398008D6DB98C CRC64;
MPARPGRLLP LLARPAALTA LLLLLLGHGG GGRWGARAQE AAAAAADGPP AADGEDGQDP
HSKHLYTADM FTHGIQSAAH FVMFFAPWCG HCQRLQPTWN DLGDKYNSME DAKVYVAKVD
CTAHSDVCSA QGVRGYPTLK LFKPGQEAVK YQGPRDFQTL ENWMLQTLNE EPVTPEPEVE
PPSAPELKQG LYELSASNFE LHVAQGDHFI KFFAPWCGHC KALAPTWEQL ALGLEHSETV
KIGKVDCTQH YELCSGNQVR GYPTLLWFRD GKKVDQYKGK RDLESLREYV ESQLQRTETG
ATETVTPSEA PVLAAEPEAD KGTVLALTEN NFDDTIAEGI TFIKFYAPWC GHCKTLAPTW
EELSKKEFPG LAGVKIAEVD CTAERNICSK YSVRGYPTLL LFRGGKKVSE HSGGRDLDSL
HRFVLSQAKD EL
//