Full text data of ZG16B
ZG16B
[Confidence: low (only semi-automatic identification from reviews)]
Zymogen granule protein 16 homolog B; Flags: Precursor
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Zymogen granule protein 16 homolog B; Flags: Precursor
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q96DA0
ID ZG16B_HUMAN Reviewed; 208 AA.
AC Q96DA0; A6NIY1; B2R4F6; Q6UW28;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 10-JUL-2007, sequence version 3.
DT 22-JAN-2014, entry version 78.
DE RecName: Full=Zymogen granule protein 16 homolog B;
DE Flags: Precursor;
GN Name=ZG16B; ORFNames=UNQ773/PRO1567;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung carcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-208.
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=11678034;
RX DOI=10.1002/1615-9861(200104)1:5<641::AID-PROT641>3.3.CO;2-I;
RA Kuster B., Mortensen P., Andersen J.S., Mann M.;
RT "Mass spectrometry allows direct identification of proteins in large
RT genomes.";
RL Proteomics 1:641-650(2001).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 53-208.
RX PubMed=21110947; DOI=10.1016/j.bbrc.2010.11.093;
RA Kanagawa M., Satoh T., Ikeda A., Nakano Y., Yagi H., Kato K.,
RA Kojima-Aikawa K., Yamaguchi Y.;
RT "Crystal structures of human secretory proteins ZG16p and ZG16b reveal
RT a Jacalin-related beta-prism fold.";
RL Biochem. Biophys. Res. Commun. 404:201-205(2011).
CC -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC -!- SIMILARITY: Belongs to the jacalin lectin family.
CC -!- CAUTION: It is uncertain whether Met-1, Met-13 or Met-31 is the
CC initiator.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ89380.1; Type=Erroneous initiation;
CC Sequence=BAG34753.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY359021; AAQ89380.1; ALT_INIT; mRNA.
DR EMBL; AC005361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471112; EAW85462.1; -; Genomic_DNA.
DR EMBL; BC009722; AAH09722.2; -; mRNA.
DR EMBL; AK311810; BAG34753.1; ALT_INIT; mRNA.
DR RefSeq; NP_660295.2; NM_145252.2.
DR UniGene; Hs.105887; -.
DR PDB; 3AQG; X-ray; 2.75 A; A/B=53-208.
DR PDBsum; 3AQG; -.
DR ProteinModelPortal; Q96DA0; -.
DR SMR; Q96DA0; 54-186.
DR IntAct; Q96DA0; 2.
DR MINT; MINT-2878507; -.
DR STRING; 9606.ENSP00000371715; -.
DR PhosphoSite; Q96DA0; -.
DR DMDM; 152031723; -.
DR PaxDb; Q96DA0; -.
DR PRIDE; Q96DA0; -.
DR DNASU; 124220; -.
DR Ensembl; ENST00000382280; ENSP00000371715; ENSG00000162078.
DR Ensembl; ENST00000572863; ENSP00000461740; ENSG00000162078.
DR GeneID; 124220; -.
DR KEGG; hsa:124220; -.
DR UCSC; uc002cru.3; human.
DR CTD; 124220; -.
DR GeneCards; GC16P002881; -.
DR HGNC; HGNC:30456; ZG16B.
DR HPA; HPA041125; -.
DR neXtProt; NX_Q96DA0; -.
DR PharmGKB; PA164727732; -.
DR eggNOG; NOG73975; -.
DR HOGENOM; HOG000155786; -.
DR InParanoid; Q96DA0; -.
DR OMA; WNYPLEE; -.
DR OrthoDB; EOG73FQQ7; -.
DR GeneWiki; LOC124220; -.
DR GenomeRNAi; 124220; -.
DR NextBio; 81240; -.
DR PRO; PR:Q96DA0; -.
DR ArrayExpress; Q96DA0; -.
DR Bgee; Q96DA0; -.
DR Genevestigator; Q96DA0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.100.10.30; -; 1.
DR InterPro; IPR001229; Mannose-bd_lectin.
DR SMART; SM00915; Jacalin; 1.
DR SUPFAM; SSF51101; SSF51101; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Glycoprotein; Lectin; Polymorphism;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1 52 Potential.
FT CHAIN 53 208 Zymogen granule protein 16 homolog B.
FT /FTId=PRO_0000248073.
FT COMPBIAS 38 46 Poly-Leu.
FT CARBOHYD 197 197 N-linked (GlcNAc...) (Potential).
FT VARIANT 133 133 M -> V (in dbSNP:rs35533993).
FT /FTId=VAR_060067.
FT STRAND 56 58
FT STRAND 61 65
FT STRAND 74 81
FT STRAND 83 97
FT STRAND 106 112
FT STRAND 119 137
FT STRAND 142 146
FT STRAND 150 155
FT STRAND 163 172
FT STRAND 175 184
SQ SEQUENCE 208 AA; 22739 MW; 313B0ED64B24CDB2 CRC64;
MGAQGAQESI KAMWRVPGTT RRPVTGESPG MHRPEAMLLL LTLALLGGPT WAGKMYGPGG
GKYFSTTEDY DHEITGLRVS VGLLLVKSVQ VKLGDSWDVK LGALGGNTQE VTLQPGEYIT
KVFVAFQAFL RGMVMYTSKD RYFYFGKLDG QISSAYPSQE GQVLVGIYGQ YQLLGIKSIG
FEWNYPLEEP TTEPPVNLTY SANSPVGR
//
ID ZG16B_HUMAN Reviewed; 208 AA.
AC Q96DA0; A6NIY1; B2R4F6; Q6UW28;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
read moreDT 10-JUL-2007, sequence version 3.
DT 22-JAN-2014, entry version 78.
DE RecName: Full=Zymogen granule protein 16 homolog B;
DE Flags: Precursor;
GN Name=ZG16B; ORFNames=UNQ773/PRO1567;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung carcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-208.
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=11678034;
RX DOI=10.1002/1615-9861(200104)1:5<641::AID-PROT641>3.3.CO;2-I;
RA Kuster B., Mortensen P., Andersen J.S., Mann M.;
RT "Mass spectrometry allows direct identification of proteins in large
RT genomes.";
RL Proteomics 1:641-650(2001).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 53-208.
RX PubMed=21110947; DOI=10.1016/j.bbrc.2010.11.093;
RA Kanagawa M., Satoh T., Ikeda A., Nakano Y., Yagi H., Kato K.,
RA Kojima-Aikawa K., Yamaguchi Y.;
RT "Crystal structures of human secretory proteins ZG16p and ZG16b reveal
RT a Jacalin-related beta-prism fold.";
RL Biochem. Biophys. Res. Commun. 404:201-205(2011).
CC -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC -!- SIMILARITY: Belongs to the jacalin lectin family.
CC -!- CAUTION: It is uncertain whether Met-1, Met-13 or Met-31 is the
CC initiator.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ89380.1; Type=Erroneous initiation;
CC Sequence=BAG34753.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY359021; AAQ89380.1; ALT_INIT; mRNA.
DR EMBL; AC005361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471112; EAW85462.1; -; Genomic_DNA.
DR EMBL; BC009722; AAH09722.2; -; mRNA.
DR EMBL; AK311810; BAG34753.1; ALT_INIT; mRNA.
DR RefSeq; NP_660295.2; NM_145252.2.
DR UniGene; Hs.105887; -.
DR PDB; 3AQG; X-ray; 2.75 A; A/B=53-208.
DR PDBsum; 3AQG; -.
DR ProteinModelPortal; Q96DA0; -.
DR SMR; Q96DA0; 54-186.
DR IntAct; Q96DA0; 2.
DR MINT; MINT-2878507; -.
DR STRING; 9606.ENSP00000371715; -.
DR PhosphoSite; Q96DA0; -.
DR DMDM; 152031723; -.
DR PaxDb; Q96DA0; -.
DR PRIDE; Q96DA0; -.
DR DNASU; 124220; -.
DR Ensembl; ENST00000382280; ENSP00000371715; ENSG00000162078.
DR Ensembl; ENST00000572863; ENSP00000461740; ENSG00000162078.
DR GeneID; 124220; -.
DR KEGG; hsa:124220; -.
DR UCSC; uc002cru.3; human.
DR CTD; 124220; -.
DR GeneCards; GC16P002881; -.
DR HGNC; HGNC:30456; ZG16B.
DR HPA; HPA041125; -.
DR neXtProt; NX_Q96DA0; -.
DR PharmGKB; PA164727732; -.
DR eggNOG; NOG73975; -.
DR HOGENOM; HOG000155786; -.
DR InParanoid; Q96DA0; -.
DR OMA; WNYPLEE; -.
DR OrthoDB; EOG73FQQ7; -.
DR GeneWiki; LOC124220; -.
DR GenomeRNAi; 124220; -.
DR NextBio; 81240; -.
DR PRO; PR:Q96DA0; -.
DR ArrayExpress; Q96DA0; -.
DR Bgee; Q96DA0; -.
DR Genevestigator; Q96DA0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.100.10.30; -; 1.
DR InterPro; IPR001229; Mannose-bd_lectin.
DR SMART; SM00915; Jacalin; 1.
DR SUPFAM; SSF51101; SSF51101; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Complete proteome; Glycoprotein; Lectin; Polymorphism;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1 52 Potential.
FT CHAIN 53 208 Zymogen granule protein 16 homolog B.
FT /FTId=PRO_0000248073.
FT COMPBIAS 38 46 Poly-Leu.
FT CARBOHYD 197 197 N-linked (GlcNAc...) (Potential).
FT VARIANT 133 133 M -> V (in dbSNP:rs35533993).
FT /FTId=VAR_060067.
FT STRAND 56 58
FT STRAND 61 65
FT STRAND 74 81
FT STRAND 83 97
FT STRAND 106 112
FT STRAND 119 137
FT STRAND 142 146
FT STRAND 150 155
FT STRAND 163 172
FT STRAND 175 184
SQ SEQUENCE 208 AA; 22739 MW; 313B0ED64B24CDB2 CRC64;
MGAQGAQESI KAMWRVPGTT RRPVTGESPG MHRPEAMLLL LTLALLGGPT WAGKMYGPGG
GKYFSTTEDY DHEITGLRVS VGLLLVKSVQ VKLGDSWDVK LGALGGNTQE VTLQPGEYIT
KVFVAFQAFL RGMVMYTSKD RYFYFGKLDG QISSAYPSQE GQVLVGIYGQ YQLLGIKSIG
FEWNYPLEEP TTEPPVNLTY SANSPVGR
//