Full text data of WDR53
WDR53
[Confidence: low (only semi-automatic identification from reviews)]
WD repeat-containing protein 53
Note: presumably soluble (membrane word is not in UniProt keywords or features)
WD repeat-containing protein 53
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q7Z5U6
ID WDR53_HUMAN Reviewed; 358 AA.
AC Q7Z5U6;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2003, sequence version 1.
DT 22-JAN-2014, entry version 93.
DE RecName: Full=WD repeat-containing protein 53;
GN Name=WDR53;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP VARIANT [LARGE SCALE ANALYSIS] CYS-60.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal
RT cancers.";
RL Science 314:268-274(2006).
CC -!- SIMILARITY: Belongs to the WD repeat WDR53 family.
CC -!- SIMILARITY: Contains 5 WD repeats.
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DR EMBL; BC054030; AAH54030.1; -; mRNA.
DR RefSeq; NP_872433.1; NM_182627.1.
DR RefSeq; XP_005269376.1; XM_005269319.1.
DR RefSeq; XP_005269377.1; XM_005269320.1.
DR UniGene; Hs.385865; -.
DR ProteinModelPortal; Q7Z5U6; -.
DR SMR; Q7Z5U6; 8-349.
DR STRING; 9606.ENSP00000328079; -.
DR DMDM; 74762439; -.
DR PaxDb; Q7Z5U6; -.
DR PRIDE; Q7Z5U6; -.
DR DNASU; 348793; -.
DR Ensembl; ENST00000332629; ENSP00000328079; ENSG00000185798.
DR GeneID; 348793; -.
DR KEGG; hsa:348793; -.
DR UCSC; uc003fwt.3; human.
DR CTD; 348793; -.
DR GeneCards; GC03M196281; -.
DR HGNC; HGNC:28786; WDR53.
DR HPA; HPA016420; -.
DR HPA; HPA019332; -.
DR MIM; 615110; gene.
DR neXtProt; NX_Q7Z5U6; -.
DR PharmGKB; PA134948456; -.
DR eggNOG; COG2319; -.
DR HOGENOM; HOG000036744; -.
DR HOVERGEN; HBG056769; -.
DR InParanoid; Q7Z5U6; -.
DR OMA; EETEGPQ; -.
DR PhylomeDB; Q7Z5U6; -.
DR SignaLink; Q7Z5U6; -.
DR ChiTaRS; WDR53; human.
DR GenomeRNAi; 348793; -.
DR NextBio; 99421; -.
DR PRO; PR:Q7Z5U6; -.
DR ArrayExpress; Q7Z5U6; -.
DR Bgee; Q7Z5U6; -.
DR CleanEx; HS_WDR53; -.
DR Genevestigator; Q7Z5U6; -.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR017986; WD40_repeat_dom.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Polymorphism; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1 358 WD repeat-containing protein 53.
FT /FTId=PRO_0000051413.
FT REPEAT 8 46 WD 1.
FT REPEAT 92 131 WD 2.
FT REPEAT 134 174 WD 3.
FT REPEAT 195 234 WD 4.
FT REPEAT 239 278 WD 5.
FT VARIANT 60 60 S -> C (in a breast cancer sample;
FT somatic mutation).
FT /FTId=VAR_035890.
FT VARIANT 338 338 H -> P (in dbSNP:rs1048032).
FT /FTId=VAR_033810.
SQ SEQUENCE 358 AA; 38989 MW; 3C9BDF46488FF111 CRC64;
MAVKWTGGHS SPVLCLNASK EGLLASGAEG GDLTAWGEDG TPLGHTRFQG ADDVTSVLFS
PSCPTKLYAS HGETISVLDV RSLKDSLDHF HVNEEEINCL SLNQTENLLA SADDSGAIKI
LDLENKKVIR SLKRHSNICS SVAFRPQRPQ SLVSCGLDMQ VMLWSLQKAR PLWITNLQED
ETEEMEGPQS PGQLLNPALA HSISVASCGN IFSCGAEDGK VRIFRVMGVK CEQELGFKGH
TSGVSQVCFL PESYLLLTGG NDGKITLWDA NSEVEKKQKS PTKRTHRKKP KRGTCTKQGG
NTNASVTDEE EHGNILPKLN IEHGEKVNWL LGTKIKGHQN ILVADQTSCI SVYPLNEF
//
ID WDR53_HUMAN Reviewed; 358 AA.
AC Q7Z5U6;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2003, sequence version 1.
DT 22-JAN-2014, entry version 93.
DE RecName: Full=WD repeat-containing protein 53;
GN Name=WDR53;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP VARIANT [LARGE SCALE ANALYSIS] CYS-60.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal
RT cancers.";
RL Science 314:268-274(2006).
CC -!- SIMILARITY: Belongs to the WD repeat WDR53 family.
CC -!- SIMILARITY: Contains 5 WD repeats.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; BC054030; AAH54030.1; -; mRNA.
DR RefSeq; NP_872433.1; NM_182627.1.
DR RefSeq; XP_005269376.1; XM_005269319.1.
DR RefSeq; XP_005269377.1; XM_005269320.1.
DR UniGene; Hs.385865; -.
DR ProteinModelPortal; Q7Z5U6; -.
DR SMR; Q7Z5U6; 8-349.
DR STRING; 9606.ENSP00000328079; -.
DR DMDM; 74762439; -.
DR PaxDb; Q7Z5U6; -.
DR PRIDE; Q7Z5U6; -.
DR DNASU; 348793; -.
DR Ensembl; ENST00000332629; ENSP00000328079; ENSG00000185798.
DR GeneID; 348793; -.
DR KEGG; hsa:348793; -.
DR UCSC; uc003fwt.3; human.
DR CTD; 348793; -.
DR GeneCards; GC03M196281; -.
DR HGNC; HGNC:28786; WDR53.
DR HPA; HPA016420; -.
DR HPA; HPA019332; -.
DR MIM; 615110; gene.
DR neXtProt; NX_Q7Z5U6; -.
DR PharmGKB; PA134948456; -.
DR eggNOG; COG2319; -.
DR HOGENOM; HOG000036744; -.
DR HOVERGEN; HBG056769; -.
DR InParanoid; Q7Z5U6; -.
DR OMA; EETEGPQ; -.
DR PhylomeDB; Q7Z5U6; -.
DR SignaLink; Q7Z5U6; -.
DR ChiTaRS; WDR53; human.
DR GenomeRNAi; 348793; -.
DR NextBio; 99421; -.
DR PRO; PR:Q7Z5U6; -.
DR ArrayExpress; Q7Z5U6; -.
DR Bgee; Q7Z5U6; -.
DR CleanEx; HS_WDR53; -.
DR Genevestigator; Q7Z5U6; -.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR017986; WD40_repeat_dom.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Complete proteome; Polymorphism; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1 358 WD repeat-containing protein 53.
FT /FTId=PRO_0000051413.
FT REPEAT 8 46 WD 1.
FT REPEAT 92 131 WD 2.
FT REPEAT 134 174 WD 3.
FT REPEAT 195 234 WD 4.
FT REPEAT 239 278 WD 5.
FT VARIANT 60 60 S -> C (in a breast cancer sample;
FT somatic mutation).
FT /FTId=VAR_035890.
FT VARIANT 338 338 H -> P (in dbSNP:rs1048032).
FT /FTId=VAR_033810.
SQ SEQUENCE 358 AA; 38989 MW; 3C9BDF46488FF111 CRC64;
MAVKWTGGHS SPVLCLNASK EGLLASGAEG GDLTAWGEDG TPLGHTRFQG ADDVTSVLFS
PSCPTKLYAS HGETISVLDV RSLKDSLDHF HVNEEEINCL SLNQTENLLA SADDSGAIKI
LDLENKKVIR SLKRHSNICS SVAFRPQRPQ SLVSCGLDMQ VMLWSLQKAR PLWITNLQED
ETEEMEGPQS PGQLLNPALA HSISVASCGN IFSCGAEDGK VRIFRVMGVK CEQELGFKGH
TSGVSQVCFL PESYLLLTGG NDGKITLWDA NSEVEKKQKS PTKRTHRKKP KRGTCTKQGG
NTNASVTDEE EHGNILPKLN IEHGEKVNWL LGTKIKGHQN ILVADQTSCI SVYPLNEF
//
MIM
615110
*RECORD*
*FIELD* NO
615110
*FIELD* TI
*615110 WD REPEAT-CONTAINING PROTEIN 53; WDR53
*FIELD* TX
DESCRIPTION
WDR53 is predicted to be an adaptor protein that regulates the
read moreinteractions of other proteins with the CUL4 (see 603137)-DDB1 (600045)
ubiquitin E3 ligase complex (Higa et al., 2006).
CLONING
By mass spectrometric analysis of proteins that interacted with the
CUL4-DDB1 complex in human cell lines, Higa et al. (2006) identified
WDR53. The deduced protein is predicted to have a large central WD40
repeat domain and short N- and C-terminal tails.
MAPPING
Hartz (2013) mapped the WDR53 gene to chromosome 3q29 based on an
alignment of the WDR53 sequence (GenBank GENBANK BC054030) with the
genomic sequence (GRCh37).
*FIELD* RF
1. Hartz, P. A.: Personal Communication. Baltimore, Md. 2/28/2013.
2. Higa, L. A.; Wu, M.; Ye, T.; Kobayashi, R.; Sun, H.; Zhang, H.
: CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins
and regulates histone methylation. Nature Cell Biol. 8: 1277-1283,
2006.
*FIELD* CD
Patricia A. Hartz: 2/28/2013
*FIELD* ED
mgross: 02/28/2013
*RECORD*
*FIELD* NO
615110
*FIELD* TI
*615110 WD REPEAT-CONTAINING PROTEIN 53; WDR53
*FIELD* TX
DESCRIPTION
WDR53 is predicted to be an adaptor protein that regulates the
read moreinteractions of other proteins with the CUL4 (see 603137)-DDB1 (600045)
ubiquitin E3 ligase complex (Higa et al., 2006).
CLONING
By mass spectrometric analysis of proteins that interacted with the
CUL4-DDB1 complex in human cell lines, Higa et al. (2006) identified
WDR53. The deduced protein is predicted to have a large central WD40
repeat domain and short N- and C-terminal tails.
MAPPING
Hartz (2013) mapped the WDR53 gene to chromosome 3q29 based on an
alignment of the WDR53 sequence (GenBank GENBANK BC054030) with the
genomic sequence (GRCh37).
*FIELD* RF
1. Hartz, P. A.: Personal Communication. Baltimore, Md. 2/28/2013.
2. Higa, L. A.; Wu, M.; Ye, T.; Kobayashi, R.; Sun, H.; Zhang, H.
: CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins
and regulates histone methylation. Nature Cell Biol. 8: 1277-1283,
2006.
*FIELD* CD
Patricia A. Hartz: 2/28/2013
*FIELD* ED
mgross: 02/28/2013