Full text data of UBXN6
UBXN6
(UBXD1, UBXDC2)
[Confidence: low (only semi-automatic identification from reviews)]
UBX domain-containing protein 6 (UBX domain-containing protein 1)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UBX domain-containing protein 6 (UBX domain-containing protein 1)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9BZV1
ID UBXN6_HUMAN Reviewed; 441 AA.
AC Q9BZV1; D6W626; Q96AH1; Q96IK9; Q9BZV0;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2001, sequence version 1.
DT 22-JAN-2014, entry version 97.
DE RecName: Full=UBX domain-containing protein 6;
DE AltName: Full=UBX domain-containing protein 1;
GN Name=UBXN6; Synonyms=UBXD1, UBXDC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX PubMed=11342112; DOI=10.1016/S0167-4781(00)00248-7;
RA Carim-Todd L., Escarceller M., Estivill X., Sumoy L.;
RT "Identification and characterization of UBXD1, a novel UBX domain-
RT containing gene on human chromosome 19p13, and its mouse ortholog.";
RL Biochim. Biophys. Acta 1517:298-301(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Skin, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH VCP; SYVN1 AND HERPUD1, AND SUBCELLULAR LOCATION.
RX PubMed=18656546; DOI=10.1016/j.biocel.2008.06.008;
RA Madsen L., Andersen K.M., Prag S., Moos T., Semple C.A., Seeger M.,
RA Hartmann-Petersen R.;
RT "Ubxd1 is a novel co-factor of the human p97 ATPase.";
RL Int. J. Biochem. Cell Biol. 40:2927-2942(2008).
RN [5]
RP FUNCTION, AND INTERACTION WITH VCP; MDM2 AND USP7.
RX PubMed=18768758; DOI=10.1091/mbc.E08-01-0067;
RA Zweitzig D.R., Shcherbik N., Haines D.S.;
RT "AAA ATPase p97 and adaptor UBXD1 suppress MDM2 ubiquitination and
RT degradation and promote constitutive p53 turnover.";
RL Mol. Biol. Cell 19:5029-5029(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP INTERACTION WITH VCPKMT.
RX PubMed=23349634; DOI=10.1371/journal.pgen.1003210;
RA Cloutier P., Lavallee-Adam M., Faubert D., Blanchette M., Coulombe B.;
RT "A newly uncovered group of distantly related lysine
RT methyltransferases preferentially interact with molecular chaperones
RT to regulate their activity.";
RL PLoS Genet. 9:E1003210-E1003210(2013).
CC -!- FUNCTION: Acts in a complex with VCP and cooperates with USP7 in
CC promoting MDM2 deubiquitination and stabilization. MDM2
CC stabilization leads to MDM2-dependent TP53 degradation.
CC -!- SUBUNIT: Interacts with VCP through the PUB domain. Interacts with
CC SYVN1, HERPUD1, MDM2 and USP7. Interacts with VCPKMT.
CC -!- INTERACTION:
CC P55072:VCP; NbExp=7; IntAct=EBI-1993899, EBI-355164;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton,
CC microtubule organizing center, centrosome. Note=Localizes at the
CC centrosome both in interphase and during mitosis.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BZV1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BZV1-2; Sequence=VSP_007453;
CC -!- TISSUE SPECIFICITY: Enhanced expression in testis.
CC -!- SIMILARITY: Contains 1 PUB (PUG) domain.
CC -!- SIMILARITY: Contains 1 UBX domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF272893; AAK13257.1; -; mRNA.
DR EMBL; AF272894; AAK13258.1; -; mRNA.
DR EMBL; CH471139; EAW69219.1; -; Genomic_DNA.
DR EMBL; CH471139; EAW69222.1; -; Genomic_DNA.
DR EMBL; BC007414; AAH07414.2; -; mRNA.
DR EMBL; BC008288; AAH08288.1; -; mRNA.
DR EMBL; BC017113; AAH17113.1; -; mRNA.
DR RefSeq; NP_001164562.1; NM_001171091.1.
DR RefSeq; NP_079517.1; NM_025241.2.
DR UniGene; Hs.435255; -.
DR ProteinModelPortal; Q9BZV1; -.
DR IntAct; Q9BZV1; 7.
DR MINT; MINT-3064689; -.
DR STRING; 9606.ENSP00000301281; -.
DR PhosphoSite; Q9BZV1; -.
DR DMDM; 30913412; -.
DR PaxDb; Q9BZV1; -.
DR PRIDE; Q9BZV1; -.
DR Ensembl; ENST00000301281; ENSP00000301281; ENSG00000167671.
DR Ensembl; ENST00000394765; ENSP00000378246; ENSG00000167671.
DR GeneID; 80700; -.
DR KEGG; hsa:80700; -.
DR UCSC; uc002mam.2; human.
DR CTD; 80700; -.
DR GeneCards; GC19M004444; -.
DR HGNC; HGNC:14928; UBXN6.
DR HPA; HPA040906; -.
DR HPA; HPA041313; -.
DR MIM; 611946; gene.
DR neXtProt; NX_Q9BZV1; -.
DR PharmGKB; PA162408446; -.
DR eggNOG; NOG265523; -.
DR HOGENOM; HOG000043787; -.
DR HOVERGEN; HBG061370; -.
DR InParanoid; Q9BZV1; -.
DR KO; K14011; -.
DR OMA; REEGSAH; -.
DR PhylomeDB; Q9BZV1; -.
DR ChiTaRS; UBXN6; human.
DR GeneWiki; UBXN6; -.
DR GenomeRNAi; 80700; -.
DR NextBio; 70993; -.
DR PRO; PR:Q9BZV1; -.
DR ArrayExpress; Q9BZV1; -.
DR Bgee; Q9BZV1; -.
DR CleanEx; HS_UBXN6; -.
DR Genevestigator; Q9BZV1; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR InterPro; IPR018997; PUB_domain.
DR InterPro; IPR006567; PUG-dom.
DR InterPro; IPR001012; UBX.
DR Pfam; PF09409; PUB; 1.
DR Pfam; PF00789; UBX; 1.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00166; UBX; 1.
DR PROSITE; PS50033; UBX; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton;
KW Nucleus; Phosphoprotein; Polymorphism; Reference proteome;
KW Ubl conjugation pathway.
FT CHAIN 1 441 UBX domain-containing protein 6.
FT /FTId=PRO_0000211025.
FT DOMAIN 175 244 PUB.
FT DOMAIN 332 408 UBX.
FT MOD_RES 96 96 Phosphoserine.
FT VAR_SEQ 1 53 Missing (in isoform 2).
FT /FTId=VSP_007453.
FT VARIANT 31 31 A -> T (in dbSNP:rs1127888).
FT /FTId=VAR_061924.
FT VARIANT 425 425 P -> L (in dbSNP:rs35436704).
FT /FTId=VAR_047821.
SQ SEQUENCE 441 AA; 49754 MW; FC06E6ADA1A1036C CRC64;
MKKFFQEFKA DIKFKSAGPG QKLKESVGEK AHKEKPNQPA PRPPRQGPTN EAQMAAAAAL
ARLEQKQSRA WGPTSQDTIR NQVRKELQAE ATVSGSPEAP GTNVVSEPRE EGSAHLAVPG
VYFTCPLTGA TLRKDQRDAC IKEAILLHFS TDPVAASIMK IYTFNKDQDR VKLGVDTIAK
YLDNIHLHPE EEKYRKIKLQ NKVFQERINC LEGTHEFFEA IGFQKVLLPA QDQEDPEEFY
VLSETTLAQP QSLERHKEQL LAAEPVRAKL DRQRRVFQPS PLASQFELPG DFFNLTAEEI
KREQRLRSEA VERLSVLRTK AMREKEEQRG LRKYNYTLLR VRLPDGCLLQ GTFYARERLG
AVYGFVREAL QSDWLPFELL ASGGQKLSED ENLALNECGL VPSALLTFSW DMAVLEDIKA
AGAEPDSILK PELLSAIEKL L
//
ID UBXN6_HUMAN Reviewed; 441 AA.
AC Q9BZV1; D6W626; Q96AH1; Q96IK9; Q9BZV0;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2001, sequence version 1.
DT 22-JAN-2014, entry version 97.
DE RecName: Full=UBX domain-containing protein 6;
DE AltName: Full=UBX domain-containing protein 1;
GN Name=UBXN6; Synonyms=UBXD1, UBXDC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX PubMed=11342112; DOI=10.1016/S0167-4781(00)00248-7;
RA Carim-Todd L., Escarceller M., Estivill X., Sumoy L.;
RT "Identification and characterization of UBXD1, a novel UBX domain-
RT containing gene on human chromosome 19p13, and its mouse ortholog.";
RL Biochim. Biophys. Acta 1517:298-301(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Skin, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH VCP; SYVN1 AND HERPUD1, AND SUBCELLULAR LOCATION.
RX PubMed=18656546; DOI=10.1016/j.biocel.2008.06.008;
RA Madsen L., Andersen K.M., Prag S., Moos T., Semple C.A., Seeger M.,
RA Hartmann-Petersen R.;
RT "Ubxd1 is a novel co-factor of the human p97 ATPase.";
RL Int. J. Biochem. Cell Biol. 40:2927-2942(2008).
RN [5]
RP FUNCTION, AND INTERACTION WITH VCP; MDM2 AND USP7.
RX PubMed=18768758; DOI=10.1091/mbc.E08-01-0067;
RA Zweitzig D.R., Shcherbik N., Haines D.S.;
RT "AAA ATPase p97 and adaptor UBXD1 suppress MDM2 ubiquitination and
RT degradation and promote constitutive p53 turnover.";
RL Mol. Biol. Cell 19:5029-5029(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP INTERACTION WITH VCPKMT.
RX PubMed=23349634; DOI=10.1371/journal.pgen.1003210;
RA Cloutier P., Lavallee-Adam M., Faubert D., Blanchette M., Coulombe B.;
RT "A newly uncovered group of distantly related lysine
RT methyltransferases preferentially interact with molecular chaperones
RT to regulate their activity.";
RL PLoS Genet. 9:E1003210-E1003210(2013).
CC -!- FUNCTION: Acts in a complex with VCP and cooperates with USP7 in
CC promoting MDM2 deubiquitination and stabilization. MDM2
CC stabilization leads to MDM2-dependent TP53 degradation.
CC -!- SUBUNIT: Interacts with VCP through the PUB domain. Interacts with
CC SYVN1, HERPUD1, MDM2 and USP7. Interacts with VCPKMT.
CC -!- INTERACTION:
CC P55072:VCP; NbExp=7; IntAct=EBI-1993899, EBI-355164;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton,
CC microtubule organizing center, centrosome. Note=Localizes at the
CC centrosome both in interphase and during mitosis.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BZV1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BZV1-2; Sequence=VSP_007453;
CC -!- TISSUE SPECIFICITY: Enhanced expression in testis.
CC -!- SIMILARITY: Contains 1 PUB (PUG) domain.
CC -!- SIMILARITY: Contains 1 UBX domain.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF272893; AAK13257.1; -; mRNA.
DR EMBL; AF272894; AAK13258.1; -; mRNA.
DR EMBL; CH471139; EAW69219.1; -; Genomic_DNA.
DR EMBL; CH471139; EAW69222.1; -; Genomic_DNA.
DR EMBL; BC007414; AAH07414.2; -; mRNA.
DR EMBL; BC008288; AAH08288.1; -; mRNA.
DR EMBL; BC017113; AAH17113.1; -; mRNA.
DR RefSeq; NP_001164562.1; NM_001171091.1.
DR RefSeq; NP_079517.1; NM_025241.2.
DR UniGene; Hs.435255; -.
DR ProteinModelPortal; Q9BZV1; -.
DR IntAct; Q9BZV1; 7.
DR MINT; MINT-3064689; -.
DR STRING; 9606.ENSP00000301281; -.
DR PhosphoSite; Q9BZV1; -.
DR DMDM; 30913412; -.
DR PaxDb; Q9BZV1; -.
DR PRIDE; Q9BZV1; -.
DR Ensembl; ENST00000301281; ENSP00000301281; ENSG00000167671.
DR Ensembl; ENST00000394765; ENSP00000378246; ENSG00000167671.
DR GeneID; 80700; -.
DR KEGG; hsa:80700; -.
DR UCSC; uc002mam.2; human.
DR CTD; 80700; -.
DR GeneCards; GC19M004444; -.
DR HGNC; HGNC:14928; UBXN6.
DR HPA; HPA040906; -.
DR HPA; HPA041313; -.
DR MIM; 611946; gene.
DR neXtProt; NX_Q9BZV1; -.
DR PharmGKB; PA162408446; -.
DR eggNOG; NOG265523; -.
DR HOGENOM; HOG000043787; -.
DR HOVERGEN; HBG061370; -.
DR InParanoid; Q9BZV1; -.
DR KO; K14011; -.
DR OMA; REEGSAH; -.
DR PhylomeDB; Q9BZV1; -.
DR ChiTaRS; UBXN6; human.
DR GeneWiki; UBXN6; -.
DR GenomeRNAi; 80700; -.
DR NextBio; 70993; -.
DR PRO; PR:Q9BZV1; -.
DR ArrayExpress; Q9BZV1; -.
DR Bgee; Q9BZV1; -.
DR CleanEx; HS_UBXN6; -.
DR Genevestigator; Q9BZV1; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR InterPro; IPR018997; PUB_domain.
DR InterPro; IPR006567; PUG-dom.
DR InterPro; IPR001012; UBX.
DR Pfam; PF09409; PUB; 1.
DR Pfam; PF00789; UBX; 1.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00166; UBX; 1.
DR PROSITE; PS50033; UBX; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton;
KW Nucleus; Phosphoprotein; Polymorphism; Reference proteome;
KW Ubl conjugation pathway.
FT CHAIN 1 441 UBX domain-containing protein 6.
FT /FTId=PRO_0000211025.
FT DOMAIN 175 244 PUB.
FT DOMAIN 332 408 UBX.
FT MOD_RES 96 96 Phosphoserine.
FT VAR_SEQ 1 53 Missing (in isoform 2).
FT /FTId=VSP_007453.
FT VARIANT 31 31 A -> T (in dbSNP:rs1127888).
FT /FTId=VAR_061924.
FT VARIANT 425 425 P -> L (in dbSNP:rs35436704).
FT /FTId=VAR_047821.
SQ SEQUENCE 441 AA; 49754 MW; FC06E6ADA1A1036C CRC64;
MKKFFQEFKA DIKFKSAGPG QKLKESVGEK AHKEKPNQPA PRPPRQGPTN EAQMAAAAAL
ARLEQKQSRA WGPTSQDTIR NQVRKELQAE ATVSGSPEAP GTNVVSEPRE EGSAHLAVPG
VYFTCPLTGA TLRKDQRDAC IKEAILLHFS TDPVAASIMK IYTFNKDQDR VKLGVDTIAK
YLDNIHLHPE EEKYRKIKLQ NKVFQERINC LEGTHEFFEA IGFQKVLLPA QDQEDPEEFY
VLSETTLAQP QSLERHKEQL LAAEPVRAKL DRQRRVFQPS PLASQFELPG DFFNLTAEEI
KREQRLRSEA VERLSVLRTK AMREKEEQRG LRKYNYTLLR VRLPDGCLLQ GTFYARERLG
AVYGFVREAL QSDWLPFELL ASGGQKLSED ENLALNECGL VPSALLTFSW DMAVLEDIKA
AGAEPDSILK PELLSAIEKL L
//
MIM
611946
*RECORD*
*FIELD* NO
611946
*FIELD* TI
*611946 UBX DOMAIN PROTEIN 6; UBXN6
;;UBX DOMAIN-CONTAINING GENE 1; UBXD1
*FIELD* TX
read more
CLONING
By database analysis, Carim-Todd et al. (2001) identified UBXD1. They
isolated 2 transcripts encoding predicting proteins of 388 and 441 amino
acids with calculated molecular masses of 43.8 and 49.7 kD,
respectively. UBXD1 contains a C-terminal UBX domain, characteristic of
ubiquitin regulatory proteins, and shares 80% and 79% amino acid
identity with the mouse and rat homologs, respectively. Northern blot
analysis of adult human tissues detected 1.6-, 1.8-, and 5.5-kb
transcripts with highest expression in testis, followed by prostate,
spleen, thymus, small intestine, colon, blood leukocytes, and uterus.
GENE STRUCTURE
Carim-Todd et al. (2001) determined that the UBXD1 gene contains 11
exons with an alternatively spliced exon 1a. The 1.8-kb transcript
contains an in-frame stop codon in exon 1a preceding a second open
reading frame and results in the shorter isoform.
MAPPING
By genomic sequence analysis, Carim-Todd et al. (2001) mapped the UBXD1
gene to chromosome 19p13.
*FIELD* RF
1. Carim-Todd, L.; Escarceller, M.; Estivill, X.; Sumoy, L.: Identification
and characterization of UBXD1, a novel UBX domain-containing gene
on human chromosome 19p13, and its mouse ortholog. Biochim. Biophys.
Acta 1517: 298-301, 2001.
*FIELD* CD
Dorothy S. Reilly: 4/16/2008
*FIELD* ED
mgross: 05/31/2013
wwang: 4/16/2008
*RECORD*
*FIELD* NO
611946
*FIELD* TI
*611946 UBX DOMAIN PROTEIN 6; UBXN6
;;UBX DOMAIN-CONTAINING GENE 1; UBXD1
*FIELD* TX
read more
CLONING
By database analysis, Carim-Todd et al. (2001) identified UBXD1. They
isolated 2 transcripts encoding predicting proteins of 388 and 441 amino
acids with calculated molecular masses of 43.8 and 49.7 kD,
respectively. UBXD1 contains a C-terminal UBX domain, characteristic of
ubiquitin regulatory proteins, and shares 80% and 79% amino acid
identity with the mouse and rat homologs, respectively. Northern blot
analysis of adult human tissues detected 1.6-, 1.8-, and 5.5-kb
transcripts with highest expression in testis, followed by prostate,
spleen, thymus, small intestine, colon, blood leukocytes, and uterus.
GENE STRUCTURE
Carim-Todd et al. (2001) determined that the UBXD1 gene contains 11
exons with an alternatively spliced exon 1a. The 1.8-kb transcript
contains an in-frame stop codon in exon 1a preceding a second open
reading frame and results in the shorter isoform.
MAPPING
By genomic sequence analysis, Carim-Todd et al. (2001) mapped the UBXD1
gene to chromosome 19p13.
*FIELD* RF
1. Carim-Todd, L.; Escarceller, M.; Estivill, X.; Sumoy, L.: Identification
and characterization of UBXD1, a novel UBX domain-containing gene
on human chromosome 19p13, and its mouse ortholog. Biochim. Biophys.
Acta 1517: 298-301, 2001.
*FIELD* CD
Dorothy S. Reilly: 4/16/2008
*FIELD* ED
mgross: 05/31/2013
wwang: 4/16/2008