Full text data of ZC3HAV1L
ZC3HAV1L
(C7orf39)
[Confidence: low (only semi-automatic identification from reviews)]
Zinc finger CCCH-type antiviral protein 1-like
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Zinc finger CCCH-type antiviral protein 1-like
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q96H79
ID ZCCHL_HUMAN Reviewed; 300 AA.
AC Q96H79; Q8WUD9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 18-MAY-2010, sequence version 2.
DT 22-JAN-2014, entry version 80.
DE RecName: Full=Zinc finger CCCH-type antiviral protein 1-like;
GN Name=ZC3HAV1L; Synonyms=C7orf39;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA Waterston R.H., Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 2-12; 142-154 AND 249-291, CLEAVAGE OF INITIATOR
RP METHIONINE, ACETYLATION AT ALA-2, AND MASS SPECTROMETRY.
RC TISSUE=Ovarian carcinoma;
RA Bienvenut W.V.;
RL Submitted (JAN-2010) to UniProtKB.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96H79-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96H79-2; Sequence=VSP_033210, VSP_033211;
CC Note=No experimental confirmation available;
CC -!- CAUTION: Despite its name, it does not contain a canonical C3H1-
CC type zinc-finger.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC083868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC008842; AAH08842.1; -; mRNA.
DR EMBL; BC020784; AAH20784.1; -; mRNA.
DR RefSeq; NP_542391.2; NM_080660.3.
DR UniGene; Hs.512833; -.
DR UniGene; Hs.659143; -.
DR ProteinModelPortal; Q96H79; -.
DR SMR; Q96H79; 3-245.
DR IntAct; Q96H79; 1.
DR PhosphoSite; Q96H79; -.
DR DMDM; 296453031; -.
DR PaxDb; Q96H79; -.
DR PRIDE; Q96H79; -.
DR DNASU; 92092; -.
DR Ensembl; ENST00000275766; ENSP00000275766; ENSG00000146858.
DR GeneID; 92092; -.
DR KEGG; hsa:92092; -.
DR UCSC; uc003vum.1; human.
DR CTD; 92092; -.
DR GeneCards; GC07M138706; -.
DR H-InvDB; HIX0007127; -.
DR HGNC; HGNC:22423; ZC3HAV1L.
DR HPA; HPA020386; -.
DR neXtProt; NX_Q96H79; -.
DR PharmGKB; PA145147600; -.
DR eggNOG; NOG44305; -.
DR HOGENOM; HOG000090210; -.
DR HOVERGEN; HBG098320; -.
DR InParanoid; Q96H79; -.
DR OMA; RLCARYQ; -.
DR OrthoDB; EOG7P5T0J; -.
DR PhylomeDB; Q96H79; -.
DR ChiTaRS; ZC3HAV1L; human.
DR GenomeRNAi; 92092; -.
DR NextBio; 77581; -.
DR PRO; PR:Q96H79; -.
DR Bgee; Q96H79; -.
DR CleanEx; HS_ZC3HAV1L; -.
DR Genevestigator; Q96H79; -.
DR InterPro; IPR026693; Zc3hav1_like.
DR PANTHER; PTHR14453:SF16; PTHR14453:SF16; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Complete proteome;
KW Direct protein sequencing; Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 300 Zinc finger CCCH-type antiviral protein
FT 1-like.
FT /FTId=PRO_0000331459.
FT MOD_RES 2 2 N-acetylalanine.
FT VAR_SEQ 87 102 SVRLCARYQRGECQAC -> GTIGACHHTQLIFLGF (in
FT isoform 2).
FT /FTId=VSP_033210.
FT VAR_SEQ 103 300 Missing (in isoform 2).
FT /FTId=VSP_033211.
FT CONFLICT 244 244 M -> I (in Ref. 2; AAH08842).
SQ SEQUENCE 300 AA; 32962 MW; 9F3B6BABA5CA0E3B CRC64;
MAEPTVCSFL TKVLCAHGGR MFLKDLRGHV ELSEARLRDV LQRAGPERFL LQEVETQEGL
GDAEAEAAAG AVGGGGTSAW RVVAVSSVRL CARYQRGECQ ACDQLHFCRR HMLGKCPNRD
CWSTCTLSHD IHTPVNMQVL KSHGLFGLNE NQLRILLLQN DPCLLPEVCL LYNKGEALYG
YCNLKDKCNK FHVCKSFVKG ECKLQTCKRS HQLIHAASLK LLQDQGLNIP SVVNFQIIST
YKHMKLHKML ENTDNSSPST EHSQGLEKQG VHAAGAAEAG PLASVPAQSA KKPCPVSCEK
//
ID ZCCHL_HUMAN Reviewed; 300 AA.
AC Q96H79; Q8WUD9;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 18-MAY-2010, sequence version 2.
DT 22-JAN-2014, entry version 80.
DE RecName: Full=Zinc finger CCCH-type antiviral protein 1-like;
GN Name=ZC3HAV1L; Synonyms=C7orf39;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA Waterston R.H., Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 2-12; 142-154 AND 249-291, CLEAVAGE OF INITIATOR
RP METHIONINE, ACETYLATION AT ALA-2, AND MASS SPECTROMETRY.
RC TISSUE=Ovarian carcinoma;
RA Bienvenut W.V.;
RL Submitted (JAN-2010) to UniProtKB.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96H79-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96H79-2; Sequence=VSP_033210, VSP_033211;
CC Note=No experimental confirmation available;
CC -!- CAUTION: Despite its name, it does not contain a canonical C3H1-
CC type zinc-finger.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AC083868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC008842; AAH08842.1; -; mRNA.
DR EMBL; BC020784; AAH20784.1; -; mRNA.
DR RefSeq; NP_542391.2; NM_080660.3.
DR UniGene; Hs.512833; -.
DR UniGene; Hs.659143; -.
DR ProteinModelPortal; Q96H79; -.
DR SMR; Q96H79; 3-245.
DR IntAct; Q96H79; 1.
DR PhosphoSite; Q96H79; -.
DR DMDM; 296453031; -.
DR PaxDb; Q96H79; -.
DR PRIDE; Q96H79; -.
DR DNASU; 92092; -.
DR Ensembl; ENST00000275766; ENSP00000275766; ENSG00000146858.
DR GeneID; 92092; -.
DR KEGG; hsa:92092; -.
DR UCSC; uc003vum.1; human.
DR CTD; 92092; -.
DR GeneCards; GC07M138706; -.
DR H-InvDB; HIX0007127; -.
DR HGNC; HGNC:22423; ZC3HAV1L.
DR HPA; HPA020386; -.
DR neXtProt; NX_Q96H79; -.
DR PharmGKB; PA145147600; -.
DR eggNOG; NOG44305; -.
DR HOGENOM; HOG000090210; -.
DR HOVERGEN; HBG098320; -.
DR InParanoid; Q96H79; -.
DR OMA; RLCARYQ; -.
DR OrthoDB; EOG7P5T0J; -.
DR PhylomeDB; Q96H79; -.
DR ChiTaRS; ZC3HAV1L; human.
DR GenomeRNAi; 92092; -.
DR NextBio; 77581; -.
DR PRO; PR:Q96H79; -.
DR Bgee; Q96H79; -.
DR CleanEx; HS_ZC3HAV1L; -.
DR Genevestigator; Q96H79; -.
DR InterPro; IPR026693; Zc3hav1_like.
DR PANTHER; PTHR14453:SF16; PTHR14453:SF16; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Complete proteome;
KW Direct protein sequencing; Reference proteome.
FT INIT_MET 1 1 Removed.
FT CHAIN 2 300 Zinc finger CCCH-type antiviral protein
FT 1-like.
FT /FTId=PRO_0000331459.
FT MOD_RES 2 2 N-acetylalanine.
FT VAR_SEQ 87 102 SVRLCARYQRGECQAC -> GTIGACHHTQLIFLGF (in
FT isoform 2).
FT /FTId=VSP_033210.
FT VAR_SEQ 103 300 Missing (in isoform 2).
FT /FTId=VSP_033211.
FT CONFLICT 244 244 M -> I (in Ref. 2; AAH08842).
SQ SEQUENCE 300 AA; 32962 MW; 9F3B6BABA5CA0E3B CRC64;
MAEPTVCSFL TKVLCAHGGR MFLKDLRGHV ELSEARLRDV LQRAGPERFL LQEVETQEGL
GDAEAEAAAG AVGGGGTSAW RVVAVSSVRL CARYQRGECQ ACDQLHFCRR HMLGKCPNRD
CWSTCTLSHD IHTPVNMQVL KSHGLFGLNE NQLRILLLQN DPCLLPEVCL LYNKGEALYG
YCNLKDKCNK FHVCKSFVKG ECKLQTCKRS HQLIHAASLK LLQDQGLNIP SVVNFQIIST
YKHMKLHKML ENTDNSSPST EHSQGLEKQG VHAAGAAEAG PLASVPAQSA KKPCPVSCEK
//