Full text data of ZFYVE19
ZFYVE19
(MPFYVE)
[Confidence: low (only semi-automatic identification from reviews)]
Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q96K21
ID ZFY19_HUMAN Reviewed; 471 AA.
AC Q96K21; B3KVB2; C9JNF4; H3BUF9; Q86WC2; Q8WU96;
DT 24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 18-MAY-2010, sequence version 3.
DT 22-JAN-2014, entry version 103.
DE RecName: Full=Zinc finger FYVE domain-containing protein 19;
DE AltName: Full=MLL partner containing FYVE domain;
GN Name=ZFYVE19; Synonyms=MPFYVE;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHROMOSOMAL TRANSLOCATION WITH
RP KMT2A/MLL1, AND TISSUE SPECIFICITY.
RX PubMed=12618766; DOI=10.1038/sj.onc.1206273;
RA Chinwalla V., Chien A., Odero M., Neilly M.B., Zeleznik-Le N.J.,
RA Rowley J.D.;
RT "A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene
RT MPFYVE on chromosome 15.";
RL Oncogene 22:1400-1410(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 19-471 (ISOFORM 1), AND VARIANT
RP ALA-376.
RC TISSUE=Ovary, and Synovium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human
RT chromosome 15.";
RL Nature 440:671-675(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-471 (ISOFORM 3), AND
RP VARIANT ALA-376.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, AND MASS
RP SPECTROMETRY.
RC TISSUE=T-cell;
RX PubMed=19367720; DOI=10.1021/pr800500r;
RA Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
RT "Phosphorylation analysis of primary human T lymphocytes using
RT sequential IMAC and titanium oxide enrichment.";
RL J. Proteome Res. 7:5167-5176(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, AND MASS
RP SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=18318008; DOI=10.1002/pmic.200700884;
RA Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,
RA Zou H., Gu J.;
RT "Large-scale phosphoproteome analysis of human liver tissue by
RT enrichment and fractionation of phosphopeptides with strong anion
RT exchange chromatography.";
RL Proteomics 8:1346-1361(2008).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, PHOSPHORYLATION
RP [LARGE SCALE ANALYSIS] AT SER-286 (ISOFORM 3), AND MASS SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-243; SER-354 AND
RP SER-463, AND MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, AND MASS
RP SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q96K21-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96K21-2; Sequence=VSP_013791;
CC Name=3;
CC IsoId=Q96K21-3; Sequence=VSP_013792;
CC Note=No experimental confirmation available. Contains a
CC phosphoserine at position 286;
CC Name=4;
CC IsoId=Q96K21-4; Sequence=VSP_046008;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Detected in brain, heart, skeletal muscle,
CC kidney and liver.
CC -!- DISEASE: Note=A chromosomal aberration involving ZFYVE19 is
CC associated with acute myeloblastic leukemia (AML). Translocation
CC t(11;15)(q23;q14) with KMT2A/MLL1.
CC -!- SIMILARITY: Contains 1 FYVE-type zinc finger.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH21092.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=AAO73862.1; Type=Frameshift; Positions=459;
CC Sequence=BAB55338.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
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DR EMBL; AF445414; AAO73862.1; ALT_FRAME; mRNA.
DR EMBL; AK027746; BAB55338.1; ALT_INIT; mRNA.
DR EMBL; AK122779; BAG53724.1; -; mRNA.
DR EMBL; AC012476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471125; EAW92451.1; -; Genomic_DNA.
DR EMBL; BC021092; AAH21092.1; ALT_INIT; mRNA.
DR RefSeq; NP_001070736.1; NM_001077268.1.
DR RefSeq; NP_001245349.1; NM_001258420.1.
DR RefSeq; NP_001245350.1; NM_001258421.1.
DR RefSeq; NP_116239.3; NM_032850.4.
DR UniGene; Hs.121676; -.
DR ProteinModelPortal; Q96K21; -.
DR SMR; Q96K21; 76-150, 418-471.
DR IntAct; Q96K21; 1.
DR STRING; 9606.ENSP00000347498; -.
DR PhosphoSite; Q96K21; -.
DR DMDM; 296453076; -.
DR PaxDb; Q96K21; -.
DR PRIDE; Q96K21; -.
DR Ensembl; ENST00000299173; ENSP00000299173; ENSG00000166140.
DR Ensembl; ENST00000336455; ENSP00000337824; ENSG00000166140.
DR Ensembl; ENST00000355341; ENSP00000347498; ENSG00000166140.
DR Ensembl; ENST00000564258; ENSP00000457617; ENSG00000166140.
DR GeneID; 84936; -.
DR KEGG; hsa:84936; -.
DR UCSC; uc001zmt.1; human.
DR CTD; 84936; -.
DR GeneCards; GC15P041099; -.
DR H-InvDB; HIX0012140; -.
DR HGNC; HGNC:20758; ZFYVE19.
DR HPA; HPA040283; -.
DR neXtProt; NX_Q96K21; -.
DR PharmGKB; PA134906967; -.
DR eggNOG; NOG291948; -.
DR HOGENOM; HOG000231992; -.
DR HOVERGEN; HBG057281; -.
DR InParanoid; Q96K21; -.
DR OMA; ASGYNIP; -.
DR GeneWiki; ZFYVE19; -.
DR GenomeRNAi; 84936; -.
DR NextBio; 75384; -.
DR PRO; PR:Q96K21; -.
DR ArrayExpress; Q96K21; -.
DR Bgee; Q96K21; -.
DR CleanEx; HS_ZFYVE19; -.
DR Genevestigator; Q96K21; -.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromosomal rearrangement; Coiled coil;
KW Complete proteome; Metal-binding; Phosphoprotein; Polymorphism;
KW Proto-oncogene; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1 471 Zinc finger FYVE domain-containing
FT protein 19.
FT /FTId=PRO_0000098718.
FT ZN_FING 74 133 FYVE-type.
FT COILED 311 375 Potential.
FT COMPBIAS 412 417 Poly-Glu.
FT COMPBIAS 421 444 Cys-rich.
FT SITE 145 146 Breakpoint for translocation to form
FT KMT2A/MLL1-ZFYVE19.
FT MOD_RES 243 243 Phosphothreonine.
FT MOD_RES 354 354 Phosphoserine.
FT MOD_RES 463 463 Phosphoserine.
FT VAR_SEQ 1 175 Missing (in isoform 4).
FT /FTId=VSP_046008.
FT VAR_SEQ 1 93 MNYDSQQPPLPPLPYAGCRRASGFPALGRGGTVPVGVWGGA
FT GQGREGRSWGEGPRGPGLGRRDLSSADPAVLGATMESRCYG
FT CAVKFTLFKKE -> MPAVAEALGQEGPPDLSRSAFLATVL
FT TSLSAAFSSMPSSAYSLPFSRSLELDYHTSSCFRGTMVKAD
FT CPVPITDLPDSSGKLQ (in isoform 2).
FT /FTId=VSP_013791.
FT VAR_SEQ 276 343 Missing (in isoform 3).
FT /FTId=VSP_013792.
FT VARIANT 210 210 R -> H (in dbSNP:rs34819163).
FT /FTId=VAR_057494.
FT VARIANT 376 376 S -> A (in dbSNP:rs690347).
FT /FTId=VAR_060474.
FT VARIANT 398 398 R -> C (in dbSNP:rs72735636).
FT /FTId=VAR_060475.
FT CONFLICT 104 104 C -> R (in Ref. 5; AAH21092).
SQ SEQUENCE 471 AA; 51546 MW; 0F07D2DDFD19864D CRC64;
MNYDSQQPPL PPLPYAGCRR ASGFPALGRG GTVPVGVWGG AGQGREGRSW GEGPRGPGLG
RRDLSSADPA VLGATMESRC YGCAVKFTLF KKEYGCKNCG RAFCSGCLSF SAAVPRTGNT
QQKVCKQCHE VLTRGSSANA SKWSPPQNYK KRVAALEAKQ KPSTSQSQGL TRQDQMIAER
LARLRQENKP KLVPSQAEIE ARLAALKDER QGSIPSTQEM EARLAALQGR VLPSQTPQPA
HHTPDTRTQA QQTQDLLTQL AAEVAIDESW KGGGPAASLQ NDLNQGGPGS TNSKRQANWS
LEEEKSRLLA EAALELREEN TRQERILALA KRLAMLRGQD PERVTLQDYR LPDSDDDEDE
ETAIQRVLQQ LTEEASLDEA SGFNIPAEQA SRPWTQPRGA EPEAQDVDPR PEAEEEELPW
CCICNEDATL RCAGCDGDLF CARCFREGHD AFELKEHQTS AYSPPRAGQE H
//
ID ZFY19_HUMAN Reviewed; 471 AA.
AC Q96K21; B3KVB2; C9JNF4; H3BUF9; Q86WC2; Q8WU96;
DT 24-MAY-2005, integrated into UniProtKB/Swiss-Prot.
read moreDT 18-MAY-2010, sequence version 3.
DT 22-JAN-2014, entry version 103.
DE RecName: Full=Zinc finger FYVE domain-containing protein 19;
DE AltName: Full=MLL partner containing FYVE domain;
GN Name=ZFYVE19; Synonyms=MPFYVE;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), CHROMOSOMAL TRANSLOCATION WITH
RP KMT2A/MLL1, AND TISSUE SPECIFICITY.
RX PubMed=12618766; DOI=10.1038/sj.onc.1206273;
RA Chinwalla V., Chien A., Odero M., Neilly M.B., Zeleznik-Le N.J.,
RA Rowley J.D.;
RT "A t(11;15) fuses MLL to two different genes, AF15q14 and a novel gene
RT MPFYVE on chromosome 15.";
RL Oncogene 22:1400-1410(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 19-471 (ISOFORM 1), AND VARIANT
RP ALA-376.
RC TISSUE=Ovary, and Synovium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human
RT chromosome 15.";
RL Nature 440:671-675(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-471 (ISOFORM 3), AND
RP VARIANT ALA-376.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, AND MASS
RP SPECTROMETRY.
RC TISSUE=T-cell;
RX PubMed=19367720; DOI=10.1021/pr800500r;
RA Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J.;
RT "Phosphorylation analysis of primary human T lymphocytes using
RT sequential IMAC and titanium oxide enrichment.";
RL J. Proteome Res. 7:5167-5176(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, AND MASS
RP SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, AND MASS
RP SPECTROMETRY.
RC TISSUE=Liver;
RX PubMed=18318008; DOI=10.1002/pmic.200700884;
RA Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,
RA Zou H., Gu J.;
RT "Large-scale phosphoproteome analysis of human liver tissue by
RT enrichment and fractionation of phosphopeptides with strong anion
RT exchange chromatography.";
RL Proteomics 8:1346-1361(2008).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, PHOSPHORYLATION
RP [LARGE SCALE ANALYSIS] AT SER-286 (ISOFORM 3), AND MASS SPECTROMETRY.
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-243; SER-354 AND
RP SER-463, AND MASS SPECTROMETRY.
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
RA Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full
RT phosphorylation site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354, AND MASS
RP SPECTROMETRY.
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA Blagoev B.;
RT "System-wide temporal characterization of the proteome and
RT phosphoproteome of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q96K21-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96K21-2; Sequence=VSP_013791;
CC Name=3;
CC IsoId=Q96K21-3; Sequence=VSP_013792;
CC Note=No experimental confirmation available. Contains a
CC phosphoserine at position 286;
CC Name=4;
CC IsoId=Q96K21-4; Sequence=VSP_046008;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Detected in brain, heart, skeletal muscle,
CC kidney and liver.
CC -!- DISEASE: Note=A chromosomal aberration involving ZFYVE19 is
CC associated with acute myeloblastic leukemia (AML). Translocation
CC t(11;15)(q23;q14) with KMT2A/MLL1.
CC -!- SIMILARITY: Contains 1 FYVE-type zinc finger.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH21092.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC Sequence=AAO73862.1; Type=Frameshift; Positions=459;
CC Sequence=BAB55338.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
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DR EMBL; AF445414; AAO73862.1; ALT_FRAME; mRNA.
DR EMBL; AK027746; BAB55338.1; ALT_INIT; mRNA.
DR EMBL; AK122779; BAG53724.1; -; mRNA.
DR EMBL; AC012476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471125; EAW92451.1; -; Genomic_DNA.
DR EMBL; BC021092; AAH21092.1; ALT_INIT; mRNA.
DR RefSeq; NP_001070736.1; NM_001077268.1.
DR RefSeq; NP_001245349.1; NM_001258420.1.
DR RefSeq; NP_001245350.1; NM_001258421.1.
DR RefSeq; NP_116239.3; NM_032850.4.
DR UniGene; Hs.121676; -.
DR ProteinModelPortal; Q96K21; -.
DR SMR; Q96K21; 76-150, 418-471.
DR IntAct; Q96K21; 1.
DR STRING; 9606.ENSP00000347498; -.
DR PhosphoSite; Q96K21; -.
DR DMDM; 296453076; -.
DR PaxDb; Q96K21; -.
DR PRIDE; Q96K21; -.
DR Ensembl; ENST00000299173; ENSP00000299173; ENSG00000166140.
DR Ensembl; ENST00000336455; ENSP00000337824; ENSG00000166140.
DR Ensembl; ENST00000355341; ENSP00000347498; ENSG00000166140.
DR Ensembl; ENST00000564258; ENSP00000457617; ENSG00000166140.
DR GeneID; 84936; -.
DR KEGG; hsa:84936; -.
DR UCSC; uc001zmt.1; human.
DR CTD; 84936; -.
DR GeneCards; GC15P041099; -.
DR H-InvDB; HIX0012140; -.
DR HGNC; HGNC:20758; ZFYVE19.
DR HPA; HPA040283; -.
DR neXtProt; NX_Q96K21; -.
DR PharmGKB; PA134906967; -.
DR eggNOG; NOG291948; -.
DR HOGENOM; HOG000231992; -.
DR HOVERGEN; HBG057281; -.
DR InParanoid; Q96K21; -.
DR OMA; ASGYNIP; -.
DR GeneWiki; ZFYVE19; -.
DR GenomeRNAi; 84936; -.
DR NextBio; 75384; -.
DR PRO; PR:Q96K21; -.
DR ArrayExpress; Q96K21; -.
DR Bgee; Q96K21; -.
DR CleanEx; HS_ZFYVE19; -.
DR Genevestigator; Q96K21; -.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromosomal rearrangement; Coiled coil;
KW Complete proteome; Metal-binding; Phosphoprotein; Polymorphism;
KW Proto-oncogene; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1 471 Zinc finger FYVE domain-containing
FT protein 19.
FT /FTId=PRO_0000098718.
FT ZN_FING 74 133 FYVE-type.
FT COILED 311 375 Potential.
FT COMPBIAS 412 417 Poly-Glu.
FT COMPBIAS 421 444 Cys-rich.
FT SITE 145 146 Breakpoint for translocation to form
FT KMT2A/MLL1-ZFYVE19.
FT MOD_RES 243 243 Phosphothreonine.
FT MOD_RES 354 354 Phosphoserine.
FT MOD_RES 463 463 Phosphoserine.
FT VAR_SEQ 1 175 Missing (in isoform 4).
FT /FTId=VSP_046008.
FT VAR_SEQ 1 93 MNYDSQQPPLPPLPYAGCRRASGFPALGRGGTVPVGVWGGA
FT GQGREGRSWGEGPRGPGLGRRDLSSADPAVLGATMESRCYG
FT CAVKFTLFKKE -> MPAVAEALGQEGPPDLSRSAFLATVL
FT TSLSAAFSSMPSSAYSLPFSRSLELDYHTSSCFRGTMVKAD
FT CPVPITDLPDSSGKLQ (in isoform 2).
FT /FTId=VSP_013791.
FT VAR_SEQ 276 343 Missing (in isoform 3).
FT /FTId=VSP_013792.
FT VARIANT 210 210 R -> H (in dbSNP:rs34819163).
FT /FTId=VAR_057494.
FT VARIANT 376 376 S -> A (in dbSNP:rs690347).
FT /FTId=VAR_060474.
FT VARIANT 398 398 R -> C (in dbSNP:rs72735636).
FT /FTId=VAR_060475.
FT CONFLICT 104 104 C -> R (in Ref. 5; AAH21092).
SQ SEQUENCE 471 AA; 51546 MW; 0F07D2DDFD19864D CRC64;
MNYDSQQPPL PPLPYAGCRR ASGFPALGRG GTVPVGVWGG AGQGREGRSW GEGPRGPGLG
RRDLSSADPA VLGATMESRC YGCAVKFTLF KKEYGCKNCG RAFCSGCLSF SAAVPRTGNT
QQKVCKQCHE VLTRGSSANA SKWSPPQNYK KRVAALEAKQ KPSTSQSQGL TRQDQMIAER
LARLRQENKP KLVPSQAEIE ARLAALKDER QGSIPSTQEM EARLAALQGR VLPSQTPQPA
HHTPDTRTQA QQTQDLLTQL AAEVAIDESW KGGGPAASLQ NDLNQGGPGS TNSKRQANWS
LEEEKSRLLA EAALELREEN TRQERILALA KRLAMLRGQD PERVTLQDYR LPDSDDDEDE
ETAIQRVLQQ LTEEASLDEA SGFNIPAEQA SRPWTQPRGA EPEAQDVDPR PEAEEEELPW
CCICNEDATL RCAGCDGDLF CARCFREGHD AFELKEHQTS AYSPPRAGQE H
//